Abstract: In some examples, a tether head assembly of a delivery system includes an inner retainer and an outer retainer that defines an aperture comprising a receptacle configured to receive an attachment member of a medical device, a passageway, and a groove. The inner retainer is movable within the groove between a second position in which the passageway is dimensioned to receive the attachment member and a first position in which the passageway is dimensioned to prevent passage of the attachment member. In some examples, a tether handle assembly defines a channel, a force transmitter within the channel, a slidable member partially received within a first end of the channel and a button partially received within a second end of the channel. Distally-directed force applied to the button may cause the force transmitter to apply proximally-directed force to the slidable member, moving the slidable member and an attached pull wire proximally.

Abstract: A system is provided that includes a first electrode configured to be located within a septal wall, and a second electrode configured to be located outside of the septal wall. The system also includes an impedance circuit configured to measure impedance along an impedance monitoring (IM) vector between the first and second electrodes. One or more processors are also provided that are configured to obtain impedance data indicative of an impedance along the IM vector with the first electrode located at different depths within the septal wall, the impedance data including a set of data values associated with different depths of the first electrode within the septal wall. The one or more processors are also configured to determine when the first electrode is located at a target depth within the septal wall based on the impedance data.

Abstract: A method for characterizing atrial fibrillation includes determining, by a processor of a computing device and based on heart data, an earliest activation time of a heart being monitored. The method also includes determining, by the processor and based on the heart data, a latest activation time of the heart. The method also includes modeling, by the processor, the earliest activation time and the latest activation time within one or more activation time maps. The method further includes identifying, by the processor, an atrial fibrillation driver based at least in part on the one or more activation time maps.

Abstract: Systems, computing platforms, and methods for sampling and analyzing common mode noise on electrocardiogram signals to help to minimize the interference to the electrocardiogram signals are disclosed. Exemplary implementations may: obtain electrocardiogram signals from one or more sensors configured to be attached to a patient and communicatively connected to a patient monitor; receive the electrocardiogram signals from one or more sensors by the patient monitor; display the electrocardiogram signals on one or more displays of the patient monitor; sample and analyze a direct current range and an alternating current spectrum to identify common mode interference levels within the obtained electrocardiogram signals; display the direct current range and the alternating current spectrum via the one or more displays of the patient monitor; and update the display of the direct current range and the alternating current spectrum in real time to identify sources of common mode interference.

Abstract: A total artificial heart system includes: at least one artificial ventricle coupled to (or capable of being coupled to) a chamber or a vessel of a human heart, and at least one drive system coupled to the artificial ventricle, the drive system including at least one implanted electric motor. The drive system causes the artificial ventricle to contract and expand.

Abstract: An example device for detecting one or more parameters of a cardiac signal is disclosed herein. The device includes one or more electrodes and sensing circuitry configured to sense a cardiac signal via the one or more electrodes. The device further includes processing circuitry configured to determine a representative signal based on the cardiac signal, the representative signal having a single polarity, and determine an end of a T-wave of the cardiac signal based on an area under the representative signal.

Abstract: An example device for detecting one or more parameters of a cardiac signal is disclosed herein. The device includes one or more electrodes and sensing circuitry configured to sense a cardiac signal via the one or more electrodes. The device further includes processing circuitry configured to determine an R-wave of the cardiac signal and determine whether the R-wave is noisy. Based on the R-wave being noisy, the processing circuitry is configured to determine whether the cardiac signal around a determined T-wave is noisy. Based on the cardiac signal around the determined T-wave not being noisy, the processing circuitry is configured to determine a QT interval or a corrected QT interval based on the determined T-wave and the determined R-wave.

Abstract: A method is proposed for determining a pulse rate through a sound-sensing means placed on an individual's trachea, the method comprising a preliminary step for recording sound signals for a lengthy duration, wherein it comprises subsequently the following steps: filtering digital signals representative of the sound signals by using an adaptive filter, applying a lowpass filter to the signals obtained in order to select the signals comprised in a specified passband, selecting a first temporal portion of filtered digital signals of a specified duration, intercorrelation with a temporal portion of filtered digital signals that follows the first temporal portion in time and is of a same duration, searching (4.6) for the intercorrelation, computing the time interval corresponding to this temporal position and computing the corresponding pulse rate throughout the recording duration, to obtain a temporal series of pulse rates S1.

Abstract: A method includes receiving or generating a volume map of at least a portion of a cavity of an organ of a body including a plurality of mapped locations, and a point cloud of locations in the cavity marked for treatment. The volume map is updated by removing a portion of the mapped locations, so that the locations marked for treatment fall on a surface of the volume map. Using the updated volume map, a map of at least a portion of the cavity is generated, the map including the locations marked for treatment. The map is displayed to user.

Abstract: In one embodiment, an assessment system includes an electrical stimulation device configured to generate current, stimulation electrodes configured to apply the current generated by the electrical stimulation device to a neck of a subject at a location that results in stimulation of a phrenic nerve of the subject, a movement sensor configured to sense movement of an upper abdomen of the subject caused by twitching of a diaphragm of the subject responsive to the stimulation of the phrenic nerve, and a controller configured to receive data sensed by the movement sensor, analyze the received data to evaluate the activity of the diaphragm, and generate an assessment of the subject's respiratory function or phrenic nerve.

