Abstract: Methods and devices are disclosed for treating or preventing infections in a subject due to Pseudomonas aeruginosa using coformycin analogs and inhibitors of Pseudomonas aeruginosa 5?-methylthioadenosine deaminase (MTADA).

Abstract: The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (I) which are inhibitors of 5?-methylthioadenosine phosphorylase or 5?-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5?-methylthioadenosine phosphorylase or 5?-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.

Abstract: The invention relates to a rheological measurement device adapted for use in a bore of an NMR magnet. The measurement device comprises a drive shaft, a drive shaft housing in which the drive shaft is located, and a torque sensor directly or indirectly attached to the drive shaft. The torque sensor is positioned substantially in line with the drive shaft.

Abstract: The invention relates to a rheology unit for use in rheology and in Rheo-NMR.

Abstract: This invention relates to certain dendrimer compounds. In particular, this invention relates to novel dendrimer compounds that can be elaborated to give increasingly large and complex compounds. These elaborated compounds can be attached to, or can encapsulate within, active agent(s) so as to beneficially modify the characteristics of that active agent. Alternatively, the elaborated compounds can themselves be beneficially modified into therapeutic agents by the attachment of inactive agents.

Abstract: The invention relates generally to oligosaccharide compounds and the use of these compounds as pharmaceuticals for treating diseases or conditions in which it is desirable to inhibit ?-secretase.

Abstract: The present invention discloses methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5?-methylthioinosine phosphorylase (MTIP) inhibitor, as well as assays for identifying such inhibitors, and compounds and pharmaceutical compositions comprising the inhibitors.

Abstract: The invention provides methods of selection of mammalian oocytes. In particular, the invention provides in-vitro methods of selection of viable oocytes from a population of mammalian oocytes by ranking and selecting viable oocytes.

Abstract: The invention relates to a mineralized composite material and methods of forming such a material. The process comprises mineralization of a chitin template with calcium carbonate. The mineralized composite material of the invention has similar properties to the natural material nacre.

Abstract: Methods and devices are disclosed for treating or preventing infections in a subject due to Pseudomonas aeruginosa using coformycin analogs and inhibitors of Pseudomonas aeruginosa 5?-methylthioadenosine deaminase (MTADA).

Abstract: The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.

Abstract: Compositions and methods for deterring and/or visually identifying oral contact with objects that are hazardous upon oral contact or ingestion are disclosed. The compositions generally comprise a colourant and a carrier and may further comprise an aversive agent, a salivating agent, and/or an emetic. The compositions may be particularly useful for application to batteries, including button cells.

Abstract: The invention relates generally to bacterial nitroreductase enzymes and methods of use thereof: More particularly, although not exclusively, said enzymes have use in non-invasive imaging techniques, monitoring of therapeutic cell populations and gene-directed enzyme prodrug therapy. The invention also relates to the use of bacterial nitroreductase enzymes in radioimaging and/or ablation of biological agents and to compositions of use in such methods.

Abstract: The invention relates to methods and compositions for identifying a candidate nucleic acid (CNA) comprising a polynucleotide sequence encoding at least a part of a natural product gene cluster (NPGC), a secondary metabolite biosynthesis cluster (SMBC), a non ribosomal peptide (NRP), a polyketide (PK) biosynthesis cluster, a protein involved in NRP and/or PK biosynthesis, a protein involved in other secondary metabolite biosynthesis, and/or a phosphopantetheinyl transferase (PPTase), by expressing the candidate nucleic acid (CNA) to form at least one PPTase, incubating the PPTase with a non ribosomal peptide synthetase (NRPS), and detecting activation of the NRPS, wherein activation indicates that said CNA comprises a polynucleotide sequence encoding at least one of the above.

Abstract: Improved button cell safety systems, methods and composition are herein disclosed. According to one embodiment, the button cell includes a cathode shell. An insulator ring with an anode cavity is at least partially positioned within the cathode shell. An anode plate is inserted in the insulator ring to engage the anode cavity.

Abstract: A magnetic assembly for a nuclear magnetic resonance apparatus includes a number of primary permanent magnets 1 disposed in an array about a longitudinal axis, the arrangement and/or characteristics of the plurality of magnets being such so as to create a zone of homogeneous magnetic field at some location along the axis forward of the array (and into the material when provided). A secondary permanent magnet 7 may be located along the longitudinal axis within the array of primary magnets and may be moveable. The primary magnets 1 have a north pole and a south pole with an axis therebetween, and may be arranged such that the axis between the poles is at an angle to the longitudinal axis.

Abstract: An oxidation process is described which involves subjecting a feedstock which contains oxidizable material to temperature, pressure and contact with an oxidant. Excess water and volatile oxidation products, such as carbon dioxide, formic acid and acetic acid, are removed in the vapor phase. A catalyst may be employed to increase the rate of reaction. Preferred catalysts include the transition metal ions. Advantageously, the process may be operated in a continuous manner wherein the feedstock is continuously introduced into a reactor and a vapor phase containing volatile oxidation products continuously removed. The process is particularly applicable to the treatment of consumer and industrial waste.

Abstract: This invention relates to a bioactive compound and to compositions which contain it. The invention further relates to methods of microtubule stabilization. In particular, it relates to a compound which has cytotoxic properties and which therefore has utility in inter alia anti-tumor treatments.