Patents Examined by Gollamudi Kishore
  • Methods of treating pulmonary disorders with liposomal amikacin formulations
    Patent number: 9724301
    Abstract: Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: August 8, 2017
    Assignee: INSMED INCORPORATED
    Inventor: Renu Gupta
  • Liposomes for the treatment of textile materials
    Patent number: 9717659
    Abstract: Liposomes with cosmetic and/or dermopharmaceutical ingredients for the care of the skin, scalp and/or hair and their use in washing agents and/or sprays for the treatment of textile materials.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: August 1, 2017
    Assignee: Lipotec, S.A.
    Inventors: Alfonso Fernandez Botello, Joseph-Lluis Viladot Petit, Raquel Delgado Gonzalez
  • Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same
    Patent number: 9713591
    Abstract: The present disclosure provides a composition of matter comprising liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the liposomes having a diameter of at least 200 nm and being embedded in a water insoluble, water absorbed cross-linked polymeric matrix. In one embodiment, the composition of matter is held within an aqueous medium, preferably being in iso-osmotic equilibrium with the intraliposomal aqueous compartments of the liposomes.
    Type: Grant
    Filed: October 11, 2009
    Date of Patent: July 25, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, LTD.
    Inventors: Yechezkel Barenholz, Rivka Cohen
  • Treatment of breast cancer
    Patent number: 9707204
    Abstract: The present invention relates to the use of a liposomal preparation for the manufacture of a pharmaceutical composition and the use of such a composition for the treatment of “triple receptor negative” breast cancer.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: July 18, 2017
    Assignee: SYNCORE BIOTECHNOLOGY CO., LTD.
    Inventors: Kay-Oliver Kliche, Axel Mescheder, Martine Piccart
  • Fluid-jet pens configured for making modulated release bioactive agents
    Patent number: 9687446
    Abstract: The present invention is drawn to methods of preparing a bioactive agent-containing emulsion for delivery to a biological system. This method can comprise the step of jetting a bioactive agent and a first fluid medium from a fluid-jet pen into a second fluid medium to form a bioactive agent-containing emulsion, wherein the second fluid comprises a continuous phase of the emulsion. Alternatively, a method of preparing a bioactive agent-containing liposome can comprise jetting a lipid-containing composition and a bioactive agent from a fluid-jet pen into a medium to form a bioactive agent-containing liposome carried by the medium. The present invention is also drawn to fluid-jet pens and systems configured for making liposome- and emulsion-containing biological agents.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: June 27, 2017
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: John Stephen Dunfield, James W. Ayres
  • Compositions comprising lecithin oils and NSAIDs for protecting the gastrointestinal tract and providing enhanced therapeutic activity
    Patent number: 9687551
    Abstract: A novel pharmaceutical composition is provided by which nonsteroidal anti-inflammatory drugs (NSAIDs) are added directly to phospholipid-containing oil such as lecithin oils or to a bio-compatible oil to which an phospholipid has been added to make a NSAID-containing formulation that possess low gastrointestinal (GI) toxicity and enhanced therapeutic activity to treat or prevent inflammation, pain, fever, platelet aggregation, tissue ulcerations and/or other tissue disorders. The composition of the invention are in the form of a non-aqueous solution, paste, suspension, dispersion, colloidal suspension or in the form of an aqueous emulsion or microemulstion for internal, oral, direct or topical administration.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: June 27, 2017
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Lenard M. Lichtenberger
  • Method of forming liposomes
    Patent number: 9675554
    Abstract: Compositions of reagents are formed by forming empty liposomes, mixing the thus-formed liposomes with a sugar solution and a regent, then drying the mixture. The compositions will generally contain less than 10% w/v sucrose. Using this procedure small liposomes are formed with high entrapment efficiency. The process is useful in the production of pharmaceuticals.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: June 13, 2017
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Gregory Gregoriadis, Brahim Zadi, Pramukh N Jayasekera
  • Liposome-encapsulated bicelles and use thereof in diluted systems
    Patent number: 9675555
    Abstract: The aim of the invention is to preserve the morphology of bicelles in high-water-content environments. For this purpose, the invention relates to a liposome comprising, in its internal aqueous medium, at least one bicelle. The bicelles concentration in said aqueous means is between 5 and 25% dry weight in relation to the end liposome. The invention also relates to the use of said liposomes for the encapsulation of active principles, as well as to the use thereof as a medicament or to produce a cosmetic product. The invention further relates to the method for obtaining said liposomes.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: June 13, 2017
    Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
    Inventors: Alfons De La Maza Rivera, Olga López Serrano, Gelen Rodríguez Delgado, Laia Rubio Toledano, Lucyana Barbosa, Guadalupe Soria Rodríguez, Ana María Planas Obradors, Mercedes Cocera Núñez
  • Hydrated lamellar phases or liposomes which contain a fatty monoamine or a cationic polymer which promotes intracellular penetration, and a cosmetic or pharmaceutical composition containing same, as well as a method of screening such a substance
    Patent number: 9655822
    Abstract: The invention relates to novel hydrated lamellar phases or liposomes which contain either polyethylenimine, or a substance which stimulates intracellular penetration selected from the group consisting of: i) a fatty monoamine of carbon-containing chain length of between C10 and C18; ii) a cationic polymer, optionally at least one fluorescent compound which is essentially inert with respect to the intracellular penetration, which enables this penetration to be visualised. These liposomes are very useful in cosmetics or in pharmacy for stimulating the intracellular penetration of a substance or active principle.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: May 23, 2017
    Assignee: BASF Beauty Care Solutions France S.A.S.
