Patents Examined by Caitlyn Mingyun Sun
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Patent number: 11808724Abstract: The present disclosure provides a sensor system including one or more sensors having a first container fluidly coupled to a second container, the second container being configured to receive a conductive media from the first container. A first movable element is slidingly engaged with the first container to cause the second container to receive the conductive media from the first container. A first electrode is positioned in the first cavity and electrically coupled to the conductive media. In some examples, a second electrode is electrically coupled to the first electrode and the conductive media. The sensor deposits the conductive media on a working electrode to form an electrochemical cell and obtain one or more material properties of the working electrode. In some examples, the sensor system includes an array of sensors which deposit the conducive media in multiple locations on a working electrode to generate a material property map.Type: GrantFiled: April 22, 2021Date of Patent: November 7, 2023Assignee: The Boeing CompanyInventor: Patrick J. Kinlen
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Patent number: 11808755Abstract: The present disclosure relates to a device, system and method for sensing functional motions of a single protein molecule via direct attachment of one or more electrodes to the molecule. The present disclosure also relates to an array, a system comprising an array and method for sequencing a biopolymer using an array.Type: GrantFiled: May 16, 2019Date of Patent: November 7, 2023Assignee: RECOGNITION ANALYTIX, INC.Inventors: Stuart Lindsay, Peiming Zhang
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Patent number: 11796499Abstract: The subject invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors with enhanced sensitivity, signal-to-noise ratios, LOD, and improved stability and reproducibility. The subject invention also provides methods for aptamer immobilization on the surface of the electrode, which favors sufficient spacing between aptamers at the microscale to achieve optimal target recognition, folding, and signal transduction. The E-AB sensors of the subject invention provide superior sensing regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target.Type: GrantFiled: December 13, 2022Date of Patent: October 24, 2023Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Yi Xiao, Yingzhu Liu, Juan Canoura
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Patent number: 11788985Abstract: Some embodiments presented here relate to chemical sensors with enhanced sensitivity and selectivity. In an embodiment, the sensor is a composite thin film that comprises (e.g., is made of) chemically-modified carbon black and a chemically-sensitive polymer base. By grafting gold nanoparticles on carbon black, the number of binding sites on the sensor thin film is increased, thereby increasing the sensitivity. Furthermore, ligand attached gold nanoparticles are grafted on carbon black to increase the binding sites on the sensor thin film in some embodiments, which results in increased sensitivity as well as improved selectivity in some cases.Type: GrantFiled: February 7, 2019Date of Patent: October 17, 2023Assignee: Stratuscent Inc.Inventors: Nicolas Levaray, Jayan Ozhikandathil, Ashok Prabhu Masilamani, Tullio Panarello
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Patent number: 11786900Abstract: A microfluidic device for the isolation of particles of at least one specific type of a sample is described. The microfluidic device comprises: a first inlet adapted to receive a sample comprising the particles of the specific type, at least part of a separation group comprising a separation unit, which comprises a main chamber and a recovery chamber and being adapted to receive the sample and to transfer at least part of the particles of the specific type from the main chamber to the recovery chamber in a selective manner with respect to further particles of the sample, a first outlet which is designed to allow the particles of the specific type to be collected outside of the device and a second outlet adapted to allow at least a portion of the sample to flow out of the main chamber and out of the microfluidic device.Type: GrantFiled: October 18, 2017Date of Patent: October 17, 2023Assignee: Menarini Silicon Biosystems S.p.A.Inventors: Gianni Medoro, Alex Calanca, Nicolò Manaresi
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Patent number: 11782022Abstract: The capillary electrophoresis apparatus according to the present invention can maintain the temperature in the longitudinal direction of each of a plurality of capillaries uniformly, such that the separation performance of the capillary electrophoresis apparatus can be stabilized, and the analysis performance can be improved.Type: GrantFiled: September 8, 2021Date of Patent: October 10, 2023Assignee: Hitachi High-Tech CorporationInventors: Wataru Sato, Motohiro Yamazaki
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Patent number: 11782023Abstract: Methods for detecting and/or discriminating between variants of an antibody contaminating protein or multiple antibodies in a sample by a physical parameter, in which the method includes: separating protein components of a sample by molecular weight or charge in one or more capillaries using capillary electrophoresis; immobilizing the protein components of the sample within the one or more capillaries; contacting the protein components within the one or more capillaries with one or more primary antibodies that specifically bind to the antibody, the contaminating protein or multiple antibodies in the sample, thereby detecting and/or discriminating between variants in the sample.Type: GrantFiled: December 17, 2019Date of Patent: October 10, 2023Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Nisha Palackal, Kun Lu, Gangadhar Dhulipala, Erica Pyles
