Patents Assigned to Valeritas, Inc.
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Patent number: 9155875Abstract: A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.Type: GrantFiled: August 21, 2013Date of Patent: October 13, 2015Assignee: Valeritas, Inc.Inventor: Devin V. McAllister
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Patent number: 9125983Abstract: A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.Type: GrantFiled: April 17, 2010Date of Patent: September 8, 2015Assignee: VALERITAS, INC.Inventors: Robert R. Gonnelli, Devin V. McAllister, Steven F. Levesque
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Patent number: 9101706Abstract: A fluid delivery device comprises a housing having a fluid reservoir. A needle is in fluid communication with the fluid reservoir in an engaged position and out of fluid communication with the fluid reservoir in armed and storage positions. A proximal end of a biasing member is coupled to the housing and a distal end of the biasing member is configured to deliver a force to the fluid reservoir. A piston member extends through the biasing member and is coupled to the distal end of the biasing member. The piston member is fixed with respect to the housing in a locked position such that the biasing member does not deliver the force to the fluid reservoir and moveable with respect to the housing in a released position such that the biasing member delivers the force to the fluid reservoir. Transitioning the needle from the storage position to the armed position transitions the piston from the locked position to the released position.Type: GrantFiled: October 12, 2010Date of Patent: August 11, 2015Assignee: VALERITAS, INC.Inventors: Robert R. Gonnelli, Steven F. Levesque
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Patent number: 9089636Abstract: The invention provides various devices for delivering Glucagon-Like Peptide-1 (7-36), in various infusion patterns and rates, to optimally stimulate carbohydrate metabolism, to inhibit gastropancreatic secretion and gastric motility, and to treat various disease conditions (including diabete) as described in the instant specification. The devices and methods of the invention provide various ways to deliver doses (escalating, constant, on demand, etc.) of GLP-1 in response to different patient need.Type: GrantFiled: July 5, 2005Date of Patent: July 28, 2015Assignee: VALERITAS, INC.Inventor: Robert R. Gonnelli
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Patent number: 9072828Abstract: Presently disclosed is a hydraulic pump device and its use thereof, especially in a fluid delivery system. In one embodiment, the fluid delivery system is an inexpensive, single-use device for slow dosing medicament applications. The fluid delivery system may employ a spring-compressed bellows crank or other combination of simple mechanisms operating according to the well-known peristaltic principle to force a volume of ultrapure bio-inert hydraulic fluid through an aperture, thereby expanding one chamber of a two chamber hydraulic cylinder. The second, fluid storage chamber, containing the medicament, is emptied through a conventional orifice in response to the expansion of the pump chamber. The medicament may then flow through any suitable infusion set into a patient removeably attached thereto.Type: GrantFiled: December 16, 2008Date of Patent: July 7, 2015Assignee: VALERITAS, INC.Inventors: Robert R. Gonnelli, Devin V. McAllister, Steven F. Levesque
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Publication number: 20150165115Abstract: Fluid delivery and measurement systems and methods are disclosed.Type: ApplicationFiled: February 24, 2015Publication date: June 18, 2015Applicant: VALERITAS, INC.Inventors: Robert R. Gonnelli, Steven F. Levesque, David Lipson, Peter F. Marshall
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Patent number: 9011392Abstract: The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.Type: GrantFiled: March 30, 2009Date of Patent: April 21, 2015Assignee: Valeritas, Inc.Inventors: Devin V. McAllister, Ciro DiMeglio
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Patent number: 8992478Abstract: Fluid delivery and measurement systems and methods are disclosed.Type: GrantFiled: January 17, 2013Date of Patent: March 31, 2015Assignee: Valeritas, Inc.Inventor: Steven F. Levesque
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Publication number: 20150000788Abstract: A vented needle comprises a distal end configured to pierce a seal of a first container having a top and a bottom surface and a seal of a second container having a top and a bottom surface. An interior lumen is configured to fluidly couple the first container and a fluid transfer device and the second container and the fluid transfer device. A middle portion is configured to engage the seals of the first container and the second container and having one or more axially extending vents. At least one of the one or more vents is configured to extend axially past the top and bottom surfaces of the seal of the first container and configured to fluidly couple the first container and ambient air outside the first container. None of the one or more vents are configured to extend axially past top and bottom surfaces of the seal of the second container.Type: ApplicationFiled: December 12, 2012Publication date: January 1, 2015Applicant: Valeritas, Inc.Inventors: Devin V. McAllister, Daniel W. Connors
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Patent number: 8920375Abstract: The microneedle devices disclosed herein in some embodiments include a substrate; one or more microneedles; a reservoir for delivery of drugs; a gas source, and, optionally, pump(s), sensor(s), and/or microprocessor(s) to control the interaction of the foregoing.Type: GrantFiled: September 23, 2002Date of Patent: December 30, 2014Assignee: Valeritas, Inc.Inventor: Robert R. Gonnelli
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Publication number: 20140336580Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.Type: ApplicationFiled: July 28, 2014Publication date: November 13, 2014Applicant: Valeritas, Inc.Inventors: Robert R. GONNELLI, Steven F. LEVESQUE, Ronald V. NARDI
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Patent number: 8858511Abstract: Fluid delivery and measurement systems and methods are disclosed.Type: GrantFiled: December 16, 2008Date of Patent: October 14, 2014Assignee: Valeritas, Inc.Inventors: Robert R. Gonnelli, Steven F. Levesque, David Lipson, Peter F. Marshall
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Patent number: 8821443Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.Type: GrantFiled: December 19, 2012Date of Patent: September 2, 2014Assignee: Valeritas, Inc.Inventors: Steven F. Levesque, Robert R. Gonnelli, Ronald V. Nardi
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Publication number: 20140236086Abstract: A fluid delivery device includes an automatic needle retraction mechanism configured to automatically retract a delivery end of a needle into a housing. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon an actuator moving from the first position to the second position. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon decoupling a bottom surface of the housing from a skin surface.Type: ApplicationFiled: April 23, 2014Publication date: August 21, 2014Applicant: VALERITAS, INC.Inventors: Steven F. LEVESQUE, Geoffrey H. JENKINS, Robert L. STANDLEY, Matthew P. JOHNSON, Daniel A. DUBE, JR.
