Abstract: Compositions and methods regarding guanidinium functionalized polycarbonates that provide potent antimicrobial activity against multidrug resistant (MDR) bacteria, including Klebsiella pneumoniae (K. pneumoniae) are provided. According to an embodiment, an antimicrobial guanidinium-functionalized polymer is provided that comprises a hydrophobic molecular backbone with cationic guanidinium moieties respectively bound to the hydrophobic molecular backbone via butyl spacer groups. The antimicrobial guanidinium-functionalized polymer self-assembles into a micelle structure with hydrophobic residuals of the antimicrobial guanidinium-functionalized polymer buried inside the micelle structure and the cationic guanidinium moieties exposed on an external surface of the micelle structure to target pathogens.

Abstract: This invention relates to medicine, more specifically, to cardiac surgery, and may be used for protecting the heart from ischemia when administering cardioplegia in normothermia or hypothermia. The general-purpose cardioplegic solution contains pharmaceutically acceptable potassium ions; magnesium ions; a base and an acid providing a pH buffer in a range of 7.1-8.9; a diuretic providing osmolality in a range of 275-460 mOsmol/kg. Said solution is used for cardiac protection in cardiopulmonary bypass, as well as for achieving asystole and maintaining the achieved asystole. The procedure for administering the general-purpose cardioplegic solution involves maintaining the achieved asystole by decreasing the flow rate of starting components of said solution relative to the flow rate of autoblood thus decreasing the solution to autoblood ratio.

Abstract: Provided herein are long lasting hair compositions, color enhancers, and markers for selecting the same.

Abstract: Provided is a polymeric micelle type DDS preparation that may efficiently exhibit pharmacological activity effects by enhancing migration characteristics, penetrability, and retention characteristics toward a diseased target tissue such as a tumor tissue or an inflammation-affected tissue, and thereby enhancing the action of a pharmacologically active substance. Disclosed is a block copolymer (A) having a hydrophilic polymer segment linked to a hydrophobic polymer segment, the hydrophilic polymer segment containing a polyethylene glycol chain, and the hydrophobic polymer segment containing a polyamino acid chain having a hydrophobic substituent in a side chain, wherein the hydrophilic polymer segment has a target binding site bonded thereto, and the main chain polymer combining the polyethylene glycol chain and the polyamino acid chain has a molecular weight of not less than 2 kilodaltons and not more than 10 kilodaltons.

Abstract: Provided are compositions suitable as hair styling compositions. Said compositions may comprise (a) at least one salt selected from the group consisting of sodium chloride, magnesium sulfate, calcium chloride, calcium phosphate and combinations thereof; and (b) at least one polyglyceryl ester having a structure represented by: wherein: R1 and R2 are each independently an alkenyl group having 9-21 carbon atoms and at least one unsaturated carbon-carbon bond, G is CH2—CH(OH)—CH2O, and n ranges from 1 to 15. Also provided are kits and methods of using said compositions.

Abstract: The present invention relates to a composition comprising a polymeric elastomeric phase and an odoriferous active compound. In particular the present invention relates to a composition comprising a polymeric elastomeric phase and an odoriferous active compound and releasing said odoriferous active compound over a given period of time. The present invention concerns also objects comprising a polymeric elastomeric phase and an odoriferous active compound and releasing said odoriferous active compound over a given period of time.

Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

Abstract: The invention relates to a composition, especially a cosmetic composition, including water, at least one film-forming agent, at least one volumizing agent, and an emulsification system comprising (i) about 2% to about 6% of low HLB emulsifier(s) (HLB value less than 8), (ii) about 2% to about 8% of intermediate HLB emulsifier(s) (HLB value of 8 to 16), and (iii) about 1% to about 8% of high HLB emulsifier(s) (HLB value greater than 16), with the compositions further including at least one colorant and/or excluding wax, as well as to methods of using such compositions.

