Abstract: A system and method for myocardial performance determination is provided. The present invention provided for generating a first dataset representing a set of events associated with a pre-defined parameter of a biomarker extracted from physiological parameters of a subject. The set of events is determined by processing the pre-defined parameter at a first level and a second level of a multi-level artificial neural network architecture recursively for a pre-defined number of times. Further, generating second dataset representing characteristics associated with the set of events by processing first dataset at third level and fourth level of multi-level artificial neural network architecture. Further, computing set of values associated with set of events by processing second dataset at fifth level of multi-level artificial neural network architecture. Further, computing myocardial performance index based on set of values. The myocardial performance index is representative of myocardial performance of the subject.

Abstract: A catheter system for treating a treatment site within or adjacent to a vessel wall or a heart valve includes an energy source, a balloon, an energy guide, and an electrical analyzer assembly. The energy source generates energy. The balloon is positionable substantially adjacent to the treatment site. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The energy guide is configured to receive energy from the energy source and guide the energy into the balloon interior. The electrical analyzer assembly is configured to monitor a balloon condition during use of the catheter system. The electrical analyzer assembly can include a first electrode, a second electrode, and an impedance detector that is electrically coupled to the first electrode and the second electrode. The impedance detector is configured to detect impedance between the first electrode and the second electrode.

Abstract: Disclosed are a system and a method for determining a probability for a person to have arrhythmia. The system comprises means for measuring heartbeat interval of the person for a period of time; an accelerometer; means for measuring an electrocardiogram of the person; a user interface for providing information and alerts, and a processor. The processor is configured to detect a period of rest of the person, based on measurement data from the accelerometer; analyze the measured heartbeat interval to determine a probability of having arrhythmia for the person; generate an alert to the user interface, if the probability exceeds a predetermined threshold value, to alert the person to measure the electrocardiogram with the means for measuring an electrocardiogram; analyze the measured electrocardiogram to determine if the probable arrhythmia is confirmed; and indicate the confirmed arrhythmia to the person via the user interface.

Abstract: A catheter system and method for treating a treatment site within or adjacent to a vessel wall or a heart valve within a body of a patient includes an energy source, an inflatable balloon, an energy guide, and an acoustic sensor. The inflatable balloon is positionable substantially adjacent to the treatment site. The inflatable balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The energy guide receives energy from the energy source and guides the energy into the balloon interior. The acoustic sensor is positioned outside the body of the patient. The acoustic sensor senses acoustic sound waves generated in the balloon fluid within the balloon interior. The acoustic sensor generates a sensor signal based at least in part on the sensed acoustic sound waves.

Abstract: Systems, eye-mountable devices, and methods that facilitate chronotherapeutic treatment of primary open-angle glaucoma are provided which enable therapeutic products to be delivered to the eye in a controlled manner only when desired. According to one embodiment, an eye-mountable device comprises a substrate having an eye-mounting surface for positioning on an eye of a patient, a sensor that obtains a plurality of measurements representative of a condition of the eye of the patient over a period of time, a therapeutic agent delivery assembly coupled, and a processor for executing a temporal model of a therapeutic agent delivery in communication with the sensor and the therapeutic agent delivery assembly. The processor receives the plurality of measurements and activates the therapeutic agent delivery assembly to administer a first amount of a drug to the eye of the patient based on the temporal model associated with the plurality of measurements.

Abstract: Disclosed is a lighting device for bright therapy and dark therapy, comprising: a light source part including a red light source, a green light source and a blue light source; a power supply part supplying a power to the light source part; and a controller adjusting, by controlling the power supply part, a bio illuminance to allow melatonin suppression value to exceed a first reference value during morning hours and to allow the melatonin suppression value to be less than a second reference value while maintaining a visual illuminance over a predetermined value during evening hours.

Abstract: A bed for therapeutic and recreational applications, comprises a frame structure, a mattress provided on the frame structure of the bed, a plurality of Light Emitting Diodes (LEDs) configured to emit electromagnetic radiation, an infrared heater assembly provided within the frame structure, the infrared heater assembly including a plurality of flexible heating elements connected with a power source, a plurality of temperature sensors provided at a plurality of locations on the frame structure and the mattress in order to generate signals in correlation with temperature values at the plurality of locations. Further, the frame structure includes a plurality of frame segments adapted to rotate to respective predetermined angles. Also, the mattress is made from at least partially transparent material and includes a fluid that is at least partially transparent.

Abstract: A novel photobiomodulation (PBM) system and method that comprehensively directs therapeutic light energy into the brain from a combination of transcranial (through the skull) and intranasal (via the nasal channels) locations. In a preferred embodiment, the PBM device works in combination with a diagnostic tool to provide enhanced treatment of abnormal brain function intelligently, automatically, and unrestricted by geographical distances.

Abstract: The present disclosure provides a delirium risk predicting method which includes receiving at least one of blood data, severity evaluation data, mental state evaluation data, and bio signal data, medication data, and medical treatment data, for an subject, predicting a delirium risk for the subject, using a delirium risk prediction model configured to predict a delirium risk, based on at least one data, the medication data, and the medical treatment data, and providing the delirium risk predicted for the subject. The at least one data, the medication data, and the medical treatment data are defined as initial data which is evaluated or measured only once for the subject and a delirium risk predicting device using the same.

