Abstract: The invention relates to a composition comprising a mixture of at least two iscom complexes each complex comprising essentially one saponin fraction from Quillaja Saponaria Molina. The complexes may be iscom complexes or iscom matrix complexes. The invention also pertains to the use of such a mixture for the preparation of an immunomodulating pharmaceutical, and adjuvant, formulations for immunization, e.g. for production of monoclonal antibodies, and a vaccine. Kits of parts comprising at least two parts, wherein each part comprises one iscom complex or one iscom matrix complex according to the invention are also embraced.
Abstract: The present invention provides a crude extract from the bark of an Acer rubrum (AR) tree and/or Picea mariana (PM), method of preparation and its use for inhibiting the signs of skin aging (such as wrinkles and/or dehydration) caused by at least one of: increased elastase activity, increased collagenase activity, decreased elastin synthesis, decreased collagen synthesis or decreased involucrin synthesis, in skin fibroblast cells, particularly those of a human subject.
Abstract: The present invention provides a composition comprising a high content of highly pure, low-cost, and safe carotenoid and a method for industrially producing the same. The present invention also provides functional food, a pharmaceutical composition and a cosmetic product comprising such a composition. The present invention further provides a method for producing a composition containing at least 80% of carotenoid, which is characterized in treating a microorganism culture with extraction using a lower alcohol at 80° C. at the lowest or a combination of water and a lower alcohol at 80° C. at the lowest, and then washing and filtrating the precipitate obtained from the extract solution with a combination of a lower alcohol and water.
Abstract: Disclosed is a method of inhibiting growth of a melanoma cancer cell. The method includes contacting the melanoma cancer cell with an effective amount of a composition and the composition contains polymethoxyflavone. The polymethoxyflavone can be applied in an amount of 0.1 ?mol/L-1000 ?mol/L. A method of treating a subject having melanoma with the above discussed composition is also included.
Abstract: The method for qualitative and quantitative detecting of the extend of use and the correct process flow of the mammalian aerobic glucose fermentation metabolic pathway (mam-aGF) in a mammalian individual is characterized in that the enzyme TKTL1 is used as indicator and target molecule and the structural and/or functional parameter of said TKTL1 in a biological sample of said individual (patient) are taken as indication for the qualitative and quantitative run of the mam-aGF in the cells and/or tissue of said individual (patient). In combination with the use of inhibitors and activators of the mam-aGF the method is further suitable for checking and controlling the mam-aGF in an individual (patient).
Abstract: The present invention relates to the use of a plant extract from the genus Galeopsis species tetrahit or a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.
Type:
Grant
Filed:
January 11, 2018
Date of Patent:
June 9, 2020
Assignee:
GIULIANI S.P.A.
Inventors:
Giammaria Giuliani, Anna Benedusi, Barbara Marzani
Abstract: The present disclosure relates to compositions containing a natural extract(s) and their fraction(s) and the use of such compositions for treatment of skin, hair and nail. For example, the present disclosure relates to compositions containing an aqueous extract of (i) Yacon leave, (ii) Amor Seco leave, or (iii) Porphyridium biomass, or a combination thereof and a pharmaceutically or cosmetically acceptable carrier use on hair skin and nails for cosmetic purposes.
Abstract: The present invention provides a pharmaceutical composition or a cosmetic product which can accelerate production of ceramide in cells. The ceramide production-accelerating agent contains a plant selected from the group consisting of Radix Heraclei Scabridi, Rhizoma Dioscoreae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Pseudobulbus Bletillae, Radix Polygoni Multiflori, Radix Platycodi, and Herba Leonuri, or an extract thereof as an active ingredient. Further, the present invention provides a moisturizing agent containing a plant selected from the group consisting of Herba Leonuri and Rhizoma Dioscoreae, or an extract thereof as an active ingredient.
Type:
Grant
Filed:
January 20, 2015
Date of Patent:
April 7, 2020
Assignees:
Zhongshan Hospital of Fudan University, Kao Corporation
Inventors:
Wan Zhang Qin, Chun Xin Yang, Fan Qi Kong, Hiroshi Nojiri, Shotaro Ito
Abstract: The present invention relates to Coix seed oil extracted from Semen Coicis, pharmaceutical preparations thereof, and the use thereof in the treatment of tumors. Specifically, the Coix seed oil contains 5 diglyceride and 11 triglyceride ingredients in the following mass percentages: 1,3-diolein 0.40-0.58%, 1-linolein-3-olein 0.91-1.31%, 1,2-diolein 0.24-0.35%, 1-olein-2-linolein 0.66-0.95%, 1,2-dilinolein 0.33-0.47%, trilinolein 4.87-6.99%, 1-olein-2,3-dilinolein 13.00-18.69%, 1-palmitin-2,3-dilinolein 5.25-7.54%, 1,3-diolein-2-linolein 13.23-19.02%, 1-palmitin-2-linolein-3-olein 10.26-14.75%, 1,3-dipalmitin-2-linolein 2.28-3.28%, triolein 14.44-20.76%, 1-palmitin-2,3-diolein 8.06-11.58%, 1-olein-2-linolein-3-stearin 1.37-1.97%, 1,3-dipalmitin-2-olein 1.52-2.19% and 1,2-diolein-3-stearin 1.29-1.86%.