Abstract: The disclosure concerns various medical devices implemented to provide a nitric oxide rich environment for anti-microbial or anti-thrombogenic benefits. The medical device generally includes a nitric oxide donor material that is contained within a sealed cavity, and a transport medium that defines and captivates the entirety of the cavity, wherein the transport medium is permeable to both water and nitric oxide. As the nitric oxide donor material becomes saturated with water from the surrounding tissue or fluids, nitric oxide is chemically released, and the resulting nitric oxide is communicated through the transport medium to a treatment site for anti-microbial and anti-thrombogenic benefits.

Abstract: Microparticles that have a multimodal pore size distribution are provided, Notably, the pore structure of the present invention can be formed without the need for complex techniques and solvent chemistries traditionally employed to form porous microparticles. Instead, the microparticles contain a polymeric material that is formed from a thermoplastic composition, which is simply strained to a certain degree to achieve the desired porous network structure.

Abstract: Methods, systems, and devices are disclosed for encapsulating biological entities with preservation of their biological activity. In one aspect, a method of encapsulating a biological entity includes templating a biocompatible material onto a biological structure to form a coating structure enclosing the biological structure, the coating structure having a size in the nanometer range, in which the coated biological structure preserves its biological activity within the coating structure. In some implementations of the method, the biological structure includes a virus and the biocompatible material includes silica.

Abstract: An improved process of making a benefit agent delivery particle and consumer products incorporating such particles are disclosed. The process comprises the steps of providing a first composition of water phase 1, water phase 2 and water phase 3. Water phase 1 comprises water and an initiator; water phase 2 comprises water, a water-soluble or dispersible amine(meth)acrylate or hydroxyl(meth)acrylate and a multifunctional (meth)acrylate. Water phase 3 comprises water, and carboxyalkyl(meth)acrylate and a base or quaternary ammonium acrylate. The first two water phases are combined to prereact the hydroxy- or amine(meth)acrylate and the multifunctional (meth)acrylate to form a multifunctional hydroxyl-amine(meth)acrylate pre-polymer.

Abstract: Polymers comprising at least one cationic functional group and at least one ultraviolet light-absorbing compound are disclosed herein. The resulting polymers exhibit ultraviolet light-absorbing properties and may be used in sunscreen compositions for skin and/or hair.

Abstract: This invention relates to a composition in the form of a water-in-oil emulsion that comprises an aqueous phase dispersed in a continuous oily phase, wherein the continuous oily phase comprises: at least one organo-modified clay, with a content by weight ranging from 0.5% to 1% relative to the total weight of said composition; at least one silicone elastomer powder coated with a silicone resin, with a content by weight ranging from 5% to 12% relative to the total weight of said composition; and at least one silicone surfactant with a content by weight ranging from 1.4% to 3% relative to the total weight of said composition; and wherein the dispersed aqueous phase comprises: water at a content by weight ranging from 15% to 25% relative to the total weight of said composition; and ethanol at a content by weight ranging from 8% to 18% relative to the total weight of said composition.

Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Abstract: A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold.

Abstract: A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold.

Abstract: The present invention relates to polymeric structures, in the form of flat membrane-like surfaces or micro- nanostruc-tures such as capsules, characterized in that it comprises a substantially two-dimensional layer of covalently-bonded monomers of R-substituted metal or metalloid oxides. Said polymeric structures in most embodiments have a crystal architecture with a hexagonal lattice, but the nature of the covalent bonds present therein impart a bending flexibility that make the polymeric structures behave as a “soft” crystal. Methods of producing such structures, composition comprising thereof and method of using thereof are also included within the present disclosure.

Abstract: The present invention relates to a dispersion of polymer particles in a liquid carbon-based medium, the said particles having a flexible polymeric core and being surface-stabilized with a block stabilizing polymer comprising at least one block that is soluble in the said carbon-based medium and at least one block that is insoluble in the said carbon-based medium. The invention also relates to a cosmetic composition comprising the said dispersion, and to a cosmetic treatment process using the said composition.

Abstract: Nanoparticles of N-halamine-derivatized crosslinked polyamide. Process of preparing the polymeric nanoparticles per se and incorporated in or on a substrate. Uses of the polymeric nanoparticles and of substrates incorporating same, particularly for reducing a formation of organic-based contaminants, e.g., load of a microorganism or of a biofilm.