Patents Assigned to Zoetis Services LLC
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Patent number: 11215614Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides a method of detecting a target analyte in a sample comprising mixing the sample with a first detection conjugate and a second detection conjugate in solution, wherein the first and second detection conjugates comprise metallic nanostructures coupled to binding partners that are capable of specifically binding to the target analyte if present in the sample to form a complex between the first detection conjugate, the analyte, and the second detection conjugate, wherein a change in an optical signal upon complex formation indicates the presence of the target analyte in the sample. Methods of preparing nanostructures and nanoalloys, as well as nanostructures and nanoalloys conjugated to binding partners, are also described.Type: GrantFiled: August 20, 2019Date of Patent: January 4, 2022Assignee: Zoetis Services LLCInventors: Rajesh K. Mehra, Vincent Chiang, Kenneth Aron, Jessica Frisz
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Patent number: 11209430Abstract: The present invention relates to analyte detection devices and methods of using such devices to detect minute quantities of a target analyte in a sample. In particular, the invention provides an analyte detection device comprising a plurality of composite metallic nanostructures conjugated to analyte binding partners and a surface containing a metallic nanolayer on which a plurality of capture molecules is immobilized. Methods of preparing composite nanostructures are also described.Type: GrantFiled: October 16, 2019Date of Patent: December 28, 2021Assignee: ZOETIS SERVICES LLCInventors: Rajesh K. Mehra, Vincent Chiang, Kenneth P. Aron, Asher Krell
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Patent number: 11204351Abstract: The invention provides methods, kits, compositions, and devices useful for detection of antibodies that bind to Ehrlichia antigens and/or for differentiation of certain Ehrlichia species from others. In particular, the invention provides methods and kits useful for identifying species of Ehrlichia using populations of isolated peptides.Type: GrantFiled: November 14, 2017Date of Patent: December 21, 2021Assignee: ZOETIS SERVICES LLCInventors: Rajesh K. Mehra, Jeremy D. Walker, Kenneth P. Aron, Dennis M. Bleile, Cristina R. Cuesico, Timothy P. Forsyth
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Patent number: 11193949Abstract: A diagnostic test reader system including two or more reader modules and at least one mother module is provided. Each of the reader modules includes a unique code and is configured for reading a specific test cartridge type. Each of the reader modules is configured to be in data communication with the mother module for receiving instructions from the mother module and for transmitting read and/or derived data to the mother module. The mother module is configured for communicating individually with each of the reader modules.Type: GrantFiled: February 13, 2018Date of Patent: December 7, 2021Assignee: Zoetis Services LLCInventors: Niels Kristian Bau-Madsen, Ole Kring
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Patent number: 11154609Abstract: This invention provides a combination vaccine which includes a porcine circovirus type 2 (PCV2) antigen and a cell free Mycoplasma hyopneumoniae (M. hyo) culture supernatant for protecting a pig against PCV2 and M. hyo infections, wherein the M. hyo culture supernatant is substantially free of PCV2 antibodies.Type: GrantFiled: April 28, 2020Date of Patent: October 26, 2021Assignee: Zoetis Services LLCInventors: Gregory P. Nitzel, Jeffrey E. Galvin, John Keith Garrett, James R. Kulawik, II, Tracy L. Ricker, Megan Marie Smutzer
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Patent number: 11141472Abstract: This invention provides a Mycoplasma hyopneumoniae (M. hyo) antigen that is compatible with antigens from other swine pathogens, wherein the M. hyo antigen is a cell free M. hyo culture supernatant which is substantially free of swine IgG.Type: GrantFiled: April 27, 2020Date of Patent: October 12, 2021Assignee: Zoetis Services LLCInventors: Jeffrey E. Galvin, Gregory P. Nitzel, John Keith Garrett, James R. Kulawik, II, Tracy L. Ricker, Megan Marie Smutzer
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Patent number: 11131675Abstract: The invention provides populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens. The peptide populations comprise peptides derived from immunogenic fragments of the Anaplasma Outer Membrane Protein proteins. The invention also provides devices, methods, and kits comprising the populations of isolated peptides useful for the detection of antibodies that bind to Anaplasma antigens and the diagnosis of anaplasmosis. Methods of identifying the particular Anaplasma species infecting a subject using the peptide populations of the invention are also disclosed.Type: GrantFiled: May 9, 2019Date of Patent: September 28, 2021Assignee: ZOETIS SERVICES LLCInventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile, Andrew P. Rogers, Timothy P. Forsyth, Jeremy D. Walker, Cristina R. Cuesico
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Patent number: 11122779Abstract: An egg grasp device is provided. Such a device includes a body and a plurality of elongated members extending from the body. The elongated members are interlaced to form a sheath capable of retaining an egg. The sheath has a distal end and a proximal end at which the elongated members are operably engaged with the body. The elongated members cooperate to define an opening at the distal end through which an egg is received when the elongated members engage and deflect about an egg such that the egg is seated within the sheath. Associated systems and methods are also provided.Type: GrantFiled: September 12, 2019Date of Patent: September 21, 2021Assignee: Zoetis Services LLCInventor: William Dongwook Suh
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Patent number: 11103573Abstract: Poultry vaccines against infectious bronchitis and Turkey Rhinotracheitis are provided. The vaccines are adjuvanted with oil emulsion containing an immunostimulatory oligonucleotide. The methods of using the vaccines are also provided.Type: GrantFiled: May 31, 2017Date of Patent: August 31, 2021Assignee: Zoetis Services LLCInventors: Carla Maria Batista de Freitas, Maria Carolina Ferreira dos Santos, Paul Joseph Dominowski, Harmen Jacob Geerligs
