Patents Examined by Jane S. Myers
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Patent number: 4227012Abstract: Oxidation of methyl benzenes with air or oxygen to form a phenolic acetate and formaldehyde or methylene diacetate may be carried out in the presence of acetic acid, phosphorus pentoxide, benzaldehyde and an acid catalyst. The resulting acetates may then be pyrolyzed to yield phenolic compounds and formaldehyde, respectively.Type: GrantFiled: November 3, 1978Date of Patent: October 7, 1980Assignee: Suntech, Inc.Inventors: George Suld, James E. Lyons, Robert W. Shinn
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Patent number: 4227016Abstract: Glyoxylic acid and hydrochloric acid are reacted with an aromatic compound having at least one substituent group selected from among the alkyl, aryl, hydroxy, alkoxy and aryloxy groups. The glyoxylic acid is used in a concentration comprised between 60 and 100% and the hydrochloric acid is used in as concentrated an aqueous solution as possible, e.g. in an organic solvent medium such as acetic acid. An acid catalyst such as zinc chloride may be used. The reaction may be carried out under pressure. The products are useful in various syntheses e.g. to produce amino acids or arylacetic acids with medicinal uses.Type: GrantFiled: December 28, 1977Date of Patent: October 7, 1980Assignee: Hoechst FranceInventors: Emmanuel Herman, Helmut Diery, Michel Soreau, Yani Christidis
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Patent number: 4224341Abstract: 5-Substituted indan-2-carboxylic acids and functional derivatives thereof having inflammation-reducing properties have the general formula ##STR1## in which R is a phenyl, phenyl-lower alkenyl, phenyl-lower alkyl, phenyl substituted by at least one of the halogens, lower alkyl, lower alkoxy, acetamido, amino, lower dialkylamino, nitro, phenyl, lower alkylsulfonyl, lower dialkylaminosulfonyl and sulfamido, cyclohexyl, furyl, lower alkylfuryl, thienyl, halothienyl, lower alkylthienyl, or pyridyl group and R' is a hydroxyl, lower alkoxy, lower dialkylaminoalkoxy, cinnamoylamido lower alkoxy, 2-hydroxyethylamino, amino or lower dialkylaminoalkyl amino group. Besides the esters and amides, the functional derivatives of the acids include the pharmacologically acceptable salts of the above compounds. The compounds are also of low toxicity, have analgesic activity and exert an antipyretic effect.Type: GrantFiled: December 14, 1977Date of Patent: September 23, 1980Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Michel Bayssat, Francis Sautel, Jean-Claude Depin, Annie Betbeder Matibet
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Patent number: 4224455Abstract: New reactive surfactants or emulsifiers useful in a broad range of emulsion polymerization processes are provided, along with processes for making and using such. The reactive surfactants are comprised of ring sulfonated half esters of maleic anhydride with alkoxylated alkyl arylols.Type: GrantFiled: November 13, 1978Date of Patent: September 23, 1980Assignee: Stepan Chemical CompanyInventor: Julius H. Deutsch
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Patent number: 4221734Abstract: A process is disclosed for the preparation of derivatives of perfluoroalkanecarboxylic acids and perfluoroalkanesulphinic acids by reacting a perfluoroalkylhalide having the general formula R.sub.F X, in which X represents an atom of chlorine, bromine, or iodine, and R.sub.F represents an unbranched or branched perfluorinated chain containing from 2 to 12 carbon atoms; with CO.sub.2 or SO.sub.2 in a solvent medium and in the presence of activated or unactivated zinc.Type: GrantFiled: December 12, 1977Date of Patent: September 9, 1980Assignee: Produits Chimiques Ugine KuhlmannInventors: Auguste Commeyras, Hubert Blancou, Andre Lantz
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Patent number: 4220592Abstract: A substituted acetonitrile such as .alpha.-isopropyl-p-chlorophenylacetonitrile is hydrolyzed using an acid to produce the corresponding substituted phenylacetic acid such as .alpha.-isopropyl-p-chlorophenylacetic acid in such a manner that, in a lot in any one hydrolysis reaction, (1) the hydrolysis is carried out in at least two steps, (2) an acid to be used in a subsequent first reaction step is a waste acid produced in a previous second reaction step and the subsequent reaction step(s) thereof if any, and (3) an acid to be used in a second reaction step and the subsequent reaction step(s) if any, is the waste acid produced in a previous second reaction step and subsequent reaction step(s), respectively, and a fresh acid.Type: GrantFiled: July 10, 1978Date of Patent: September 2, 1980Assignee: Sumitomo Chemical Company, LimitedInventors: Keiji Kagawa, Naoya Kanda, Fujio Masuko, Hirotoshi Nakanishi
