Abstract: Fusion proteins, comprising at least one single chain antibody fragment (scFV), and a cancer antigen or marker, or a fragment thereof are provided. The scFV is capable of selectively binding to a cytokine released by chimeric antigen receptor (CAR) expressing cell such as interferon gamma (IFN-?) or tumor necrosis factor alpha (TNF-?). The cancer antigen or marker may comprise the extracellular domain of CD19. Methods for isolating or purifying CAR expressing cells using fusion proteins are provided.

Abstract: A device for providing a therapeutic stimulus to a subject is provided. The device may comprise a material, a network of flexible cells, at least one channel, and a working material. The material may be configured to cover a portion of the subject and may have an inner surface for engaging a surface of the subject and an exterior surface facing away from the surface of the subject. The network of flexible cells may be coupled to the material and each flexible cell may have an internal cavity. The working material may be disposed within the internal cavities of the flexible cells. The at least one channel may be arranged to allow exchange of the working material between flexible cells due to application of force upon the network from movement of the surface of the subject.

Abstract: A method for forming a nanomaterial coating through solute-assisted assembly is provided. The method includes steps of: providing a mixture comprising a solvent, a solute, and a nanomaterial or particle; applying sonication to the mixture; and contacting a substrate with the mixture so as to form a coating of the nanomaterial or the particle onto the substrate. The solute is selected from a salt, a sugar, an acid, a base, or a combination thereof. The present disclosure also provides the resulting products comprising the nanomaterial coating for flexible electronics and functional textiles.

Abstract: A ventilator apparatus includes a linear electro-mechanical actuator that interfaces with a self-inflating bag including an inlet configured to receive air and an outlet configured to expend the air. A three-way valve is coupled to the outlet via a first flowmeter, an ambient environment via a second flowmeter, and a patient via an endotracheal tube. The first and/or second flowmeters are coupled to pressure transducer(s). A control unit is coupled to the linear electro-mechanical actuator and the first and second flowmeters and includes a control panel, memory including programmed instructions stored thereon, and processor(s) configured to execute the stored programmed instructions to set an inhalation time and an exhalation time. A current inspiratory pressure and a current tidal volume are obtained from the pressure transducer(s) and/or the first flowmeter. A stroke of the linear electro-mechanical actuator is then controlled to facilitate inspiratory and expiratory phases of a respiratory cycle.

Abstract: A compressed gas energy storage system to provide isothermal compression/expansion for energy storage includes a housing defining an envelope including an internal volume; a phase change material (PCM) partially filling the internal volume; a dendritic (hierarchical) gas flow path through the PCM; and a piston driven by a drive mechanism and that moves relative to the PCM within the housing.

Abstract: A pharmaceutical composition and a method of using the same for killing cancer cells are provided. The pharmaceutical composition comprising effective amounts of one oxidizable diphenol and a manganese porphyrin in one-part dosage form or in a two-part dosage form. The oxidizable diphenol and the manganese porphyrin can be administrated to a subject in need thereof simultaneously or sequentially.

Abstract: A test apparatus or system for testing impact induced brain trauma a method of making and a method using the same are provided. The system includes a head model, which includes a skull component, a brain component, and a fluid component. The skull component has a wall defining an interior chamber. The brain component includes a gel material and is disposed within the interior chamber. The fluid component is disposed inside the interior chamber. The system may also include a fluid tank fluidly coupled with the skull component and configured to provide the fluid component into the interior chamber. The head model may further include a layer of porous media disposed between the brain component and the interior wall surface of the skull component. The system may include at least one impact element for providing an impact on the head model. The impact is translational or rotational or both.

Abstract: A test apparatus or system for testing impact induced brain trauma a method of making and a method using the same are provided. The system includes a head model, which includes a skull component, a brain component, and a fluid component. The skull component has a wall defining an interior chamber. The brain component includes a gel material and is disposed within the interior chamber. The fluid component is disposed inside the interior chamber. The system may also include a fluid tank fluidly coupled with the skull component and configured to provide the fluid component into the interior chamber. The head model may further include a layer of porous media disposed between the brain component and the interior wall surface of the skull component. The system may include at least one impact element for providing an impact on the head model. The impact is translational or rotational or both.

Abstract: The present disclosure relates to a diagnostic tool, and, more particularly, to a diagnostic tool for analyzing and using the results of a flow mediated dilation test.

Abstract: A machine implemented method for simulated sports training includes the steps displaying a simulated environment having one or more virtual objects of a sporting event; displaying to a user a moving object in the simulated environment in accordance with object path data representing an object path and conditions of motion of the moving object as a function of time; correlating soundscape data to the object path data, the soundscape data being dependent on both object path of the moving object in the object path and the conditions of motion; and outputting sound to the user based on the correlated soundscape data either before or during displaying to the user the moving object, thereby providing spatial auditory clues for assisting tracking eye movements of the user to train the user to anticipate or recognize a trajectory of the moving object.

