Abstract: A method for anatomical diagnosis includes measuring, using a catheter that includes a position sensor and an electrode, over multiple cycles of a beating heart, electrical activity and mechanical motion at a plurality of locations contacted by the catheter on a heart wall within a chamber of the heart. Based on the measured mechanical motion, a magnitude of a mechanical strain is computed over the cycles at the locations. In one embodiment, the computed strain is used in identifying a group of the locations at which the magnitude of the mechanical strain is below a predefined strain threshold and a voltage of the electrical activity is below a predefined voltage threshold as a locus of scar tissue. In another embodiment, a pathological condition of the heart is identified based on a characteristic of the mechanical strain computed over the left ventricle during the diastolic phase.

Abstract: An ophthalmic device for treating an eye includes a laser source, a scanner system and an application head with a focusing optic and a patient interface for docking the application head onto the eye. Moreover, the ophthalmic device includes a measurement system for optically capturing eye structures when the application head is docked to the eye and a circuit which is configured to determine reference structures of the eye, which are arranged in ring-shaped fashion about the center axis of the anterior chamber of the eye, from the captured eye structures and to arrange a defined three-dimensional treatment model with respect to these reference structures in order to process a three-dimensional treatment pattern in accordance with the arranged three-dimensional treatment model in the eye.

Abstract: An electrical stimulation system includes a sheath that includes conductive points that are operative to facilitate electrical stimulation to a bodily portion of a user. Drive-sense circuits (DSCs) generate electrical stimulation signals based on reference signals and provide those electrical stimulation signals via electrodes to the conductive points of the sheath. The electrical stimulation signal is coupled into respective locations of the bodily portion of the user that are in proximity to or in contact with the conductive points of the sheath. In addition, the DSCs sense, via the conductive points of the sheath and via the electrodes, changes of the electrical stimulation signals based on coupling of them into the respective locations of the bodily portion of the user. The DSCs provide digital signals that are representative of the changes of the electrical stimulation signals to one or more processing modules that includes and/or is coupled to memory.

Abstract: Apparatus is provided for facilitating percutaneous delivery of an implant to a target site of a body of a subject. The apparatus includes a delivery tool that includes a needle that defines a lumen through which the implant passes. The needle has a proximal end and a distal end, and defines a triple-grind bevel at the distal end. The triple-grind bevel defines a primary grind and two side-grinds. The side-grinds do not extend to meet each other to define a point at a distal-most part of the needle. Other embodiments are also described.

Abstract: Electrical current can be delivered to the skin to treat hyperhidrosis or other conditions using wearable and non-wearable devices. Wearable devices to deliver electrical current can include an inner assembly that carries one or more electrodes and an outer assembly that can be worn over the inner assembly. Contact between electrodes and the user's skin can be promoted using suction, support components, or filler materials. Non-wearable devices can be grasped by a user or otherwise placed into contact with a treatment site for delivery of electrical current to the user's skin. Electrode lay-out for wearable and non-wearable devices can be optimized for current density distribution across the electrode.

Abstract: Systems, devices, and methods for tracking and determining the motion of a cardiac implant is disclosed. The motion of the implant is determined by transmitting acoustic energy to a tissue location using an acoustic controller-transmitter comprising an array of acoustic transducers; wherein the implant is configured to convert the transmitted acoustic energy to electrical energy; and the tracking is achieved by determining the electrical energy delivered to the tissue throughout one or more cardiac cycles in order to create a motion profile of the cardiac implant.

Abstract: In some examples, a coil electrode assembly includes a coil electrode including a plurality of windings and extending from an electrode proximal end to an electrode distal end, the coil electrode defining an electrode lumen from the electrode proximal end to the electrode distal end. The coil electrode assembly further includes an insulative tube extending within the lumen of the coil electrode such that the coil electrode extends along an outer surface of the insulative tube. The coil electrode is partially embedded within the insulative tube when the insulative tube is in an expanded state to maintain a spacing between the windings.

Abstract: A leadless pacemaker device for providing an intra-cardiac pacing includes processing circuitry configured to generate ventricular pacing signals for stimulating ventricular activity at a ventricular pacing rate, a first sensor configuration receiving a first sense signal, and a second sensor configuration receiving a second sense signal. The processing circuitry derives, in a first sensing state, atrial events from the first sense signal for controlling the ventricular pacing rate based on the atrial events. The processing circuitry switches, based on at least one switching criterion, from the first sensing state to a second sensing state in which the processing circuitry derives atrial events from the second sense signal. The second sense signal is received by the second sensor configuration for detection of atrial events and the second sensor configuration is a motion sensor or a sound sensor. A method for operating the pacemaker device is also provided.

Abstract: A medical device includes a motion sensor for producing a motion signal including cardiac event signals. The medical device generates a ventricular pacing pulse upon expiration of a pacing interval. The medical device determines a synchrony metric from the motion signal after a delivered ventricular pacing pulse and adjusts the pacing interval based on the synchrony metric.

Abstract: Systems and methods make possible the placement of one or more electrode leads in a tissue region for providing functional and/or therapeutic stimulation to tissue. The systems and methods are adapted to provide the relief of pain.