Abstract: The present disclosure provides a device for state-dependent pudendal nerve stimulation for bladder control in a subject and methods of making and using the same.

Abstract: Apparatus and methods are described including electrodes (22) configured to be placed upon a portion of a body of a subject, and a user interface device (26). A computer processor (24) applies a neuromodulation treatment to the subject, by driving electrical pulses into the portion of the subject's body via the electrodes, and generates an output on the user interface device that indicates to the subject a physiological effect that the neuromodulation treatment has upon the subject's body. Other applications are also applied.

Abstract: A system for adjusting neuromodulation parameters used by a neuromodulator operably connected to a plurality of electrodes to modulate a neural target, may comprise a translation trigger detector configured to determine that a translation trigger has occurred, a first parameter setting storage configured to store first parameter settings for use by the neuromodulator to modulate the neural target, and a neuromodulation parameter translator. The neuromodulation parameter translator may be operably connected to the translation trigger detector to automatically translate the first parameter settings into a second parameter settings in response to determining the translation trigger has occurred, and replace the first parameter settings with the second parameter settings, or store the second parameter settings in a second parameter setting storage.

Abstract: Systems, devices, and methods for optimizing a physiological measurement are described herein. A system may include a wearable band that is wearable by a subject, a user device attached to the wearable band, and a measurement device configured to the physiological measurement. The user device may include a first communication device and a user interface. The measurement device may include a hollow housing, a processing device disposed within the housing, an elastic coupling member disposed within the housing, a physiological sensor coupled to the housing by the elastic coupling member, and a second communication device. The physiological sensor may take the physiological measurement and communicate the physiological measurement to the user device. The user interface may display the physiological measurement to the subject. The physiological measurement device and the user device may be attached to the same wearable band that is worn by the subject.

Abstract: An implantable medical system including an implantable stimulator device and an implantable auxiliary device. An implantable cable electrically connects the implantable stimulator device and the implantable auxiliary device. The implantable auxiliary device has an auxiliary device rechargeable battery and an auxiliary component. The implantable medical system is configured to selectively operate in a first mode or a second mode. The implantable medical system is configured to, based on the mode, control charging the auxiliary device rechargeable battery from the implantable stimulator device over the implantable cable and control transmission of an auxiliary device signal from the auxiliary component to the implantable stimulator device over the implantable cable.

Abstract: An electrotherapeutic device for treating a visual disease using microcurrent stimulation is provided. The device includes a signal generator in which a waveform controller digitally controls a waveform signal source so as to generate a waveform in which one or more waveform parameters (e.g., pulse width, pulse period, pulse position, pulse coding, peak current amplitude, duty cycle, and/or pulse shape) are varied in accordance with a protocol for treating a visual disease. The device also includes an applicator connected to the signal generator and configured to apply the waveform to at least one stimulation point within an eye region.

Abstract: Provided are conformable light delivery devices for increasing light penetration depth and related methods. The device comprises a tissue penetrating member having a distal end and a proximal end, the tissue penetrating member configured to penetrate the tissue of the patient to be inserted into the tissue, wherein the tissue penetrating member is at least partially optically transparent along a surface of the tissue penetrating member positioned between the distal end of the tissue penetrating member and the proximal end of the tissue penetrating member to provide optical transmission of at least a portion of the light through the surface of the tissue penetrating member, thereby allowing at least the portion of the light to be delivered into the tissue of the patient when the tissue penetrating member is inserted into the tissue; and a substrate that supports the tissue penetrating member.

Abstract: A system including a medical device is provided. The medical device includes at least one sensor configured to acquire first data descriptive of a patient, first memory storing a plurality of templates, and at least one processor coupled to the at least one sensor and the first memory. The at least one processor is configured to identify a first template of the plurality of templates that is similar to the first data, to determine first difference data based on the first template and the first data, and to store the first difference data in association with the first template. The system may further include the programmable device.

Abstract: A implantable neural electrode assembly is described. The implantable neural electrode assembly includes a plurality of open-ended rings alternatingly connected to a spine. An inner layer of the open-ended rings is formed from a drug-loaded material (e.g., silicone that has been loaded with a steroid) and an outer layer is formed from a drug-free material. One or more electrode assemblies are connected to the inner layer and oriented towards a center of a cylinder defined by the plurality of open-ended rings.

Abstract: An apparatus for classifying stress includes an electrocardiogram (ECG) measurement module configured to measure an ECG signal in a first state, an idle state, and an ECG signal in a second state in which noise, having various magnitudes, is generated, a feature point extraction module configured to extract a feature point of each of the measured ECG signal in the first state and the measured ECG signal in the second state, and a clustering module configured to perform K-means clustering on the ECG signals in the first and second states based on the extracted feature points to classify stress.