Abstract: There is described herein the use of mirtazapine in methods for the treatment of inflammatory disorders, autoimmune disease, and PBC.

Abstract: A method of treating a mammalian subject having hematologic, non-tumorous cancer cells is disclosed. The method comprises the steps of: (A) administering to such a mammalian subject a therapeutically effective amount of a halogenated xanthene, a pharmaceutically acceptable salt or a C1-C4 alkyl ester thereof as a first cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable aqueous medium. The mammalian subject is maintained for a period of time sufficient to induce death of hematologic, non-tumorous cancer cells. A contemplated administration is typically repeated. A contemplated treatment method can also be carried out in conjunction with administration to said mammalian subject of a second therapeutically effective amount of a second, differently-acting cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable medium. The second cancer cytotoxic agent can be a small molecule or an intact antibody or paratope-containing portion thereof.

Abstract: The invention provides a membrane-free redox cell utilizing auxiliary electrodes that facilitate fast charging and discharging of anolyte and catholyte for electrochemical energy storage. The anode and cathode chambers are ionically separated, and electrically connected through a conductor joining auxiliary electrodes comprised of a redox material. In use, charging/discharging of the galvanic cell takes place between primary electrodes, and the redox material is immersed in the electrolyte in both anode and cathode chambers.

Abstract: Methods of reducing symptoms of opioid withdrawal syndrome and risk of relapse to drug seeking are provided. The method comprises administering to the subject an effective amount of probenecid.

Abstract: A medicament for treating or preventing pruritus is provided. For the medicament for treating or preventing pruritus, a compound having a blocking action on Cav3.2T-type calcium channels represented by General Formulas (I) to (VI), a tautomer of the compound, a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an active ingredient.

Abstract: The invention provides highly reactive nano-sized alumina particle compositions, including alumina compositions with a BET surface areas on the order of 2000 m2/g. Also disclosed are impregnated alumina supports comprising materials that are metal oxides or carbonates. Methods for the synthesis and fabrication of these compositions are provided, along methods for the use of these compositions as sorbents.

Abstract: Systems and methods for use in aiding an inertial navigation system during a GNSS signal outage. An ultrasonic transceiver is positioned adjacent a wheel of a vehicle and reflections of the emitted signal are used to determine changes of direction and/or to determine a distance traveled by the vehicle. For changes of direction, the transceiver is adjacent to a front wheel such that left or right turns cause the wheel to interrupt a signal path from the transceiver to a reflector. For distance estimates, the transceiver is adjacent a back wheel of the vehicle. The ultrasonic signal is reflected off of solid sections of the wheel or passes through void sections of the wheel. The measurements obtained can be processed in various ways to estimate number of rotations of the wheel and, accordingly, the distance traveled by the vehicle.

Abstract: The present disclosure relates to analogs of N-acetyl glucosamine fluorinated at 4- and/or 6-position(s) and derivatives of xylose at anomeric position for the treatment of a neurological disease, inflammation, cancer and a central nervous system injury.

Abstract: This disclosure provides methods of making functionalized PEG iron oxide nanoparticles.

Abstract: There is described a pipe apparatus having two circular coaxial layers, inner and outer, defining an annular gap therebetween. At least one segmentation ring with a predesigned opening is placed within the annular gap. The pipe system is composed of interconnected pipe apparatuses of the same type. Compact wireless stations are embedded in the segmentation rings within sealed predesigned openings forming a wireless information and communication network (WICN). Each segmentation ring incorporates a pressure relief mechanism. When a layer of a given pipe apparatus breaks and fluid leaks into the annular gap in a given segment, the segmentation rings surrounding that segment temporarily retain the fluid and the WICN is disturbed in the affected area. At least one external central unit monitors WICN activity and integrity inside the pipe system and detects such leakage, before the leak spreads to another segment of the pipe system, without reaching the outside environment.

Abstract: A method of screening a compound or a composition for use in modulating opioid withdrawal symptoms in a mammal. The method comprises the steps of: selecting a group of test animals; separating the group into two subgroups; inducing Panx1 activation or expression in both subgroups; dosing a first subgroup with a candidate compound; dosing a second subgroup with a placebo; measuring ATP released in spinal microglia of test animals in the first subgroup and in the spinal microglia of test animals in the second subgroup; quantifying the difference in ATP released in spinal microglia of test animals in the first subgroup and in the spinal microglia of test animals in the second subgroup; if the difference in the ATP released in the first subgroup and the APT released in the second subgroup is greater than 25%, then formulating the candidate compound into a pharmaceutical composition.

