Patent number: 11154569
Abstract: A method for treating or preventing a disease or condition that operates by calcium transport through the mitochondrial calcium uniporter (MCU), the method comprising administering to a subject a therapeutically effective amount of an MCU inhibitor having the following structure: wherein L1, L2, L3, L4, L5, L6, L7, L8, X1, and X2 are independently selected from halide, amine groups —NR1R2R3, phosphine groups —PR5R6R7, carboxylate groups R4C(O)O—, and solvent molecules, and provided that at least one of L1, L2, L3, L4, L5, L6, L7, L8, X1, and X2 is selected from amine or phosphine groups; wherein R1, R2, R3, and R4 are independently selected from hydrogen atoms and hydrocarbon groups having up to six carbon atoms, wherein two of R1, R2, and R3 within a —NR1R2R3 group are optionally interconnected to form an N-containing ring; and R groups in adjacent amino or phosphine groups may optionally interconnect.
Type:
Grant
Filed:
February 15, 2019
Date of Patent:
October 26, 2021
Assignees:
CORNELL UNIVERSITY, TEMPLE UNIVERSITY
Inventors:
Justin Wilson, Madesh Muniswamy, Sarah R. Nathan
Patent number: 11116710
Abstract: The present invention is the use of a compound of formula (I) or a (pharmaceutically) acceptable salt thereof, wherein (a) X denotes CH?CH or CZ1=CZ2, wherein if Z1 is H then Z2 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt and if Z2 is H then Z1 denotes a radical selected from the group consisting of OH, NH2, NHMe, NMe2, OMe and OEt, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH, wherein n is 2 to 5 and R denotes a radical selected from the group consisting of H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt and NEt2, or (b) X denotes O, Y denotes a radical selected from the group consisting of NH2, NHMe, NMe2, NHEt, O—(CH2)n—OH and OMe, wherein n is 2 to 5 and R denotes H, OH, Me, Et, OMe, OEt, NH2, NHMe, NMe2, NHEt, NEt2 as antimicrobial agent as well as to composition comprising said agent.
Type:
Grant
Filed:
October 11, 2016
Date of Patent:
September 14, 2021
Assignee:
Symrise AG
Inventors:
Manuel Pesaro, Bernd Hölscher, Benoit Join