Patents Examined by James M. Spear
  • Pharmaceutical tablets comprising an NSAID and a prostaglandin
    Patent number: 6740340
    Abstract: A pharmaceutical tablet which incorporates two smaller tablets, one of which comprises an NSAID and the other of which comprises misoprostol.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: May 25, 2004
    Inventor: Bernard Charles Sherman
  • Solid cosmetics
    Patent number: 6740328
    Abstract: A solid cosmetic composition, which drastically improves the shape-retaining ability and usability, which has a good, tender feeling, good spreadability when applied and is glossy looking is provided by use of a wax composition solidifier, which has a good shape-retaining ability without use of a conventional solidifier such as ceresin is provided. A solid cosmetic composition has (a) Fischer-Tropsch wax having average molecular weight of 300 to 1200 and (b) Microcrystalline wax in the weight ratio of (a):(b)=60:40 to 99.9:0.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: May 25, 2004
    Assignee: Shiseido Company, Ltd.
    Inventors: Kunihiko Yoshida, Tomiyuki Nanba
  • Nail enamel compositions containing bismuth oxychloride
    Patent number: 6740314
    Abstract: Nail enamel compositions of the present invention for coating natural or synthetic human nails broadly include the ingredients of one or more film forming components, preferably nitrocellulose having a molecular weight greater than 56,000, one or more solvents and bismuth oxychloride.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: May 25, 2004
    Assignee: Kirker-Enterprises, Inc.
    Inventors: Robert L. Socci, Anatoly Ismailer
  • Controlled release hydrocodone formulations
    Patent number: 6733783
    Abstract: A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: May 11, 2004
    Assignee: Euro-Celtique S.A.
    Inventors: Benjamin Oshlack, John K. Masselink, Hua-Pin Huang, Alfred P. Tonelli
  • Pharmaceutical mixture comprising a profen
    Patent number: 6726929
    Abstract: A pharmaceutical mixture comprising a profen is described which has a profen content of over 85% and contains up to 1% of a nonionic surfactant having an HLB of ≧9 and also a customary disintegrant and a lubricant and optionally a microcrystalline cellulose.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: April 27, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Heinz Einig, Harald Hach, Richard C. Thompson, Raymond Eason, Bernd W. Müller
  • Cosmetic lip product with sour flavor
    Patent number: 6723307
    Abstract: Methods for making a sour tasting cosmetic lip product containing one or more acids dissolved in a base composition, and the products formed thereby, are disclosed. The products possess a pleasing sour taste while not producing irritation or burning on the lips or mouth. Ingredients such as sunblocks, moisturizers and vitamins may be added to the compositions depending on the properties desired in the final product. The compositions according to the present invention comprise from about 2% to about 25% by weight acid and are preferably anhydrous.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: April 20, 2004
    Assignee: Bonne Bell, Inc.
    Inventors: Albert C. Rose, III, Barbara L. Cashmere, Paul J. Breha, III, Janet W. Thompson
  • Oil-free pharmaceutical compositions containing cyclosporin A
    Patent number: 6723339
    Abstract: The present invention provides a hard gelatine capsule containing a pharmaceutical composition comprising cyclosporin A in a mixture with a surfactant of HLB value at least 10, substantially free of any oil and when a hydrophilic phase is present, the hydrophilic phase being a polyethylene glycol and/or a lower alkanol provided that any lower alkanol present is present in less than 12% of the total weight of the composition absent the hard gelatine capsule.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: April 20, 2004
    Assignee: Novartis AG
    Inventors: Armin Meinzer, Barbara Haeberlin
  • Edible coating composition
    Patent number: 6723342
    Abstract: An edible, hardenable coating composition containing microcrystalline cellulose and carrageenan and at least one of a strengthening polymer, a plasticizer, a surface active agent or a combination thereof. The coating composition of the present invention may be applied to pharmaceutical and veterinary solid dosage forms, confectionery, seeds, animal feed, fertilizers, pesticide tablets, and foods and provides an elegant prompt release coating which does not retard the release of active ingredients from the coated substrate.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: April 20, 2004
    Assignee: FMC Corporation
    Inventors: Michael Augello, Sheila M. Dell, Domingo C. Tuason, James J. Modliszewski, Thomas A. Ruszkay, David E. Werner
  • Methods and compositions for treating intervertebral disc degeneration
    Patent number: 6723335
    Abstract: A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: April 20, 2004
    Inventors: Jeffrey William Moehlenbruck, John Paul Ranieri
  • Method for increasing the active loading of compressible composition forms
    Patent number: 6716453
    Abstract: A process for increasing the percentage of active ingredient relative to non-active excipient in a compressible formulation, and also for reducing tablet size, by excluding an amount of the excipient and including in its place a reduced amount of a polysaccharide material.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: April 6, 2004
    Assignee: Verion, Inc.
    Inventors: Jerome W. Harden, Duane Glover, Bruce K. Redding, Jr.
  • Method for production of microcapsules
    Patent number: 6716456
    Abstract: The invention provides a process for microencapsulating a pharmaceutical substrate comprising the steps of: a) adding insoluble or sparingly soluble particles of the substrate to be microencapsulated to a stable buffer solution having a high ionic strength; b) dissolving a membrane-forming ionic polymer in the buffer; c) forming a coacervate by adding a water-complexing compound causing phase separation of the resulting mixture; and d) allowing the deposition of the coacervate onto the substrate so as to create a coating of polymer around the substrate.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: April 6, 2004
    Assignee: Eurand International S.p.A.