    Inventors: Eric Perrier, Valerie Andre, Isabelle Bonnet
  • Methods for the preparation of liposomes comprising drugs
    Patent number: 9655846
    Abstract: Provided herein are methods for preparing liposomes comprising docetaxel and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts in the process. In certain embodiments, the liposomal preparations are used in the treatment of diseases or disorders.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: May 23, 2017
    Inventor: Indu Javeri
  • Methods of using dual-effect liposome in therapy
    Patent number: 9649323
    Abstract: The invention provides a method for treating target in need of such a treatments in a subject, comprising (a) administering a liposome containing a photosensitizer and a drug to a subject and (b) irradiating targets at least one time at appropriate time(s). In particular, the irradiation is performed at least two times.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: May 16, 2017
    Assignees: NATIONAL TAIWAN UNIVERSITY, TAIPEI MEDICAL UNIVERSITY
    Inventors: Chin-Tin Chen, Tsuimin Tsai
  • Multilayered dosage form
    Patent number: 9622979
    Abstract: The present invention relates to a multilayered coated tablet comprising at least three layers, i.e., first, second and third layer wherein the first and third layers contain at least one active pharmaceutical ingredient and the second layer is either a placebo or an immediate-release drug layer. Further, the tablet has a delayed-release coating, wherein the coating may contain one or more pore-forming agents and/or orifices on one or both sides. Furthermore, it may contain an immediate-release layer of the drug over the delayed-release coating layer. The present invention further relates to processes for preparing such a multilayered coated tablet.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 18, 2017
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Murali Krishna Bhavarisetti, Kumaravel Vivek, Sreekanth Narravula, Romi Barat Singh
  • Production of multivesicular liposomes
    Patent number: 9585838
    Abstract: Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.
    Type: Grant
    Filed: February 25, 2007
    Date of Patent: March 7, 2017
    Assignee: Pacira Pharmaceuticals, Inc.
    Inventors: Hartoun Hartounian, Dagmar Meissner, Clint B. Pepper
  • Agent for treating myelofibrosis
    Patent number: 9572886
    Abstract: Disclosed is a substance delivery carrier for an extracellular-matrix-producing cell in the bone marrow, which comprises a retinoid. Also disclosed in an agent for treating myelofibrosis by utilizing a substance capable of regulating the activity or proliferation of an extracellular-matrix-producing cell in the bone marrow.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: February 21, 2017
    Assignee: Nitto Denko Corporation
    Inventor: Yoshiro Niitsu
  • Geodate delivery vehicles
    Patent number: 9566237
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: February 14, 2017
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
  • Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
    Patent number: 9545457
    Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: January 17, 2017
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Poh K. Hui, John E. Bishop, Eleodoro S. Madrigal, Jr.
  • Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy
    Patent number: 9526705
    Abstract: Lipidated glycosaminoglycan particles, prepared by reacting a glycosaminoglycan with at least one lipid to cross-link the carboxylic acid groups in the glycosaminoglycan with a primary amine in the lipid, are used to encapsulate drugs for use in the treatment of pathological conditions in an animal.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 27, 2016
    Assignee: TEL-AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P.
    Inventors: Rimona Margalit, Dan Peer
  • Dried reconstituted vesicle formation for pharmaceutical application
    Patent number: 9526761
    Abstract: The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More particularly, it relates to DRVs comprising at least one lipid and a fusion promoting agent which after reconstitution form large multilamellar liposomes encapsulating an active agent in an aqueous phase.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: December 27, 2016
    Assignee: SCIL Technology GmbH
    Inventors: Klaus Hellerbrand, Andreas Schuetz, Rainer Sigl
  • Compositions and methods for treating cancer
    Patent number: 9526709
    Abstract: The present invention provides, in part, compositions and methods for treating cancer using a combination of C6-ceramide and other anti-cancer agents.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: December 27, 2016
    Assignee: Chemo-Enhanced LLC
    Inventor: Harold J. Wanebo
  • Nitazoxadine composition and process to prepare same
    Patent number: 9498441
    Abstract: Disclosed is a pharmaceutical nitazoxanide composition comprising: (a) an immediate release fraction comprising nitazoxanide non-coated granules or non-granulated powder, and (b) a pH-dependent release fraction comprising granules of nitazoxanide coated with one or more polymers having a pH-dependent solubility.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: November 22, 2016
    Assignee: SIEGFRIED RHEIN S.A. DE C.V.
    Inventor: Esteban Alejandro Fiore