Abstract: This disclosure teaches a method of inactivating bacterial toxins, such as produced by Vibrio cholerae and Escherichia coli (hereinafter V. cholerae and E. coli) that are responsible for diarrhea in warm-blooded animals, comprising the placing of an effective dosage of ascorbic acid salts thereof, or derivatives such as the ester ascorbyl palmitate in the intestinal tract.Definition: Ascorbic acid, salts thereof, and derivatives thereof such as ascorbyl palmetate have been identified as suitable detoxifying material according to this invention. For the sake brevity, the term "ascorbic acid" hereinafter shall include the salts and esters.Diarrhea as used herein will include other toxins effecting the lower duodenum and intestines.

Abstract: Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.

Abstract: The fact that Lycorine can be used for suppression of the immune system of mammals is described. Lycorine is therefore suitable for the therapy of autoimmune diseases, immune complex diseases and allergic and rheumatic conditions and for prophylaxis against transplant rejections.

Abstract: Arthropodicidal compositions in the form of synergistic combinations of (A) cyano-(4-fluoro-3-phenoxyphenyl)-methyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate plus (B) O-ethyl-O-[4-(methylthio)-phenyl]-S-propyl phosphorodithioate, (A) plus (C) N.sup.1 -(4-chloro-O-tolyl)-N,N-dimethylformamidine, (A) plus (B) plus (C), (A) plus (D) 1-(tricyclohexylstannyl)-1H-1,2,4-triazole, (A) plus (E) tricyclohexyl hydroxystannane, or (A) plus (F) hexakis-(2-methyl-2-phenylpropyl)-distannoxane, which are individually known compounds, which combinations possess synergistic arthropidicidal properties especially for the control of mites.

Abstract: The invention relates to a dyeing composition for keratinous fibres containing at least one 4-bis(.beta.-hydroxyethyl)amino-2-nitro-1-(N-substituted amino)benzene compound in which the substitution is C.sub.1 -C.sub.3 alkyl or .beta.-hydroxyethyl; this composition contains as co-solubilization agent at least one dye of formula (II) ##STR1## in which formula: R.sub.2 denotes a C.sub.2 -C.sub.3 hydroxyalkyl group;R.sub.3 denotes a C.sub.2 -C.sub.3 hydroxyalkyl group; with the proviso that, if R.sub.3 =CH.sub.2 CH.sub.2 OH, R.sub.2 is necessarily an .alpha.-hydroxyethyl or hydroxypropyl radical.

Abstract: This invention is directed to m-phenylenediamine derivatives and salts thereof and to compositions of the developer-coupler type of the dyeing of hair, consisting essentially of m-phenylenediamine derivatives or salts thereof as coupling components and, as developer components, conventional components used in oxidation dyes.

Abstract: The present invention relates to an agricultural and horticultural fungicidal composition containing as active ingredients tolclofos-methyl [O,O-dimethyl O-(2,6-dichloro-4-methylphenyl) phosphorothiaoate] and an N,N'-ethylenebis(dithiocarbamate) type fungicide.

Abstract: A prostaglandin emulsion composition comprising a prostaglandin emulsified with a phosphatidylethanolamine-free phospholipid, the composition being suitable for intravenous administration.

Abstract: There are disclosed novel formulations of avermectin compounds and a substrate which demonstrate markedly enhanced insecticidal activity over that which would be observed with other formulations. Avermectin natural product compounds and certain semisynthetic derivatives thereof are compounds known to be highly effective broad-spectrum antiparasitic and pesticidal agents. However, when such compounds are formulated into the instant composition, the activity observed is increased to at least 10-times that which would be expected. The instant substrate is preferably a highly dispersed, amorphous form of hydrophyllic silicon dioxide.

Abstract: The present invention provides stabilized pesticidal emulsions in which (5-Benzyl-3-furyl)methyl 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylate may be used as the sole active ingredient or in combination with other pesticidal agents without the development of the unpleasant odor characteristic of that compound.

Abstract: The present invention provides stabilized oil-based pesticidal compositions in which (5-Benzyl-3-furyl)methyl 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylate may be used as the sole active ingredient or in combination with other pesticidal agents without the development of the unpleasant odor characteristic of that compound.

Abstract: A number of esters of maleic and fumaric acids were found to exhibit potent anticlostridial activity.

Abstract: A corrosion resistant insecticidal composition for use in aerosol containers includes an organophosphorous pesticide, an emulsifier, an aerosol propellant, an aqueous carrier and as a corrosion inhibiting system, an organic corrosion inhibitor and an inorganic corrosion inhibitor.

Abstract: Pesticidal compositions based on nontoxic, naturally unstable insecticides (pyrethrum, synthetic pyrethroids and mixtures thereof) include a liquid alkyl aryl silicone polymer which stabilizes the insecticide to provide an extended effective killing life. The compositions additionally include a synergist to provide an immediate killing action and an antioxidant to protect the insecticide against destruction by oxygen. Ultraviolet protectants and insect repellents may also be included. Applications include control of insect pests to animals and plants and general purpose insect control. Exemplary formulations are given for compositions to be applied as sprays, dips, powdered or dusts, foggers and shampoos.

Abstract: The invention relates to a dyeing composition for keratinous fibres containing, in a suitable vehicle, at least one nitrated direct dye of the 2-nitro-paraphenylenediamine series, in which the amino group in position 4 is mono- or disubstituted with lower alkyl or hydroxyalkyl radicals and in which the amino group in position 1 is optionally monosubstituted with a lower alkyl or hydroxyalkyl radial, and the aromatic ring can be substituted or unsubstituted on the remaining positions; the invention consists in introducing into such a composition an imidazolidinedione or one of its substitution derivatives, to improve the solubility of the abovementioned nitrated direct dye by a co-solubilization phenomenon. The invention also relates to a process for dyeing keratinous fibres using such compositions.

Abstract: There are disclosed novel compounds which are derived from 22,23-dihydro avermectin Bla aglycone, 13-deoxy-22,23 dihydro overmectin Bla aglycone and 13-deoxy-22,23-dihydro overmectin Blb aglycone. The six compounds are hydroxy adducts of the substrate avermectin compound at the 12a, 24, 24a, 26, 26a and 27 positions. The hydroxy adducts are prepared by incubating the substrate with the microorganism Cunninghamella blakesleeana and isolating the hydroxy adducts from the fermentation broth. The compounds are highly potent antiparasitic, insecticidal and anthelmintic agents.

Abstract: A method of reducing pathologically excessive levels of activity of collagenolytic enzymes in mammals to substantially normal levels by administering 10-100% of the normal antibiotic therapeutic dose of a tetracycline is disclosed.

Abstract: A variety of substances are known which promote host resistance to bacterial and viral infections. Lowever, because of the unpredictable vagaries of such organisms, there is seemingly a never ending need for antimicrobials, particularly those with antiviral activity. Antimicrobials are provided herein which are effective in inducing resistance to infections due to such bacteria as staphylococci and such viruses as RS virus.

Abstract: Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Abstract: Compositions containing certain bicyclic lactones and having insect repellent properties are disclosed. Such compositions comprise a compound of the formula: ##STR1## or the corresponding unsaturated compound thereof having the formula: ##STR2## wherein R, R', R" and R'" each are lower alkyl or hydrogen; wherein y is an integer from 1-3, and x and z each are 0 or 1, with the proviso that y is 1 or 2 when x is 1; and a carrier. A method of using such a repellent composition to repel an insect from a situs comprises applying to such situs an effective amount of the composition, with or without the carrier, and thereby repelling the insect from the situs.