Abstract: The present invention relates to a composition for cleansing and/or moisturizing skin. The compositions of the invention which provide a cosmetic or dermatological composition for cleansing and/or moisturizing skin, preferably compositions used for showering or bathing, comprise: a) at least one alkyl ether carboxylate, b) at least one ethoxylated glycerol ester, c) at least one oily substance, d) water, e) optionally one or more emulsifiers, f) optionally additional surfactants, and g) optionally cosmetically or pharmaceutically acceptable excipients or active ingredients; characterized by containing a minimum of 20% by weight, preferably 30% by weight, of component (c) with respect to the total weight of the active material of the composition. Additionally, the invention provides a method for cleansing and/or moisturizing skin using the compositions of the invention.
Abstract: Methods of administering a composition that comprises plant extracts selected from the group consisting of Quercus infectoria, Rhus chinensis and Terminalia chebula containing compounds such as gallic acid, derivative of gallic acid, gallotannins and hydrosable tannins, which have been found to control coccidiosis in poultry and, more specifically, coccidiosis caused by Eimeria spp. The plant extracts result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.
Abstract: The present invention is related to the use of an overground part of Hedychium coronarium Koenig in lowering blood glucose, increasing insulin levels and treating and/or preventing diabetes without overly reducing blood glucose in a subject; i.e., not reducing blood glucose in a fasting subject. The present invention also relates to an extract and composition of the overground part of Hedychium coronarium Koenig and its use in lowering blood glucose, increasing insulin levels and treating and/or preventing diabetes.
Type:
Grant
Filed:
November 22, 2016
Date of Patent:
February 18, 2020
Assignee:
Development Center for Biotechnology
Inventors:
Rey Yuh Wu, Yu-Yuan Wu, Lung-Yu Kuan, Klim King
Abstract: Methods for ameliorating the effects of benign prostate hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) in men, comprising orally administering an effective amount of multi-carotenoids compositions. Multi-carotenoids composition for oral administration comprising about 71% by weight, of a tomato extract containing therein about 2% to 10% by weight of lycopene, about 0.25% to 2% by weight of phytoene, and about 0.2% to 2% by weight of phytofluene, and about 29% by weight, of a suitable encapsulating matrix. A suitable encapsulating matrix is an edible oil exemplified by soya oil, pumpkin seed oil, grape-seed oil and the like. The tomato extract may additionally comprise one or more of at least one carotene selected from the group comprising ?-carotene, ?-carotene, and ?-carotene, a phytosterol, a tocopheral and a phospholipid. Use of multi-carotenoids compositions for the treatment of urinary tract malfunctions including benign prostate hyperplasia and lower urinary tract symptoms.
Abstract: Compositions containing one or more compounds with inhibitory effect on a 5-HT3a and/or NK-1 receptor are effective for preventing or treating idiopathic vomiting in a mammal.
Type:
Grant
Filed:
March 6, 2014
Date of Patent:
February 4, 2020
Assignee:
Mars, Incorporated
Inventors:
Jean Soon Park, Ping Hu, Yakang Lin, Lori Ann Reinsalu
Abstract: Some embodiments of the present disclosure include a therapeutic extract for selectively treating skin disorders, such as acne and rosacea. The therapeutic extract may include glycerin; water, such as reverse osmosis water; blackcurrant; pine; gluconolactone; citric acid; and sodium benzoate. In embodiments, the blackcurrant may be organic ribes nigrum and may be derived from fruit of a blackcurrant plant. Moreover, the pine may be pinus spp and may be derived from a needle of a pine plant.
Abstract: Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.
Type:
Grant
Filed:
July 25, 2016
Date of Patent:
November 26, 2019
Assignee:
Amazentis SA
Inventors:
Christopher Rinsch, William Blanco-Bose, Bernard Schneider, Charles Thomas, Carmen Sandi, Johan Auwerx, Penelope Andreux, Richardus Houtkooper, Eija Pirinen, Laurent Mouchiroud, David Genoux
Abstract: The present invention discloses a method for separating flavonoid substances in Camellia nitidissima Chi based on a magnetic nanoparticles-PAMAM nano composites, which comprises the following steps: preparing PAMAM dendrimer, then using the PAMAM dendrimer to prepare the magnetic nanoparticles-PAMAM nano composites, then adding the obtained magnetic nanoparticles-PAMAM nano composites in a Camellia nitidissima Chi extract, extracting and performing magnetic separation on the flavonoid substances in Camellia nitidissima Chi under ultrasound or microwave condition. According to the present invention, flavonoid substances with faintly acid characteristics are extracted and adsorbed in a plant concentrate such as Camellia nitidissima Chi or Hedyotis diffusa etc. based on the magnetic nanoparticles-PAMAM nano composites, in a successive step, high efficiency separation of the flavonoid substances can be realized by the technologies such as magnetic separation and microwave-assisted extraction.
Abstract: An improved plant medicament composition, comprising an extract of Sorghum bicolor plant material for treating sickle cell disease is described. A method for the preparation of said composition having the property of inhibiting sickle cells is also provided.
Abstract: The present invention relates to the cosmetic use of dedifferentiated plant cells of a plant of the Rosa sp. genus, or of an extract or a lyophilizate of said cells, as an active agent for caring for aged skin or aged hair. It also relates to rose dedifferentiated cells, in particular Lancôme rose dedifferentiated cells.
Abstract: The present invention refers to the use of extracts from selected and stabilized cell lines comprising phenylpropanoids with high anti-oxidant capacity having a verbascoside titer of between 20% and 90% and a chromophore-free fraction of between 80% and 10%, in human and veterinary medicine, and for nutritional and cosmetic purposes.
Type:
Grant
Filed:
May 14, 2010
Date of Patent:
October 29, 2019
Assignee:
CRODA ITALIANA S. P. A.
Inventors:
Renzo Dal Monte, Roberto Dal Toso, Anacleto Minghetti, Nicoletta Crespi Perellino, Giovanna Pressi