Patents Assigned to Villanova University
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Patent number: 10136639Abstract: The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —NR?2, —N—C(O)R?, —N—C(O)CR??CR?, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —NR?2, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, and —OCF3. R? is H or a C1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.Type: GrantFiled: November 5, 2014Date of Patent: November 27, 2018Assignees: Villanova University, Temple University of the Commonwealth System of Higher EducationInventors: William Wuest, Kevin Patrick Minbiole
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Publication number: 20170261416Abstract: An impact test system includes a head model having a head exterior component; a skull component; a brain component; a fluid component; an interior cavity surface; and a translucent cover, wherein the head model is coupled with a mount, the brain component and fluid components are configured within the interior cavity, and wherein the translucent cover is configured over a portion of the brain component and fluid component. A mount is configured to a least partially restrain the head model. A camera is configured to take a plurality of images of the brain and the fluid components through the translucent cover when the head model is under an impact force.Type: ApplicationFiled: March 11, 2016Publication date: September 14, 2017Applicant: Villanova UniversityInventors: Qianhong WU, Kei-Peng JEN, Rungun NATHAN, Chris W. Townend
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Publication number: 20160278375Abstract: The present disclosure provides an antimicrobial composition including a compound which is a biscationic or triscationic amphiphile, and the method of making such an antimicrobial composition, and the method of using such a compound or composition for antimicrobial use. The antimicrobial composition can include a compound having the formula (I) wherein R is a methylene group unsubstituted or optionally substituted, s is an integer in the range from 1 to 6, R1, R2, R3 or R4 is H or a C1-4 alkyl unsubstituted or optionally substituted, X is a halogen, m and n are integers in the range from 5 to 25, and m is not equal to n. Alternatively, the antimicrobial composition can comprise a compound having the formula (III) or (IV) wherein R1, R2, R3, R4 R5, or R6 is H or a C1-4 alkyl unsubstituted or optionally substituted, X or Y is a halogen, and m and n are integers in the range from 5 to 25.Type: ApplicationFiled: November 5, 2014Publication date: September 29, 2016Applicants: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, VILLANOVA UNIVERSITYInventors: William WUEST, Kevin Patrick MINBIOLE
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Publication number: 20160262384Abstract: The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —NR?2, —N—C(0)R?, —N—C(0)CR??CR?, —SH, —SR?, -0-C(0)R?, —C(0)R?, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —NR?2, —SH, —SR?, -0-C(0)R?, —C(0)R?, —CF3, and —OCF3. R? is H or a C1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.Type: ApplicationFiled: November 5, 2014Publication date: September 15, 2016Applicants: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, VILLANOVA UNIVERSITYInventors: William WUEST, Kevin Patrick MINBIOLE
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Publication number: 20160242413Abstract: The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula R1, R2, R3, R4, R5, R6, R10, or R11 is H or a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —N—C(O)R?, —N—C(O)CR??CR?, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R7, R8 or R9 is a C1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR?, —NH2, —NHR?, —SH, —SR?, —O—C(O)R?, —C(O)R?, —CF3, and —OCF3. R? is H or a C1-4 alkyl. X or Y is a halogen. m and n are integers in the range from 1 to 25.Type: ApplicationFiled: May 5, 2016Publication date: August 25, 2016Applicants: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, VILLANOVA UNIVERSITYInventors: William WUEST, Kevin Patrick MINBIOLE
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Patent number: 9184611Abstract: A system and method for determining the health of a battery. A primary coil may be positioned along a first portion of a battery and a secondary coil may be positioned along a second portion of the battery. The primary coil may then be excited with a signal, and an electromagnetic field induced in the secondary coil by the excited primary coil may be measured. A state of health of the battery may thus correlate to the measured electromagnetic field during operation of the battery. This state of health may be determined as a function of electrolyte stratification, current profile, electrode structure, electrode surface degradation, and combinations thereof.Type: GrantFiled: October 8, 2012Date of Patent: November 10, 2015Assignee: Villanova UniversityInventors: Neeta Khare, Pritpal Singh, John Vassiliou
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Patent number: 8835752Abstract: A multi-junction photovoltaic cell includes at least two P-N junctions electrically connected to each other in series. Each P-N junction includes a P-type absorber layer and a N-type emitter layer, each P-type absorber layer including a plurality of alternating thin film layers of zinc telluride and lead telluride, wherein zinc telluride and lead telluride have respective bandgaps when in bulk thickness and the effective bandgap of each P-type absorber layer is between the respective bandgaps. The effective bandgap of at least one P-type absorber layer is different from that of at least one other P-type absorber layer.Type: GrantFiled: May 11, 2009Date of Patent: September 16, 2014Assignee: Villanova UniversityInventor: Pritpal Singh
