Abstract: Acid-labile active compounds are prepared in suppository form, particularly for rectal administration.

Abstract: An environmentally friendly method of loading nicotine onto cation exchange resins under anhydrous conditions is described. The method eliminates many of the processing problems that are associated with loading in aqueous media.

Abstract: Acetaminophen compositions are disclosed which are capable of being directly compressed, without addition of other components, into an tablet dosage form, and which include, based on the total weight of the dry components of the composition, from about 80 percent by weight to about 98 percent by weight acetaminophen, a fluidizing agent, a binder compound, a starch, a disintegrant and a lubricant.

Abstract: The present invention provides a dual release solid dosage form containing a first composition that releases oseltamivir in a controlled manner and a second composition that releases an H1 antagonist in a rapid and/or immediate manner. A wide range of H1 antagonist antihistamines, especially fexofenadine and loratadine, can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. The device is useful for the treatment of respiratory congestion and other viral infection associated symptoms.

Abstract: A food supplement with advantageous physiological effects containing the following essential constituents in a support material (e.g. dairy products, margarine, fruit juice, plant juice, yeast, pectin or olive oil): lecithin, red wine extract and D-alpha-tocopherolacetate in amount ranging from 0.05 to 10.0 parts by weight.

Abstract: Customized implants for use in reconstructive bone surgeries where anatomical accuracy and bone adaptation are important, such as plastic and craniomaxillofacial reconstructions. This implant comprises a porous surface layer and a tough inner core of interpenetrating phase composite. The porous surface layer enhances the biocompatibility, tissue ingrowth, and implant stability. The tough inner core improves the mechanical properties of the implant with a high fracture toughness and a low modulus. The anatomical accuracy of the implants will minimize the intra-operative manipulation required to maintain a stable host bone-implant interface.

Abstract: The invention relates to stable ophthalmic preparations including the penetrant antiphlogistic diclofenac or salts thereof and the penetrant antibiotic ofloxacin present in the form of the racemate, an enantiomer, particularly levofloxacin, or the corresponding hydrochloride thereof. The preparations may be used for treating eye infections and/or inflammations and for preventing infections before and after eye surgery.

Abstract: The present invention relates to a biocompatible and biodegradable block copolymer of poly(alkylene oxide) and poly(p-dioxanone), which is soluble in organic solvents, and a drug delivery composition comprising the same.

Abstract: An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeutically active plasma concentration for a relatively long period of time is disclosed.

Abstract: A method is provided for preparing a drug delivery material and device comprising cross-linking a biological polymer with a cross-linking agent and loading the cross-linked biopolymer with a bioactive agent. Preferred embodiments are disclosed wherein the drug delivery material is used in a catheter securing, drug delivery device, in a wound dressing, and in a wound dressing for percutaneous catheters.

Abstract: A sustained/prolonged release pharmaceutical dosage form is disclosed. The form comprises a hard shell capsule and a formulation comprising (a) a water insoluble medicant, (b) a high melting fatty ester, (c) a low viscosity oil, (d) a cellulosic polymer, and (e) a non-ionic surfactant.

Abstract: Controlled release of liquid, active agent formulations is provided by dispersing porous particles containing the liquid active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.

Abstract: A composition comprising cyclodextrin and an &agr;-hydroxy acid complexed by the cyclodextrin. A pharmaceutical preparation comprising a cyclodextrin-&agr;-hydroxy acid complex and a pharmaceutically acceptable adjuvant. A combination of a cyclodextrin/&agr;-hydroxy acid complex and an applicator having an applicator head with alternating grooves and ridges disposed on the applicator head. A method of treating a skin area comprising applying a cyclodextrin/&agr;-hydroxy acid complex to the skin area in a pharmaceutically effective amount.

Abstract: A nutritional supplement for promoting the health of salivary glands and supporting the normal or healthy swallowing in a person includes ingredients obtainable from turmeric, ginger, and horseradish. The nutritional supplement may also be used to treat symptoms such as symptoms of a common cold, a sore throat, congestion, mucositis, laryngitis, arthritis, mucous membrane inflammation and sialorrhea is disclosed. This nutritional supplement can be orally administered a person. The nutritional supplement may further include optional ingredients such as ingredients obtainable from slippery elm bark powder and green tea, as well as other optional ingredients. This nutritional supplement may further include a pharmaceutically acceptable carrier for oral administration. A method of promoting the health of salivary glands, supporting the normal or healthy swallowing and/or treating sialorrhea in a person involves administering the nutritional supplement orally to a person one to six times daily, as needed.

Abstract: The present invention provides a process for producing cefaclor crystalline bulk material having a dissolution rate in a capsule of ≧80% in water in 30 minutes. One process route includes reducing the water content of cefaclor dihydrates or bulk material containing cefaclor dihydrate to produce a cefaclor form having a water content ≦2%. The cefaclor having the lower water content can then be rehydrated to a water content from 3.0 to 6.5% without adversely affecting the dissolution rate. An alternative process includes the addition of at least 0.05% of cefaclor related substances to inhibit conversion of the monohydate to the dihydate form.

Abstract: Methods for providing nutrition and for enhancing neurological development of preterm infants are disclosed. Also disclosed is an improved nutritional composition containing specified amounts of DHA and AA as well as their precursor essential fatty acids alpha-linolenic and linoleic acids. The methods involve feeding LCP supplemented, nutrient-enriched formulas for an extended feeding regimen, typically until at least 3 months corrected age (CA), preferably to 6 or even 12 months CA. The neurological developments, for example, visual development, motor development and language development were enhanced without findings of anthropometric growth faltering or inhibition.

Abstract: An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.

Abstract: The invention relates to a controlled release tablet which in part or as a whole contains water-insoluble linear polysaccharides, preferably the polysaccharide poly(1,4-&agr;-D-glucan), in the form of microparticles, as retardation material. The tablet is also capable of controllably releasing an active agent.

Abstract: A novel composition for treating symptoms such as symptoms of a common cold, a sore throat, congestion, laryngitis, mucous membrane inflammation and sialorrhea is disclosed. The composition includes ingredients to obtainable from turmeric extract, ginger root powder, and horseradish root powder. This composition can be orally administered a patient. The composition may further include ingredients obtainable from slippery elm bark powder and green tea. This composition may further include a pharmaceutically acceptable carrier for oral administration. A method of administering this composition orally to a patient to treat symptoms of a common cold, a sore throat, congestion, laryngitis, mucositis, sialorrhea and mucous membrane inflammation is also disclosed. To treat these symptoms, the composition is administered to a patient suffering one to fifteen times daily, as needed. To achieve the best effect, the composition should be held in the mouth of a patient for 5 to 60 minutes.

Abstract: A chewing gum composition for controlling malodorous breath when chewed comprising a gum base having present therein a breath freshening amount of a water soluble zinc ion releasing salt and a phosphate salt mixture of alkali metal pyrophosphate and polyphosphate salts at a weight ratio of about 2:1 to 1:3 whereby the presence of the phosphate salt mixture enhances and extends the release of the zinc ion during the period of chewing.