Patents Examined by Charesse Evans
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Patent number: 6932980Abstract: The present invention is to a safe, biodegradable trace metal binding system that effectively delivers chromium, cobalt, copper, iron, manganese, molybdenum, selenium and zinc to animals. The method of preparing an animal foodstuff composition involves the steps of: providing transgenic algal cells comprising a nucleotide sequence, the nucleotide sequence being capable of expressing a non-native metal-binding protein in the transgenic algal cells; binding the metal-binding protein with at least one metal so as to produce a metal-bound adduct of the metal-binding protein; and admixing the metal-bound adduct with animal foodstuff. The invention is also to a animal foodstuff composition comprising animal foodstuff and transgenic algal cells expressing a non-native metal-binding protein in the transgenic algal cells, such that the transgenic algal cells contain the metal-binding protein and the metal-binding protein being bound to a metal.Type: GrantFiled: January 18, 2001Date of Patent: August 23, 2005Inventors: Richard Sayre, Richard Wagner
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Nutritional composition, methods of producing said composition and methods of using said composition
Patent number: 6899891Abstract: Nutritional compositions comprising at least one of aloe vera, hydrolyzed collagen, garcinia cambogia, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are disclosed. Nutritional compositions comprising aloe vera, hydrolyzed collagen, garcinia cambogia tea, fenugreek tea, coleus forskohli tea, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are also disclosed. Methods for preparing and using these compositions are additionally provided.Type: GrantFiled: November 29, 2001Date of Patent: May 31, 2005Inventor: Harry J. Siskind -
Patent number: 6858231Abstract: A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.Type: GrantFiled: January 8, 2003Date of Patent: February 22, 2005Assignee: J. Rettenmaier & Soehne GmbH + Co. KGInventors: Bob E. Sherwood, John H. Staniforth, Edward A. Hunter
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Patent number: 6844009Abstract: The invention concerns novel media in the form of complex dispersions, method for preparing same and their uses. Said media consist of a first medium in the form of droplets wherein is dispersed a phase containing organized double layers of surfactants, preferably in the form of multilamellar vesicles, said droplets being in emulsion in a second medium called continuous phase non-miscible with the first medium. Said media can be used as base for cosmetic compositions. They can contain active principles, in particular for controlling their release and/or protecting and/or controlling their pH. They can also be used to make polymer microspheres containing an active principle. They are also useful as antigen vector.Type: GrantFiled: March 16, 2000Date of Patent: January 18, 2005Assignee: CapsulisInventors: Corinne Degert, Philippe Poulin, Stéphane Ugazio, René Laversanne, Didier Roux
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Patent number: 6793933Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to enhance the immune system (e.g., increase the activity of T and B lymphocytes and natural killer cells) in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.Type: GrantFiled: June 28, 2002Date of Patent: September 21, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6759055Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to improve kidney functions (e.g., restoring urine secretion and/or lowering blood urea nitrogen, serum proteinuria, and/or serum creatinine levels) in a subject as a result of having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making such compositions.Type: GrantFiled: June 28, 2002Date of Patent: July 6, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6756050Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to improve the memory of a mammal. Also included are methods of making such compositions.Type: GrantFiled: June 28, 2002Date of Patent: June 29, 2004Assignee: Ultra Biotech LimitedInventor: Larry Ling Yuk Cheung
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Patent number: 6753008Abstract: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells are characterized by their ability to normalize the serum level of GPT, AP and/or LDH-5 in a mammal, said ability resulting from their having been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength. Also included are methods of making and using these compositions.Type: GrantFiled: June 28, 2002Date of Patent: June 22, 2004Assignee: Ultra Biotech LimitedInventor: Ling Yuk Cheung
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Patent number: 6743445Abstract: A method of coating an active material is provided. The method comprises contacting an active material with a film-forming composition comprising an aqueous dispersion of an amylose-alcohol complex, an insoluble film-forming polymer and a plasticiser at a temperature of less than 60° C. The method finds particular application in the preparation of dosage forms comprising active materials that are unstable at temperatures in excess of 60° C. The compositions prepared in accordance with the method can be used to deliver an active material to the colon.Type: GrantFiled: May 3, 2002Date of Patent: June 1, 2004Assignee: BTG International LimitedInventors: John Michael Newton, Chuei Wuei Leong
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Patent number: 6737076Abstract: A hypoallergenic composition for the induction of protein tolerance in at risk individuals of protein allergy. The composition contains (i) a “non allergenic” protein extensively hydrolyzed basis and/or of (ii) a free amino acid basis. The composition contains, as an active ingredient, at least one tolerogenic peptide of the allergenic protein.Type: GrantFiled: July 16, 2001Date of Patent: May 18, 2004Assignee: Nestec S.A.Inventors: Rodolphe Fritsche, Sophie Pecquet, Lionel Bovetto, Francoise Maynard
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Patent number: 6733788Abstract: A system for delivering solute to a target location within a mammalian body, the system including a medical device, a thermosensitive cellulose gel structure over the medical device, and a biologically active solute within said gel structure. The gel structure deswells and expels the biologically active solute with an increase in gel temperature. The invention includes a method of delivering solute to a target location, where the method includes the steps of providing a thermosensitive cellulose gel structure, wherein the gel structure is loaded with a solute; positioning the loaded gel structure to the target location; and increasing the temperature of the loaded gel structure.Type: GrantFiled: May 23, 2000Date of Patent: May 11, 2004Assignee: SciMed Life Systems, Inc.Inventors: James F. McBride, Stevin H. Gehrke, John P. Fisher
