Abstract: Novel unsaturated polylactone acrylates are produced by the reaction of an unsaturated polylactone, such as that produced in the reaction of a lactone with tetrahydrobenzyl alcohol, and a lower-alkyl acrylate under transesterification conditions. The unsaturated polylactone acrylate product may be subsequently epoxidized to form novel 3,4-epoxy polylactone acrylates.

Abstract: This invention provides 6-substituted-4-(amino or substituted amino)tetrahydrobenz[c,d]indole serotonin agonists useful in treating a variety of conditions associated with serotonin function.

Abstract: The invention relates to the compounds of the formula ##STR1## wherein the C(.dbd.NH)--NHR.sub.3 group may be in tautomeric or isomeric form, and phamaceutically acceptable salts thereof. The compounds are useful as selective LTB.sub.4 receptor antagonists.

Abstract: The invention relates to novel methylenebisphosphonic acid ester amide derivatives of general formula (I), in which formula W.sup.1, W.sup.2, W.sup.3 and W.sup.4 are independently the group OR.sup.1 or the group NR.sup.2 R.sup.3 wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen or straight or branched, optionally unsaturated C.sub.1 -C.sub.22 -alkyl, optionally substituted, optionally unsaturated C.sub.3 -C.sub.10 -cycloalkyl, aryl, aralkyl or silyl SiR.sub.3, or the groups R.sup.2 and R.sup.3 form together with the adjacent nitrogen atom a 3 to 10-membered saturated, partly saturated or aromatic heterocyclic ring, wherein in addition to the nitrogen atom, there may be one or two heteroatoms from the group N, O and S, provided that in formula (I) at least one of the groups W.sup.1, W.sup.2, W.sup.3 and W.sup.4 is hydroxy and at least one of the groups W.sup.1, W.sup.2, W.sup.3 and W.sup.4 is amino group NR.sup.2 R.sup.3, Q.sup.1 and Q.sup.

Abstract: Radiation-curable urethane acrylate compounds containing amine and urea groups and based on di- or polyisocyanates, hydroxy compounds and amines contain secondary or tertiary amino groups which are bonded to isocyanate via hydroxyl groups and are obtainable by an addition reaction of primary or secondary amines with hydroxyacrylates.

Abstract: 3,5-Di-tertiary-butyl-4-hydroxyphenyloxy- or thioalkylene N-hydroxyamides, N-hydroxythioamides, N-hydroxyureas, and N-hydroxythioureas, and pharmaceutically acceptable base salts thereof, pharmaceutical compositions thereof, and methods of manufacture thereof are described. The compounds are said to be selective, potent 5-lipoxygenase inhibitors and useful in treating, for example, inflammatory and allergic conditions.

Abstract: Colorless precursors of preformed image dyes are provided which are useful as the color image-forming materials in thermal imaging systems. These colorless precursors possess at least one thermal protecting group that undergoes fragmentation upon heating and at least one leaving group that undergoes irreversible elimination upon heating, said protecting and leaving groups maintaining the precursor in its colorless form until heat is applied to effect removal of these groups whereby the precursor is converted to an image dye.

Abstract: The invention concerns 2-aminocarboxylic acids and derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing them for the inhibition of protein kinase C and thus for the prevention and/or treatment of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertension, of inflammatory processes, allergies, cancers, and certain degenerative damages of the central nervous system.

Abstract: Arylsulfonamide derivatives of .alpha.-amino dicarboxylic acids such as aspartic acid and glutamic acid posses anti-cholecystokinin activity. They are useful in the treatment of cholecystokinin-related disorders such as anorexia nervosa, pancreatic inflammation, biliary tract disease, Zollinger-Ellison syndrome and various psychiatric disorders, as well as in the potentiation of opiate analgesia, and in the treatment of certain cancers.

Abstract: The new intermediate products of general formula I ##STR1## in which R.sup.1 stands for a hydrogen atom or a straight-chain or branched alkyl group with 1 to 4 carbon atoms,R.sup.2 stands for a hydrogen atom or a methyl group,R.sup.3 stands for a hydrogen atom,R.sup.4 stands for an acyloxy group with 1 to 4 carbon atoms in the acyl radical orR.sup.3 and R.sup.4 together stand for a keto-oxygen atom, are suitable in an excellent way for introducing a .DELTA..sup.1 double bond in the steroid skelton with the simultaneous presence of a .DELTA..sup.4 double bond, as well as a saturated carbonyl group, by clevage of hydrogen iodide with a base in an amidic solvent at elevated temperature. If R.sup.2 stands for a hydrogen atom, the A-ring is aromatized after the hydrogen iodide cleavage. For the production of a new intermediate products, special iodization processes, which partially also allow a stereoselective control of the iodization, are used.

Abstract: Allosteric hemoglobin modifier compounds having the general structural formula: ##STR1## wherein the R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 moieties may be hydrogen, halogen or alkyl groups and may be the same or different, and wherein the R.sub.7 and R.sub.8 moieties may be hydrogen or methyl groups and may be the same or different.

Abstract: The invention describes new salts and amides of 4-hydroxybutyric acid with the aim of improving the pharmacological and therapeutic properties of 4-hydroxybutyric acid.

Abstract: A compound of the formula:R--NHCOOCH(CH.sub.2 OCH.sub.2 CHOHCH.sub.2 OH).sub.2 (I)wherein R is a C.sub.10 -C.sub.20 alkyl, optionally unsaturated, is employed in the preparation of wax microdispersions useful particularly in cosmetic composition for the hair.

Abstract: Amino acid derivatives of the general formula (I) ##STR1## are disclosed. The active compounds are suitable for use as plant protection agents, in particular as fungicides.

Abstract: Compounds having the structural formula ##STR1## where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes, rice planthopper, tobacco budworm, and southern corn rootworm. Methods for making these compounds are also set forth.

Abstract: The invention relates to a method for the purification of benzoic acid, which is obtainable through oxidation of the corresponding toluene derivative, by treating it with a --NH.sub.2 or --NHR containing component in which R represents a carbon containing group, said component being applied to a support.

Abstract: Compounds of formula (I) are diuretic agents for treating various cardiovascular diseases including hypertension, heart failure and renal insufficiency.

Abstract: A process for producing crystalline ibuprofen having a crystal habit characterized by a particle length larger than 75 microns average and a length to width aspect ratio of greater than about 4 to 1 to about 5 to 1. The process involves crystallizing ibuprofen from a saturated solution of ibuprofen in a liquid hydrocarbon solvent by seeding and cooling such solution to a temperature of about 0.degree. C. to about -20.degree. C. at a rate to retard primary nucleation and promote secondary nucleation. The crystalline ibuprofen is separated from the slurry produced from such cooling.

Abstract: Novel substituted .beta. amino acid derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.

Abstract: A process for the preparation of dihydroxy polyphenyl compounds is disclosed which comprises the simultaneous steps of (a) contacting the corresponding diisoalkyl polyphenyl compound or an oxidation intermediate thereof with oxygen under reaction conditions sufficient to form a corresponding dihydroperoxyalkyl polyphenyl compound and (b) contacting the dihydroperoxyalkyl polyphenyl compound with an acid under reaction conditions sufficient to form the corresponding dihydroxy polyphenyl compound. In addition, the intermediate dihydroperoxyalkyl polyphenyl compound is a novel compound.