Abstract: A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.
Type:
Grant
Filed:
July 18, 2019
Date of Patent:
October 3, 2023
Assignee:
The Johns Hopkins University
Inventors:
Sashank Reddy, Russell Martin, Xiaowei Li, Calvin Chang, Kevin Colbert, Hai-Quan Mao
Abstract: Methods of forming spinel ferrite nanoparticles containing a chromium-substituted copper ferrite as well as properties (e.g. particle size, crystallite size, pore size, surface area) of these spinel ferrite nanoparticles are described. Methods of preventing or reducing microbe growth on a surface by applying these spinel ferrite nanoparticles onto the surface in the form of a suspension or an antimicrobial product are also described.
Abstract: A method for forming a bioactive agent spatially patterned includes providing a photocrosslinkable hydrogel that includes a photocrosslinkable base polymer, photocrosslinkable bioactive agent coupling polymer macromers, and at least one bioactive agent that couples to the photocrosslinkable bioactive agent coupling polymer macromer, an selectively exposing discrete portions of the photocrosslinkable hydrogel to actinic radiation effective to initiate cross-linking of the base polymer and the bioactive agent coupling polymer macromers at the exposed portions.
Abstract: Polymers comprising at least one cationic functional group and at least one ultraviolet light-absorbing compound are disclosed herein. The polymers exhibit ultraviolet light-absorbing properties and may be used in sunscreen compositions for skin and/or hair.
Abstract: A porous carbon material composite formed of a porous carbon material and a functional material and equipped with high functionality. The porous carbon material composite is formed of (A) a porous carbon material obtainable from a plant-derived material having a silicon (Si) content of 5 wt % or higher as a raw material; and (B) a functional material adhered on the porous carbon material, and has a specific surface area of 10 m2/g or greater as determined by the nitrogen BET method and a pore volume of 0.1 cm3/g or greater as determined by the BJH method and MP method.
Abstract: Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.
Type:
Grant
Filed:
December 10, 2020
Date of Patent:
June 27, 2023
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
Inanc Ortac, Gen Yong, Michael Benchimol, Sadik C. Esener
Abstract: An absorbable iron-based instrument is provided having an iron-based substrate, a zinc-containing protector in contact with the iron-based substrate, and a degradable polyester in contact with the iron-based substrate and/or the zinc-containing protector. The range of the ratio of the mass of the zinc-containing protector to the mass of the iron-based substrate is 1:200 to 1:2. In the degradable polyester, the mass fraction of a low-molecular-weight part with a molecular weight of less than 10,000 is less than or equal to 5%; alternatively, in the degradable polyester, the mass fraction of a residual monomer is less than or equal to 2%.
Type:
Grant
Filed:
December 19, 2017
Date of Patent:
June 27, 2023
Assignee:
Lifetech Scientific (Shenzhen) Co. Ltd.
Inventors:
Hongtao Sun, Deyuan Zhang, Jun Hu, Liping Chen
Abstract: This invention describes compositions comprising at least 75 mg/mL of solubilized otherwise poorly soluble drug in an aqueous environment, wherein the composition further comprises a combination of 3 or more acids. Methods of providing analgesia, anti-pyretic effects or reducing pain in a subject presenting with a pain condition, and methods of reducing administration site irritation, inflammation or a combination thereof in a subject presenting with a pain condition, comprising the steps of administering such compositions and infusion pumps containing such compositions are also described.
Type:
Grant
Filed:
May 10, 2018
Date of Patent:
June 13, 2023
Assignee:
United Therapeutics Corporation
Inventors:
Michael Laird Hurrey, Drazen Ostovic, Peter Noymer
Abstract: Storage stable organopolysiloxane gels, preparable in commercial quantities are prepared by the hydrosilylation reaction of a silicone resin containing a hydrosilyatable group, a short chain Si—H-functional silicone, and a long chain Si—H-functional silicone.
Abstract: Methods of forming spinel ferrite nanoparticles containing a chromium-substituted copper ferrite as well as properties (e.g. particle size, crystallite size, pore size, surface area) of these spinel ferrite nanoparticles are described. Methods of preventing or reducing microbe growth on a surface by applying these spinel ferrite nanoparticles onto the surface in the form of a suspension or an antimicrobial product are also described.
Abstract: Embodiments of the present disclosure provide for compositions including polymer particles, methods of making compositions, methods of using the composition, stimuli-responsive methods of delivering agents, and the like.
Type:
Grant
Filed:
December 29, 2016
Date of Patent:
April 18, 2023
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Brent S. Sumerlin, Shaun Paul Jensen, Megan R. Hill, Mingsheng Chen, Gloria A Moore, Zhenli L He, Sangwoo Park
Abstract: Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically acceptable salt thereof, and methods of using same to treat certain disorders. In an embodiment, the conjugated polymer comprises poly (vinyl alcohol) covalently bound to ATRA through an ester linkage.
Type:
Grant
Filed:
June 23, 2016
Date of Patent:
February 28, 2023
Assignee:
Massachusetts Institute of Technology
Inventors:
Steven A. Castleberry, Mohiuddin A. Quadir, Paula T. Hammond
Abstract: Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.
Type:
Grant
Filed:
March 12, 2020
Date of Patent:
February 21, 2023
Assignees:
UNM Rainforest Innovations, Duke University
Inventors:
Gabriel P. Lopez, Joseph R. Simon, Nick J. Carroll, Ashutosh Chilkoti
Abstract: A discrete dispensed product with a first portion and a second portion at least partially surrounding the first portion. The product provides a premium and distinct appearance to consumers.
Type:
Grant
Filed:
June 28, 2019
Date of Patent:
February 21, 2023
Assignee:
The Procter & Gamble Company
Inventors:
Joseph Michael Zukowski, Sudeep Chakravarty, Yu Wang, Suxuan Gong, Michiko Ohya, Wai Seen Ho
Abstract: The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.
Type:
Grant
Filed:
September 29, 2017
Date of Patent:
February 7, 2023
Assignee:
The University of Chicago
Inventors:
John C. Alverdy, Matthew Tirrell, Olga Y. Zaborina, Jun Mao, Wei Chen
Abstract: An adhesive matrix and adhesive formulation are described. The adhesive matrix is comprised of a hydrophilic domain and a hydrophobic domain, and a therapeutically active agent contained in the matrix in a supersaturated, stable, condition. The hydrophilic domain and the hydrophobic domain are co-soluble in a solvent system, to provide a homogeneous blend in which the active agent is solubilized. The proportion of the hydrophilic domain and hydrophobic domain is selected to optimize, or maximize, solubility of active agent in the matrix.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
January 3, 2023
Assignee:
Corium, LLC
Inventors:
Eun Soo Lee, Amit K. Jain, Parminder Singh
Abstract: The present disclosure relates to microcapsules, methods of using such microcapsules in the delivery of drugs and probiotic microbes to subjects in need thereof, and methods of using such microcapsules for in vitro culture of microbes. In particular, the microcapsules comprise novel siloxane-based membranes that maintains transport properties essential to communication and growth of microbes.
Type:
Grant
Filed:
October 7, 2019
Date of Patent:
December 27, 2022
Assignee:
UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors:
Tagbo Herman Roland Niepa, Shanna-Leigh Davidson
Abstract: Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (I?I). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.
Abstract: Ophthalmic lenses and light filters containing special additives that have fluorescence emission in the near infrared region of wavelengths—in order to enhance phototherapy for the human eye when it is exposed to sunlight and artificial lighting.