Abstract: A method of treating a mammalian subject having hematologic, non-tumorous cancer cells is disclosed. The method comprises the steps of: (A) administering to such a mammalian subject a therapeutically effective amount of a halogenated xanthene, a pharmaceutically acceptable salt or a C1-C4 alkyl ester thereof as a first cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable aqueous medium. The mammalian subject is maintained for a period of time sufficient to induce death of hematologic, non-tumorous cancer cells. A contemplated administration is typically repeated. A contemplated treatment method can also be carried out in conjunction with administration to said mammalian subject of a second therapeutically effective amount of a second, differently-acting cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable medium. The second cancer cytotoxic agent can be a small molecule or an intact antibody or paratope-containing portion thereof.

Abstract: A method of treating a pediatric cancerous solid tumor in a mammalian subject is disclosed that comprises intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor. Another contemplated method comprises the steps of intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor and systemically administering a tumor-inhibiting effective amount of a systemic anti-cancer medication that provides synergistic cytotoxicity with the halogenated xanthene. The two administrations can occur concurrently, or one prior to the other.

Abstract: Systems and methods for detecting and counting steps. Acceleration data is used to determine acceleration norms. Peaks and valleys in the resulting acceleration norms data are then detected. These peaks and valleys are indicative of steps and are validated using measurements from gyroscopes and magnetometers. The systems and methods can thus be used to assist in location tracking and/or navigation.

Abstract: Systems and methods for detecting spoofed or illegitimate GNSS signals. A processor receives GNSS data and processes this data to extract acceleration, angular velocity, and height or altitude variation data. For the same time period, sensor data from IMU (inertial measurement unit) sensors and from a barometer are received by the processor. From the sensor data, the processor extracts similar acceleration, angular velocity, and height variation data. These two sets of data are then correlated and correlation coefficients are calculated. These correlation coefficients are then used to calculate a decision statistic. The decision statistic is compared with a predetermined value and, if the decision statistic is below a predetermined value, then the GNSS data is considered to be illegitimate or spoofed.

Abstract: This disclosure provides therapeutic compositions and methods for inducing an anti-inflammatory response and/or treating inflammation in the gastrointestinal tract and/or accumulating gut microbial antigen-specific anti-inflammatory T cells in a patient in need thereof.

Abstract: Oligomeric compounds useful as organic conjugated materials in electronic devices. Oligomeric compounds contain three or more or four or more of certain PDI units bonded to an organic core. The organic core contains one, two or more thiophene rings. The organic core can contain two or more thiophene rings separated by a linker group; two or more thiophene rings directly fused to each other or indirectly fused to each other through an optionally substituted aromatic or non-aromatic carbocylic ring system or an optionally substituted aromatic heterocyclic or non-aromatic heterocyclic ring system; or each of two or more thiophene rings is fused to an aromatic or non-aromatic carbocylic ring system or an aromatic heterocyclic or non-aromatic heterocyclic ring system and the resulting fused rings containing a thiophene ring are each separated by a linker group M. Methods for making oligomeric compounds by direct heteroarylation are provided.

Abstract: The invention provides a membrane-free redox cell utilizing auxiliary electrodes that facilitate fast charging and discharging of anolyte and catholyte for electrochemical energy storage. The anode and cathode chambers are ionically separated, and electrically connected through a conductor joining auxiliary electrodes comprised of a redox material. In use, charging/discharging of the galvanic cell takes place between primary electrodes, and the redox material is immersed in the electrolyte in both anode and cathode chambers.

Abstract: The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating various disorders, including cancers.

Abstract: This disclosure provides therapeutic compositions and methods for treating multiple sclerosis or a multiple sclerosis-related disorder in a subject in need thereof comprising administering an effective amount of an antigen-MHC-nanoparticle complex to the subject, wherein the antigen is a multiple sclerosis-related antigen.

Abstract: Processes are provided for the oxidative solubilization of metal-containing petroleum cokes in a basic aqueous solution, so as to segregate a solid metal-containing residue from a solubilized and demineralized organics fraction. Oxidation conditions are provided that optimize the yield of soluble partial oxidation products and minimize the generation of CO2. In some embodiments, a nanocrystalline copper tetrasilicate oxidation catalyst belonging to the Gillespite group of minerals may be used (Cuprorivaite (CaCuSi4O10), Wesselsite (SrCuSi4O10), Effenbergerite (BaCuSi4O10), or combinations thereof). The pH of the solubilized organics fraction may be reduced, under conditions that precipitate an upgraded carbonaceous material, in some embodiments comprising humic acid analogs, yielding a barren leachate solution.

Abstract: Methods are disclosed for dispersing nanoparticles in solvents, involving the use of a cationic species and an anionic species, where at least one of the ionic species is soluble in the nonpolar solvent and the other ionic species has a relatively strong affinity for the surface of the nanoparticles. The cationic species and the anionic species together form a cluster of ion pairs shielding the nanoparticles and enhancing their dispersibility in the nonpolar solvent.