Abstract: Viral infections in a target region can be inhibited by imposing an alternating electric field in the target region for a duration of time. The alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus. Optionally, the inhibition of viral infections using the alternating electric field approach can be combined with delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the alternating electric fields are imposed.

Abstract: A method for uterine activity monitoring may include: acquiring a plurality of signals from a plurality of sensors during uterine activity; processing the plurality of signals to extract a plurality of uterine electrical activity characteristics; analyzing the plurality of uterine electrical activity characteristics; and classifying the uterine activity as one of: a preterm labor contraction, a labor contraction, a Braxton-Hicks contraction, and a state of no contraction. A method of assessing over time a pre-term birth risk of a pregnant female may include: calculating a baseline pre-term birth risk score based on a user input; acquiring, over time, a signal from a sensor; analyzing the signal to extract a parameter of interest, such that the parameter of interest comprises a physiological parameter; and calculating an instant pre-term birth risk score based, at least in part, on the parameter of interest and the user input.

Abstract: Embodiments described relate to techniques for identifying and characterizing biological structures using machine learning techniques. These techniques may be employed to enable a device to identify the particular type of tissue and/or cells (e.g., platelets, smooth muscle cells, or endothelial cells) in, for example, a biological structure, which may be a tissue or a lesion of a duct (e.g., vasculature) in an animal (e.g., a human or non-human animal), among other structures. The machine learning techniques may use raw impedance spectroscopy measurement data in addition to values derived from that raw data. In addition, the machine learning techniques may be used to select frequencies at which to measure impedance and select features to extract from the measured impedance at the selected frequencies to arrive at a small set of frequencies that allow for reliable differentiation.

Abstract: The present invention relates to a respiratory sensing device attached to a patient's body and configured to acquire information regarding the patient's respiratory condition by sensing a vibration generated due to the patient's respiration using the piezoelectric effect and a respiratory monitoring system configured to output the acquired information regarding the patient's respiratory state.

Abstract: In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation at a first intensity during a therapeutic portion and to emit probe radiation with a second intensity which is less than the first intensity during a probe portion. The system may also include one or more optical elements configured to direct the therapeutic portion and the probe portion into an eye of a patient and to collect reflected radiation from the eye of the patient. The reflected radiation may be indicative of dynamics of microbubbles in the cells of the eye of the patient.

Abstract: Embodiments of the present disclosure relate to heart sound measurements using mobile devices. In an embodiment, a medical system for monitoring heart sounds of a subject comprises a medical device configured to obtain, during a first sampling interval, a first physiological signal. The medical system further comprises a mobile device comprising an accelerator, wherein the accelerator is configured to obtain, during a second sampling interval, a second physiological signal. And, the medical system comprises an analysis component configured to extract heart sounds data from the second physiological signal.

Abstract: An infant treatment device includes a light source and a blanket. When the treatment device is configured to warm an infant, a laser diode is used to provide warming light. The warming light passes along an optic cable having a plurality of optic fibers each having a fiber ending. The fiber endings are spaced along is diffuser. The diffuser is designed to spread the warming light to create multiple heating zones. A control circuit is used to control the operation of the laser diode. The treatment device is designed such that the light source and blanket can be separated and connected when desired such that the light source can be used with more than one blanket. In another embodiment, the light source can include a diode design for use in phototherapy treatment.

Abstract: A pneumatic compression assembly that includes a sleeve having an outer layer and an inner layer that defines a sleeve interior configured to receive a body part of a user, and at least a first vibration assembly configured to provide vibration to the body part of the user. A plurality of inflatable compartments are arranged longitudinally along the sleeve between the inner layer and the outer layer. The first vibration assembly includes a plurality of vibration motors positioned between the inner layer and the outer layer of the sleeve.

Abstract: Sensor apparatuses, methods of operating the sensor apparatuses, and systems including the sensor apparatuses are disclosed. Methods of analyzing electromechanical characteristics of a heart are also disclosed.

Abstract: The present invention relates to a method of analysing cardiac data relating to a patient, comprising: providing cardiac data relating to the patient—optionally by using a means for providing physiological data (20); determining one or more properties of the data, wherein the or each property is determined over a particular context length, the context length being selected based on the or each property—optionally using an analysis module (24); comparing the or each property against a respective predetermined threshold value, thereby to indicate a probability of the patient experiencing a cardiac event—optionally using a means for providing an output (26); and providing an output based on the comparison. A system and apparatus corresponding to this method is also disclosed.

Abstract: There is provided a process for treatment of rhinitis by diode laser ablation of the posterior nasal nerves. The laser diode delivery device with elongated optic tip is inserted through a patient's nostril and has the length, flexibility and a curvature to reach both above and under the patient's middle turbinate for treatment to both posterior nasal nerves. Skin and tissue temperature is raised to approximately 60-65° C. with the process. Optimal treatment wavelength was found to be approximately 380-450 nanometers with blue lasers.