Abstract: Embodiments of a reduced pressure system and methods for operating the system are disclosed. In some embodiments, the system can include one or more processors responsible for various functions associated with various levels of responsiveness, such as interfacing with a user, controlling a vacuum pump, providing network connectivity, etc. The system can present GUI screens for controlling and monitoring its operation. The system can determine and monitor flow of fluid in the system by utilizing one or more of the following: monitoring the speed of a pump motor, monitoring flow of fluid in a portion of a fluid flow path by using a calibrated fluid flow restrictor, and monitoring one or more characteristics of the pressure pulses. The system can provide external connectivity for accomplishing various activities, such as location tracking of the system, compliance monitoring, tracking of operational data, remote selection and adjustment of therapy settings, etc.

Abstract: A system for calculating cardiac output (CO) of a patient undergoing veno-arterial extracorporeal oxygenation includes measuring first oxygenated blood flow rate by a pump in the extracorporeal blood oxygenation circuit as introduced into an arterial portion of the patient circulation system and a corresponding arterial oxygen saturation, then changing the pump flow rate, such as decreasing, to produce a corresponding change in arterial oxygen saturation (wherein such change is outside of normal operating variances, operating errors or drift), which change in the arterial oxygen saturation is measured. From the first flow rate and the second flow rate along with the corresponding measured arterial oxygen saturation, the CO of the patient can be calculated, without reliance upon a measure of venous oxygen saturation.

Abstract: A blood pump system including an optical sensor configured to detect an optical signal during pumping operation of the blood pump, and an optical fiber configured to transmit the optical signal from the optical fiber sensor to an evaluation device communicatively coupled to the optical fiber sensor. The evaluation device is configured to receive as inputs the transmitted optical signal and a signal indicative of the motor current and determine a mechanical failure event associated with the blood pump based on the motor current and the optical signal.

Abstract: The present invention relates to a device and a method for FIG. 2 treating fat cells taken from a patient and intended for a transplant. More specifically, it relates to a device and a method by suctioning which makes it possible to separate the viable fat cells from the residues and elements which are not transplantable.

Abstract: The urine collection insert, or infant urine collector, is an insert for placement inside a typical diaper. Placement of the insertion preferably occurs with the first diapering after birth. The infant's urine is channeled into a portal, through a one-way valve, and into a reservoir. Coincident with the next diaper change, the insert is collected and the urine withdrawn for testing. Throughout the process, all chain-of-custody requirements being followed. The design of the urine collection insert prevents contamination from the infant's feces, most likely to be meconium—the feces of a newborn formed from epithelial cells, lanugo (hair), mucus, amniotic fluid, bile, and water. By avoiding contamination, the integrity of the sample will be maintained and accuracy of results increased, whether positive or negative.

Abstract: A catheter directionally conducts a pulsating body fluid and has a line segment defining an inner volume. A pump chamber section is arranged proximally as an extension of the line segment and defines a pump chamber having a frame therein accommodating a balloon. A first opening connects the inner volume to an external volume and a second opening is arranged proximally from the first opening to connect the inner volume to the external volume. A check valve is assigned to the second opening and the check valve includes a valve foil having an aperture formed therein offset from the second opening. A third opening communicates with the pump chamber. The frame is of a shape memory material which provides rigidity for a pulsatile operation of the balloon. During operation, the pulsating body fluid is conveyed in the inner volume directionally between the first and second opening by operating the balloon.

Abstract: A leg strap assembly is provided for supporting a urine bag on a user's leg. The leg strap assembly includes a pair of straps selectively couplable with the urine bag, wherein each strap of the leg strap assembly includes a central band and a pair of outer bands extending outward from each end portion of the central band. The central band has a larger width than the each of the outer bands to provide comfort to the user.

Abstract: The utility model relates to rectally installed devices for intestinal gases drainage. User comfort is improved due to the fact that the device for silent removal and collection of intestinal gases is made in the form of a hollow oblong housing with two collar projections, proximal and distal, on the outer surface of the oblong housing, between which there is a window connected in the flowing medium with the outlet; there is a stop at the outlet. The window may consist of several inlets located circumferentially between the collar protrusions; there are drainage grooves on the outer side of the distal collar protrusion.

Abstract: Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate.

Abstract: A flow control device for a compressible bottle may include a reservoir, the reservoir comprising an ophthalmic formulation disposed therein, the ophthalmic formulation comprising an ophthalmic agent and a preservative; a reservoir interface, disposed at a mouth of the reservoir, the reservoir interface comprising one or more apertures, the one or more apertures in the reservoir interface fluidically connecting an interior of the reservoir and an exterior of the reservoir; a nozzle, the nozzle comprising: an outlet and a nozzle cap, the nozzle cap comprising one or more apertures, the one or more apertures in the nozzle cap fluidically connecting the outlet and a reservoir-facing surface of the nozzle; and an axis of rotation, wherein rotation of the nozzle about the axis of rotation relative to the reservoir aligns the one or more apertures in the reservoir interface with the one or more apertures in the nozzle cap.

