Abstract: The present disclosure provides compositions comprising chemerin and the methods of use thereof. The compositions of the disclosure are useful in the treatment of cancer.
Type:
Grant
Filed:
January 9, 2017
Date of Patent:
March 26, 2024
Assignee:
Washington University
Inventors:
Russell Pachynski, Holbrook Kohrt, Jason Yonehiro, Brian Zabel
Abstract: Among the various aspects of the present disclosure is the provision of a methods for increasing chemotherapy sensitivity or decreasing chemotherapy resistance using BET inhibitors.
Type:
Grant
Filed:
July 9, 2021
Date of Patent:
March 26, 2024
Assignee:
Washington University
Inventors:
Robi Mitra, Arnav Moudgil, Michael Nathaniel Wilkinson
Abstract: Provided herein are methods for determining the severity of glaucoma using expression levels of GDF15. Determining the severity of glaucoma can aid in making treatment decisions.
Abstract: A binary code similarity detection system that compares a target binary code to a source code by comparing the target binary code to a comparing binary generated by compiling the source code. Rather than using a comparing binary generated using a random or fixed compiling configuration, the system identifies the compiling configuration of the target binary code and compares the target binary code to a comparing binary generated using the same compiling configuration as the target binary code. The compiling configuration of the target binary code may be identified by a neural network (e.g., a graph attention network trained on attributed function call graphs of binary codes with known compiling configurations). The target binary code and the comparing binary may be compared using a graph neural network (e.g., a graph triplet loss network) that compares attributed control flow graphs of the of the target binary code and the comparing binary.
Abstract: The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.
Type:
Grant
Filed:
April 19, 2019
Date of Patent:
March 19, 2024
Assignee:
Washington University
Inventors:
Stephen Pak, David Perlmutter, Gary Silverman
Abstract: The present invention provides methods for treating pruritus having a neurogenic component in a subject in need thereof comprising administering a therapeutically effective amount of a JAK1 inhibitor based on a benzimidazole core, a purine core, or a pyrrolo pyridine core.
Abstract: The present disclosure describes a fast-scanning optical-resolution photoacoustic (fsOR-PAE) endoscope for imaging vasculature within tissues in vivo that includes an ultrasonic transducer and a scanning mirror within a lumen of an elongate casing. The scanning mirror is configured to direct the laser pulses from the pulsed laser source to a focal spot outside the casing in a scanning pattern via an imaging window formed in the casing. The scanning mirror is further configured to direct a plurality of photoacoustic signals from the focal spot to the ultrasonic transducer via the imaging window.
Type:
Grant
Filed:
December 22, 2020
Date of Patent:
March 12, 2024
Assignees:
Washington University, California Institute of Technology
Inventors:
Lihong Wang, Konstantin Maslov, Methodius Tuuli, Molly Stout, George Macones, Chiye Li, Junhui Shi, Yuan Qu
Abstract: Various methods of diagnosing and monitoring a subject infected with a Plasmodium parasite are described. Also, compositions and methods for attracting mosquitos are also described.
Type:
Grant
Filed:
August 27, 2018
Date of Patent:
March 12, 2024
Assignee:
Washington University
Inventors:
Audrey Odom John, Chad Schaber, Indi Trehan, Baranidharan Raman, Nalin Katta
Abstract: The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
Type:
Grant
Filed:
August 24, 2021
Date of Patent:
March 12, 2024
Assignee:
Washington University
Inventors:
David Holtzman, Hong Jiang, Thu Nga Bien-Ly, Mark S. Dennis, Jing Guo, Adam P. Silverman, Ryan J. Watts, Yin Zhang
Abstract: Systems and methods for detecting oscillations in neural signals are disclosed that provide for high precision and specificity in detecting neural oscillations in time and frequency domains. The disclosed systems and methods identify oscillations according to criteria including 1/f noise, number of cycles, and auto-correlation. The disclosed method detects periodic signals and filters out spurious oscillations associated with harmonic frequencies.
Abstract: A system for defending against a side channel attack. The system includes a reuse distance buffer configured to measure one or more reuse distances for a microarchitecture block according to information of marker candidates and information of target events of a microarchitecture block; and a defense actuator configured to determine existence of a side channel attack in the microarchitecture block according to the one or more reuse distances for the microarchitecture block.
