Patents Examined by Gollamudi Kishore
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Patent number: 10307491Abstract: Provided herein are liposomal particles. In particular, provided herein are liposomal particles comprising molecules (e.g., antigens or drugs) and uses thereof (e.g., as a vaccine (e.g., intranasal vaccine) or drug delivery system). For example, in some embodiments, the present disclosure provides a composition comprising: a molecule encapsulated in a liposome comprising one or more cationic lipids and hyaluronic acid (HA). In some embodiments, the one or more lipids are DOTAP and/or DOPE. In some embodiments, the HA is thiolated. In some embodiments, the thiolated HA is conjugated to thiolated PEG.Type: GrantFiled: January 28, 2016Date of Patent: June 4, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: James Jaehyun Moon, Yuchen Fan, Preety Sahdev, Joseph Bazzill
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Patent number: 10272040Abstract: The present invention is directed to a liposomal formulation for ocular drug delivery comprising (i) liposomes comprising at least one lipid bilayer, and (ii) a prostaglandin drug and/or a prostaglandin derivative associated in the liposomes, wherein the liposomes have a mean diameter of less than 2???. The present invention is also directed to a pharmaceutical comprising the liposomal formulation and a method of producing the liposomal formulation for ocular drug delivery. Additionally, the present invention is directed to a method of treating or preventing an ocular disease, comprising administering the liposomal formulation or the pharmaceutical composition to a subject in need thereof.Type: GrantFiled: August 12, 2011Date of Patent: April 30, 2019Assignees: Nanyang Technological University, Singapore Health Services Pte LtdInventors: Subramanian Venkatraman, Jayaganesh V. Natarajan, Tina Wong, Yin Chiang Freddy Boey
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Patent number: 10265271Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.Type: GrantFiled: May 16, 2008Date of Patent: April 23, 2019Assignee: Biosphere Medical, Inc.Inventors: Jean-Marie Vogel, Egisto Boschetti
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Patent number: 10265269Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.Type: GrantFiled: May 9, 2018Date of Patent: April 23, 2019Assignee: BIOrest Ltd.Inventors: Yoram Richter, Yehuda Zelig, Omar Elmalak, Dror Eyal
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Patent number: 10258570Abstract: The invention relates to liposomes for pulmonary application, advantageously comprising at least one first and at least one second phospholipid, cholesterol, and at least one active substance and/or colorant, wherein the first phospholipid is a phosphatidylcholine, preferably DSPC, and the second phospholipid is a phosphatidylcholine or an ethanolamine, preferably selected from the group DMPC, DPPC, DPPE. It is thereby advantageous if the first and the second phospholipid are present at a molar ratio of 0.5:1 to 10:1, preferably at a ratio of 6:1 to 2:1, in particular preferably at a ratio of 3:1. It is further advantageous if the molar ratio between phospholipids and cholesterol is between 10:1 and 1:1, preferably between 6:1 and 3:1, in particular preferably 4:1. The second phospholipid is further preferably DMPC or DPPE, in particular preferably DPPE. The size of the liposomes is advantageously between 0.05 ?m and 5 ?m, preferably between 0.2 ?m and 2.Type: GrantFiled: June 29, 2010Date of Patent: April 16, 2019Assignee: Lung Biotechnology Inc.Inventors: Tobias Gessler, Thomas Schmehl, Monika Rieger
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Patent number: 10251839Abstract: Novel lipid vesicle compositions comprising lipids derived from olive oil fatty acids known as olivates, methods of their preparation, and methods of their use in cosmetics, food, dermatologics, and pharmaceuticals.Type: GrantFiled: January 22, 2008Date of Patent: April 9, 2019Assignee: IGI Laboratories, Inc.Inventors: Nadya Lawrence, Rosemarie Lorenzo
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Patent number: 10251901Abstract: The present invention relates to a formulation of thermosensitive liposomes, and more specifically to a formulation of liposomes comprising phospholipids and a surface active agent, wherein the liposomes support long term storage at temperatures less than or equal to about 8° C., control degradate formation to maximize product potency and release their contents at mild hyperthermic temperatures. Methods of making formulations are also described.Type: GrantFiled: November 29, 2016Date of Patent: April 9, 2019Assignee: Celsion CorporationInventors: Robert A. Reed, Daishui Su
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Patent number: 10238687Abstract: A liposomal rehydration salt formulation comprising phosphatidylcholine liposomes, salts, water, and a percentage inclusion ratio of salts (salts retained within said liposomes/total salts) of at least 40%; and a process for preparing said formulation using tangential ultrafiltration.Type: GrantFiled: October 3, 2017Date of Patent: March 26, 2019Assignee: EINSOF BIOHEALTH LIMITEDInventors: Alcides Nicastro, Alejandro Luis Barbarini
