Abstract: A system and method of adjusting a field of view in an imaging system includes transmitting light across a transmission optical path and defining a field of view encompassing both uniform and spatially tenuous target objects within the transmitted light. A sensor within a return optical path of reflected light from at least a portion of one of the target objects allows a data processing computer to compile an image from a series of data outputs from the sensor. The image is analyzed to determine a region of interest within the image and by dynamically adjusting the light source, the computer is configured to change the field of view of the light source such that the image includes a higher resolution and/or signal intensity for the region of interest. The region of interest may include at least one spatially tenuous target object.

Abstract: An automated magazine loading device having an ammunition hopper adapted to receive a firearm cartridge and a conveyor coupled to the ammunition hopper. The conveyor is configured to transport the firearm cartridge to a projectile indexer located in proximity to the conveyor and the conveyor is configured to deposit the firearm cartridge into the projectile indexer in a first orientation. The projectile indexer is configured to reorient the firearm cartridge into a second orientation. The projectile indexer also includes a port for receiving a magazine therein. Finally, the automated magazine loading device includes an actuator for engaging the firearm cartridge and inserting the firearm cartridge into the magazine.

Abstract: Angelman Syndrome (AS) is a genetic disorder occurring in approximately one in every 15,000 births. It is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. The gene responsible for AS was discovered to be UBE3A and encodes for E6-AP, an ubiquitin ligase. A unique feature of this gene is that it undergoes maternal imprinting in a neuron-specific manner. In the majority of AS cases, there is a mutation or deletion in the maternally inherited UBE3A gene, although other cases are the result of uniparental disomy or mismethylation of the maternal gene. While most human disorders characterized by severe mental retardation involve abnormalities in brain structure, no gross anatomical changes are associated with AS. We have generated a Ube3a protein with additional sequences that should allow the secretion from cells and uptake by neighboring neuronal cells. This would confer a functional E6-AP protein into the neurons and rescue disease pathology.

Abstract: The present disclosure presents various systems and methods for implementing a physical unclonable function device. One such method comprises providing an integrated circuit having a plurality of set/reset flip flop logic circuits, wherein each of the set/reset flip flop logic circuits enters a metastable state for a particular input sequence. The method includes varying circuit parameters for each of the plurality of set/reset flip flop logic circuits to account for manufacturing variations in the set/reset flip flop logic circuits and enable generating a stable but random output in response to the particular input sequence. Thus, by applying the particular input sequence to the integrated circuit, a unique identifier for the integrated circuit can be derived from an output response of the plurality of set/reset flip flop logic circuits.

Abstract: A hydrogen evolution assisted electroplating nozzle includes a nozzle tip configured to interface with a portion of a substructure. The nozzle also includes an inner coaxial tube connected to a reservoir containing an electrolyte and an anode, the inner coaxial tube configured to dispense the electrolyte through the nozzle tip onto the portion of the substructure. The nozzle also includes an outer coaxial tube encompassing the inner coaxial tube, the outer coaxial tube configured to extract the electrolyte from the portion of the substructure. The nozzle also includes at least one contact pin configured to make electrical contact with a conductive track on the substrate.

Abstract: A deep tendon reflex-eliciting device actuated by pressure against a patient's skin, which releases a spring-loaded mass that delivers an impulse through a fully-enclosed housing. This device includes a weight contained within the casings, and a mainspring in communication with the weight. The mainspring has a bias toward expansion. In the compressed position, the mainspring is also compressed, and the weight is pushed backwards into the rear casing. The weight is released to be driven forward by the mainspring. The weight strikes the inside of the forward casing, delivering an impulse to a surface against Which the device is pressed. A reset spring can push apart the forward and rear casings to reset the device to its expanded position. A case screw is also included which is able to consistently set the impact force of the device.

Abstract: The clustered regularly interspaced short palindromic repeat (CRISPR) gene editing technique, based on the non-homologous end-joining (NHEJ) repair pathway, can efficiently generate gene knockouts of variably sizes. More precise genome editing, either the insertion or deletion of a desired fragment, can be done by combining the homology-directed-repair (HDR) pathway with CRISPR cleavage. HDR-mediated gene knock-in experiments are inefficient, with no reports of successful gene knock-in with DNA fragments larger than 4 kb. Targeted insertion of large DNA fragments (7.4 and 5.8 kb) into the genomes of mouse embryonic stem cells and zygotes, respectively, using the CRISPR/HDR technique without NHEJ inhibitors was performed and indicate that CRISPR/HDR without NHEJ inhibitors can result in highly efficient gene knock-in, equivalent to CRISPR/HDR with NHEJ inhibitors.

Abstract: Disclosed are various embodiments for performing a join operation using a graphics processing unit (GPU). The GPU can receive input data including sequences or tuples. The GPU can initialize a histogram in a memory location shared by threads. The GPU can build the histogram of hash values for the sequences. The GPU can reorder the sequences based on the histogram. The GPU can probe partitions and store the results in a buffer pool. The GPU can output the results of the join.

