Abstract: A robotic surgical tool comprises a handle having a first end and a second end, a lead screw and at least one spline extendable between the first and second ends of the handle, and a carriage movably mountable to the lead screw at a carriage nut. The carriage includes an elevator layer and one or more additional layers removably coupled to the elevator layer. An elongate shaft may be provided that extends distally from the one or more additional layers and penetrates the elevator layer and the first end when the one or more additional layers are coupled to the elevator layer. An end effector may be arranged at a distal end of the elongate shaft.

Abstract: A cusp catastrophe approach is provided for predicting an occurrence of an ischemic myocardial event (e.g., acute myocardial infarction) for a human patient based on measurements of a vital sign via one or more sensors. The one or more sensors may comprise a user-wearable device. A cusp catastrophe model is used to process the vital signs measured. In some aspects, the cusp catastrophe model is used for processing a time series constructed from the vital sign measurements. In aspects, the time series may also include historical vital signs of the patient stored in an electronic health record system. A likelihood of the patient experiencing a myocardial ischemia occurrence is determined based on an output of the cusp catastrophe model satisfying a threshold. Based on the likelihood determined, a response action is initiated.

Abstract: A method of classifying a mental state of a user using a computing device, which includes a microphone, a camera, a display, a wireless communication unit, and a processor, and a mental state classification server is provided. The method comprises: by the microphone, detecting ambient noise of the user; by the camera, generating an image by photographing a face of the user; by the processor, checking whether each of ambient noise of the user, ambient brightness of the face of the user obtained from the image, and a face position of the user obtained from the image is suitable for a heart rate variability measurement environment; by the processor, controlling to display on the display images indicating whether each of the ambient noise, the ambient brightness, and the face position is suitable for the heart rate variability.

Abstract: A cryo-system for treating a body part of an individual by cryotherapy, which includes two parts. The first part is either i) a cryo-probe suitable for internal cooling, which includes a penetrating segment in communication with a cryogen source and is at least smaller than 1/10th of the body part's biggest volume and/or at least one dimension smaller than 1 cm or ii) a cryo-probe suitable for external cooling, which includes a non-penetrating segment in communication with a cryogen source. The second part is either i) an assembly of at least two nanoparticles bound to each other or associated with each other via binding or associating material or ii) at least one nanoparticle, which includes iron and at least one other metal than iron. The assembly of at least two nanoparticles or the at least one nanoparticle may be cooled by the cryo-probe or by switching on the cryo-probe.

Abstract: Apparatus (100) for training oral muscle tone, the apparatus (100) includes a mouthpiece (103) having first electrode means (132a, 132b, 133a, 133b) associated with the mouthpiece (103) and second electrode means (152a, 152b) for location exterior of the mouth of the user, electrical circuitry operatively connected to the first (132a, 132b, 133a, 133b) and second (152a, 152b) electrode means, wherein the apparatus (100) is configured to provide, in use, via the first (132a, 132b, 133a, 133b) and/or second (152a, 152b) electrode means electrical stimulation to one or more oral muscles to increase resting muscle tone and/or muscle tone during sleep, the second electrode means (152a, 152b) including a first and second electrode (152a, 152b), the first and second electrodes (152a, 152b) of the second electrode means being located or locatable lateral of a midline of the face of the user.

Abstract: A laser beam treatment system that delivers laser beam pulses to a dental treatment area according to a particular pattern is described. In various instances, the spacing of the pattern (e.g., locations at which pulses are delivered and the distances therebetween) and/or the timing of the pattern (e.g., amount of time between the delivery of pulses to a first location and a later location that abuts the first location) can have a demonstrable effect on ablation performance. The effects can include, for example: improved ablation efficiency, improved surface smoothness, improved material removal rate, and/or the absence of melt, carbonization or other negative surface features.

Abstract: An exchanger for medical use comprises: a box-like body having a base, an upper end, a peripheral wall that delimits a heat exchange chamber; the body having: a first aperture from which a fluid to be thermo-regulated enters and a first exit of the thermo-regulated fluid; a second delivery aperture of a thermo-regulator fluid and a second exit of the thermo-regulated fluid; a heat exchange element that exchanges heat by lapping, housed in the exchange chamber and held between two holding elements, dividing the exchange chamber into a zone where the thermo-regulator fluid flows and a zone where the fluid to be thermo-regulated flows, which are fluid-dynamically separated from each other; a collection compartment to collect the air separated from the fluid to be thermo-regulated, obtained in the opposite end, connected to the thermo-regulation chamber and equipped with an aperture toward the outside; the box-like body has a second housing chamber for a pumping group, connected with the heat exchange chamber.

Abstract: An apparatus yields signals that are equivalent to ECG signals and allow determination of a heartbeat interval or heart rate from bio-vibration signals including vibrations derived from heartbeats. An ECG meter acquires ECG signals of a sample, and a piezoelectric sensor acquires bio-vibration signals of the sample simultaneously. The bio-vibration signals include beating vibration signals derived from heartbeats. A learning unit of a prediction modeling apparatus establishes a prediction model by machine learning in which ECG signals are used as teaching data, and model input signals obtained by performing a specified processing on the bio-vibration signals are input. The learning unit delivers the prediction model to a prediction unit of a signal processing apparatus. The prediction model predicts and outputs pECG signals upon input of model input signals obtained by performing a specified processing on bio-vibration signals acquired from a subject under prediction with a piezoelectric sensor.

Abstract: An apparatus for locating a source of vibrational cardiac energy within a human, includes a data processing system configured to accept vibrational cardiac data collected by at least three transducers during a plurality of heart cycles. A computer readable medium containing executable computer program instructions which, when executed by the data processing system, cause the data processing system to perform steps that include, performing a time-to-frequency transformation on the vibrational cardiac data acquired within at least a portion of the heart cycles. The time-to-frequency transformation is applied to the vibrational cardiac data acquired synchronously from each transducer to obtain a plurality of complex frequency spectra. The steps include identifying a vernier band (VB) of frequency associated with a feature derived from the plurality of complex frequency spectra.