Abstract: Embodiments of systems and methods for GNSS and INS integration are described In an embodiment, the method includes receiving a GNSS signal from a GNSS signal source at an antenna coupled to a GNSS receiver. The method may also include generating GNSS data in response to the GNSS signal. Additionally, the method may include communicating the GNSS data to an INS system. The method may also include generating an IMU signal with an IMU sensor. The method may further include generating IMU data in response to the IMU signal. Also, the method may include integrating the IMU data with the GNSS data in a navigation processing unit of an INS. The method may further include generating INS data in response to the integrated IMU data and the GNSS data.

Abstract: Combinations of a nitroprusside, such as sodium nitroprusside (SNP; Na2[Fe(CN)5NO].2H2O) and a nitrate, are provided, together with methods for the combined use of the nitroprusside and the nitrate as metabolic inhibitors of microbial cultures. The microbial cultures may include sulfate reducing bacteria (SRB) in aqueous culture. This metabolic inhibition may for example be implemented in the presence of a hydrocarbon, for example in an oil reservoir or in oil field systems and facilities. When applied to an SRB culture in the presence of a hydrocarbon, the combination of the nitroprusside and the nitrate may accordingly be used to ameliorate the biological formation of sulfides, particularly hydrogen sulfide.

Abstract: Techniques in horizontal well completions that facilitate multistage fracturing may be performed in shale gas reservoirs. The techniques may involve the creation of large scale fracture networks, connecting the reservoir and the wellbore, facilitated by activating pre-existing natural fractures (NFs). In addition, geo-mechanical characteristics facilitate the optimization of maximum stimulated reservoir volumes (SRVs). In particular, completion optimization patterns are provided for horizontal wellbores, designated herein as altered alternate fracturing (AAF) completions. Completion optimization patterns may involve a multi-step combination of simultaneous and alternate fracturing patterns. Additionally, the dynamic evolution and progression of NF growth are modeled using a variety of alternative criteria. Further, specific analyses are provided of how the well completion pattern influences the fracture network.

Abstract: In alternative aspects, the invention provides electrocoagulation processes and apparatus in which the anode oscillates in the electrochemical cell. In some embodiments, this facilitates control of the mixing conditions at the electrode surface independently from the flow through the cell. A constant DC current may be applied in the electrocoagulation, so that as the anode moves closer to a cathode, the cell voltage will oscillate. This may for example be carried out to provide a comparable degree of electrocoagulation with a net reduction in the energy consumption compared to a non-oscillating cell.

Abstract: An induction machine with integrated magnetic gears is disclosed. The machine comprises two rotors and two stators. An outer stator has ferromagnetic material, producing a rotating magnetic field with a defined number of pole pairs synchronized with a supply frequency. A high speed rotor has ferromagnetic material and a combination of rotor bars and permanent magnet pole pieces selected so that the permanent magnet pole pieces do not interact with the outer stator magnetic field. The high speed rotor rotation is asynchronously coupled to the outer stator magnetic field. An inner stator has ferromagnetic steel segments that modulate the field produced by the high speed rotor permanent magnets. A low speed inner rotor has ferromagnetic material and permanent magnet pole pieces, the low speed inner rotor counter-rotating to the high speed rotor. The low speed inner rotor is synchronously coupled to the high speed rotor using modulation harmonics.

Abstract: There is described a pipe apparatus having two circular coaxial layers, inner and outer, defining an annular gap therebetween. At least one segmentation ring with a predesigned opening is placed within the annular gap. The pipe system is composed of interconnected pipe apparatuses of the same type. Compact wireless stations are embedded in the segmentation rings within sealed predesigned openings forming a wireless information and communication network (WICN). Each segmentation ring incorporates a pressure relief mechanism. When a layer of a given pipe apparatus breaks and fluid leaks into the annular gap in a given segment, the segmentation rings surrounding that segment temporarily retain the fluid and the WICN is disturbed in the affected area. At least one external central unit monitors WICN activity and integrity inside the pipe system and detects such leakage, before the leak spreads to another segment of the pipe system, without reaching the outside environment.

Abstract: PDI derivatives useful as opto-electronically active materials or for the synthesis of such materials. Certain compounds herein function as efficient electron acceptors and are useful as electron active components of electronic devices.

Abstract: Oligomeric compounds useful as organic conjugated materials in electronic devices. Oligomeric compounds contain three or more or four or more of certain PDI units bonded to an organic core. The organic core contains one, two or more thiophene rings. The organic core can contain two or more thiophene rings separated by a linker group; two or more thiophene rings directly fused to each other or indirectly fused to each other through an optionally substituted aromatic or non-aromatic carbocylic ring system or an optionally substituted aromatic heterocyclic or non-aromatic heterocyclic ring system; or each of two or more thiophene rings is fused to an aromatic or non-aromatic carbocylic ring system or an aromatic heterocyclic or non-aromatic heterocyclic ring system and the resulting fused rings containing a thiophene ring are each separated by a linker group M. Methods for making oligomeric compounds by direct heteroarylation are provided.

Abstract: The present invention provides phosphonium-crosslinked chitosan (PCC) and methods for using the same for removal of heavy metal-ion(s) from a solution as well as methods for producing said phosphonium-crosslinked chitosan.