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Patent number: 6726918Abstract: Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodible polymer, wherein the implant delivers the agent to the vitreous in an amount sufficient to reach a concentration equivalent to at least about 0.05 &mgr;g/ml dexamethasone within about 48 hours and maintains a concentration equivalent to at least about 0.03 &mgr;g/ml dexamethasone for at least about three weeks.Type: GrantFiled: October 20, 2000Date of Patent: April 27, 2004Assignee: Oculex Pharmaceuticals, Inc.Inventors: Vernon G. Wong, Mae W. L. Hu
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Patent number: 6726919Abstract: A sterile, injectable homogenized dispersion of micromatrices or microdroplets having a mean diameter from about 50 nm to about 1000 nm comprising about 1% to about 7.5% of propofol, about 1% to about 8% of a propofol-soluble diluent, and about 0.67% to about 5% of a surface stabilizing amphiphilic agent suspended in an aqueous medium containing a synergetic quantity of antimicrobial agent and a tonicity modifying amount of a pharmaceutically acceptable water-soluble hydroxyl-group-containing excipient, wherein the ratio of propofol to diluent is in the range of about 0.25 to about 7.5 while the ratio of propofol to amphiphilic agent is in the range from about 0.4 to about 1.5, and wherein the viscosity of the dispersion is in the range of 1.1 to 8 cps, processes for the formation of the dispersion, and methods of use are disclosed.Type: GrantFiled: June 14, 2001Date of Patent: April 27, 2004Assignee: RTP Pharma, Inc.Inventors: Gary W. Pace, Michael G. Vachon, Awadesh K. Mishra, Robert A. Snow
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Patent number: 6719993Abstract: Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.Type: GrantFiled: March 29, 2002Date of Patent: April 13, 2004Assignee: Skeletal Kinetics, LLCInventor: Brent R. Constantz
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Patent number: 6716444Abstract: A drug eluting medical device is disclosed. The device includes a barrier layer for reducing the rate of release of a drug.Type: GrantFiled: September 28, 2000Date of Patent: April 6, 2004Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Daniel Castro, Stephen D. Pacetti
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Patent number: 6703045Abstract: A composition useful for reducing serum glucose levels by an oral controlled release system and a method for treating diabetes in a human being by controlling the blood glucose level (BGL) and reducing the complications associated with diabetic hyperglycemia and also the long term management of Non-Insulin Dependent Diabetes Mellitus (NIDDM) by avoiding the problems associated with the tight control of BGL, i.e., hypoglycemia tolerance and seizures. The composition is directed to a solid, hydrophilic matrix controlled release oral dosage form where the dosage form contains a therapeutically effective amount of antidiabetic drug in the matrix ensuring complete bioavailability of the drug from the matrix of the tablet.Type: GrantFiled: August 21, 2001Date of Patent: March 9, 2004Assignee: Council of Scientific & Industrial ResearchInventors: Sanju Dhawan, Anil Kumar Singla
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Patent number: 6689346Abstract: A reshapable hair styling composition comprising at least one acrylic copolymer comprising: (a) units derived from at least one monomer chosen from (meth)acrylate esters of C4 to C18 straight and branched chain alkyl alcohols, (b) units derived from at least one monomer chosen from (meth)acrylate esters of saturated and unsaturated cyclic alcohols containing 6 to 20 carbon atoms, (c) optionally units derived from at least one monomer chosen from hydrophilic monomers, and (d) optionally units derived from at least one monomer other than (a), (b), and (c) monomers, wherein said composition provides a reshapable effect.Type: GrantFiled: October 25, 2000Date of Patent: February 10, 2004Assignee: L'OrealInventors: Isabelle Rollat, Henri Samain
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Patent number: 6685926Abstract: A method of conditioning and oxidatively dyeing human hair includes applying an oxidative hair dyeing composition to the human hair in order to dye the human hair and, simultaneously or subsequently to the applying of the oxidative hair dyeing composition, applying a particular hair conditioning composition to the hair. This hair conditioning composition has a pH value of from 3.4 to 3.9, which corresponds to an isoelectric point of the human hair, and contains from 0.001 to 2.5% by weight of a cationic polymer, an optional pH buffer and preferably additional conditioning ingredients, such as a cationic surfactant and/or a fatty alcohol.Type: GrantFiled: November 13, 2001Date of Patent: February 3, 2004Assignee: Wella AktiengesellschaftInventors: Ursula Hehner, Herbert Deutz, Petra Braun, Ernst Flemming
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Patent number: 6667050Abstract: The present invention relates to a chewable, palatable oral contraceptive tablet, comprising an oral contraceptive agent, a chewable carrier suitable for human consumption, and not comprising a ferrocene compound, as well as use of these tablets in a method of human female oral contraception, and in a method of enhancing compliance with a human female oral contraceptive regimen.Type: GrantFiled: June 12, 2001Date of Patent: December 23, 2003Assignee: Galen (Chemicals) LimitedInventors: Roger M. Boissonneault, Tina M. deVries
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Patent number: RE38522Abstract: The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone powder. The bone powder has a particle size ranging from about 100 to about 850 microns and is mixed in a high molecular weight hydrogel carrier, the hydrogel component of the carrier ranging from about 0.3 to 3.0% of the composition and having a molecular weight of about at least 10,000 Daltons. The composition contains about 25% to about 40% bone powder and can be additionally provided with BMP's and a sodium phosphate buffer.Type: GrantFiled: February 28, 2002Date of Patent: May 25, 2004Assignee: Musculoskeletal Transplant FoundationInventors: Arthur A. Gertzman, Moon Hae Sunwoo