Abstract: Disclosed are tetraalkyl enthenylidenebisphosphonates and a method for their manufacture. These compounds are suitable for use as antimicrobial agents in combating a number of pathogenic microorganisms, such as bacteria, yeasts, viruses, fungi and protozoa, when used together with a pharmaceutically-acceptable carrier. Also disclosed is a method for treating infectious diseases by administering a safe and effective amount of these tetraalkyl ethenylidenebisphosphonates.
Type:
Grant
Filed:
April 23, 1986
Date of Patent:
April 11, 1989
Assignee:
The Procter & Gamble Company
Inventors:
Charles R. Degenhardt, Duane L. Charbonneau
Abstract: The present invention relates to a cosmetic comprising a neutral polysaccharide obtained from an acid-fast bacterium. This cosmetic smoothly spreads on the skin without sticking to the skin to give moistness to the skin. Furthermore, the cosmetic covers the skin and shows an excellent moisture-retaining action, and exerts an effect of preventing or moderating the rough skin.
Abstract: Described are the uses of dimethyl disulfide having the structure: ##STR1## and dibutyl succinate having the structure: ##STR2## taken alone or taken in combination as attractants for mosquitos (Culicidae). The dibutyl succinate and dimethyl disulfide taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
Type:
Grant
Filed:
August 29, 1986
Date of Patent:
April 4, 1989
Assignees:
International Flavors & Fragrances Inc., The University of Florida
Inventors:
Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
Abstract: Described are the uses of N,N-diethyl-m-toluamide having the structure: ##STR1## and the ethyl ester of 2-methyl-3-pentenoic acid having the structure: ##STR2## taken alone or in combination as attractions for mosquitos (Culicidae). The N,N-diethyl-m-toluamide and the ethyl ester of 2-methyl-3-pentenoic acid taken along or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
Type:
Grant
Filed:
March 17, 1987
Date of Patent:
March 28, 1989
Assignees:
International Flavors & Fragrances Inc., The University of Florida
Inventors:
Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.
Type:
Grant
Filed:
March 30, 1987
Date of Patent:
March 28, 1989
Assignee:
Warner-Lambert Company
Inventors:
Gerhard Satzinger, Manfred Herrmann, Edgar Fritschi, Ute Weiershausen
Abstract: Method for the effective management of Herpes Simplex including the administration of an effective dosage of phenol, 4,4'-(2-pyridinyl methylene) bis diacetate (ester), in combination with a carrier, vitamins, or other therapeutic agents, and an effective dosage product comprising phenol, 4,4'-(2-pyridinyl methylene) bis,- diacetate (ester) for carrying out the method.
Abstract: Described are the N,N-diethyl-m-toluamide having the structure: ##STR1## and the ethyl ester of 2-methyl-3-pentenoic acid having the structure: ##STR2## taken alone or taken in combination as attractants for house flies (Musca domestica L. (Diptera:Muscidae)). The N,N-diethyl-m-toluamide and ethyl ester of 2-methyl-3-pentenoic acid taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
Type:
Grant
Filed:
March 17, 1987
Date of Patent:
February 28, 1989
Assignees:
International Flavors & Fragrances Inc., The University of Florida
Inventors:
Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
Abstract: Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking agents, thereby increasing the sensitivity of the resistant cell to tetracycline type antibiotics.
Type:
Grant
Filed:
November 18, 1982
Date of Patent:
February 21, 1989
Assignee:
Trustees of Tufts College, Tufts University
Abstract: Described are the uses of methyl-isoeugenol having the structure: ##STR1## n-dodecanol having the structure: ##STR2## and 1-(2-butenoyl)-2,6,6-trimethyl-1,3-cyclohexadiene having the structure: ##STR3## taken alone or taken in combination as attractants house flies (Musca domestica L. (Diptera:Muscidae)) and Stored Products Moths. The methyl-isoeugenol, n-dodecanol and 1-(2-butenoyl)-1,3-cyclohexadiene taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
Type:
Grant
Filed:
November 14, 1986
Date of Patent:
January 31, 1989
Assignees:
International Flavors & Fragrances Inc., The University of Florida
Inventors:
Richard A. Wilson, Jerry F. Butler, Donald Withycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
Abstract: Described are the uses of dimethyl disulfide having the structure: ##STR1## and dibutyl succinate having the structure: ##STR2## taken alone or taken in combination as attractants for sand flies (Psychodidae), house flies and beetles (Coleoptera). The dimethyl disulfide itself is specifically useful as an attractant for house flies and the dibutyl succinate is specifically useful as an attractant for Coleoptera and Psychodidae. The dibutyl succinate and dimethyl disulfide taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.
