Patents Assigned to Yeda Research and Development Co. Ltd. at the Weizmann
Institute of Science
-
Publication number: 20150238582Abstract: A method for treating a disease, disorder, condition or injury of the Central Nervous System (CNS) in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of an active ingredient, such as a non-encephalitogenic or weakly encephalitogenic combination of a Th1 adjuvant and a CNS-specific antigen, causing activation of the choroid plexus of said subject and maintaining said activation by reducing immunosuppression and establishing Th1-type immune response at the choroid plexus thus allowing either anti-inflammatory immune cells or immune cells which acquire a healing phenotype at the cerebrospinal fluid to pass through the choroid plexus, and accumulate at a site of damage in the CNS caused by said disease, disorder, condition or injury is provided.Type: ApplicationFiled: September 10, 2013Publication date: August 27, 2015Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCEInventors: Michal Eisenbach-Schwartz, Nir Friedman, Kuti Baruch, Gilad Kunis, Liora Cahalon, Neta Rosenzweig, Aleksandra Deczkowska
-
Patent number: 9067052Abstract: Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.Type: GrantFiled: March 2, 2010Date of Patent: June 30, 2015Assignee: YEDA RESEARCH AND DEVELOPMENT CO., LTD. at The Weizmann Institute of ScienceInventors: Elisha Moses, Assaf Rotem
-
Patent number: 9033862Abstract: Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.Type: GrantFiled: March 2, 2010Date of Patent: May 19, 2015Assignee: YEDA RESEARCH AND DEVELOPMENT CO., LTD. at The Weizmann Institute of ScienceInventors: Elisha Moses, Assaf Rotem
-
Publication number: 20140249352Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.Type: ApplicationFiled: March 12, 2014Publication date: September 4, 2014Applicants: BRAINSWAY, LTD., Yeda Research & Development Co. Ltd. at the Weizmann Institute of Science, Government of the United States of America, As Represented by the Secretary,Inventors: ABRAHAM ZANGEN, YIFTACH ROTH, PEDRO C. MIRANDA, DAVID HAZANI, MARK HALLETT
-
Patent number: 8771163Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.Type: GrantFiled: March 4, 2013Date of Patent: July 8, 2014Assignees: Brainsway, Ltd., Yeda Research & Development Co. Ltd. at the Weizmann Institute of Science, The United States of America as Represented by the Secretary, Department of Health and Human ServicesInventors: Abraham Zangen, Yiftach Roth, Pedro C. Miranda, David Hazani, Mark Hallett
-
Publication number: 20130178692Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.Type: ApplicationFiled: March 4, 2013Publication date: July 11, 2013Applicants: BRAINSWAY, INC., YEDA RESEARCH & DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE, GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTHInventors: BRAINSWAY, INC., GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPART, YEDA RESEARCH & DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE
-
Patent number: 8388510Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.Type: GrantFiled: July 10, 2011Date of Patent: March 5, 2013Assignees: Brainsway, Inc., Yeda Research & Development Co. Ltd. at the Weizmann Institute of Science, The United States of America as Represented by the Secretary Department of Health and Human ServicesInventors: Abraham Zangen, Yiftach Roth, Pedro C. Miranda, David Hazani, Mark Hallet
-
Publication number: 20130045535Abstract: A cell culturing system is provided. The cell culturing system includes a cell niche defined by a niche base and niche walls, at least one of which includes a fluid pathway formed therein. The niche wall material is selected capable of enabling diffusion into the niche of a fluid flowing between an inlet and an outlet of the fluid pathway.Type: ApplicationFiled: April 26, 2011Publication date: February 21, 2013Applicant: Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Yoav Soen, Saar Golan
-
Patent number: 8330026Abstract: The invention relates to the use of NF-?B inducing kinase (NIK) and related molecules for the modulation of signal activities controlled by cytokines, and some new such molecules.Type: GrantFiled: April 15, 2003Date of Patent: December 11, 2012Assignee: Yeda Research and Development Co., Ltd., Weizmann Institute of ScienceInventors: David Wallach, Parameswaran Ramakrishnan, Taisia Shmushkovich
-
Patent number: 8277371Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.Type: GrantFiled: July 10, 2011Date of Patent: October 2, 2012Assignees: Brainsway, Inc., Yeda Research & Development Co. Ltd. at the Weizmann Institute of Science, The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Abraham Zangen, Yiftach Roth, Pedro C. Miranda, David Hazani, Mark Hallet
-
Publication number: 20120209534Abstract: A method of analyzing liquid is disclosed. The method comprises: obtaining data pertaining to a dripping pattern characterizing formation of liquid drops as a function of the time, and comparing the dripping pattern to a reference dripping pattern.Type: ApplicationFiled: October 19, 2010Publication date: August 16, 2012Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD. AT THE WEIZMANN INSTITUTE OF SCIENCEInventors: Dan Shahar, Ziv Reich, Ruti Kapon
-
