Abstract: An asymmetric magnet for use in performing MRI of a patient's head. The magnet has a patient end. The magnet provides an offset imaging volume (35) in a recess with an isocentre that is positioned closer to the patient end than an opposite end. The magnet has at least three groups of coils (44, 45, 46) in a generally tapering arrangement. The magnet also has an additional group of coils (47). A first group of coils (44) overlaps the additional group of coils (47), such that a bottom portion (47?) of the additional group of coils (47) is positioned closer to the patient end of the magnet than a top portion (44?) of the first group of coils (44).

Abstract: A computer-implemented method to capture and detect clusters in, or determined by, a set V of discrete digital data comprising; computing, from the set V, an abstract separation system ASS that consists of a finite set S, whose elements are called separations; of a predetermined transitive, antisymmetric and reflexive order relation ? on S; and of an order-reversing involution *: S?S, that is, a mapping s?s* with the property that, (s*)*=s and that r?s implies s*<r* for all r, s?S; predetermining a set of consistency requirements (CRs), that is, a set F of subsets of S; computing, from the ASS (S,?, *), one or more abstract tangles, that is, any set T?S that contains exactly one of each pair {s, s*} for s?S, and does not contain any of the forbidden configurations F?F as a subset; or determining that there is no abstract tangle; and determining that any abstract tangle T represents a cluster in, or determined by, the data set V.

Abstract: Provided herein are inhibitors of DNA methyltransferase 1 (an enzyme responsible for the maintenance of DNA CpG methylation marks in human cells) and their use for inhibiting DNA methyltransferase 1. The invention relates to compounds, pharmaceutical compositions, and methods for inhibiting DNA methyltransferase 1.

Abstract: The present invention concerns an ammonia production method comprising the steps of: providing at least one rare earth nitride material or layer in a chamber; creating a vacuum or an inert atmosphere in the chamber; and providing hydrogen H2 to react with nitrogen N released at an external surface of the at least one rare earth nitride material or layer to produce ammonia.

Abstract: The present invention encompasses non-ribosomal peptides and non-ribosomal peptide synthetases, and the preparation and use thereof. Specifically encompassed are methods for preparing non-ribosomal peptide synthetases, methods for preparing non-ribosomal peptides from these enzymes, as well as polynucleotides used for producing these enzymes, libraries comprising these polynucleotides, and microbial strains comprising these polynucleotides.

Abstract: This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics.

Abstract: A magnet (7) for use in an apparatus (1) for performing magnetic resonance imaging (MRI) of a patient's head is an asymmetric magnet (7) comprising a plurality of coils (45, 46, 47) that are aligned along a cylindrical axis (29) to provide a magnetic field on the cylindrical axis (29). The magnet (7) has a patient end (23) arranged to be positioned adjacent or against a patient's shoulders with the patient's shoulders outside the magnet (7). The magnet has a recess (27) for receipt of the patient's head and extending into the magnet (7) from the patient end (23). The magnet (7) is configured to provide an imaging volume (35) that is positioned along the cylindrical axis (29) of the magnet (7) in the recess (27), and at least a major part of the imaging volume (35) has a substantially linear non-zero magnetic field gradient along the cylindrical axis (29).

Abstract: The present invention concerns a structure or device comprising a rare earth nitride material, and a removable capping for passivating the rare earth nitride material.

Abstract: Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering to the subject an inhibitor of H.

Abstract: The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neurodegenerative disorders, Niemann-Pick Type C disease, or dermatological conditions.

Abstract: A system for determining a relative position associated to a first receiver and a second receiver includes a code module 402 configured to receive location data associated to the first receiver, receive location data associated to the second receiver, and determine a first estimate relative position associated to the first receiver and the second receiver; a float module 404 configured to determine a second estimate relative position associated to the first receiver and the second receiver at least partly from the first estimate relative position; a fix module 406 configured to determine a third estimate relative position associated to the first receiver and the second receiver at least partly from the second estimate relative position; and a sidereal module 408 configured to determine a fourth estimate relative position associated to the first receiver and the second receiver at least partly from the third estimate relative position.