Type:
Grant
Filed:
June 27, 1986
Date of Patent:
January 31, 1989
Assignees:
International Flavors & Fragrances Inc., The University of Florida
Inventors:
Richard A. Wilson, Jerry F. Butler, Donald Whithycombe, Braja D. Mookherjee, Ira Katz, Kenneth R. Schrankel
Abstract: A capillary cosmetic composition for washing or disentangling hair comprises in an appropriate cosmetic vehicle at least one plant extract, the active principle of which is at least one saponin and at least one cationic polymer.
Type:
Grant
Filed:
August 18, 1986
Date of Patent:
January 24, 1989
Assignee:
Societe Anonyme dite: L'Oreal
Inventors:
Jean-Francois Grollier, Bernard Beauquey
Abstract: Wood preservative compositions containing as active ingredients compounds of copper, of chromium and of arsenic are produced by mixing copper arsenate and sodium dichromate in an aqueous medium into which is introduced strong acid, for example sulphuric acid, effective to achieve a soluble product. The acid addition is preferably effective to reduce the pH to below 0. The composition so produced is a homogeneous paste which may be dissolved in water to working concentration and used for the preservation of wood by impregnation techniques.
Abstract: A drug/liposome composition comprising an aqueous suspension of liposomes and, entrapped in the lipid bilayer region of the liposomes, an anthraquinone drug containing quinone and hydroquinone functionalities on adjacent anthracene rings. An iron-specific trihydroxamic chelating agent contained in the bulk aqueous phase of the suspension and a lipophilic free-radical scavenger contained in the bilayer region of the liposome cooperate to reduce chemical modification of both drug and lipid components of the composition. A preferred composition containing doxorubicin and alpha-tocopherol entrapped in the liposomes, and ferrioxamine in the aqueous suspension phase is effective in treating human neoplasms, with significantly reduced side effects over those produced by free-drug administration.
Type:
Grant
Filed:
December 6, 1985
Date of Patent:
January 10, 1989
Assignees:
Yissum Research and Development Company of the Hebrew University of Jerusalem, Hadassah Medical Organization
Abstract: Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life.Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.
Type:
Grant
Filed:
July 30, 1986
Date of Patent:
December 13, 1988
Assignee:
Burroughs Wellcome Co.
Inventors:
John F. Batchelor, Richard M. Hyde, David J. Livingstone
Abstract: A method for the treatment and/or prophylaxis of reversible airways obstruction and asthma in mammals, which method comprises administering to the mammal in need of said treatment an effective amount of a compound of formula (I): ##STR1## wherein R.sub.1 -R.sub.8 and X are as set forth herein.
Abstract: This invention is directed to oxidation hair dye compositions and their use in the dyeing of human hair. The compositions consist essentially of precursors comprising 2,3-diamino-6-methoxy-pyridines and aromatic amines or diamines. The combination of oxidation dye precursors according to the invention gives bright, deep blue dye finishes having high stability to heat and light.
Type:
Grant
Filed:
October 7, 1985
Date of Patent:
November 15, 1988
Assignee:
Henkel Kommanditgesellschaft auf Aktien
Inventors:
Norbert Maak, Peter Flemming, Dieter Schrader
Abstract: Composition containing:a--from 20 to 40% of iprodione,b--an oil-in-water emulsion containing 50 to 160% by weight, relative to the iprodione, of an oil of which the hydrophilic/lipophilic balance has a value of 9 to 12, andc--from 0.1 to 2% by weight of an emulsifier of the ethylene oxide/fatty alcohol condensate type.Composition for the protection of plants against fungal diseases.
Abstract: Hydrosoluble pharmaceutical compositions containing, as the active principal, salts of (-)cis-1,2-epoxypropylphosphonic acid with aminoacids such as arginine, ornithine, lysine, cysteine, and the like, characterized by containing a hydrophyllic organic base.
Abstract: The compounds of the following general structural formula (I) ##STR1## wherein R is hydrogen or a pharmaceutically acceptable salt thereof, are .beta.-ketoacyl-coenzyme A thiolase inhibitors and are useful as antihypercholesterolemic agents for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, such as arteriosclerosis, hyperlipidemia and familial hypercholesterolemia.