Patent number: 8244063Abstract: A method includes measuring the likelihood that two different space-time video segments could have resulted from a similar underlying motion field without computing the field. The method may be employed to identify locations in a video sequence where at least one behavioral phenomenon similar to that demonstrated in the video segment occurs. For example, the phenomenon might be a dynamic behavior, an action, a rigid motion, and/or a non-rigid motion.Type: GrantFiled: April 11, 2006Date of Patent: August 14, 2012Assignee: Yeda Research & Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Eli Shechtman, Michal Irani
-
Publication number: 20120184481Abstract: The present invention provides anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising at least one altered phosphorylation site, polynucleotides encoding same and uses thereof. Particularly, the present invention provides variants of human PEDF comprising at least one amino acid substitution at serine residues (24), (114), and (227). The PEDF variants are potent anti-angiogenic factors, and thus useful in treating diseases or disorders associated with neovascularization.Type: ApplicationFiled: April 3, 2012Publication date: July 19, 2012Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. at the Weizmann Institute of ScienceInventors: Rony Seger, Galia Maik-Rachline
-
Publication number: 20120171233Abstract: The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing these peptides.Type: ApplicationFiled: November 1, 2011Publication date: July 5, 2012Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. at The Weizmann Institute of ScienceInventors: Johannes Herkel, Irun R. Cohen, Varda Rotter, Ansgar W. Lohse, Neta Erez, Avishai Mimran, Na'aman Kam
-
Publication number: 20120164668Abstract: The invention relates to methods, devices and systems for an enhanced, ultrasound assisted immunoassay (such as a Western blot immunoassay). In particular, there are provided methods, devices and system for the automated and enhanced processing of a membrane having proteins associated therewith, wherein the processing includes the use of ultrasonic energy.Type: ApplicationFiled: July 27, 2010Publication date: June 28, 2012Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. at the Weizmann Institute of ScienceInventor: Peter Starokadomskyy
-
Patent number: 8200648Abstract: A method includes finding regions of a reference signal which provide at least one of: local evidence scores and a global evidence score. The local evidence scores indicate local similarity of the regions of the reference signal to regions of a query signal and the global evidence score defines the extent of a global similarity of the query signal to the reference signal. A media exploring device is also included which includes an importance encoder and a media explorer. The importance encoder generates importance scores of at least portions of digital media as a function of at least one of local evidence scores and global evidence scores. The media explorer enables exploring through the digital media according to (i) the importance scores, (ii) data associations/links induced by the evidence scores between different portions of the digital media. The device may also include a media player to play the digital media with adaptive speeds as a function of the importance scores.Type: GrantFiled: August 7, 2007Date of Patent: June 12, 2012Assignee: Yeda Research & Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Oren Boiman, Michal Irani
-
Patent number: 8106010Abstract: The present invention relates to anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising a plurality of altered phosphorylation sites, polynucleotides encoding same and uses thereof. In particular, the PEDF variants of the present invention provide superior anti-angiogenic activity and high neurotrophic activity and are useful in treating diseases associated with neovascularization and with neurodegenerative conditions.Type: GrantFiled: November 14, 2006Date of Patent: January 31, 2012Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Galia Maik-Rachline, Rony Seger
-
Publication number: 20110301093Abstract: The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.Type: ApplicationFiled: June 3, 2011Publication date: December 8, 2011Applicant: Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Adi Kimchi, Einat Zalckvar
-
Publication number: 20110300559Abstract: The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.Type: ApplicationFiled: June 3, 2011Publication date: December 8, 2011Applicant: Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventors: Adi Kimchi, Einat Zalckvar
-
Publication number: 20110288159Abstract: A nucleic acid construct and construct system are disclosed. The nucleic acid construct and system comprise a regulatory sequence which regulates inducible expression of a polypeptide of interest, the regulatory sequence comprising a choroid plexus specific promoter, with the proviso that the choroid plexus specific promoter is not a transthyretin promoter. Pharmaceutical compositions comprising same and uses thereof are also disclosed.Type: ApplicationFiled: March 25, 2009Publication date: November 24, 2011Applicant: Yeda Research and Development Co. Ltd. at the Weizmann Institute of ScienceInventor: Alon Chen