Abstract: An optical stimulation system includes a light source; an optical lead coupled, or coupleable, to the light source; at least one of a calibration table or a calibration formula, generated by a calibration procedure specifically using the light source and the optical lead of the optical stimulation system; and a control unit coupled, or coupleable, to the light source. The control module includes a memory to store the at least one of the calibration table or the calibration formula, and a processor coupled to the memory and configured for receiving a target light output level, using the at least one of the calibration table or the calibration formula to determine at least one operational parameter for generating the target light output level, and directing the light source, using the at least one operational parameter, to generate light at the target light output level.

Abstract: This invention relates to devices and methods for the electrochemical removal of unwanted deposits in humans and animals, or for prevention of bone loss following implantation of metal and other surgical materials in the body. A selected voltage is applied using direct current and an electrode to discourage growth or remove deposits, including bone spurs, and may be applied using microneedles in skin contact with a human or animal.

Abstract: A method of assessing Fallopian tubal patency includes introducing a distension medium into a patient's uterus, introducing a contrasting medium into the uterus, and observing the contrasting medium, for example, via a hysteroscope, to determine whether the contrasting medium flows into one or both Fallopian tubes. A device for assessing Fallopian tubal patency includes a chamber for receiving contrast media, a flow path through the chamber for delivering distension media to a patient's uterus, and a flow controller for regulating the flow of distension media to the patient's uterus. The flow path is configured to permit flow of contrast media from the chamber into the flow path.

Abstract: Systems and methods are provided to combine multiple stimulation modalities to significantly increase the effectiveness of non-invasive stimulation. Multiple sensor and stimulation devices and modalities can be combined into a single, compact unit that minimizes the need for additional sensors or stimulation devices. The system features several subunits, referred to as sensory and stimulation devices (SSD), that are integrated into a headphone setup. The system is controlled by a centralized controller that communicates with all of the SSDs and with an external computer system that delivers learning material synchronized with the delivery of stimulations and the collection of user responses based on physiological signals.

Abstract: Methods and devices herein are provided for managing atrial (A) pacing in connection with premature atrial contracts (PAC). The methods and devices obtain an atrial pace-on-PAC (APAC) interval and cardiac activity (CA) signals. The methods and devices are configured to: i) during a first cardiac beat; following a ventricular paced (VP) or ventricular sensed (VS) event, activate a timer for a post ventricular-atrial refractory period (PVARP) interval; and determine whether a first atrial refractory (AR) event occurs during the PVARP interval; ii) during a second cardiac beat; in response to the detecting that the first AR event occurred, initiate an APAC interval; during the APAC interval for the second cardiac beat, determine whether a second AR event occurs; and update a count of APAC events when the second AR event occurs; and iii) repeat i) and ii) for multiple cardiac beats, to track the count of APAC events.

Abstract: A medical treatment system for determining administration of medications to a patient is disclosed. The system uses a plurality of sensors to perform a first set of physiologic measurements in a right side of the heart and a second set of physiologic measurements in a left side of the heart. The system also includes a receiver configured to receive measurement data regarding the first and second sets of physiologic measurements and output to a display device the received measurement data.

Abstract: A subject's Default Mode Network is accessed through corresponding measurements of the Micro-Coherence Oximetry Network Strength (MCO-S). An associated MCO-S system (100) includes a wearable (102), a user device (112) and a processing platform (123). The wearable (102) collects subject information sufficient to enable monitoring and optimization of the subject's Default Mode Network include sensors such as pulse oximetry instrumentation and EEG electrodes to obtain brainwave data, oxygen saturation data, heart rate variability data, and galvanic skin conductance data. Information from the sensors may be communicated to a user device (112), such as a cell phone or VR headset. The user device (112) communicates with a remote processing platform (123) that may execute artificial intelligence functionality and other logic in connection with assessing the patient's micro-coherence network strength and optimizing behavior modification protocols in relation to attributes and objectives of the subject.

Abstract: A method for using beauty instrument with mask is provided. The method comprises providing a beauty instrument with mask comprising a flexible mask and a controller, applying the flexible mask of on a user's face, and turning on the controller and selecting a function button on the controller, inputting a current to a plurality of functional layers in the flexible mask, and stimulating face skin with the current.

Abstract: Methods and systems for use of the Q-wave to R-wave interval to guide placement of a leadless cardiac pacemaker are disclosed. An implant delivery device is equipped with sensing electrodes to sense R-wave onset in a ventricle of a patient's heart to allow placement at a location of last or latest onset of the R-wave. Guidance tools are provided to assist in determination of the Q-wave to R-wave interval during implantation. For a chronic system, a cooperative approach is disclosed in which an implantable medical device and a leadless cardiac pacemaker exchange data to determine Q-wave to R-wave intervals and enhance cardiac resynchronization therapy delivery by the leadless cardiac pacemaker.

Abstract: A leadless pacemaker device configured to provide for an intra-cardiac pacing, including: processing circuitry configured to generate ventricular pacing signals for stimulating ventricular activity, and a reception device for receiving a sensing signal indicative of an atrial activity, wherein the processing circuitry is configured to detect an atrial event derived from said sensing signal, wherein the atrial event is a valid atrial sense event, where a series of atrial events lie within a range for a normal atrial rate, and/or when the atrial rate variability is within a certain range indicating a regular atrial rhythm, wherein in case a valid atrial sense event is detected, the processing circuitry is further configured to: determine ventricular pacing events according to atrial events, calculate ventricular-atrial time delays, determine a correction value based a measured time delay and the calculated time delay, and adjust the ventricular pacing timing based on the correction value.