Abstract: Various embodiments provide a wellness tracking device with a base plate that may be utilized as a combination electrode by a variety of sensors. The base plate may be a multi-material electrode that includes a conductor and a transparent or semi-transparent material to enable optical sensing. In certain embodiments, the base plate supports a plurality of different sensors, which may selectively utilize the base plate as an electrode.

Abstract: A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively.

Abstract: The invention relates mainly to an optical guide for diffusing a light radiation through a surface, which is essentially characterized in that it includes a base (3,31) comprising or able to hold at least one diffusion rod (2, 2a; 35a, 35b, 35c) whose lower diffusion end (7, 7a; 38a, 38b, 38c) protrudes from said base (3) and is intended to be applied on or near said surface, and whose upper collecting end (6,6a; 37a, 37b, 37c) is intended to be located near and opposite a power supplied light source (36a, 36b, 36c), and in that the diffusion rod (2, 2a; 35a, 35b, 35c) comprises a material able to transmit light from its collecting end (6,6a; 37a, 37b, 37c) up to its diffusion end (7, 7a; 38a, 38b, 38c). The invention also relates to an irradiation module and to an irradiation device adapted to the transcranial and/or transcutaneous irradiation by light radiation.

Abstract: A probe of a target identification system can be extended via a first lumen of a viewing instrument, such as for illuminating an area beyond a distal end of the viewing instrument via an optical path of the viewing instrument. An optical response to the illumination of the area can be received via an optical path of the probe and can be split from other optical signals of the optical path. The optical response information can be used to identify characteristics of a target and to adjust parameters of a working instrument such as a working instrument contemporaneously using the probe.

Abstract: A garment includes a fabric base layer and at least one side-emitting optical fiber retained to or integrated with the fabric base layer. The fabric base layer can stretch in the grain and cross grain direction of the fabric base layer. The at least one side-emitting optical fiber is located in at least one light-emitting zone to be located over a targeted body area of the person wearing the garment, and is configured to receive light from a light source and in the at least one light-emitting zone is configured to project light having a therapeutic wavelength toward the targeted body area.

Abstract: Dermatological systems and methods for providing picosecond laser pulses at a plurality of treatment wavelengths, wherein at least one of the wavelengths is provided by an optical parametric oscillator (OPO) capable of providing picosecond laser pulses at a wavelength for treating one or more target tissue types such as a sebaceous gland, sebum, or collagen. In some embodiments, multiple OPOs may be provided to enable a wide range of selectable treatment wavelengths.

Abstract: Modulated light therapy devices for treatment of dermatological disorders of the scalp are provided. An exemplary device includes a flexible printed circuit board (FPCB) supporting at least one light emitting device having an emitter height. The FPCB includes multiple interconnected panels and bending regions defined in and between at least some of the interconnected panels as to allow the FPCB to be configured in a concave shape to cover at least a portion of a cranial vertex of the patient. At least one light-transmissive layer proximate to the FPCB is configured to transmit (e.g., incoherent) light emissions generated by at least one light emitting device. At least one standoff is configured to be arranged between the FPCB and the scalp of the patient, wherein the at least one standoff includes a standoff height that exceeds the emitter height.

Abstract: A pulse generating device for delivery of electrical pulses to a desired tissue and configured to be connected to needle electrodes arranged at the desired tissue. The device comprises a determining module configured to determine a primary voltage amplitude of a first pulse and a number of consecutive pulses to be generated. Further, the device comprises a pulse generator configured to generate one or more of the determined number of consecutive pulses such that the generated first pulse has the primary voltage amplitude and that the generated consecutive pulses have a respective voltage amplitude consecutively decreasing between consecutive pulses, whereby an increase in a current value of the generated consecutive pulses above a threshold value is avoided. Furthermore, the device comprises a terminating module configured to terminate generation of the one or more pulses when a value of a total absorbed energy exceeds a threshold value.

Abstract: A treatment tool includes an elongated shaft that has a bending mechanism at a distal end thereof; a bending operation part that is connected to a proximal-end side of the shaft in order to operate the bending mechanism; a connection sleeve that is provided at a connection section of the bending operation part where the bending operation part and the shaft are connected, and that rotatably holds the shaft; a rotation operation member that is provided at the proximal-end side of the shaft and that rotates the shaft; and a stopper member that can be made to slide outside the connection sleeve along a direction of a longitudinal axis of the shaft and that is engaged with both the rotation operation member and the connection sleeve at a specific position in a range of movement thereof, thereby locking rotation of the shaft with respect to the connection sleeve.

Abstract: Dermatological systems and methods for providing a picosecond laser treatment a plurality of treatment wavelengths, at least one of which is provide by an optical parametric oscillator (OPO) capable of providing picosecond laser pulses at a wavelength in the red region of the visible electromagnetic spectrum for treating one or more target tissue types. In some embodiments, the OPO is capable of providing picosecond laser pulses at a wavelength in one of the near-infrared and the infrared region of the electromagnetic spectrum.