Type:
Grant
Filed:
February 22, 2021
Date of Patent:
March 5, 2024
Assignee:
The George Washington University
Inventors:
Guru Prasadh Venkataramani, Milo{hacek over (s)} Doroslova{hacek over (c)}ki, Hongyu Fang
Abstract: An integrated photonics computing system implements a residue number system (RNS) to achieve orders of magnitude improvements in computational speed per watt over the current state-of-the-art. RNS and nanophotonics have a natural affinity where most operations can be achieved as spatial routing using electrically controlled directional coupler switches, thereby giving rise to an innovative processing-in-network (PIN) paradigm. The system provides a path for attojoule-per-bit efficient and fast electro-optic switching devices, and uses them to develop optical compute engines based on residue arithmetic leading to multi-purpose nanophotonic computing.
Type:
Grant
Filed:
February 25, 2019
Date of Patent:
March 5, 2024
Assignee:
The George Washington University
Inventors:
Jiaxin Peng, Tarek El-Ghazawi, Volker J. Sorger, Shuai Sun
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
Type:
Grant
Filed:
October 14, 2021
Date of Patent:
March 5, 2024
Assignees:
The Washington University, The Arizona Board of Regents for and on Behalf of Arizona State University
Inventors:
Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.
Abstract: A diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject is described. The DOT system includes a source subsystem configured to generate optical waves, a probe coupled to the source subsystem and configured to emit the optical waves generated by the source subsystem toward the lesion region and to detect optical waves reflected by the lesion region, a detection subsystem configured to convert the optical waves detected by the probe to digital signals, and a computing device including a processor and a memory. The memory includes instructions that program the processor to receive the digital signals sent from the detection subsystem and perform reconstruction using a depth-regularized reconstruction algorithm combined with a semi-automated interactive convolutional neural network (CNN) for depth-dependent reconstruction of absorption distribution.
Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.
Type:
Grant
Filed:
October 22, 2021
Date of Patent:
February 20, 2024
Assignees:
Washington University, Disarm Therapeutics, Inc.
Inventors:
Jeffrey Milbrandt, Kow Essuman, Yo Sasaki, Aaron Diantonio, Xianrong Mao, Rajesh Devraj, Raul Eduardo Krauss, Robert Owen Hughes
Abstract: Devices and methods for joining a first and second tissue in a patient are disclosed that include a base with a plurality of recurved tines oriented to a tine axis and extending from a first surface of the base. The tines provide unidirectional traction of the first tissue along the tine axis toward the first surface. The first tissue is secured to the first surface of the device at the plurality of recurved tines and the second tissue is secured to the device at a second surface opposite the first surface to join the first and second tissues.
Type:
Application
Filed:
October 5, 2020
Publication date:
February 15, 2024
Applicants:
Washington University, Columbia University
Inventors:
Guy Genin, Ethan Hoppe, Dong Hwan Yoon, Stavros Thomopoulos, Iden Kurtaliaj, Liana Tedesco, David Kovacevic, Victor Birman, Lester Smith, Leesa Galatz, William Levine
Abstract: The present disclosure provides methods of treating cancer in a subject including administering a therapeutic composition comprising an ATR inhibitor and a hypomethylating agent. Methods of inducing DNA replication stress or cell death in a cancer cell are also provided. The combination of an ATR inhibitor and hypomethylating agent is particularly useful for treating TP53-mutated cancers, such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
Abstract: The present disclosure provides for methods of activating an immune cell in a subject by administering to the subject a CYR61 activating agent, as well as methods of treating ocular neovascularization in a subject by administering a CYR61 activating agent to an immune cell to form a treated immune cell and administering the treated immune cell to the subject.
Type:
Application
Filed:
August 11, 2023
Publication date:
February 15, 2024
Applicant:
Washington University
Inventors:
Rajendra Apte, Joseph Lin, Philip Ruzycki
Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an NKG2D ligand or PD1 ligand and may improve immunotherapy by limiting side effects associated with immunotherapy. The present disclosure also encompasses compositions and methods for recruiting cytotoxic lymphocytes to target cells using NKG2D receptor ligands or PD1 ligands. The compositions disclosed herein comprise a NKG2D receptor ligand and a targeting molecule and may improve immunotherapy by limiting side effects associated with immunotherapy.
Type:
Grant
Filed:
April 23, 2021
Date of Patent:
February 13, 2024
Assignee:
Washington University
Inventors:
Alexander Sasha Krupnick, Daved Henry Fremont, Eric Reed Lazear, John Westwick