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Patent number: 11094050Abstract: Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. A method may include aligning an apparatus to an imaging device. The apparatus may include a set of wells defined by a first layer coupled to a second layer. The first layer may be substantially transparent to infrared radiation. The second layer may define a channel. The second layer may be substantially absorbent to the infrared radiation. The apparatus may further include a third layer coupled to the second layer and define an opening configured to receive a fluid. The third layer may be substantially transparent to the infrared radiation. A set of images of the apparatus may be generated using the imaging device. Bonding information may be generated based on the set of images.Type: GrantFiled: August 22, 2019Date of Patent: August 17, 2021Assignee: Zoetis Services LLCInventors: Robert Justice Shartle, Gregory Trigub
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Patent number: 11090376Abstract: The present invention provides modified live European PRRS viruses (whether or not recombinant) that have been at all times cultured, maintained, and/or attenuated on non-simian cells, typically porcine cells, wherein such cells express a porcine CD163 receptor, and whereinby vaccines prepared from such viruses are safe and efficacious, and permit the pre-weaning single dose vaccination of swine, typically as early as Day 1 of life.Type: GrantFiled: December 14, 2017Date of Patent: August 17, 2021Assignee: Zoetis Services LLCInventors: Jay Gregory Calvert, Monica Balasch, Maria Fort, Douglas S. Pearce, Marcia L. Keith
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Patent number: 11085028Abstract: A harvesting apparatus adapted to harvest egg fluid from an avian egg is provided. Such an apparatus includes a frame. A harvesting assembly is operably engaged with the frame. The harvesting assembly includes a plurality of nozzles configured to remove egg fluid from an egg. The nozzles are configured to rotate from a vertically off-axis angled position toward a vertical position. A suction assembly is in fluid communication with the nozzles for harvesting egg fluid from an egg. An associated method is also provided.Type: GrantFiled: August 8, 2019Date of Patent: August 10, 2021Assignee: Zoetis Services LLCInventors: Joseph Federowicz, Louis Pallay
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Patent number: 11077968Abstract: The invention relates to a so-called stabilization method, consisting of completing the filling of traveling egg trays. In each of the successive trays, eggs taken from an available egg reservoir are deposited in empty locations. This reservoir is made up of egg receiving cells that are movable along rows of cells in series. Depending on a filling state of the tray being treated identifying the distribution of the empty locations relative to the full locations, the reservoir is automatically configured in a configuration of egg-bearing cells complementary to said filling state of the tray in progress, so as to next transfer eggs between the reservoir and the tray in progress by correspondence between empty locations and full locations in the tray and the presence or absence of an egg-bearing cell in the reservoir.Type: GrantFiled: November 18, 2019Date of Patent: August 3, 2021Assignee: Zoetis Services LLCInventors: Pierre Robert, Franck Robert
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Patent number: 11058763Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus (“PEDV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture.Type: GrantFiled: February 26, 2016Date of Patent: July 13, 2021Assignees: Zoetis Services LLC, Iowa State University Research Foundation, Inc.Inventors: Jianqiang Zhang, Qi Chen, Phillip Gauger, Darin Madson, John Morgan Hardham, Meggan Bandrick, Jay Gregory Calvert, James Richard Thompson, Mira Ivanova Stoeva, Walter Valdez
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Patent number: 10982002Abstract: The present disclosure encompasses novel anti-NGF antibodies, antigen binding proteins and polynucleotides encoding the same. The disclosure further provides use of the novel antibodies, antigen binding proteins and/or nucleotide of the invention for the treatment and/or prevention of NGF related disorders, particularly in for the management of pain.Type: GrantFiled: January 18, 2019Date of Patent: April 20, 2021Assignee: Zoetis Services LLCInventors: Sebastian C. J. Steiniger, William Dunkle, Catherine Rugg, Steven A. Dunham
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Patent number: 10969385Abstract: The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed.Type: GrantFiled: June 24, 2019Date of Patent: April 6, 2021Assignee: ZOETIS SERVICES LLCInventors: Rajesh K. Mehra, Kenneth P. Aron
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Patent number: 10967058Abstract: Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.Type: GrantFiled: April 3, 2019Date of Patent: April 6, 2021Assignees: Zoetis Services LLC, United States of America, as represented by the Secretary of AgricultureInventors: Paul Joseph Dominowski, John Morgan Hardham, James Alan Jackson, Cyril Gerard Gay, Luis Leandro Rodriguez, Peter William Krug, Aida Elizabeth Rieder
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Patent number: 10953088Abstract: The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.Type: GrantFiled: February 22, 2019Date of Patent: March 23, 2021Assignee: Zoetis Services LLCInventors: Jacqueline Gayle Marx, John Morgan Hardham, Paul J. Dominowski, Vicki Jon Rapp Gabrielson, Monica Balasch Sanuy, Marta Cabana Sumsi, Laia Plaja Dilme, Alicia Urniza Hostench, Oscar Romero Galindo
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Patent number: 10953080Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.Type: GrantFiled: October 22, 2018Date of Patent: March 23, 2021Assignee: Zoetis Services LLCInventors: Paul Joseph Dominowski, Dennis L. Foss, Guillermo Gallo, John Morgan Hardham, Richard Lee Krebs, Sandra Ann Marie Lightle, Suman Mahan, Sangita Mediratta, Kaori Mohr, Duncan Mwangi, Sharath K. Rai, Sarah A. Salmon, Shaunak Vora, Lauren Wilmes
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Patent number: 10948487Abstract: The invention provides peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions and mixtures comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic and/or granulocytic ehrlichiosis.Type: GrantFiled: August 27, 2019Date of Patent: March 16, 2021Assignee: Zoetis Services LLCInventors: Rajesh K. Mehra, Kenneth P. Aron, Dennis M. Bleile, Timothy P. Forsyth, Jeremy D. Walker, Cristina R. Cuesico