Abstract: Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

Abstract: An electrode multiplexing physiological parameter monitoring ring, comprising a built-in power supply (2), a microprocessor module (1), an electrocardiogram monitoring analog front end (3), a skin conductance monitoring module (4), a first electrode (6), and a second electrode (7). The microprocessor module (1) is connected to the electrocardiogram monitoring analog front end (3) and the skin conductance monitoring module (4). The first electrode (6) and the second electrode (7) are connected to the electrocardiogram monitoring analog front end (3), and the electrocardiogram monitoring analog front end (3) processes electrocardiogram signals collected by the first electrode (6) and the second electrode (7). The first electrode (6) and the second electrode (7) are further connected to the skin conductance monitoring module (4), and the skin conductance monitoring module (4) processes skin impedance signals collected by the first electrode (6) and the second electrode (7).

Abstract: The process for classifying anesthetic depth includes: collecting of biological signals, conditioning of said signals, monitoring of activity of the central and autonomic systems, measurement of indexes and classification of patterns in anesthetic depth. The activity includes: i) Awake: Vigil—Ak. and recovery of verbal response—Rc. ii) Light Anesthesia: Light induction anesthesia—Li. Light recovery—Lr, Light dose, increase in drugs or patient movement (La), iii) General anesthesia: General anesthesia—Ga, one minute after the start of the surgery, and iv) Deep anesthesia: identification of the EEG burst-suppression pattern (BSP) associated with deep anesthesia.

Abstract: A health monitoring device for detecting blood pressure having a blood pressure sensor including a first fiber Bragg grating (FBG) with a refractive index is configured to be placed in contact with a person's skin approximate to an artery or vein. A baseline sensor that includes a second fiber Bragg grating (FBG) also having a refractive index is configured to be placed in contact with a person's skin away from an artery or vein to provide a baseline refractive index. The device pulses light waves through the FBGs to provide a processor with reading of the refractive index from the FBGs. Based on the effective shifts of the Bragg wavelength due to axial strain on the FBGs, a blood pressure estimator estimates systolic and diastolic blood pressure based on a calibration curve comparing pressure against strain.

Abstract: A computerized method for controlling the operation of a laser therapy device is disclosed. A laser therapy device comprising laser diodes has a microprocessor for storing and executing instructions pertaining to the operation of the laser diodes within certain parameters. The computerized method detects the movement of the laser therapy device and alters the output of the laser diodes when a movement signal exceeds predetermined threshold parameters. The computerized method detects difference in temperature in certain areas, and patterns in temperature differences, for assistance in diagnosing ailments. The computerized method also detects differences in skin color to determine treatment areas. The computerized method also measures the distance of the laser therapy device to a treatment area. The microprocessor executes instructions then which can alter the output of the laser diodes or generate an alarm signal based on measurements received.

Abstract: A computerized method for controlling the operation of a laser therapy device is disclosed. A laser therapy device comprising laser diodes has a microprocessor for storing and executing instructions pertaining to the operation of the laser diodes within certain parameters. The computerized method detects the movement of the laser therapy device and alters the output of the laser diodes when a movement signal exceeds predetermined threshold parameters. The computerized method detects difference in temperature in certain areas, and patterns in temperature differences, for assistance in diagnosing ailments. The computerized method also detects differences in skin color to determine treatment areas. The computerized method also measures the distance of the laser therapy device to a treatment area. The microprocessor executes instructions then which can alter the output of the laser diodes or generate an alarm signal based on measurements received.

Abstract: Provided is a biological information measuring instrument which can be easily and reliably worn on an appropriate position of an arm by a user. The biological information measuring instrument includes: a belt portion that is worn on a user's arm in a circumferential direction of the arm and disposed with a sensor for detecting a displacement of an arm muscle; and a case portion that is attached to a predetermined portion of the belt portion and houses a circuit component that processes a signal of the displacement detected by the sensor. The case portion has a shape of protruding from the belt portion in a longitudinal direction of the arm when the belt portion is worn on the arm, and amounts D1 and D2 of protrusions protruding in the longitudinal direction are different between one protrusion and the other protrusion.

Abstract: An implantable medical device is configured determine a numerical value of a variable that is monitored by the implantable medical device and convert the numerical value to a data sequence of modulated electrical stimulation rate intervals. The implantable medical device delivers electrical stimulation pulses according to the data sequence of modulated stimulation rate intervals to cause a modulated rate of activation of excitable tissue of a patient corresponding to the modulated stimulation rate intervals. The modulated rate of activation is detectable by a rate monitor for demodulation to the numerical value of the monitored variable data value. In some examples, the implantable medical device is a pacemaker delivering cardiac pacing pulses according to modulated pacing rate intervals to cause a modulated heart rate of the patient detectable by a heart rate monitor for demodulation to the numerical value of the monitored variable.

Abstract: This document describes an electrode assembly for use with a defibrillator, the electrode assembly comprising at least one electrode including a first surface that can be affixed to either of a pediatric patient and an adult patient and a second surface, wherein a majority of the second surface includes pictorial instructions related to use of the electrode assembly; and a chest compression sensor attached to the at least one electrode, wherein the at least one electrode is configured to be used on an adult patient when the electrode assembly is in a first orientation, and wherein the at least one electrode is configured to be used on a pediatric patient when the electrode assembly is in a second orientation.

Abstract: An ICD multimode system comprises a microcontroller or FPGA having a memory, a differentially driven phased array amplifier, one or more sensors, and a wireless transmitter/receiver. Based upon sensor data and demand criteria programmed into the memory, the system provides late systolic impulse (LSI) therapy to treat congestive heart failure (CHF) and ventricle level-shifting (VLS) therapy to block unwanted PVCs to prevent VT or VF dynamically and use a phased array amplifier therapy to accurately manage CRT. An external echocardiogram and ultrasound system adjusts the therapies administered based upon sensor and demand data in real time to allow a patient's heart to function at a level of improved performance and increase ejection fraction EF.