Abstract: The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from free radical interaction with a target molecule.

Abstract: A device for aggregating cells includes a cavity. The cavity includes a plurality of microwells for receiving at least one cell. Each of the microwells includes a vertical sidewall and a curved bottom. The microwells are made in a hydrogel layer. Each of said microwells has a diameter and an interwell distance between one microwell and another microwell, wherein a ratio for the interwell distance to the diameter is less than or equal to 1/10.

Abstract: Cell counting device A cell counting device and a method of using a cell counting device are disclosed. The cell counting device comprises a chamber for receiving a sample, at least one light source to emit light towards a section of the chamber. The section of the chamber comprises a sub-sample of the sample. The cell counting device also comprises a light detector to receive a light emitted from the section of the chamber and to generate an electronic signal associated with the received light, and a controller. The controller is configured to estimate the number of photoactive cells in the sample by calculating the distribution of variable fluorescence [Fv] values of a predetermined number of sub-samples about the mean Fv value.

Abstract: Aspects of the present disclosure include methods and systems for automated analysis of clinical fluid samples, such as urine, blood, or cerebral spinal fluid, where the number of fluid samples in increased or optimized without negatively impacting the accuracy of the analysis of a given fluid sample.

Abstract: A sensing device includes a first sensor configured to capture a first analyte in a fluid medium and to generate a first signal in response to capturing the first analyte. The sensing device also includes a second sensor configured to capture a second analyte in the fluid medium and to generate a second signal in response to capturing the second analyte, where the second analyte is different from the first analyte. The sensing device further includes a detector configured to collect the first and second signals to provide a total signal and to calculate a total concentration of the first and the second analyte in the fluid medium based on the total signal.

Abstract: A method for identifying an origin of Chrysanthemi flos is provided, which belongs to the technical field of chemical analysis and detection, and comprises the following steps: mixing Chrysanthemi flos extract with aluminum ion solution, and gold nano-clusters (AuNCs) solution in a solvent, standing for reaction, detecting fluorescence intensity of Chrysanthemi flos, comparing the fluorescence intensity of Chrysanthemi flos to be detected with that of Chrysanthemi flos from a target origin, and determining whether they are from a same origin.

Abstract: One non-limiting and exemplary embodiment provides a metal microscopic structure capable of detecting a low-concentration analyte with high sensitivity. The metal microscopic structure includes a base member including multiple protrusions arrayed at predetermined intervals, and multiple projections made of a metal film covering the base member and configured to generate surface plasmons upon irradiation with light. A film thickness of the metal film positioned in a bottom portion of a gap between every adjacent two of the multiple projections is greater than a height of the multiple protrusions and is more than or equal to 90% and less than or equal to 100% of a film thickness of the metal film deposited on top portions of the multiple protrusions.

Abstract: A method for evaluating and controlling roasting and degree (level) of roast in food items including but not limited to: coffee, cocoa, beans, nuts, grains and seeds, involves collecting spectra of the gases (including water vapor) emitted during roasting in the mid-infrared region using either mid-infrared source or visible light to include Raman scattering. The changes in the spectra, due to absorption by molecular vibrations in the gases emitted during roasting are evaluated in real time during roasting. These data may be processed in frequency or time domain. The spectra and change in spectra are correlated with a roasting profile to mark the inception of roasting, progress of roasting and maturity/achievement of degree of a roast. The information can be transmitted to the roaster or controller to monitor the roasting progress and can be used to adjust parameters as desired during roasting.

Abstract: The invention relates to a method for detecting a dengue infection in a patient blood sample, comprising the steps: a) Performing an analysis of prespecified parameters of blood platelets and prespecified types of blood cells in the sample and determining parameter values for the prespecified parameters of the platelets and the prespecified types of cells; b) Obtaining sample parameters from the values determined in step a); and c) Evaluating the sample parameters in relation to a prespecified criterion, wherein, if the criterion is fulfilled, a dengue infection is present.

Abstract: The present disclosure is to provide a measurement chip, a measuring device, and a measuring method which can accurately estimate an analyte concentration with a simple configuration. A measurement chip may include a propagation layer, an introductory part, a drawn-out part and a reaction part. Through the propagation layer, light may propagate. The introductory part may introduce the light into the propagation layer. The drawn-out part may draw the light from the propagation layer. The reaction part may have, in a surface of the propagation layer where a reactant that reacts to a substance to be detected is formed, an area where a content of the reactant changes monotonously in a perpendicular direction perpendicular to a propagating direction of the light, over a given length in the propagating direction.

Abstract: The present invention relates to a method for production of an improved sensor surface for an SPR instrument, comprising forming a self assembled monolayer (SAM) on a surface and attaching ligands and protein resistant groups, preferably polyethylene glycol (PEG), directly to functional groups on said surface. The invention also relates to a sensor surface produced by these methods use thereof in SPR (surface plasmon resonance) assays or interactions.