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Publication number: 20130088204Abstract: A system and method for determining the health of a battery. A primary coil may be positioned along a first portion of a battery and a secondary coil may be positioned along a second portion of the battery. The primary coil may then be excited with a signal, and an electromagnetic field induced in the secondary coil by the excited primary coil may be measured. A state of health of the battery may thus correlate to the measured electromagnetic field during operation of the battery. This state of health may be determined as a function of electrolyte stratification, current profile, electrode structure, electrode surface degradation, and combinations thereof.Type: ApplicationFiled: October 8, 2012Publication date: April 11, 2013Applicant: Villanova UniversityInventor: Villanova University
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Patent number: 8156433Abstract: An embodied music system. The system creates an interactive interface between a listener and the external environment. The system includes a physical device located in the environment that provides sensory input to the listener. An audio signal of the system is adapted to be heard by the listener. An encoder embeds inaudible control data into the audio signal. A decoder extracts the control data from the audio signal and transmits the control data to the physical device, thereby controlling operation of the device. Finally, an audio reproduction device is connected to the decoder and plays the audio signal for the listener. The embodied music system allows the listener to experience multi-sensory compositions.Type: GrantFiled: January 19, 2011Date of Patent: April 10, 2012Assignee: Villanova UniversityInventors: Robert Gerard Pietrusko, Chandrasekhar Nataraj
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Publication number: 20110155207Abstract: A multi junction photovoltaic cell includes at least two P-N junctions electrically connected to each other in series. Each P-N junction includes a P-type absorber layer and a N-type emitter layer, each P-type absorber layer including a plurality of alternating thin film layers of zinc telluride and lead telluride, wherein zinc telluride and lead telluride have respective bandgaps when in bulk thickness and the effective bandgap of each P-type absorber layer is between the respective bandgaps, The effective bandgap of at least one P-type absorber layer is different from that of at least one other P-type absorber layer.Type: ApplicationFiled: May 11, 2009Publication date: June 30, 2011Applicant: VILLANOVA UNIVERSITYInventor: Pritpal Singh
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Publication number: 20100269952Abstract: A delivery system for filling a microstructured or nanostructured optical fiber (MOF/NOF) includes a MOF/NOF having first and second ends. The first end of the MOF/NOF is disposed in a first chamber configured to have a first pressure, and the second end of the MOF/NOF is disposed in a second chamber configured to have a second pressure that is less than the first pressure. A material source introduces a material into the first chamber. A light source is oriented to emit light into one of the ends of the MOF/NOF. An optical detection system for monitoring filling of the MOF/NOF detects the light emitted by the light source from the other of the ends of the MOF/NOF.Type: ApplicationFiled: April 21, 2010Publication date: October 28, 2010Applicant: Villanova UniversityInventor: Rosalind M. Wynne
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Publication number: 20100033181Abstract: A self-stabilized, levitating MEMS (Micro Electro-Mechanical Systems) resonator is provided for detection of magnetic resonance spectra of electrons and nuclei in magnetic resonance force microscopy (MRFM) measurements. The present MRFM system includes a levitating micro-disk having electrically-controlled force sensitivity. To achieve imaging on the scale of a single nuclear spin, the force sensitivity of the measurement must be on the order of 1 aN (atto-Newton) or less. For about a 1 aN force to produce deflections comparable to an angstrom for interferometer detection, the stiffness or spring constant (k) of the resonator will typically be less than 1 ?N/m (micro-Newtons per meter). Since the resonator is to be driven with an oscillating force at its resonance, there is a quality-factor (Q) enhancement of the amplitude of the motion. As a result, the k/Q ratio is preferably less than 1×10?8 N/m and is achievable with the contemplated levitating micro-disk resonator.Type: ApplicationFiled: August 7, 2009Publication date: February 11, 2010Applicant: Villanova UniversityInventor: Mark A. Jupina
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Patent number: 7190141Abstract: A modular exoskeletal device adapted to fit the lower extremities of a patient during rehabilitation. The device has only two actuators during the standing stage of rehabilitation. Two additional actuators can be added, as modules, during the walking stage of rehabilitation. The actuators are affixed to the patient and provide controlled motion to at least one of the joints of the patient. A stationary control unit is separated from the patient. The control unit communicates with and directs the actuators, and has a hybrid control algorithm, such that the actuator forces are adjusted as the patient regains control of some joint motions, which is based upon the sliding-mode control theory. A back brace is affixed to the patient and helps to keep the torso of the patient in a stable, substantially vertical position.Type: GrantFiled: January 27, 2006Date of Patent: March 13, 2007Assignee: Villanova UniversityInventors: Hashem Ashrafiuon, Mehdi Nikkhah