Abstract: Provided is a method of detecting the R peak of an electrocardiogram (ECG) signal using an adaptive median filter. The method includes allowing an ECG signal (hereinafter, referred to as a first ECG signal) received from an ECG signal measuring apparatus having a predetermined sampling rate to pass through an adaptive median filter, calculating a difference value between the first ECG signal and a signal (hereinafter, referred to as a second ECG signal) passing through the adaptive median filter, extracting R peak candidate groups by applying a maximum filtering size and an adaptive threshold applicable in the adaptive median filter to the calculated difference value between the first and second ECG signals, and detecting an R peak candidate group having a maximum value among the R peak candidate groups as an R peak.

Abstract: A stimulation therapy system dynamically modifies therapy intensity based on measured neurotransmitter levels. In some examples, the system delivers, via an electrode implanted in a brain of a patient and stimulation circuitry, an electrical stimulus; monitors an electrical current generated by the stimulation circuitry to deliver the electrical stimulus; determines, based on the electrical current, a value representative of a concentration of dopamine in the brain of the patient; determines, based on the value representative of the concentration of dopamine, a value for one or more stimulation parameters that at least partially define electrical stimulation therapy; and delivers, via the electrode, the electrical stimulation therapy.

Abstract: The present invention relates to an apparatus for fractional treatment of skin tissue of a patient comprising a handpiece, at least one first electrode and at least one second electrode, arranged on a base plate for applying radio frequency energy, to at least one layer of the skin, wherein the apparatus is adapted to apply electrical energy to the skin tissue with a first pulse and a second pulse following the first pulse, with the first pulse being a low energy level pulse and the second pulse being a high energy level pulse having a higher energy level than the low energy level pulse.

Abstract: The present invention relates to the medical field, in particular to the treatment of neurological disorders. More specifically the present invention relates to a nanoparticle or nanoparticles' aggregate for use in prevention or treatment of a neurological disease or at least one symptom thereof in a subject when the nanoparticle or nanoparticles' aggregate is exposed to an electric field, wherein the nanoparticle's or nanoparticles' aggregate's material is selected from a conductor material, a semiconductor material, an insulator material with a dielectric constant ?ijk equal to or above 200, and an insulator material with a dielectric constant ?ijk equal to or below 100. It further relates to compositions and kits comprising such nanoparticles and/or nanoparticles' aggregates as well as to uses thereof.

Abstract: The present invention relates to a mask-shaped skin treatment device and system. The device comprises one or more coupling agent detectors configured to detect presence of coupling agent on one or more skin portions of a user and one or more heating elements configured to cause local heating of one or more skin portions of the user. The one or more heating elements are configured to cause heat selectively based on the presence of coupling agent measured by the one or more coupling agent detectors.

Abstract: The present disclosure relates to a device, method and system for calculating, estimating, or monitoring the blood pressure of a subject based on physiological features and personalized models. At least one processor, when executing instructions, may perform one or more of the following operations. A first signal representing a pulse wave relating to heart activity of a subject may be received. A plurality of second signals representing time-varying information on a pulse wave of the subject may be received. A personalized model for the subject may be designated. Effective physiological features of the subject based on the plurality of second signals may be determined. A blood pressure of the subject based on the effective physiological features and the designated model for the subject may be calculated.

Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.

Abstract: One aspect is a process for producing a segmented electrode, including providing a pipe made of metal having an outer side and an inner side, wherein the inner side of the pipe forms a hollow space. A support structure is arranged in the hollow space, so that the support structure mechanically stabilizes the pipe. Intermediate spaces are formed in the pipe, which define a plurality of segments in the pipe. An electrically insulating material is introduced into the intermediate spaces and thus forming electrically insulating areas, wherein a boundary layer is in each case defined between the segments and the areas. The pipe is cut so that several segmented ring-shaped electrodes are formed therefrom. The support structure is removed from the pipe.

Abstract: A blood pressure monitor configured to removably mount to a cuff in a substantially symmetrical position with respect to a width of the cuff can include a housing defining an interior, a first port, and a second port. The first port can: secure to a first prong of the cuff when the cuff is mounted in a first orientation; receive and secure to a second prong of the cuff when the cuff is mounted in a second orientation; and enable fluid communication between the interior and at least one of a first fluid passage within the first prong and a second fluid passage within the second prong. The second port can: secure to the second prong of the cuff when the cuff is mounted in the first orientation; and receive and secure to the first prong of the cuff when the cuff is mounted in the second orientation.

Abstract: Disclosed is a muscle stimulation system, comprising a wearable garment including a plurality of electrodes, and a processor; wherein the processor is configured to define one or more regions of interest (ROI) for electrode activation via a subset of the plurality of electrodes, and provide electrical muscle stimulation, via the subset of the plurality of electrodes, to the ROI.

Abstract: A catheter system includes a catheter including an elongate body having an expandable medical device coupled with a distal end thereof, and an introducer sheath assembly disposed over a proximal section of the catheter. The introducer sheath assembly includes an introducer sheath disposed over the catheter to form a gap therebetween, and a tubular plug. The introducer sheath includes an elongate body extending from a proximal end to a distal end and defining a lumen therein. The tubular plug extends through the lumen and includes an elongate body extending from a proximal end to a distal end that protrudes from the introducer sheath distal end. The plug is disposed between the catheter and the introducer sheath to occlude the gap. The plug is releasably fixed relative to the introducer sheath such that the plug is removable from the lumen to allow the expandable medical device to pass therethrough.