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Patent number: 8740847Abstract: A fluid delivery device includes an automatic needle retraction mechanism configured to automatically retract a delivery end of a needle into a housing. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon an actuator moving from the first position to the second position. In one embodiment, the needle assembly is configured to automatically withdraw the delivery end of the needle into the housing upon decoupling a bottom surface of the housing from a skin surface.Type: GrantFiled: June 9, 2011Date of Patent: June 3, 2014Assignee: Valeritas, Inc.Inventors: Steven F. Levesque, Geoffrey H. Jenkins, Robert L. Standley, Matthew P. Johnson, Daniel A. Dube, Jr.
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Patent number: 8734395Abstract: A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.Type: GrantFiled: August 21, 2013Date of Patent: May 27, 2014Assignee: Valeritas, Inc.Inventor: Devin V. McAllister
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Publication number: 20140124092Abstract: A fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir includes a metering reservoir and a manifold that forms at least part of a first channel that is fluidly connected with the metering reservoir. The first channel comprises a first cannula extending from the manifold. The manifold forms at least part of a second channel fluidly connected with the metering reservoir. The second channel comprises a second cannula extending from the manifold. A third channel extends through the manifold and comprises a third cannula having a first end proximate a distal end of the first cannula and a second end proximate a distal end of the second cannula. A first check valve is disposed within the first channel and a second check valve is disposed within the second channel.Type: ApplicationFiled: January 16, 2014Publication date: May 8, 2014Applicant: VALERITAS, INC.Inventors: Robert R. Gonnelli, Robert L. Standley, Steven F. Levesque
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Patent number: 8667996Abstract: A fluid transfer device for transferring fluid between a supply reservoir and a fill reservoir includes a metering reservoir and a manifold that forms at least part of a first channel that is fluidly connected with the metering reservoir. The first channel comprises a first cannula extending from the manifold. The manifold forms at least part of a second channel fluidly connected with the metering reservoir. The second channel comprises a second cannula extending from the manifold. A third channel extends through the manifold and comprises a third cannula having a first end proximate a distal end of the first cannula and a second end proximate a distal end of the second cannula. A first check valve is disposed within the first channel and a second check valve is disposed within the second channel.Type: GrantFiled: May 4, 2010Date of Patent: March 11, 2014Assignee: Valeritas, Inc.Inventors: Robert R. Gonnelli, Steven F. Levesque, Robert L. Standley
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Publication number: 20130338596Abstract: A method and apparatus for application of a microneedle patch to a skin surface of a patient includes use of an applicator. The applicator includes a housing, a slidably disposed applicator plate, and a compression spring. The applicator plate is moveable between a retracted position and a deployed position, and has an engaging surface suitable for mashing up against a microneedle patch and pressing it against a skin surface. A docking system transfers the microneedle patch from a support to the applicator without requiring a user to handle the microneedle patch directly. Once mounted in the applicator, the microneedle patch is deployed against a skin surface of a patient for delivery of a desired agent via a microneedle array contained on the patch.Type: ApplicationFiled: August 21, 2013Publication date: December 19, 2013Applicant: Valeritas, Inc.Inventor: Devin V. McAllister
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Patent number: D706415Type: GrantFiled: June 17, 2013Date of Patent: June 3, 2014Assignee: Valeritas, Inc.Inventors: Steven F. Levesque, Robert R. Gonnelli, Robert L. Standley, Mario T. Capolongo