Abstract: A cosmetic composition for the first step of an operation for the permanent deformation of hair, the composition containing an N-mercaptoalkylalkanediamide or one of its cosmetically acceptable salts as a reducing agent, including new N-mercaptoalkylalkanediamide disulphides and new N-mercaptoalkylalkanediamides, and its use in a process for the permanent deformation of hair.

Abstract: The pyrethrin-based nonphytotoxic arthropodicide is effective against a wide range of pests and is suitable for domestic and gardening uses. The composition comprises a trigliceride component derived from vegetable seed oils, a pyrethrum extract, and one or more surfactants. Optionally, antioxidants and emulsifiers may be added as well.

Abstract: The invention relates to color-stable tablets for the therapeutic drug oxcarbazepine, which tablets are provided with a hydrophilic, permeable layer containing white pigments and a hydrophilic, permeable outer layer containing white pigments in combination with iron(II) oxide pigments.

Abstract: A long wearing, durable, non-smearing type wax based pigmented lipstick product including volatile solvents, non-volatile silicone polymer, oil soluble liquid phase and dry powder phase, is made to have improved moisturizing properties by incorporating a mixture of moisturizers which includes essential fatty acids provided by diisoarachidyl dilinoleate, fatty acid ester of .alpha.-tocopherol, a cholesteryl/behenyl/octyldodecyl/lauroyl glutamate complex, and lauryl pyrrolidone carboxylic acid ester.

Abstract: A cosmetic skin-cleansing mask composition which contains, as its principal cleansing constituent, graded or calibrated spheroidal polyamide particles which are dispersed in an aqueous gel, the particles being present in an amount greater than or equal to 12% by weight relative to the total weight of the composition.These particles impart to the composition a texture and qualities which are close to those of a cream.

Abstract: A totally-fused pellet and a process and a device for preparing the totally-fused pellet are provided. Conditions are applied to the pelleting material to melt the material uniformly such that the phase transition of all of the material occurs approximately simultaneously. The material is removed from the melting conditions immediately upon the melting of the material and the material is subjected immediately to cooling conditions. The resulting totally-fused pellet contains no thermal degradation impurities.

Abstract: The present invention relates to a water-borne nail polish formulation which is non-flammable, non-toxic and is practically odorless comprising the use of water-dispersible ingredients. The water-based nail polish formulation comprises from about 10 to about 80%/wt. of a water-dispersible aliphatic urethane, from about 1.0 to about 10.0%/wt. of a hardening agent, from about 3.0 to about 10.0%/wt. of a plasticizer agent, and the balance being a isopropyl alcohol:water solvent mixture. The nail polish formulation of the present invention eliminates the use of any noxious or toxic components, such as nitrocellulose, toluene, styrene, MEK and the like.

Abstract: A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.

Abstract: Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by direct compression/dry mix tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.

Abstract: The invention relates to a process for preparing a pharmaceutical preparation having neuromuscular blocking activity in a vial by dissolving vecuroniumbromide or an analogue thereof in water saturated with carbondioxide or an organic solvent, filling the solution thus obtained into the vial to provide therein the required unit dosage form of vecuronium bromide or an analogue thereof, removing the solvent, i.e. water or organic solvent in the vial by lyophilization or evaporation, and hermetically closing the vial. The invention also relates to a method of preparing an aqueous injection solution starting from said vial by dissolving the contents of the vial either in an amino acid solution of sufficient concentration so as to obtain a final physiological pH or in a pharmaceutically acceptable buffer system of pH 7 to 7.4.

Abstract: The hair shaping composition for permanent shaping of hair contains a cysteine ester of the formula (I):HS--CH.sub.2 --CH(NH.sub.2)--COO--CH.sub.2 --CH.sub.2 --R (I)as a keratin-reducing material, wherein R is a hydroxy group, alkoxy groups, a poly(alkoxy) group or a hydroxypoly(alkoxy) group, or one of its acid additional salts. Cysteine ester compounds and their methods of preparation are also described. Preferred embodiments of the hair shaping composition have a pH of from 4.5 to 9.0 and contain from 4 to 30% by weight of the cysteine ester or its acid addition salt and provide a safe and uniform shaping of hair without allergic or sensitizing reactions.

Abstract: The diamagnetic semiconducting molecular crystal tetrasilver tetroxide (Ag.sub.4 O.sub.4) is utilized for destroying the AIDS virus, destroying AIDS synergistic pathogens and immunity suppressing moieties (ISM) in humans.A single intravenous injection of the devices is all that is required for efficacy at levels of about 40 PPM of human blood. The device molecular crystal contains two mono and two trivalent silver ions capable of "firing" electrons capable of electrocuting the AIDS virus, pathogens and ISM. When administered into the bloodstream, the device electrons will be triggered by pathogens, a proliferating virus and ISM, and when fired will simultaneously trigger a redox chelation mechanism resulting in divalent silver moieties which chelate and bind active sites of the entities destroying them. The devices are completely non-toxic. However, they put stress on the liver causing hepatomegaly, but there is no loss of liver function.

