Abstract: Methods and systems are described for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.

Abstract: Systems, apparatus, methods and computer-readable storage media facilitating trusted pairing between an implantable medical device (IMD) and an external device are provided. In one embodiment, an IMD includes a housing configured to be implanted within a patient, a memory and circuitry within the housing and a processor that executes executable components stored in the memory.

Abstract: The present disclosure is directed towards devices, methods, and related systems that are minutely-invasively delivered to the brain parenchyma, subdural or subarachnoid space where the devices, methods, and systems directly interface with central nervous system media (i.e., fluid or tissue) enabling detecting, sensing, measuring, stimulating, altering and/or modulating of the media or tissue surfaces.

Abstract: In part the disclosure relates to methods of treating acne, excessive sweating, unwanted hair, and/or unwanted blood vessels. The method may include providing a needle array comprising a plurality of needles; inserting plurality of needles into a dermis of a treatment area; detecting a location of an enlarged sebaceous gland; and energizing one or more of the plurality of needles to treat sebaceous glands, one or more sweat glands, vascular legions, unwanted hair follicles and/or unwanted blood vessels.

Abstract: An electrode cuff includes a first elongate portion and a second elongate portion. The first elongate portion is configured to removably contact a length of a nerve while the second elongate portion extends outwardly at an angle relative to a first side edge of the first elongate portion to at least partially wrap about the nerve. The electrode cuff includes a first series of electrodes that is spaced apart longitudinally along the first elongate portion. A width of the second elongate portion is sized to fit between adjacent branches extending from a nerve.

Abstract: A neuromodulation probe includes a body and at least one coil set. The body has a first axis and a length along the first axis. The at least one coil set includes at least one coil, and the at least one coil is formed by winding spirally a conductive wire plural times about a second axis inside the body or on an outer surface of the body. The second axis is parallel to the first axis. The at least one coil has two opposite wire ends for providing an electric current to flow in or out of the at least one coil.

Abstract: The present disclosure relates to an EMS electrode pad. Each electrode may be provided to correspond to the shape and size of the divided area according to the virtual line. The EMS electrode pad and the EMS method using the same according to the present invention may minimize the edge current effect by the shape of the electrode to which electric energy is applied. In addition, energy transfer efficiency may be improved by capacitive coupling between the electrode and the skin. In addition, due to the coating of the electrode, a rate of contact with an affected part may be increased so that current may be applied evenly to each part.

Abstract: Representative methods, apparatus and systems are disclosed for providing concurrent electrical stimulation and electrical recording in a human or non-human subject, such as for neuromodulation, with the apparatus coupleable to an electrode array. A representative apparatus is typically an integrated circuit including: stimulation circuits, recording circuits, and blocking circuits responsive to control signals to block the stimulation voltage or current on an electrode from a corresponding recording circuit, while other recording circuits may simultaneously record electrical signals from other electrodes and generate recorded data.

Abstract: A method comprises establishing communication between a therapy device implantable in a patient and a consumer electronic device operable by the patient. The method comprises controlling, by the consumer electronic device, a predetermined set of therapy device functions in response to patient inputs to the consumer electronic device. The method also comprises transmitting therapy data from the therapy device to the consumer electronic device. The method further comprises presenting therapy data on a display of the consumer electronic device.

Abstract: Rapid assessment of microcirculation in tissue to realize closed-loop systems is provided. Microcirculatory assessment systems according to embodiments described herein allow a user to assess changes in local blood flow in microvasculature in real-time using conventional electrical techniques. Some embodiments provide a closed-loop system that allows calibrated doses of electrical stimulation to be delivered in a deep brain stimulation (DBS) system depending on blood flow changes (in specific regions of the brain) being fed back to a controller. The approach described here is readily translatable with very minimal changes to existing hardware. Such closed-loop systems will improve the accuracy of electrode placement in DBS surgery and potentially reduce surgery time, optimize the delivery of electrical stimulation, increase battery life of implantable DBS systems, reduce post-surgical visits to medical practitioners and improve the quality of life of patients.

Abstract: Described herein are methods, devices, and systems for improving R-wave detection sensitivity and positive predictive value, and for improving arrhythmia detection accuracy. Certain embodiments involve determining whether to classify a potential R-wave as a false R-wave (or more specifically, an over-sensed P-wave) by determining a measure of magnitude of a first portion of the signal corresponding to a first window following the potential R-wave, determining the measure of magnitude of a second portion of the signal corresponding to a second window following the first window, and classifying the potential R-wave as a false R-wave if the measure of magnitude of the second portion of the signal is at least a specified extent larger (e.g., at least 3 times larger) than the measure of magnitude of the first portion of the signal. Certain embodiments also involve adjusting an R-wave marker for a potential R-wave that is classified as a false R-wave.

Abstract: A stimulation system comprising: an implantable lead having a proximal end and a distal end, and at least one electrode along its distal end; an implantable neuromodulation stimulator disposed along the proximal end of the implantable lead; and an external device comprising a battery, a transmitter, and an antenna. The implantable lead is integral to the implantable neuromodulation stimulator. Methods of providing stimulation are also described.