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Patent number: 11782018Abstract: A gas sensor element includes a solid electrolyte plate, and a measurement electrode and a reference electrode provided on surfaces of the solid electrolyte plate. In a section plane of the reference electrode along a thickness direction, noble metal regions, solid electrolyte regions, mixed regions, and void spaces are present. When a ratio of an area B of the mixed regions in the section plane with respect to an area A of the reference electrode in the section plane is a mixed region ratio B/A, and a ratio of an area C of the void spaces in the section plane with respect to the area A of the reference electrode in the section plane is a void space ratio C/A, a parameter value as a product of the mixed region ratio B/A and the void space ratio C/A falls within a range of 0.001 to 0.01.Type: GrantFiled: December 14, 2016Date of Patent: October 10, 2023Assignee: DENSO CORPORATIONInventors: Masatoshi Ikeda, Makoto Ito
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Patent number: 11779926Abstract: An electrowetting-based droplet actuator includes top and bottom substrates, a droplet-operation gap between the top and bottom substrates, the droplet-operation gap including a gradually-reduced gap height in a direction of droplet flow when in use, and spaced electrodes embedded in the bottom substrate spanning a region thereof corresponding to the gradually-reduced gap height. A method includes gradually reducing a gap height in section(s) of a droplet-operation gap between top and bottom substrates of an electrowetting-based droplet actuator, the gradually reducing being in a direction of droplet flow when in use from a large-gap inlet to a small-gap outlet (relative sizes), the large-gap inlet being larger in height, the bottom substrate including spaced electrodes embedded therein spanning a region of the bottom substrate corresponding to the gradually reduced gap height, and moving dispensed droplet(s) of liquid in the direction of droplet flow using the spaced electrodes and an applied voltage.Type: GrantFiled: November 9, 2018Date of Patent: October 10, 2023Assignee: ILLUMINA, INC.Inventors: Jennifer Olivia Foley, Darren Segale, Cyril Delattre
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Patent number: 11782006Abstract: A sensing system includes a charge sensor including two electrodes and an electrically conductive channel connecting the two electrodes. The sensing system also includes a charged molecule attached to the electrically conductive channel. The charged molecule includes a recognition site to reversibly bind a label of a labeled nucleotide; has an unbound favored conformation associated with an unbound charge configuration; and has a favored conformation associated with a charge configuration when the recognition site is bound to the label. The charge configuration is different from the unbound charge configuration. The sensing system further includes a polymerase attached to the electrically conductive channel or to the charged molecule.Type: GrantFiled: December 3, 2019Date of Patent: October 10, 2023Assignee: Illumina, Inc.Inventors: Boyan Boyanov, Sergio Peisajovich, Jeffrey G. Mandell
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Patent number: 11779861Abstract: Various aspects described herein relate to electrochemical devices, e.g., for separation of one or more biomolecules from a solution, and methods of using the same. Methods for using the electrochemical devices for biocatalysis are also described herein.Type: GrantFiled: October 27, 2017Date of Patent: October 10, 2023Assignee: Massachusetts Institute of TechnologyInventors: Xiao Su, Trevor Alan Hatton
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Patent number: 11782012Abstract: A fluid analyzer for analyzing fluid samples comprising one or more analytes and a method of calibrating such. The fluid analyzer includes a control system to control at least one automated valve to pass at least three calibration reagents through a fluid channel to a secondary ion selective electrode, a primary ion selective electrode, and a reference electrode, and determine calibration information using calibration logic from signals generated by a meter, control the at least one automated valve to selectively pass different subsets of the at least three calibration reagents through the fluid channel to the secondary ion selective electrode, the primary ion selective electrode, and the reference electrode, and determine re-calibration information using the signals generated by the meter and at least one of the calibration information and re-calibration logic.Type: GrantFiled: December 2, 2022Date of Patent: October 10, 2023Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Wei Zhang, Brian Holman, Kevin Horan
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Patent number: 11779928Abstract: A method of operating an electrowetting on dielectric (EWOD) device performs electrowetting operations on fluids dispensed into the EWOD device, which provides enhanced operation for using multiple non-polar filler fluids.Type: GrantFiled: June 28, 2022Date of Patent: October 10, 2023Assignee: Sharp Life Science (EU) LimitedInventors: Lesley Anne Parry-Jones, Emma Jayne Walton
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Patent number: 11782020Abstract: An embodiment provides a method for modifying a carbon region on a boron-doped diamond electrode surface, comprising: placing a boron-doped diamond electrode surface in an aqueous solution, wherein the aqueous solution comprises an ionic treatment solution; applying a voltage difference across the boron-doped diamond electrode surface; and modifying a carbon region on an area of the boron-doped diamond electrode surface, wherein the modifying is responsive to application of the voltage while the boron-doped diamond electrode surface is in the aqueous solution, wherein the modification continues until a desired signal of the carbon region is reached. Other aspects are described and claimed.Type: GrantFiled: December 18, 2020Date of Patent: October 10, 2023Assignees: HACH LANGE GMBH, UNIVERSITY OF WARWICKInventors: Zoë Duncan, Joshua James Tully