Abstract: Silica modified vaterite Janus nanoparticles are provided, together with methods for the synthesis of such particles. The disclosed methods make use of a Pickering emulsion, in a scalable aqueous process. The silica-modified surface is amenable to chemical modification, for example with physiologically acceptable labels.

Abstract: Combinations of a nitroprusside, such as sodium nitroprusside (SNP; Na2[Fe(CN)5NO].2H2O) and a nitrate, are provided, together with methods for the combined use of the nitroprusside and the nitrate as metabolic inhibitors of microbial cultures. The microbial cultures may include sulfate reducing bacteria (SRB) in aqueous culture. This metabolic inhibition may for example be implemented in the presence of a hydrocarbon, for example in an oil reservoir or in oil field systems and facilities. When applied to an SRB culture in the presence of a hydrocarbon, the combination of the nitroprusside and the nitrate may accordingly be used to ameliorate the biological formation of sulfides, particularly hydrogen sulfide.

Abstract: Systems and methods relating to analog-to-digital converters. A delay block receives an input signal at the same time as a coarse ADC (CADC) block. The CADC block produces a multi-bit output and this output is applied to a signal processing block. The delay block delays the input signal from being applied to the signal processing block until the output of the CADC block has been applied/configures the signal processing block. The signal processing block may be a signal shifter, the output of which is ultimately applied to a fine ADC (FADC) block. In an alternative, the signal processing block may be the FADC block. Regardless of the configuration, the output of the CADC is delayed until the output of the FADC block is available. The outputs of the CADC and the FADC blocks are then simultaneously applied to an encoder that produces the overall system output.

Abstract: Method for making a Zn MOF of formula Zn2Ht2CL, where Ht is 1,2,4-triazolate or a combination of 1,2,4-triazolate and one or more other cycloazocarbyl compound, and CL is oxalate or a combination of oxalate and one or more chelating ligand other than oxalate. More specifically, the Zn MOF is Zn2Tz2Ox, where Tz is 1,2,4-triazolate and Ox is oxalate. The method includes reacting 2 molar equivalents of 1,2,4-triazole or the combination with cycloazocarbyl compound with 1 molar equivalent of oxalate or the combination with other chelating ligand and adding 2 molar equivalents of Zn2+ to form the Zn MOF. The solvent used can be a lower alcohol or a miscible mixture of water and a lower alcohol. One or both reaction steps are conducted at a temperature less than or equal to 120° C. and can be conducted at room temperature and ambient pressure.

Abstract: A method of inducing a Type I interferon response in a mammalian subject that presents with a microbial infection, cancerous tumor or hematological malignancy that comprises administering an amount of a halogenated xanthene as discussed above, effective to induce the Type I interferon response. A method of enhancing a mammalian immunogen-specific immune response that comprises contacting mammalian cells, in vivo or present in a mammalian cell growth supporting medium, with an adjuvant-effective amount of a halogenated xanthene, and an immunogen to which that response is to be enhanced. A mammalian HX compound-adjuvanted vaccine composition that contains an immunogen present in a vaccine-effective amount along with an adjuvant-effective amount of a halogenated xanthene (HX) compound and one or more excipients present at about 0.001% by weight to 10% by weight of the vaccine composition dissolved or dispersed in a pharmaceutically acceptable diluent.

Abstract: The present invention relates to methods and systems for predicting biomechanical response to wedged insoles. In accordance with one aspect, a method for predicting a biomechanical response to a wedged insole is provided. In a further aspect, a system for predicting a biomechanical response to wedged insole is provided.

Abstract: A method of treating a pediatric cancerous solid tumor in a mammalian subject is disclosed that comprises intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor. Another contemplated method comprises the steps of intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor and systemically administering a tumor-inhibiting effective amount of a systemic anti-cancer medication that provides synergistic cytotoxicity with the halogenated xanthene. The two administrations can occur concurrently, or one prior to the other.

Abstract: There is described herein a metal organic framework (MOF) composite material, the composite material having a MOF entrapped within a hydrogel.

Abstract: A system for controlling a drill string located in a borehole. The drill string has a top portion and a bottom hole assembly (BHA) coupled thereto. The system includes: a processor; sensors coupled to the top portion of the drill string and to the processor. The sensors configured to measure values of variables of the top portion of the drill string, to obtain top portion measured value. A non-transitory tangible computer readable medium having instructions recorded thereon are carried out by the processor to obtain a soft sensor to generate estimated values of variables of the BHA in accordance with the top portion measured values and in accordance with angular motion equations of the drill string. A drill string controller is configured to generate a control signal in accordance with the estimated values of variables of the BHA to control the top portion in accordance with the control signal.