    Inventors: Luigi Giovanni Mapelli, Luca Dobetti
  • Formulation and delivery method to enhance antioxidant potency of vitamin E
    Patent number: 6716451
    Abstract: A formulation to deliver a full-spectrum of Vitamin E isomers for improved antioxidant capacity, bioavailability, dissolution and efficacy. The formulation includes dl-&agr;-tocopheryl acetate or dl-&agr;-tocopheryl succinate (synthetic Vitamin E), natural Vitamin E and mixed tocopherols, such as &agr;-, &bgr;-, &ggr;- and &dgr;-tocopherol, as well as four isomers (&agr;, &bgr;, &ggr; and &dgr;) of tocotrienols. This formulation is designed to deliver at least 17-times the antioxidant capacity of synthetic Vitamin E (dl-&agr;-tocopheryl acetate), and at least twice the antioxidant capacity of natural Vitamin E (d-&agr;-tocopherol) as measured by oxygen radical absorbance capacity (ORAC) assay. The potent antioxidant capacity of this formula affords protection against oxidative damage of cell membranes, heart disease, cancer and eye and skin disease.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: April 6, 2004
    Assignee: Soft Gel Technologies, Inc.
    Inventors: Ronald G. Udell, Siva P. Hari, Mel Rich
  • Intraocular lens containing releasable medication
    Patent number: 6713080
    Abstract: The present invention relates to an intra-ocular lens that is made from hydrophilic polymer. An effective amount of medicine is dispersed in the mass of the of the polymer and when implanted in the eye of a subject, the lens releases the medicine into the intra-ocular tissues so that the medicine is in the vicinity of the site where action is needed.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: March 30, 2004
    Assignee: Ioltechnologie-Production
    Inventors: Jean-Marc Aiache, Gilbert Serpin, Said El Meski, Philippe Tourrette
  • Melt-extrusion multiparticulates
    Patent number: 6706281
    Abstract: A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.
    Type: Grant
    Filed: January 2, 2002
    Date of Patent: March 16, 2004
    Assignee: Euro-Celtique, S.A.
    Inventors: Benjamin Oshlack, Mark Chasin, Hua-Pin Huang
  • Polyelectrolyte coverings on biological templates
    Patent number: 6699501
    Abstract: The invention relates to a method for producing capsules provided with a polyelectrolyte covering, and to the capsules obtained using this method.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: March 2, 2004
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften. e.V.
    Inventors: Björn Neu, Hans Bäumler, Edwin Donath, Sergio Moya, Gleb Sukhobukov, Helmuth Möhwald, Frank Caruso
  • Method and apparatus for producing effervescent shaving composition
    Patent number: 6696054
    Abstract: A method for producing a shaving lather utilizes a composition produces a lather and carbon dioxide when a liquid is added to the shaving composition.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: February 24, 2004
    Inventor: Paul M. Falanga
  • Phosphate-binding polymer preparation technical field
    Patent number: 6696087
    Abstract: A tablet containing a phosphate-binding polymer, which has an average particle size of 400 &mgr;m or less, contains particles of 500 &mgr;m or less in particle size at a ratio of 90% or more and has a moisture content of 1 to 14%, together with crystalline cellulose and/or low substituted hydroxypropylcellulose and contains the active component at a high ratio, is excellent in the ability to bind to phosphate, and quickly disintegrates in an acidic to a neutral region.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: February 24, 2004
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Katsuya Matsuda, Ryuji Kubota
  • Solid solution beadlet
    Patent number: 6692767
    Abstract: Disclosed is a beadlet comprising (i) a hydrophobic long chain fatty acid or ester material; (ii) a surfactant; and (iii) a therapeutic agent which in admixture form a solid solution at room temperature. The hydrophobic material preferably has a melting point of about 40 to about 100° C., and is most preferably glyceryl behenate. The surfactant is preferably a polyglycolyzed glyceride, polyoxyethylene sorbate, ethylene or propylene block copolymer or combinations thereof, and is most preferably polyoxyethylene 20 sorbitan monolaurate.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: February 17, 2004
    Assignee: Shire Laboratories Inc.
    Inventors: Beth A. Burnside, Charlotte M. McGuinness, Edward M. Rudnic, Richard A. Couch, Xiaodi Guo, Alexander K. Tustian
  • Sustained-release particles
    Patent number: 6692769
    Abstract: The present invention discloses sustained release particles having a mean particle size of 300 &mgr;m, or less, comprising a drug-containing core substance coated with a mixed coating of a hydrophobic organic compound-water-insoluble polymer, which prevents sticking during compression molding when producing oral sustained release tablets, a preparation method of those sustained release particles, and a preparation method of tablets using those sustained release particles.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: February 17, 2004
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Takashi Ishibashi, Keigo Nagao, Kengo Ikegami, Hiroyuki Yoshino, Masakazu Mizobe
  • Topical application of chromophores for hair removal
    Patent number: 6685927
    Abstract: A device and method is disclosed for permanent or semi-permanent removal of hair through the activation of microparticles introduced into hair follicles. Microparticles are incorporated into a composition that is topically applied to the skin. These microparticles containing or consisting of chromophores or chemically activated molecules are of a variety of shapes and sizes. Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50 microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin without entering other areas of the skin, such as the stratum corneum or sweat gland channels. Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means activates the chromophore or chemically activated compounds, thus destroying the hair follicle without damaging other areas of the skin.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: February 3, 2004
    Assignee: CeramOptec Industries, Inc.
    Inventors: Chryslain Sumian, Wolfgang Neuberger, Serge Mordon