Abstract: The invention relates generally to medical devices and methods for reducing the intraocular pressure in an animal eye and, more particularly, to stent type devices for permitting aqueous outflow from the eye's anterior chamber and associated methods thereof for the treatment of glaucoma. Some aspects provide a self-trephining glaucoma stent and methods thereof which advantageously allow for a “one-step” procedure in which the incision and placement of the stent are accomplished by a single device and operation. This desirably allows for a faster, safer, and less expensive surgical procedure.

Abstract: In vivo and ex vivo positionable filtration devices are provided that are functionalized to bind one or more therapeutic agents in blood flowing in a blood vessel.

Abstract: A kit preparation that enables drug dose adjustment. The kit preparation includes a bag which contains an infusion solution or pure water and at least one drug enclosing part in which a drug is enclosed and which is provided with a sealing part. The drug enclosing part is connected to the bag via the sealing part; and, when the sealing part is released, the bag is communicated with the drug enclosing part and thus the drug is poured into the bag so that a dispensing work can be carried out.

Abstract: A system includes an endoscope defining a proximal end, a distal end and an elongated shaft extending between the proximal end and the distal end of the endoscope. A fluid collecting sheath defines a proximal end and a distal end. The fluid collecting sheath is configured for insertion into a vaginal opening. The fluid collecting sheath includes fluid collecting apertures defined at the distal end of the fluid collecting sheath. A fluid line is in fluid communication with the fluid collecting apertures. A channel is formed in the fluid collecting sheath. The channel extends between the proximal end and the distal end of the fluid collecting sheath. The channel defines an opening therein. The channel of the fluid collecting sheath is configured to operably engage the elongated shaft of the endoscope by passing the elongated shaft of the endoscope through the opening of the channel.

Abstract: A heat exchanger for a blood circulation circuit comprises a hollow fiber membrane layer having a plurality of hollow fiber membranes, and a fixing portion fixing both end portions of the hollow fiber membranes from outsides of the hollow fiber membranes. The fixing portion mainly contains polyurethane, and each of the hollow fiber membranes has a heat conductive layer containing high density polyethylene, and an adhesion layer provided on an outside of the heat conductive layer, bonded to the fixing portion, and mainly containing a modified polyolefin resin.

Abstract: A nasal rinsing cap suitable for standard water bottle is disclosed. The body portion of the device can be attached to the top of the bottle. It has a cylindrical void matching the threaded portion of the bottle and a one-way fluid valve attached to another void extending from the cylindrical void and through the body portion. The body portion also includes a one-way air valve allowing the entry of air into the bottle. A top portion is removably or openably attached to the body portion. It has a tubular opening starting near the body portion and extending through the top portion. The top portion is configured so that it has a tip to be contacted with the user's nasal cavities. The top portion also has a pressure zone for closing the fluid valve by applying a pressure on it.

Abstract: Methods and apparatuses are disclosed for applying negative pressure to a wound site. In some embodiments, the apparatus comprises a source of negative pressure, a processing element, and a memory comprising instructions configured to, when executed on the processing element, cause the apparatus to attempt to generate, via the source of negative pressure, a desired negative pressure at the wound site. If the desired negative pressure has not been generated after a first predetermined period of time, the instructions cause the apparatus to: deactivate the source of negative pressure for a second predetermined period of time, and subsequently attempt to generate the desired negative pressure at the wound site.

Abstract: An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.

Abstract: Delivery devices, systems and methods are provided for inserting an implant into an eye. The delivery or inserter devices or systems can be used to dispose or implant an ocular stent or implant, such as a shunt, in communication with a suprachoroidal space of the eye. The implant can drain fluid from an anterior chamber of the eye to a physiologic outflow path of the eye, such as, the suprachoroidal space or other portion of the uveoscleral outflow path. The delivery or inserter devices or systems can be used in conjunction with other ocular surgery, for example, but not limited to, cataract surgery through a preformed corneal incision, or independently with the inserter configured to make a corneal incision. The implant can be preloaded with or within the inserter to advantageously provide a sterile, easy-to-use package for use by an operator.

Abstract: Embodiments of negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a pump assembly and a wound dressing configured to be positioned over a wound. The pump assembly and the wound dressing can be fluidically connected to facilitate delivery of negative pressure to a wound via a fluid flow path. The system can be configured to efficiently deliver negative pressure and to detect and indicate presence of conditions, such as a blockage in a fluid flow path. Monitoring of the conditions can be performed by detecting a level of activity of a pump of the pump assembly.