Patents Examined by Bernard Dentz
  • 5-substituted 2-(alkoxymethyl)furans
    Patent number: 8231693
    Abstract: The present invention concerns a method for the manufacture of a 5-substituted 2-(alkoxymethyl)furan (or a mixture of such furans) by reacting a starting material comprising at least a 5-substituted furfural with hydrogen in the presence of an alcohol and a catalyst system.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: July 31, 2012
    Assignee: Furanix Technologies B.V.
    Inventor: Gerardus Johannes Maria Gruter
  • Flow reactors for chemical conversions with heterogeneous catalysts
    Patent number: 8232415
    Abstract: Improved apparatus for use in process systems which include exothermic chemical conversions of organic compounds to value added products is disclosed, more particularly, flow reactors for exothermic chemical conversions using a fixed heterogeneous catalyst with means for control of the exotherm.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: July 31, 2012
    Assignee: BP Corporation North America Inc.
    Inventors: Hassan Taheri, Curtis D. Dickinson, Paul A. Jacobson
  • Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using the same
    Patent number: 8227627
    Abstract: Described herein are ?9-THC prodrugs, methods of making ?9-THC prodrugs, formulations comprising ?9-THC prodrugs and methods of using ?9-THC. One embodiment described herein relates to the transdermal administration of a ?9-THC prodrug for treating and preventing diseases and/or disorders.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: July 24, 2012
    Assignee: Alltranz Inc.
    Inventors: Audra Lynn Stinchcomb, Miroslaw Jerzy Golinski, Dana Carmel Hammell, Jeffery Lynn Howard
  • Process for the preparation of tetranorlabdane derivatives
    Patent number: 8227629
    Abstract: The present invention concerns a process for the preparation of a compound of formula (I), wherein the dotted line is a single bond and n is 1 or the dotted line is a double bond and n is 0, and wherein the relative configuration is as shown, in the form of any one of its diastereoisomers or enantiomers or mixtures thereof.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: July 24, 2012
    Assignee: Firmenich SA
    Inventor: Charles Fehr
  • Extraction of lipids from oleaginous material
    Patent number: 8222437
    Abstract: Systems and methods for extracting lipids of varying polarities from oleaginous material.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: July 17, 2012
    Assignee: Arizona Board of Regents For and On Behalf Of Arizona State University
    Inventors: Aniket Kale, Qiang Hu, Milton Sommerfeld
  • 2H-chromenes annelated at C-Cand methods of making and using thereof
    Patent number: 8217188
    Abstract: Described herein are C5-C6 annelated naphthopyrans that possess at least one electron-withdrawing group. The compounds possess desirable properties such as increased fading kinetics. Also described herein are new methods for synthesizing 2H-chromenes annelated at C5-C6. The methods involve less stringent reaction conditions as well as provide increased reaction yields. The methods permit the synthesis of a wide variety of substituted naphthopyrans that can be temperature sensitive, which was not possible with previous synthetic routes.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: July 10, 2012
    Assignee: Corning Incorporated
    Inventors: Suresh Das, Bruno Dufour, Mangalam S Nair, Kokkuvayil V Radhakrishnan
  • Process for integrated co-production of hydrogen peroxide and epoxidized esters
    Patent number: 8217191
    Abstract: A process for the integral production and reactive consumption of hydrogen peroxide combines oxidation of a high-boiling secondary alcohol to form hydrogen peroxide and the ketone analog, recycle of a hydrogenated ketone/alcohol stream to the oxidation step, and epoxidation of unsaturated fatty acid esters utilizing a gaseous hydrogen peroxide stream as it is produced. The epoxidized esters are known to have desirable characteristics for use as plasticizers and similar products.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: July 10, 2012
    Inventor: John E. Aiken
  • Process for producing optically active cis-silyl olefin oxide compound
    Patent number: 8217184
    Abstract: The present invention provides an efficient production method of an optically active cis-silylolefin oxide compound useful as an intermediate for various compounds. A production method of an optically active cis-silylolefin oxide compound by subjecting an optically active cis-silylolefin compound to an asymmetric oxidation with a high enantioselectivity and a high chemical yield by utilizing as a catalyst, an optically active titanium complex of Formula (1), Formula (2): or the like.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: July 10, 2012
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Tsutomu Katsuki, Kazuhiro Matsumoto, Takuya Kubo
  • Chromenone potassium channel blockers and uses thereof
    Patent number: 8217189
    Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: July 10, 2012
    Assignee: Bionomics Limited
    Inventors: Bernard Luke Flynn, Jonathan B. Baell, Andrew J. Harvey, Jason Hugh Chaplin, Dharam Paul, Jorgen Alvar Mould
  • Method for producing propylene oxide
    Patent number: 8211822
    Abstract: Process for preparing propylene oxide, which comprises at least the steps (i) and (ii): (i) providing a catalyst comprising at least one porous oxidic material; (ii) reacting propene with a hydroperoxide in at least one nitrile as solvent or in a solvent mixture comprising at least one nitrile in the presence of the catalyst of (i), wherein the at least one porous oxidic material is a zeolite which is assigned X-ray-crystallographically to the MWW type.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: July 3, 2012
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Mueller, Georg Krug, Peter Rudolf, Joaquim Henrique Teles, Hans-Georg Goebbel, Peter Bassler
  • Extraction with fractionation of oil and co-products from oleaginous material
    Patent number: 8212060
    Abstract: Systems and methods for extracting lipids of varying polarities from oleaginous material.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: July 3, 2012
    Assignee: Arizona Board of Regents For and On Behalf Of Arizona State University
    Inventors: Aniket Kale, Qiang Hu, Milton Sommerfeld
  • Process for producing vinylene carbonate
    Patent number: 8203006
    Abstract: The present invention relates to the industrial production of vinylene carbonate (VC) by eliminating hydrogen chloride from chloroethylene glycol carbonate (CGC) or solid catalysts in the gas phase, the reaction being carried out over a catalyst bed agitated by thorough mixing.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 19, 2012
    Assignee: Saltigo GmbH
    Inventors: Reinhard Langer, Anke Beckmann, Andreas Schulze Tilling, Paul Wagner, Leslaw Mleczko, Sigurd Buchholz
  • Method for stabilizing quercetin
    Patent number: 8202900
    Abstract: This invention relates to a method for stabilizing quercetin by placing it in a solution containing vitamin B3 and vitamin C and assessing stability of the quercetin in the mixture.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: June 19, 2012
    Assignee: Quercegen Pharmaceuticals LLC
    Inventor: Thomas Christian Lines
  • 3?,4?,5-trimethoxy flavone derivatives as stimulant of mucus secretion, method for the same, and pharmaceutical composition comprising the same
    Patent number: 8203011
    Abstract: The present invention provides a 3?,4?,5-trimethoxy flavone derivative and a pharmaceutically acceptable salt thereof, preparation thereof, and a pharmaceutical composition for the treatment and prevention of dry eye syndrome comprising the same as an active ingredient. The 3?,4?,5-trimethoxy flavone derivative and its pharmaceutically acceptable salt inhibit corneal damage through excellent stimulatory action on mucus secretion in the conjunctiva and therefore may be effective as a prophylactic or therapeutic agent for dry eye syndrome.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: June 19, 2012
    Assignee: Dong-A Pharm. Co., Ltd.
