Patents Examined by H. Sarah Park
  • Chemically stable and oromucosally absorbable gel compositions of a pharmaceutical active agent in a multi-chambered delivery system
    Patent number: 9682039
    Abstract: An oromucosally absorbable liquid composition for administration to a human patient comprises one liquid containing a pH-sensitive pharmaceutically active together with one or more optional suitable pharmaceutical excipients in a first compartment; and a second liquid at pH greater than 5 containing a buffer or alkaline components together with one or more optional suitable pharmaceutical excipients in a second distinct compartment; the first and second compartments maintaining separation of the first and second liquids during storage and allowing for mixing of the two liquids to form an oromucosally absorbable composition at the point of use.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: June 20, 2017
    Assignee: MUCODEL PHARMA LLC
    Inventor: Madhu Hariharan
  • Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery
    Patent number: 9669192
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: June 6, 2017
    Assignee: Surmodics, Inc.
    Inventors: James Howard Arps, Andrew G. Bach
  • Methods and compositions for producing hydrogel capsules coated for low permeability and physical integrity
    Patent number: 9661875
    Abstract: Methods and compositions for producing hydrogel capsules enveloped with at least one coating layer is disclosed. The coating formulations deposited on the surface of the capsules can improve the physical integrity and the water-retention properties of the alginate beads. The coating formulations can be sequentially applied in various combinations to obtain desirable properties, such as improved physical integrity, mechanical strength, and low permeability, that can extend the shelf-life of the capsules when incorporated into various consumer products.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: May 30, 2017
    Assignee: Philip Morris USA Inc.
    Inventors: Georgios D. Karles, Daqing Wu, Shuzhong Zhuang
  • Solid pharmaceutical compositions and processes for their production
    Patent number: 9655856
    Abstract: This invention provides novel solid pharmaceutical compositions and processes for the bulk production of said compositions. This invention also provides methods of using the pharmaceutical compositions in the treatment of cancer.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: May 23, 2017
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Bhavishya Mittal
  • Non-invasive refractive treatment using nanoparticles
    Patent number: 9642698
    Abstract: Embodiments of this invention generally relate to systems and methods for optical treatment and more particularly to non-invasive refractive treatment method based on sub wavelength particle implantation. In an embodiment, a method for optical treatment identifies an optical aberration of an eye, determines a dopant delivery device configuration in response to the optical aberration of the eye, wherein the determined dopant delivery device is configured to impose a desired correction to the eye to mitigate the identified optical aberration of the eye by applying a doping pattern to the eye so as to locally change a refractive index of the eye.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: May 9, 2017
    Assignee: AMO Wavefront Sciences, LLC
    Inventors: Thomas D. Raymond, Richard J. Copland
  • Anti-blepharitis compositions and their use
    Patent number: 9642887
    Abstract: Compositions and methods for the prevention and treatment of blepharitis, where the compositions include verbascoside, oligopeptide-10, and sulfonated shale oil, and the preparation of such compositions.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 9, 2017
    Inventors: Shetal Amit Shah, Amit Rajendra Shah
  • Method for adjusting drug release level from the intrachoroidal implant and method for the treatment using the intrachoroidal implant
    Patent number: 9642864
    Abstract: An implant for a living body is designed so that the drug release level can be adjusted to make it possible to perform treatment corresponding to the severity of disease state and the effectiveness of the drug on each individual. The implant includes a drug, and is inserted into a target part of a living body to effect sustained release of the drug, the implant including a photoactive agent that accelerates the release of the drug when irradiated with laser light. The implant is inserted into a living body, and laser light is appropriately applied to the implant to adjust the release level of the drug released into the living body. An eye disease or the like is treated using the above method.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: May 9, 2017
    Inventor: Masatoshi Murata
  • Medical tablet, and manufacturing method and manufacturing apparatus for medical tablet
    Patent number: 9610225
    Abstract: An object is to provide a tablet manufacturing apparatus capable of supplying an IC chip to a desired position of pharmaceutical powder with a high accuracy and suppressing a positional displacement. The IC chip is supported by a positioning guide with a chip main body in a downward manner, and is held in a state of being positioned above pharmaceutical powder filled in a die hole before compression. The IC chip is supplied by a pusher.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: April 4, 2017
    Assignees: Otsuka Pharmaceutical Co., Ltd., Omori Machinery Co., Ltd.
    Inventors: Etsuhiro Maeda, Yasutoshi Kohata
  • Preparations of effervescent formulations comprising cephalosporin and uses thereof
    Patent number: 9603794
    Abstract: The present invention relates to a process for preparing effervescent dosage forms comprising at least one antibiotic of cephalosporin group. The present invention also relates to effervescent formulations and preparations comprising antibiotics of second generation cephalosporin.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: March 28, 2017
    Inventor: Mahmut Bilgic
  • Non-invasive refractive treatment using nanoparticles
    Patent number: 9603699
    Abstract: Embodiments of this invention generally relate to systems and methods for optical treatment and more particularly to non-invasive refractive treatment method based on sub wavelength particle implantation. In an embodiment, a method for optical treatment identifies an optical aberration of an eye, determines a dopant delivery device configuration in response to the optical aberration of the eye, wherein the determined dopant delivery device is configured to impose a desired correction to the eye to mitigate the identified optical aberration of the eye by applying a doping pattern to the eye so as to locally change a refractive index of the eye.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: March 28, 2017
    Assignee: AMO Wavefront Sciences, LLC
    Inventors: Thomas D. Raymond, Richard J. Copland
  • Propynylaminoindan transdermal compositions
    Patent number: 9597301
    Abstract: Propynylaminoindan (e.g., Rasagiline) transdermal compositions are provided. Aspects of the transdermal compositions include a matrix of the propynylaminoindan in a pressure sensitive adhesive comprising a carboxylated polymer. In some instances, the matrix further includes a cationic acrylic copolymer. Also provided are methods of using the transdermal compositions and kits containing the transdermal compositions.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: March 21, 2017
    Assignee: Teikoku Pharma USA, Inc.