Abstract: A rendering process and system that may be used to composite virtual objects in panoramic video to provide a virtual reality and augmented reality experience. The process includes receiving low dynamic range (LDR) video data, e.g. 360° video; generating radiance maps, such as diffuse and specular maps, from the LDR data; inverse tone mapping the LDR data of the maps to generate high dynamic range (HDR) data for the maps; and receiving at least one virtual object and applying image based lighting (IBL) to the virtual object using the HDR data of the maps. A perceptually based threshold is also applied to radiance maps to detect prominent pixels, and using the prominent pixels as salient lights for image based shadowing (IBS) associated the virtual object. Objects are composited 360° video in real time using IBL and IBS without precomputation allowing user interaction with the objects.

Abstract: The present technology is directed to compounds, compositions, and methods related to non-morphinan-like mu opioid receptor agonists of Formula I. Compounds of the present technology demonstrate remarkable potency and selectivity for the mu opioid receptor, while also exhibiting a significant reduction (or, essentially, absence) of the negative side effects of many morphine-derived compounds.

Abstract: A spectrometer apparatus for measuring spectra of a liquid sample, such as a beverage like wine. The apparatus has an integrating cavity with a reflective inner wall to receive a cuvette containing the liquid sample within the integrating cavity. A combination of light inlet ports and light outlet ports are provided to receive light from at least one light source and deliver light to a spectrometer. A light path adjuster is configured to selectively adjust a light path through the integrating cavity so at least two distinct light paths are provided wherein when the light path adjuster is in a first configuration, the apparatus is in transmission mode in which light from the light source follows a first light path; when the light path adjuster is in a second configuration, the apparatus is in a diffusely reflecting mode in which light from the light source follows a second light path.

Abstract: This invention relates generally to the use of 5?-methylthioadenosine phosphorylase (MTAP) inhibitors for the treatment of lung diseases associated with inflammation, such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Small molecule inhibitors of MTAP can sustain accumulation of endogenous MTA to therapeutically beneficial levels resulting in decreased inflammation in CF and COPD.

Abstract: The present technology is directed to compounds, compositions, and methods related to non-morphinan-like mu opioid receptor agonists. Compounds of the present technology demonstrate remarkable potency and selectivity for the mu opioid receptor, while also exhibiting a significant reduction (or, essentially, absence) of the negative side effects of many morphine-derived compounds.

Abstract: The present invention provides for a method of optimisation of a polynucleotide sequence for use in an aptamer based assay, comprising adding additional bases to the ligand binding domain. The invention also covers methods of detecting target molecules in a sample using 5 optimised polynucleotide sequences in a suitable detection assay.

Abstract: Method for the detection of glutamine and its analogues are provided by the present disclosure. Also provided are methods for measuring the levels of glutamine and its analogues, including diagnostic methods. Further provided are methods that utilise glutamine analogues for the synthesis of coloured pigments and other useful agents. The methods comprise the use of a nonribosomal peptide synthetase (NRPS) under conditions to produce an indigoidine or indigoidine-related pigment.

Abstract: A rendering process and system that may be used to composite virtual objects in panoramic video to provide a virtual reality and augmented reality experience. The process includes receiving low dynamic range (LDR) video data, e.g. 360° video; generating radiance maps, such as diffuse and specular maps, from the LDR data; inverse tone mapping the LDR data of the maps to generate high dynamic range (HDR) data for the maps; and receiving at least one virtual object and applying image based lighting (IBL) to the virtual object using the HDR data of the maps. A perceptually based threshold is also applied to radiance maps to detect prominent pixels, and using the prominent pixels as salient lights for image based shadowing (IBS) associated the virtual object. Objects are composited 360° video in real time using IBL and IBS without precomputation allowing user interaction with the objects.

Abstract: A spectrometer apparatus (1) is provided for measuring spectra of a liquid sample, such as a beverage such as wine. The apparatus (1) comprises an integrating cavity (3) comprising a reflective inner wall or walls (5), configured to receive a cuvette (7) containing the liquid sample within the integrating cavity (5). A combination of light inlet ports P1, P2 and light outlet ports P3, P4 are provided to receive light from at least one light source (9) and to deliver light to a spectrometer (11).