Abstract: Various examples are provided for low cost disposable medical sensors fabricated on glass, paper or plastics, and applications thereof. In one example, a medical sensor includes a base structure comprising a functionalized sensing area; and a transistor disposed on the base structure adjacent to the functionalized sensing area. In another example, a medical sensor includes a base structure comprising a functionalized sensing area disposed on a first electrode pad and a reference sensing area disposed on a second electrode pad separated from the first electrode pad; and a transistor having a gate electrically coupled to the second electrode pad of the base structure. A gate pulse applied to the functionalized sensing can produce a drain current corresponding to an amount of a target present in a sample disposed on the base structure.

Abstract: The present disclosure relates to a measuring arrangement for measuring an ozone content in a measured medium, including: a first sensor surface and a second sensor surface; a first cover element adjacent the first sensor surface and including an ozone binder that binds ozone without releasing oxygen or any species further reacting to form oxygen; a second cover element adjacent the second sensor surface and including an ozone converter that reacts with ozone to form oxygen; a measuring sensor configured to generate a first measurement signal dependent on the oxygen concentration at the first sensor surface and a second measurement signal dependent on the oxygen concentration at the second sensor surface; and an electronic evaluation unit configured to determine the ozone content in the measured medium based on the first and the second measurement signals.

Abstract: A method for optically detecting biomarkers in a biosensor is disclosed, wherein the optical detection obtains spatially and spectrally resolved optical signals from a sample on a biosensor, and one or more of these spatially and spectrally resolved optical signals can be analyzed in parallel with image acquisition. The image analysis comprises reading data of the acquired images, correcting them to reduce inhomogeneities and noise, localizing particles in the images, characterizing each particle individually to obtain its position and characterization parameters, and classifying the particles based on their characterization parameters. Using the number of particles per class for all the acquired images of the sample, a statistical value is calculated per sample and each statistical value is correlated with an indication of the presence of a biomarker in the sample.

Abstract: The present invention provides a sensing device for detecting an analyte containing a non-metallic element such as F. A working sensor has a 3D array of voids each having a void internal wall. The void internal walls have cavities each having a cavity internal wall made from a material containing the non-metallic element. A binding of the analytes to the cavities induces a detectable variation of the optical property of the 3D array of voids. The invention exhibits numerous technical merits such as high sensitivity, high specificity, fast detection, ease of operation, low power consumption, zero chemical release, and low operation cost, among others.

Abstract: In-situ fluorimeters and methods and systems for collecting and analyzing sensor data to predict water source contamination are provided. In one embodiment, a method is provided that includes receiving sensor data regarding a water source. Changepoints may then be calculated within the sensor data and the sensor data may be split into intervals at the changepoints. A machine learning model may then be used to classify the intervals and a predicted contamination event for the water source may be identified based on the classified intervals. In another embodiment, an in-situ fluorimeter is provided. The in-situ fluorimeter comprises one or more UV LEDs centered around a pre-set excitation wavelength (e.g., a TLF excitation wavelength), a bandpass filter, a lens, a photodiode system, a machine learning platform; and an alarm triggered by contamination events, wherein the alarm is calibrated through the machine learning system.

Abstract: [Task] To provide an automatic analysis apparatus including a photomultiplier tube which controls a sensitivity of the photomultiplier tube without adjusting a high voltage value. [Solution] An automatic analysis apparatus according to the present invention includes a photomultiplier tube which detects light from a reaction vessel; a determination unit which determines an output signal of the photomultiplier tube in a case where the photomultiplier tube is irradiated with first light; and a control unit which irradiates the photomultiplier tube with second light to lower a sensitivity of the photomultiplier tube in accordance with a determination result by the determination unit.

Abstract: Disclosed is a microorganism inoculation device, which comprises a workbench, wherein support columns are provided on the upper surface of the workbench, a limiting plate is provided in the middle part of the supporting column, an injection head is provided in the middle part of the limiting plate, an air cylinder is provided in the middle part of the lower surface of the workbench, a piston rod of the air cylinder is fixedly connected with the middle part of the upper surface of a lifting plate, guide rods are provided on the upper surface of the lifting plate, the upper end of the guide rod is fixedly connected with a tray, the left and right sides of the upper surface of the tray are fixedly connected with the lower part of a fixed bracket, the middle part of the injection head is slidably connected with the limiting plate.

Abstract: A specimen measurement device which detects a measurement object material according to the present embodiment, includes: a magnetic field applicator configured to apply a magnetic field to a measurement cartridge including a substrate, a first substance fixed on the substrate and specifically reacting with the measurement object material, a magnetic particle, and a substance fixed on the magnetic particle and specifically acting with the measurement object material; a detector configured to detect light passing through the substrate; and a controller configured to control the magnetic field applicator to perform a first operation to apply a first magnetic field in a direction to move the magnetic particle away from the substrate when a specimen solution containing the measurement object material is introduced into the measurement cartridge, and then perform a second operation to apply a second magnetic field in a direction to move the magnetic particle toward the substrate.

Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.