Abstract: A tumor treating system for the delivery of tumor treating electric fields to a patient including a control device, a field generator, and electrodes. The control device has a frequency range, a firing configuration and a firing sequence. The field generator generates electrical signals within the frequency range. The electrodes are placed in optimized locations on the patient. Each electrode includes a ceramic layer, a metalized layer and a circuit element. The metalized layer is coupled to the ceramic layer on one side of the ceramic layer. The metalized layer has an outer surface facing away from the ceramic layer. The circuit element is coupled to the metalized layer. The coupling of the circuit element to the metalized layer is across substantially all of the outer surface of the metalized layer. The circuit element conducts the electrical signals to the metalized layer as directed by the control device.

Abstract: A electrical treatment device (100) includes a band-like member (20), a first electrode portion (41), a second electrode portion (42), a first mark portion (31) configured to be aligned with a specific position of a right lower limb when the band-like member (20) is wrapped around the right lower limb such that the first electrode portion (41) is guided to a first target position and the second electrode portion (42) is guided to a second target position, and a second mark portion (32) configured to be aligned with a specific position of a left lower limb when the band-like member (20) is wrapped around the left lower limb such that the first electrode portion (41) is guided to a third target position and the second electrode portion (42) is guided to a fourth target position.

Abstract: An example fixation component for an implantable medical device (IMD) includes a base and a plurality of tines configured be deployed with a target deployment stiffness to engage tissue a target implant site while maintaining a target deflection stiffness after deployment. The base defines a longitudinal axis of the fixation component and is fixedly attached near the distal end of the IMD. Each tine is spaced apart from one another around a perimeter of the distal end of the IMD and extend from the base. A shape of each tine is selected to control each of the target deployment stiffness and target deflection stiffness.

Abstract: A robotic surgical tool comprises a handle having a first end and a second end, a lead screw and at least one spline extendable between the first and second ends of the handle, and a carriage movably mountable to the lead screw at a carriage nut. The carriage includes an elevator layer and one or more additional layers removably coupled to the elevator layer. An elongate shaft may be provided that extends distally from the one or more additional layers and penetrates the elevator layer and the first end when the one or more additional layers are coupled to the elevator layer. An end effector may be arranged at a distal end of the elongate shaft.

Abstract: A cusp catastrophe approach is provided for predicting an occurrence of an ischemic myocardial event (e.g., acute myocardial infarction) for a human patient based on measurements of a vital sign via one or more sensors. The one or more sensors may comprise a user-wearable device. A cusp catastrophe model is used to process the vital signs measured. In some aspects, the cusp catastrophe model is used for processing a time series constructed from the vital sign measurements. In aspects, the time series may also include historical vital signs of the patient stored in an electronic health record system. A likelihood of the patient experiencing a myocardial ischemia occurrence is determined based on an output of the cusp catastrophe model satisfying a threshold. Based on the likelihood determined, a response action is initiated.

Abstract: A method of classifying a mental state of a user using a computing device, which includes a microphone, a camera, a display, a wireless communication unit, and a processor, and a mental state classification server is provided. The method comprises: by the microphone, detecting ambient noise of the user; by the camera, generating an image by photographing a face of the user; by the processor, checking whether each of ambient noise of the user, ambient brightness of the face of the user obtained from the image, and a face position of the user obtained from the image is suitable for a heart rate variability measurement environment; by the processor, controlling to display on the display images indicating whether each of the ambient noise, the ambient brightness, and the face position is suitable for the heart rate variability.

Abstract: A cryo-system for treating a body part of an individual by cryotherapy, which includes two parts. The first part is either i) a cryo-probe suitable for internal cooling, which includes a penetrating segment in communication with a cryogen source and is at least smaller than 1/10th of the body part's biggest volume and/or at least one dimension smaller than 1 cm or ii) a cryo-probe suitable for external cooling, which includes a non-penetrating segment in communication with a cryogen source. The second part is either i) an assembly of at least two nanoparticles bound to each other or associated with each other via binding or associating material or ii) at least one nanoparticle, which includes iron and at least one other metal than iron. The assembly of at least two nanoparticles or the at least one nanoparticle may be cooled by the cryo-probe or by switching on the cryo-probe.

Abstract: Apparatus (100) for training oral muscle tone, the apparatus (100) includes a mouthpiece (103) having first electrode means (132a, 132b, 133a, 133b) associated with the mouthpiece (103) and second electrode means (152a, 152b) for location exterior of the mouth of the user, electrical circuitry operatively connected to the first (132a, 132b, 133a, 133b) and second (152a, 152b) electrode means, wherein the apparatus (100) is configured to provide, in use, via the first (132a, 132b, 133a, 133b) and/or second (152a, 152b) electrode means electrical stimulation to one or more oral muscles to increase resting muscle tone and/or muscle tone during sleep, the second electrode means (152a, 152b) including a first and second electrode (152a, 152b), the first and second electrodes (152a, 152b) of the second electrode means being located or locatable lateral of a midline of the face of the user.