Abstract: Education curricula materials include encoded indicia such as a QR code that contains information related to identifying requested augmented reality image data from a server over a network. By scanning the QR code, a computer uses its decoding software to create a data set for transmitting to the server. The data set may include an identifier for selected augmented reality image data associated with the user's curriculum, information about the curriculum at issue, the academic level of the user, and any other data necessary to ensure that the most appropriate augmented reality image data is transmitted back to the computer. The server transmits comprehensive augmented reality image data back to the computer for viewing on a computerized display accessible by a student. Part of the content may include an interactive pedagogical agent that helps the student with a part of the instruction related to a portion of the curriculum.

Abstract: An off-the-shelf oral splint that is operatively secured to the maxilla and mandible to assist in reduction and provide maintenance of reduction of maxillary and mandibular fractures in the edentulous or partially edentulous patient. The oral splint is fabricated into a plurality of standardized sizes. These sizes are determined by imaging a population of jaws, measuring dimensions thereof, manipulating (e.g., calculating the mean) these dimensions, and generating a size that is representative of a subset of that population. This can be done for all sizes that would represent individuals in that population. The splint itself is fabricated virtually by creating “U-shapes”, splitting them horizontally into halves, creating an evacuation channel, and generating a coupling mechanism to hold the halves together. The splint can then be printed or otherwise manufactured.

Abstract: Disclosed are compositions and methods for ex vivo expansion of tumor-infiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumor-infiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes expanded by the disclosed methods.

Abstract: An electrochromic device including a single unitary active layer with a dye having a nitrogen group and a conducting polymer having a nitrogen group. The active layer has a first color in an oxidized state and a second color in a reduced state; the electrochromic device has no other active layer.

Abstract: In one embodiment, a robotic end effector configured to mount to a robotic manipulator includes gripping elements configured to grasp objects, a drive mechanism configured to open and close the gripping elements, a central controller configured to control operation of the drive mechanism and the gripper elements, the central controller hosting a control program that enables control of the end effector independent of the robotic manipulator, and at least one of a forward-facing ultrasonic distance sensor configured to measure a distance between the gripping elements and an object to be grasped, and a forward-facing camera mounted between the gripping elements configured to capture video data of an object to be grasped.

Abstract: A system and method utilizing a novel dynamic sidelobe multiplexing (DSM) is proposed for the applications in beamspace multiple-input multiple-output (MIMO) systems. The DSM technique pre-codes the transmitted data over transmitter beams in order to open up a new path to the receiver.

Abstract: Disclose herein is a portable platform based on a direct digital synthesizer (DDS) is investigated for the orthogonal SAW sensor, integrating signal synthesis, gain control, phase/amplitude measurement, and data processing in a small, portable electronic system. The disclosed platform allows for simultaneous removal of non-specific binding proteins, and mixing, as well as improved incubation time.

Abstract: Identifying insect species integrates image processing, feature selection, unsupervised clustering, and a support vector machine (SVM) learning algorithm for classification. Results with a total of 101 mosquito specimens spread across nine different vector carrying species demonstrate high accuracy in species identification. When implemented as a smart-phone application, the latency and energy consumption were minimal. The currently manual process of species identification and recording can be sped up, while also minimizing the ensuing cognitive workload of personnel. Citizens at large can use the system in their own homes for self-awareness and share insect identification data with public health agencies.

Abstract: The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of A? peptide in neural tissue. The subject invention also concerns materials and methods for treating and/or preventing stress disorders, such as post-traumatic stress disorder (PTSD). In one embodiment, a method of the invention comprises administering a therapeutically effective amount of cotinine, or a pharmaceutically acceptable salt thereof, to a person or animal in need of treatment. The methods of the invention can be used to prevent and/or treat Alzheimer's disease, Parkinson's disease, and/or Down's syndrome. The subject invention also concerns compositions that comprise cotinine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or adjuvant.

Abstract: An apparatus and method are provided for mitigating performance degradation in digital low-dropout voltage regulators (DLDOs) caused by the effects of aging on the power transistors of the DLDO, such as by the effects of negative bias temperature instability (NBTI)-induced aging, for example. The apparatus comprises a shift register for use in a DLDO that is configured to activate and deactivate power transistors of the DLDO to evenly distribute electrical stress among the transistors in a way that mitigates performance degradation of the DLDO under various load current conditions. In addition, the shift register and methodology can be implemented in such a way that nearly no extra power and area overhead are consumed.

Abstract: Disclosed are various embodiments for integrated diffuse correlation spectroscopy. A first control signal can be sent to a switch to cause an integrator to integrate a current from a photodiode. An integrated current can be received from the integrator, and a data signal can be sent to a computing device based at least in part on the integrated current. A second control signal can be sent to a switch to cause the integrator to cease integrating the current from the photodiode.