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Patent number: 4219660Abstract: There are disclosed herein derivatives of bisfunctionalized compounds, wherein said compounds have been formed by the introduction of a nitro group and a hydroxyl group in the form of an ester into a conjugated diene molecule by treatment of said conjugated dienes with nitric acid in the presence of a carboxylic acid anhydride. The novel compounds produced by this process are useful as bactericides, fungicides and valuable organic synthesis intermediates.Type: GrantFiled: June 24, 1977Date of Patent: August 26, 1980Assignee: Hoffmann-La Roche Inc.Inventor: Pius A. Wehrli
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Patent number: 4219625Abstract: As an additive imparting oil and water repellency, durable against laundering and abrasion, to PET fibers: a partially or fully acylated polyol, especially pentaerythritol, glycerol, hydroquinone or ethylene glycol, acylated with a phthalic or terephthalic monoester having a perfluorinated alkyl or alkoxyalkyl C.sub.2 to C.sub.20 radical, especially C.sub.5 to C.sub.10 n-alkyl or (CF.sub.2).sub.n OR.sub.f where R.sub.f is C.sub.1 to C.sub.6 perfluoroalkyl, especially perfluoroisopropyl and (CF.sub.2).sub.n is a straight chain C.sub.2 to C.sub.10 diradical.Type: GrantFiled: December 16, 1977Date of Patent: August 26, 1980Assignee: Allied Chemical CorporationInventors: Frank Mares, Bryce C. Oxenrider, Cyril Woolf
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Patent number: 4218473Abstract: The present invention relates to derivatives of 4-cyclohexyl-1-naphthalene-acetic acid of formula ##STR1## wherein R is a lower alkyl group and pharmaceutically acceptable salts and derivatives thereof the invention also relates to pharmaceutic compositions containing such derivatives.These derivatives are useful as drugs, notably for the treatment of inflammatory syndromes.Type: GrantFiled: September 26, 1978Date of Patent: August 19, 1980Assignee: Centre Europeen de Recherches MauvernayInventors: Jean-Jacques Godfroid, Efroim Steiner
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Patent number: 4218470Abstract: Novel cardiocirculatory analeptics are prepared, which are epinine esters as obtained by reacting epinine (N-methyldopamine) with branched-chain aliphatic carboxylic acids. Exemplary members are 3,4-di-O-butyrylepinine and 3,4-di-O-pivaloylepinine. These medicaments are effective also by the oral route of administration, contrary to the hitherto commonly used dopamine derivatives which are rapidly destroyed by metabolization when administered orally.Type: GrantFiled: July 28, 1977Date of Patent: August 19, 1980Assignee: Simes Societa Italiana Medicinali e Sintetici S.p.A.Inventors: Cesare Casagrande, Giorgio Ferrari
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Patent number: 4216337Abstract: A process for preparing esters which comprises reacting a polycarboxylic acid with an alcohol, removing the unreacted alcohol from the resultant esterification reaction mixture, heating the crude ester at a temperature of 160.degree. to 340.degree. C., contacting the heat-treated crude ester with an adsorbent, and recovering the ester of high purity. The ester obtained has superior electrical insulation, transparency and thermal stability.Type: GrantFiled: July 10, 1978Date of Patent: August 5, 1980Assignee: Mitsubishi Gas Chemical Co., Inc.Inventors: Makoto Baba, Teruyuki Ninomiya, Chieko Ono
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Patent number: 4212991Abstract: Highly pure terephthalic acid is prepared from di-potassium terephthalate. The terephthalic acid so produced aids in the direct production of high quality polyester fiber.Type: GrantFiled: May 5, 1977Date of Patent: July 15, 1980Assignee: Rhone-Poulenc IndustriesInventors: Jean-Claude Choulet, Andre Laily
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Patent number: 4212989Abstract: In a process for producing a carboxylic acid or its ester by reacting an alcohol or an ether with carbon monoxide, the improvement wherein the reaction is performed in the presence of, as a solvent, an aryl ester of an aliphatic carboxylic acid represented by the formula ##STR1## wherein n is an integer of 1 to 5, R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl or alkenyl, and R.sub.2 represents hydrogen, alkyl, aryl, alkenyl, hydroxymethyl, acyl, acyloxy, formyl, carboxy, hydroxy, halogen, sulfo, nitro, nitroso, amino, acid amide or cyano, and two or more R.sub.2 groups may be the same or different, and the substituents R.sub.2 may be bonded to each other to form a penta- or hexa-carbocyclic or heterocyclic ring.Type: GrantFiled: October 26, 1978Date of Patent: July 15, 1980Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Tomiya Isshiki, Yasuhiko Kijima, Yuh Miyauchi