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Patent number: 6224775Abstract: A method for separating a mixture of at least two chemical compounds which first involves loading and sintering a frit material in a capillary to form a first retaining frit. After removing substantially all unsintered frit material from the capillary, a packing material made up of a substrate coated with a linear carbohydrate polymer is loaded into the capillary adjacent to the first retaining frit to form a stationary phase. More frit material is loaded in the capillary and is sintered to form a second retaining frit adjacent to the packing material on the side opposite from the first retaining frit. Substantially all unsintered frit material is again removed from the capillary. The chemical mixture is then introduced into the capillary at one of the retaining frits, and migration of the mixture across the packing material is induced by applying a voltage across the capillary. Differences in electroosmotic flow velocity between the compounds cause them to separate during migration.Type: GrantFiled: September 3, 1998Date of Patent: May 1, 2001Assignee: Villanova UniversityInventors: Joe P. Foley, Sally J. Grieb
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Patent number: 4307084Abstract: An aqueous, biologically-compatible, reversible, oxygen-carrying system comprising a novel metallated porphine-carbohydrate-fatty acid complex, particularly a novel tetra-(p-carboxyphenyl)porphine-iron(II)-dextran-octanoate complex, useful as a synthetic respiratory pigment, and a method for preparing same. The complexes may be dissolved in a suitable electrolyte and used as a substitute for red blood cells.Type: GrantFiled: November 28, 1980Date of Patent: December 22, 1981Assignee: Villanova UniversityInventors: Joseph J. Drabick, Saul I. Shupack
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Patent number: 4118285Abstract: Herein are disclosed an improved method and apparatus for separating a mixture of liquids of differing volatilities by fractional distillation in a plate-type apparatus. Plates consisting at least in part of a porous structure having capillary-type passages extending between openings on one side of the plate and openings on the other side of the plate are employed. The capillary-type passages are adapted to be wetted and filled at least in part by the liquid condensate resulting from the condensation of a vapor mixture, with the consequent formation of menisci in the capillary-type passages and the generation of capillary pressures that cause the condensed liquid to be lodged within the capillary-type passages and transmitted through the plate while preventing the passage of vapor.Type: GrantFiled: April 29, 1975Date of Patent: October 3, 1978Assignee: Villanova UniversityInventor: George Chiayou Yeh
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Patent number: 4054414Abstract: Microanalytical method for the simultaneous determination of the elements, carbon, hydrogen, sulfur, chlorine, bromine, iodine and nitrogen in a single, small sample of an organic material, said method comprising the steps of: (a) substantially instantaneously igniting and rapidly and completely combusting a small sample of limited size in a heated combustion zone in a pressurized atmosphere of substantially pure oxygen; (b) conducting the gaseous mixture of combustion products in excess oxygen through a heated equilibrium zone; (c) conducting the effluent from the equilibrium zone through a gas chromatographic separation zone containing an adsorbent material adapted to separate combustion products of the said elements each from the others; (d) conducting the effluent from the separation zone through detecting means to quantitatively and separately measure the amount of the combustion product of each of the elements; (e) calculating from the amounts of the several combustion products the percentage content ofType: GrantFiled: November 30, 1976Date of Patent: October 18, 1977Assignee: Villanova UniversityInventors: Robert Lee Grob, Peter Wilson Rulon
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Patent number: 4013411Abstract: A method for testing biological materials, and especially those obtained from the human body, for the presence of the hepatitis associated antigen (HAA), in which Zeise's salt, or another water soluble platinum or palladium salt containing a trans directing group which enables the noble metal-containing moiety of the salt to react with the hepatitis associated antigen (HAA) or related materials, is mixed with the material to be tested in the presence of water, causing the formation of characteristic visible turbidity in the mixture which persists after agitation if HAA is present. Any slight turbidity observed initially in normal sera disappears upon agitation if the test sample is free from the hepatitis associated antigen. Also disclosed are test reagents consisting of the platinum and palladium salts in aqueous solutions containing non-interfering stabilizing salts such as sodium and potassium chloride and equivalents.Type: GrantFiled: July 19, 1974Date of Patent: March 22, 1977Assignee: Villanova UniversityInventors: Saul I. Shupack, Stephen F. Malin