Abstract: This disclosure relates to diagnosing a nature and magnitude of faults within electrical and mechanical systems.

Abstract: Disclosed herein are methods of making (4aR,6S,8aR)-6-((R)-1-hydroxyethyl)-6,8a-dihydropyrano[3,2-b]pyran-2-(4aH)-one (2) and methods of making (4aR,6S,8aR)-6-cyano-6,8a-dihydropyrano-[3,2-b]pyran-2(4aH)-one (4). Other pyranopyrans were also synthesized. Also compositions containing (4aR,6S,8aR)-6-cyano-6,8a-dihydropyrano-[3,2-b]pyran-2(4aH)-one (4) (or other pyranopyrans described herein) and optionally a carrier. In addition, methods for killing microorganisms or weeds on or in an object or area involving contacting the object or area with an effective microorganisms or weeds killing amount of a composition containing (4aR,6S,8aR)-6-cyano-6,8a-dihydropyrano-[3,2-b]pyran-2(4aH)-one (4) (or other pyranopyrans described herein) and optionally a carrier.

Abstract: The present invention includes novel polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.

Abstract: A machine implemented method for simulated sports training includes the steps displaying a simulated environment having one or more virtual objects of a sporting event; displaying to a user a moving object in the simulated environment in accordance with object path data representing an object path and conditions of motion of the moving object as a function of time; correlating soundscape data to the object path data, the soundscape data being dependent on both object path of the moving object in the object path and the conditions of motion; and outputting sound to the user based on the correlated soundscape data either before or during displaying to the user the moving object, thereby providing spatial auditory clues for assisting tracking eye movements of the user to train the user to anticipate or recognize a trajectory of the moving object.

Abstract: A machine implemented method for simulated sports training includes the steps displaying a simulated environment having one or more virtual objects of a sporting event; displaying to a user a moving object in the simulated environment in accordance with object path data representing an object path and conditions of motion of the moving object as a function of time; correlating soundscape data to the object path data, the soundscape data being dependent on both object path of the moving object in the object path and the conditions of motion; and outputting sound to the user based on the correlated soundscape data either before or during displaying to the user the moving object, thereby providing spatial auditory clues for assisting tracking eye movements of the user to train the user to anticipate or recognize a trajectory of the moving object.

Abstract: A system and a method are provided for cooling devices and recovering waste heat. A plurality of heat absorption devices in direct or indirect thermal contact with a plurality electronic devices, and comprise channels to receive an evaporable working liquid, which becomes a first 2-phase mixture having a first liquid portion and a first vapor portion upon absorption of heat from the devices. At least one compressor compresses the first vapor portion to form a compressed vapor having elevated pressure and temperature. At least one heat exchanger condenses the compressed vapor to liquid so as to release the heat. An expansion device is used to expand the liquid to provide a second 2-phase mixture comprising a second liquid portion and a second vapor portion. In at least one vapor-liquid separator, the first liquid portion and the second liquid portion are fed back to the plurality of heat absorption devices. The second vapor portion is fed back to the at least one compressor.

Abstract: A system and a method are provided for cooling heat-generating devices. A plurality of heat exchangers are in thermal communication with a plurality electronic devices. Each of the plurality of heat exchangers includes at least one channel configured to receive and circulate a working liquid. Each of the plurality of heat exchangers may be a cold plate, an air cooler, and a combination thereof. The plurality of heat exchangers include at least one cold plate in direct contact with at least one of the plurality of electronic device. At least one air cooler circulates air and convectively absorbs heat from the remaining electronic devices.

Abstract: The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —NR?2, —N—C(O)R?, —N—C(O)CR??CR?, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, and —OCF3. R? is H or a C1-4 alkyl. X or Y is a halogen. m and n are integers in the range from 1 to 25.

Abstract: A test apparatus or system for testing impact induced brain trauma a method of making and a method using the same are provided. The system includes a head model, which includes a skull component, a brain component, and a fluid component. The skull component has a wall defining an interior chamber. The brain component includes a gel material and is disposed within the interior chamber. The fluid component is disposed inside the interior chamber. The system may also include a fluid tank fluidly coupled with the skull component and configured to provide the fluid component into the interior chamber. The head model may further include a layer of porous media disposed between the brain component and the interior wall surface of the skull component. The system may include at least one impact element for providing an impact on the head model. The impact is translational or rotational or both.

Abstract: An impact test system includes a head model having a head exterior component; a skull component; a brain component; a fluid component; an interior cavity surface; and a translucent cover, wherein the head model is coupled with a mount, the brain component and fluid components are configured within the interior cavity, and wherein the translucent cover is configured over a portion of the brain component and fluid component. A mount is configured to a least partially restrain the head model. A camera is configured to take a plurality of images of the brain and the fluid components through the translucent cover when the head model is under an impact force.