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Patent number: 4209636Abstract: Novel polyfunctional compounds and a novel process for their preparation are disclosed. These compounds may be converted into the acid or salt forms of cis and trans aconitic acids as well as into a racemic mixture of isocitric acid, alloisocitric acid and the lactones of isocitric acid and alloisocitric acid and their salts. All of the acid and salt forms produced are useful as metal sequestrants and/or detergent builders. The novel polyfunctional compounds can also be saponified to their corresponding alkali metal salts which, in turn, are also metal ion sequestering agents and detergent builders. The polyfunctional compounds are the reaction products obtained from the reaction of selected salts of monoalkyl esters of maleic acid with selected active hydrogen containing compounds.Type: GrantFiled: May 15, 1978Date of Patent: June 24, 1980Assignee: Lever Brothers CompanyInventors: Eddie N. Gutierrez, Vincent Lamberti
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Patent number: 4209638Abstract: Disclosed is a process for increasing the proportion of a desired enantiomer of a 2-arylpropionic acid which comprises heating at a temperature of at least 80.degree. C. a mixture comprising an inert liquid organic diluent and a salt of the 2-arylpropionic acid with an enantiomer of a chiral organic nitrogenous base, the base and the diluent being such that the salt of the racemic acid has a solubility of 0.1 to 10% w/v in the diluent at the operating temperature and in which process a proportion of the salt is undissolved in the diluent, whereby a proportion of one optical isomer of the acid component of the salt is converted into its enantiomer, and collecting the salt of which the acid component has an increased proportion of that enantiomer.Type: GrantFiled: September 25, 1978Date of Patent: June 24, 1980Assignee: The Boots Company LimitedInventors: John S. Nicholson, James G. Tantum
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Patent number: 4206310Abstract: An improved process for producing an ester from a carboxylic acid and an alcohol which comprises reacting said carboxylic acid with said alcohol by the use of a 1-substituted-2-halopyridinium salt or a 1-substituted-2-haloquinolinium salt as a condensing agent in the presence of a hydrogen halide captor. According to this process, various esters, even if they have some steric hindrances, may be obtained in good yields.Type: GrantFiled: September 8, 1978Date of Patent: June 3, 1980Assignee: Sumitomo Chemical Company, LimitedInventors: Teruaki Mukaiyama, Masahiro Usui, Kazuhiko Saigo, Eiichiro Shimada
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Patent number: 4205087Abstract: Novel di-(substituted phenyl)methoxy acetic acids, alkyl homologues and related salts, ester and amides thereof, together with processes for their manufacture, and pharmaceutical compositions. A representative compound is di-(4-chlorophenyl)methyloxy acetic acid. The compounds possess anti-arthritic properties and in some cases, in addition, an effect on a factor involved in atherosclerotic disease.Type: GrantFiled: April 26, 1977Date of Patent: May 27, 1980Assignee: Imperial Chemical Industries LimitedInventor: Wilson S. Waring
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Patent number: 4204070Abstract: A process for preparing bis(hydroxyethyl)terephthalate and its low molecular weight oligomers in a reactor equipped with a rectifying column which comprises suspending or dissolving terephthalic acid in molten bis(hydroxyethyl)terephthalate and its low molecular weight oligomers at a temperature above the dew point of ethylene glycol and feeding gaseous or liquid ethylene glycol into the suspension or the solution to react it with the terephthalic acid, where the amount of ethylene glycol fed into the reactor is controlled so as to maintain the temperature inside the rectifying column at a temperature at which the ethylene glycol does not substantially distill off from the rectifying column and the partial pressure of the ethylene glycol is maximized.Type: GrantFiled: April 23, 1976Date of Patent: May 20, 1980Assignee: Fuji Photo Film Co., Ltd.Inventors: Fumiyuki Suzuki, Toshimitu Okutu, Keitaro Ohe
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Patent number: 4201866Abstract: This invention is directed to novel compounds having .beta.-adrenergic blocking activity. The compounds are represented by the following structural formula: ##STR1## wherein R.sup.1 is hydrogen or methyl, R.sup.2 is hydrogen or lower alkyl and their pharmaceutically acceptable salts.Type: GrantFiled: December 12, 1977Date of Patent: May 6, 1980Assignee: American Home Products CorporationInventor: Jun Hasegawa
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Patent number: 4198520Abstract: Compounds containing a lipophilic radical, a polyethyleneoxy group and an ethylenically unsaturated radical are disclosed. The compounds are useful as nonionic monomeric emulsion stabilizers.Type: GrantFiled: October 21, 1977Date of Patent: April 15, 1980Assignee: The Kendall CompanyInventors: Carlos M. Samour, Mildred C. Richards