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Patent number: 10220000Abstract: Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.Type: GrantFiled: December 19, 2017Date of Patent: March 5, 2019Assignees: The Board of Trustees of the University of Arkansas, BioVentures, LLCInventors: Daniel Fologea, Ralph Henry, Greg Salamo, Yuriy Mazur, Michael J. Borrelli
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Patent number: 10182997Abstract: The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analog encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system. Suitable colloidal drug delivery systems also include nanoparticles, nanocapsules, microparticles or block copolymer micelles. The colloidal drug delivery system encapsulating curcumin or a curcumin analog is administered parenterally in a pharmaceutically acceptable carrier.Type: GrantFiled: March 14, 2016Date of Patent: January 22, 2019Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Razelle Kurzrock, Lan Li, Kapil Mehta, Bharat Aggarwal
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Patent number: 10179095Abstract: An autophage activating resveratrol topical composition includes a ceramide or a pseudoceramide, a fatty acid, a phytosterol, and a resveratrol. The ceramide or pseudoceramide, the fatty acid, the phytosterol, and the resveratrol form a multi-layered encapsulation system. A method of inducing autophagy in skin includes applying the autophage activating resveratrol topical composition to a skin, and inducing autophagy in the skin to improve skin barrier function and skin self-purification function.Type: GrantFiled: June 7, 2018Date of Patent: January 15, 2019Assignee: DR. RAYMOND LABORATORIESInventors: Byeong Deog Park, Chae Hyeong Park
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Patent number: 10172796Abstract: Novel encapsulated umirolimus and umirolimus polymer conjugate formulations having enhanced permeability and retention at tumor sites. Also provided are methods for treating cancer by administering the umirolimus formulations.Type: GrantFiled: December 2, 2013Date of Patent: January 8, 2019Assignee: Manli International Ltd.Inventors: Ting-Bin Yu, Shih-Horng Su
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Patent number: 10166184Abstract: Lyophilized liposomal formulations with two or more encapsulated drugs are disclosed. These formulations display superior drug retention profiles and also maintain size distribution following lyophilization and reconstitution.Type: GrantFiled: February 7, 2018Date of Patent: January 1, 2019Assignee: CELATOR PHARMACEUTICALS INC.Inventors: Donna Cabral-Lilly, Lawrence Mayer, Paul Tardi, David Watkins, Yi Zeng
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Patent number: 10159646Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: GrantFiled: August 12, 2013Date of Patent: December 25, 2018Assignee: ALTUM-AVRO PHARMA PARTNERSHIPInventor: Praveen Kumar
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Patent number: 10123974Abstract: Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.Type: GrantFiled: March 6, 2013Date of Patent: November 13, 2018Assignee: Pacira Pharmaceuticals, Inc.Inventors: Louie Daniel Garcia, Liangjin Zhu, William Joseph Lambert, Gary Patou
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Patent number: 10098981Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a proteinaceous substrate and a crosslinking agent, such as a stabilized aldehyde crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.Type: GrantFiled: July 21, 2015Date of Patent: October 16, 2018Assignee: Baxter International Inc.Inventors: Kemal Schankereli, Ronald Dieck
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Patent number: 10092515Abstract: The present invention provides an intravenous liposomal formulation of a low dose polymyxin B or a pharmaceutical composition thereof. The present invention also provides methods utilizing the intravenous liposomal formulation or its pharmaceutical composition for increasing the therapeutic efficacy during treatment of a bacterial infection in a subject, for decreasing exposure of renal tissue to the polymyxin B during a course of polymyxin B treatment and for lowering exposure to polymyxin B in renal tissues in a subject receiving polymyxin B treatment.Type: GrantFiled: November 20, 2017Date of Patent: October 9, 2018Assignee: University of Houston SystemInventors: Vincent Tam, Diana Chow, Jie Gohlke
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Patent number: 10092516Abstract: The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size.Type: GrantFiled: June 17, 2015Date of Patent: October 9, 2018Assignee: THERASYN SENSORS, INC.Inventor: Mary P. McCourt
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Patent number: 10064882Abstract: Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.Type: GrantFiled: June 30, 2017Date of Patent: September 4, 2018Assignee: INSMED INCORPORATEDInventor: Renu Gupta
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Patent number: 10058507Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.Type: GrantFiled: January 7, 2016Date of Patent: August 28, 2018Assignee: CELATOR PHARMACEUTICALS, INC.Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Andrew Janoff, Lawrence Mayer, Marcel Bally