    Inventors: Seul-Min Choi, Kyung-Koo Kang, Dong-Sung Kim, Jeong-Hoon Kim, Byoung-Ok Ahn, Moo-Hi Yoo, Mi-Jeong Seo, Ju-Mi Kim, Yong-Duck Kim, Sun-Woo Jang, Yong-Sung Shon
  • Anti-microorganism terpenic composition
    Patent number: 8198321
    Abstract: The invention relates to a terpenic composition for use as an anti-micro-organism or anti-viral agent comprising a cyclic terpenic compound obtained from a terpene of the general formula (C5H8)n, n being in the range of 2 to 5; and to a vector-forming organic substance, associated to the said cyclic terpenic compound.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: June 12, 2012
    Inventor: Aurèle Henri Mannarini
  • 5-hydroxy-2-methyl-4H-pyran-4-one esters as novel tyrosinase inhibitors
    Patent number: 8183398
    Abstract: Skin brightening compositions based on esters of 5-hydroxy-2-methyl-4H-pyran-4-one. Also disclosed are methods of making the compositions as well as methods of using the compositions.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: May 22, 2012
    Assignee: Eastman Chemical Company
    Inventors: Michael Fitzpatrick Wempe, Jeffrey Michael Clauson, Liu Deng
  • Integrated hydro-oxidation process with separation of an olefin oxide product stream
    Patent number: 8183399
    Abstract: An integrated process providing for a gas phase hydro-oxidation of an olefin, preferably, propylene, with oxygen in the presence of hydrogen and a catalyst under reaction conditions such as to form a gaseous hydro-oxidation effluent stream containing an olefin oxide product, preferably, propylene oxide, water, unconverted olefin, oxygen, and hydrogen; and further providing for separation and recovery of the olefin oxide product from the effluent stream. The separation involves feeding the hydro-oxidation effluent stream into a first distillation column employing a liquid reflux rectification agent to obtain a first overhead stream containing unconverted olefin, oxygen, and hydrogen, which is recycled to the hydro-oxidation reactor, and a first bottoms stream containing water and the olefin oxide, from which upon further separation a purified olefin oxide product is recovered.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: May 22, 2012
    Inventors: David Trent, Katherine Pividal, Jon Siddall, Lanny Robbins
  • Process for the preparation of cyclopropyl carboxylic acid esters and derivatives
    Patent number: 8183412
    Abstract: The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities; and to certain intermediates provided by these processes.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: May 22, 2012
    Assignee: AstraZeneca AB
    Inventors: Adrian Clark, Elfyn Jones, Ulf Larsson, Anna Minidis
  • Alkylene oxide recovery systems
    Patent number: 8183400
    Abstract: Embodiments of the present disclosure include processes and systems for recovering alkylene oxide. System embodiments include a stripping section located in an alkylene oxide recovery column to convert a feed stream comprising to a first gas phase portion comprising alkylene oxide, a condensing zone comprising at least a first condenser and a second condenser configured in series, and a reabsorption region located in the alkylene oxide recovery column above the last of the at least two condensers.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: May 22, 2012
    Assignee: Dow Technology Investments LLC
    Inventors: John F. Szul, James H. Mccain, Floyd L. Pfeffer, Harvey E. Andresen, Phillip R. Fairchild, Kent E. Newman
  • Compositions and methods for treating cancer
    Patent number: 8183395
    Abstract: Compounds of formulas I-IV: (I), (II), (III) (IV), wherein: R1 and R4-R23 are independently selected from H and 1-3 carbon lower alkyl; and R2 and R3 are independently selected from H, 1-3 carbon lower O II alkyl, and —C—Ra, wherein Ra is 1-3 carbon lower alkyl. Pharmaceutical compositions, which include any of Compounds I-IV and a pharmaceutically acceptable carrier, methods of inducing tumor cell apoptosis by administering to a patient in need thereof an effective amount of any of Compounds I-IV, and methods for obtaining any of Compounds I-IV by extracting the compound from coral are also provided.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: May 22, 2012
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Paul Falkowski, Eric H. Andrianasolo, Liti Haramaty, Eileen White, Richard Lutz