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Patent number: 11782017Abstract: On a cross sectional surface X1 of a pump electrode 3 in a gas sensor element forming a gas sensor, a noble metal area 31 having Pt—Au aggregations, a solid electrolyte area 32 having solid electrolyte aggregations, a mixture area in which Pt—Au alloy and solid electrolyte are distributed, and pores 34. The mixture area 33 is formed within a range of 30 to 90% in an overall area of the cross sectional surface X1, excepting the pores 34. The pores are formed adjacent to the mixture area 33.Type: GrantFiled: July 4, 2016Date of Patent: October 10, 2023Assignees: DENSO CORPORATION, KABUSHIKIKAISHA TOYOTA CHUO KENKYUSHOInventors: Mitsunobu Nakatou, Keigo Mizutani, Takashi Araki, Tadashi Nakamura
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Patent number: 11782016Abstract: A gas sensor which detects a concentration of a specific gas contained in a gas to be measured is provided with a gas sensor element. The gas sensor element has an ion conductive solid electrolyte body, a measuring gas electrode which is mounted on a surface of the solid electrolyte body, a reference gas electrode mounted on a surface of the solid electrolyte body, and a catalyst layer mounted on an outer-side relative to the measuring gas electrode-side. The catalyst layer contains a metal catalyst loaded onto a carrier. The metal catalyst is a Pt single substance, and has a specific surface area defined by the equation below of equal to or more than 0.01 to equal to or less than 23: Specific surface area=total surface area of metal catalyst which exists on an electrode unit surface area/actual surface area of electrode per electrode unit surface area.Type: GrantFiled: May 11, 2018Date of Patent: October 10, 2023Assignee: DENSO CORPORATIONInventors: Junta Zushi, Makoto Ito
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Patent number: 11782013Abstract: A sensor device is for detecting metal. The sensor device may have a substrate, an electrode on the substrate, and a biopolymer-metal composite film on the electrode. The biopolymer-metal composite film may include a metal and a biopolymer. The sensor device may further have circuitry coupled to the electrode and configured to apply a sensing signal to the electrode.Type: GrantFiled: August 6, 2019Date of Patent: October 10, 2023Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Hyoung Jin Cho, Woo Hyoung Lee, Xiaochen Wang, Jae-Hoon Hwang, Pawan Pathak
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Patent number: 11782014Abstract: Disclosed are internal electrolyte layers for ion selective electrodes, wherein the internal electrolyte layers contain carbon paste doped with a metal salt. Also disclosed are ion selective electrodes and sensor array assemblies containing the internal electrolyte layers. Also disclosed are methods of producing and using the internal electrolyte layers, ion selective electrodes, and sensor array assemblies.Type: GrantFiled: May 8, 2018Date of Patent: October 10, 2023Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Wei Zhang, Robert Bergquist, Amir Dolaty, Todd Andrade, Amanda Whittaker
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Patent number: 11782055Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for performing immunoassay tests on a sample. The A sensing apparatus is provided for detecting a plurality of different target analytes in a sample. The apparatus may comprise an array of sensing devices provided on a substrate, each sensing device in the array comprising a working electrode having (1) semiconducting nanostructures disposed thereon and (2) a capture reagent coupled to the semiconducting nanostructures that selectively binds to a different target analyte in the sample. The apparatus may also comprise sensing circuitry that (1) simultaneously detects changes to electron and ion mobility and charge accumulation in the array of sensing devices when the capture reagents in the array of sensing devices selectively bind to the plurality of different target analytes, and (2) determines the presence and concentrations of the plurality of different target analytes in the sample based on the detected changes.Type: GrantFiled: October 19, 2017Date of Patent: October 10, 2023Assignees: EnLiSense, LLC, Board of Regents, The University of Texas SystemInventors: Sriram Muthukumar, Shalini Prasad
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Patent number: 11782008Abstract: Disclosed is an apparatus for determining a process variable of a medium in a containment, comprising first and second oscillatory elements, first and second driving/receiving units, and electronics. The first driving/receiving unit is embodied to excite the first oscillatory element using a first electrical excitation signal to execute mechanical oscillations, and to receive the mechanical oscillations of the first oscillatory element and to convert such into a first electrical, received signal, wherein the second driving/receiving unit is embodied to excite the second oscillatory element by means of a second electrical excitation signal to execute mechanical oscillations, and to receive the mechanical oscillations of the second oscillatory element and to convert such into a second electrical, received signal, and wherein the electronics is embodied to determine the process variable from the first received signal and/or the second received signal.Type: GrantFiled: July 29, 2020Date of Patent: October 10, 2023Assignee: Endress+Hauser Conducta GmbH+Co. KGInventors: Erik Hennings, Dagmar Kaschuba, Marco Bezzon