Abstract: The present invention relates to a leave-on hair care composition comprising: (i) from about 0.1% to about 10%, by weight, of a cationic crosslinked polymeric conditioning agent comprising the monomer units (A).sub.m (B).sub.n (C).sub.p and a crosslinking agent wherein: (A) is a dialkylaminoalkyl acrylate monomer or a quaternary ammonium or acid addition salt thereof; (B) is a dialkylaminoalkyl methacrylate monomer or a quaternary ammonium or acid addition salt thereof; (C) is a nonionic monomer polymerizable with (A) or (B); m, n, and p are independently zero or greater, but at least one of m or n is one or greater; (ii) from about 0.1% to about 10%, by weight, of a salt; and (iii) from about 60% to about 99.8%, by weight, of a polar solvent; wherein the weight ratio of said cationic crosslinked polymeric conditioning agent to said salt is from about 1:25 to about 25:1; wherein the viscosity of the composition is from about 10 cP to about 500 cP as measured using a Brookfield Viscometer, Spindel #41, at 25.

Abstract: A modified amalgam composition forming an adhesive bond with tooth structure treated with a dental adhesive. The modified amalgam can be prepared by admixing particulate additives into conventional amalgam alloy powder to form a modified alloy powder and then triturating the modified alloy powder with mercury. The modified amalgam when applied to a prepared tooth cavity that has been precoated with an acrylate- or methacrylate-functional dental adhesive results in an adhesive bond between the modified amalgam and coated tooth structure. Preferred particulate additives for the amalgam alloy powder are acrylate- or methacrylate-functional polymers, metal salts of acrylates or methacrylates, nonmetallic fillers, oxidizing agents and reducing agents.

Abstract: Antimicrobial metal-based compositions, which are photostable, non-staining, and which are easily absorbed into lipophilic matrices, contain silver cations, complexed by acyclic polyether polymers through the formation of a "host-guest relationship" where the acyclic polyether is the "host" and the silver cation is the "guest," wherein stabilization of this "host-guest relationship" is accomplished through the use of excess anions. The compositions are useful for topical treatment of infections caused by bacteria, fungus and viruses in humans and animals and for treating medical devices, foams and adhesives to impart infection-resistance.

Abstract: A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective to treat adenosine depletion. A method of treating asthma in a subject in need of such treatment is also disclosed. The method comprises administering to the subject dehydroepiandrosterone, analogs thereof, or pharmaceutically acceptable salts thereof in an amount effective to treat asthma.

Abstract: A method and apparatus applies radiant energy through the skin to an underlying subcutaneous layer or deeper soft tissue layers that includes loculations of fat with fibrous septae made of collagen tissue. This creates a desired contour effect without substantially modifying melanocytes and other epithelial cells in the epidermis. A membrane conforms a contacting exterior surface of the membrane to a skin layer. One or more thermal electrodes positioned in the membrane. A focussing element focuses thermal energy to the underlying collagen tissue. The focusing element and the electrolytic solution create a reverse thermal gradient from the skin to the collagen tissue. A thermal power source is coupled to the thermal electrodes.

Abstract: The present invention is an occlusive or semi-occlusive barrier moisturizing lotion useful for treating pathologies of the skin. The lotion is composed of an oil-in-water emulsion that includes water, one or more emollients, at least one polyhydric alcohol, a barrier polymer, and a therapeutical agent, preferably a dermatological agent such as a steroid. When the lotion is applied to the skin and dries, a polymeric film forms on the surface of the lotion to retain the therapeutic agent in contact with the surface of the skin. The emollient system of the lotion provides a moisturizing and soothing effect on the skin, and the occlusive/semi-occlusive nature of the lotion causes hydration of the skin to facilitate and enhance penetration of the drug into the skin.

Abstract: A method for combatting cellulitis or reducing localized fatty excesses involves administering a body slimming amount of a composition which contains, as the sole slimming agent, an .alpha.-tocopherol, benzyl, xanthinol or hexyl nicotinate, or .alpha.-tocopherol acetate.

Abstract: The invention relates to a delayed action preparation which comprises a core comprising a drug and a swelling agent and an outer membrane comprising a biodegradable high molecular weight substance characterized in that the swelling agent is contained in a sufficient amount to cause a explosion of the outer membrane of biodegradable high molecular weight substance at a definite time after administration. This preparation provides for free control over the timing of drug release and is suited for administration not only by the oral route but also by the intramuscular, subcutaneous and other routes.