    Inventors: Jianye Wen, Richard D. Hamlin
  • Surface-treated and plate-like powder for cosmetic compositions and solid powdery cosmetic composition blended therewith
    Patent number: 9597268
    Abstract: A plate-like powder for cosmetics, powder is surface treated with a silicone gel, enhancing moldability and impact resistance of a solid powdery cosmetic composition as well as a solid powdery cosmetic composition. The surface-treated powder exhibits smooth and light touchiness, has moist usability, and excellent adhesion to skin. The surface-treated powder is blended into a powdery cosmetic composition, enhancing moldability and impact resistance of the composition and removed by an applicator.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: March 21, 2017
    Assignee: MIYOSHI KASEI, INC.
    Inventor: Yukio Hasegawa
  • Surface-treated powders and cosmetic compositions in which such powders are mixed
    Patent number: 9597269
    Abstract: The invention is directed to the cosmetic powder surface-treated with a silicone gel, wherein the surface treatment with the silicone gel affords excellent water repellency, the exhibits smooth and light touch, and affords moist usability peculiar to the silicone gel and excellent adhesion to skin for the cosmetic powder. The powder is an inorganic powder, an organic powder or a composite powder thereof. The silicone gel is obtained by hydrolysis and condensation reacting an organopolysiloxane containing at least a diorganopolysiloxane having reactive opposite ends shown in the following formula (1) and a silane coupling agent having the following formula (2) with at least two hydrolyzable groups in one molecule or a reactive polysiloxane of the following formula (3) as a crosslinking agent. (1) R1R22SiO—(R22SiO)L—SiR1R22; (2) R3R4nSiX(3-n); and (3) R53SiO—(R52SiO)n-SiR53.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: March 21, 2017
    Assignee: MIYOSHI KASEI, INC.
    Inventor: Yukio Hasegawa
  • Uses of compounds and mixtures from mycelia
    Patent number: 9572760
    Abstract: The present invention relates to novel uses of compounds from Antrodia cinnamomea mycelia and mixtures comprising the compounds. The novel uses comprise whitening skin, combating skin ageing, reducing scar formation, inducing or enhancing liver regeneration, or treating fibrosis or a fibrosis-associated disorder in a subject in need thereof. The compounds have the formula and preferably are selected from 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*,4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, and 3R*,4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: February 21, 2017
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Kai-Wen Huang, Chia-Chin Sheu
  • Citrate-rich calcium-magnesium supplement and uses thereof
    Patent number: 9539283
    Abstract: Disclosed is an effervescent preparation of calcium and magnesium with additional citric acid in a defined ratio. Also disclosed is the use of these compositions to raise cardioprotective citrate and magnesium in serum to help prevent heart attacks from calcium supplements, and to provide bioavailable calcium and magnesium to prevent osteoporosis-related fractures and low blood magnesium from the use of proton pump inhibitors.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: January 10, 2017
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Charles Y. C. Pak, Khashayar Sakhaee, Orson W. Moe
  • Interpolymer network delivery system
    Patent number: 9511147
    Abstract: This invention relates to compositions and applications for an mterpolymer network delivery system containing iodine.
    Type: Grant
    Filed: August 12, 2012
    Date of Patent: December 6, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Carmine P. Iovine, Niraj Ramachandran
  • Pharmaceutical composition for the treatment of Duchenne muscular dystrophy
    Patent number: 9492433
    Abstract: This invention relates to pharmaceutical compositions comprising 5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole (C1100), to processes for preparing the compositions, and to various therapeutic uses of the combinations. Also provided is a method of treatment of Duchenne muscular dystrophy or Becker muscular dystrophy using the compositions.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: November 15, 2016
    Assignee: Summit Corporation Plc
    Inventors: Jonathon Mark Tinsley, Neil Robinson
  • Chemosensory receptor ligand-based therapies
    Patent number: 9486463
    Abstract: Provided herein are methods of modulating hormone concentrations in a subject comprising the administration of a composition comprising a chemosensory receptor ligand, wherein the composition is adapted to deliver the ligand to one or more regions of the intestine of said subject. Also provided are methods directed to the modulation of circulating concentrations of one or more of GLP-1 (total), GLP-1 (active), GLP-2, oxyntomodulin, PYY (total), PYY 3-36, CCK, GIP, insulin, C-peptide, glycentin, uroguanylin amylin, and ghrelin (total), ghrelin (active) and glucagon.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: November 8, 2016
    Assignee: AMBRA BIOSCIENCE LLC
    Inventors: Alain D. Baron, Martin R. Brown, Christopher R. G. Jones, Mark S. Fineman
  • Biguanide compositions and methods of treating metabolic disorders
    Patent number: 9480663
    Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: November 1, 2016
    Assignee: ELCELYX THERAPEUTICS, INC.
    Inventors: Alain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
  • Biguanide compositions and methods of treating metabolic disorders
    Patent number: 9481642
    Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: November 1, 2016
    Assignee: ELCELYX THERAPEUTICS, INC.
    Inventors: Alain D. Baron, Mark S. Fineman, Nigel R. A. Beeley