Patents Examined by Janice Y Silverman
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Patent number: 11957815Abstract: An artificial tissue construct for nerve repair and regeneration includes a biocompatible and biodegradable nerve guidance matrix comprising a plurality of biopolymers that include chitosan, gelatin, collagen and hyaluronic acid. A cross-linker includes glutaraldehyde. The nerve guidance matrix is formed as a three-dimensional scaffold polyelectrolyte complex (PEC). A subconfluent and grown monolayer of at least one of human mesenchymal stem cells, mesenchymal stem cells, differentiated Schwann cells and neuronal cells is on the biocompatible and biodegradable nerve guidance matrix for direct implantation or delivery. A method of making the artificial tissue construct is disclosed.Type: GrantFiled: November 12, 2020Date of Patent: April 16, 2024Assignee: DATT LIFE SCIENCES PRIVATE LIMITEDInventors: Rajan Datt, Siddharth Pandey, Poonam Meena, Mukesh Kumar, Nitin Khatri, Rakesh Kumar Nagar
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Patent number: 11944640Abstract: The invention relates to pharmaceutical compositions comprising a zinc2+ salt and a ?-polyglutamic acid carrier, and, optionally, an NF-kB inhibitor as a tumor-sensitizing agent, and methods for using such compositions to treat tumors in patients. Methods include administering a liquid dosage form or a solid dosage form of a therapeutically effective amount of a Zn(II) salt and a ?-polyglutamic acid carrier to a patient in need thereof. Methods of treating a broad spectrum of human tumors, including tumors with a drug-resistant phenotype, using the disclosed compositions are provided. Tumors that respond to the pharmaceutical compositions disclosed herein include neuroendocrine (neuroblastoma), gastric, uterine, and lung tumors.Type: GrantFiled: October 31, 2017Date of Patent: April 2, 2024Assignee: XYLONIX PTE. LTD.Inventor: Jinhyuk Fred Chung
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Patent number: 11944655Abstract: The invention is directed to a microcapsule and the method to obtain it. The microcapsule comprises a core in the form of a lipid sphere coated by a protein film, wherein the lipid sphere comprises sporulated microorganisms and at least one lipid wall material, and the protein film is a mix of carbohydrate, protein material and water. The method to obtain this microcapsule includes the stages of mixing sphere components, mixing protein film components, homogenizing the protein film and the subsequent coating of the lipid sphere by means of fluidization with the protein film.Type: GrantFiled: September 30, 2020Date of Patent: April 2, 2024Assignee: Alpina Productos Alimenticios, S.A.Inventors: Bernadette Francisca Klotz Ceberio, Maria Ximena Quintanilla Carvajal
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Patent number: 11937602Abstract: Antimicrobial compositions including at least one acid and at least one anionic surfactant are provided. In particular, food contact antimicrobial compositions including at least one acid and at least one anionic surfactant provide efficacious virucidal activity, including against Norovirus, having acceptable use solution pH that do not require use of personal protective equipment (PPE), are surface compatible and do not leave residues on treated surfaces. Methods of cleaning a surface with the compositions are also provided and may beneficially eliminate the need to rinse the antimicrobial compositions after use.Type: GrantFiled: September 26, 2018Date of Patent: March 26, 2024Assignee: ECOLAB USA INC.Inventors: Wendy Lo, Derrick Anderson, Erik Olson, Catherine Hanson, Junzhong Li, David D. McSherry, Stacy Fawbush, Kaitlin Lake, Gerard Hinrichs, Joshua Luedtke, Richard Staub
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Patent number: 11920162Abstract: Ex-vivo culture systems are provided. Accordingly there is provided a culture system comprising a culture medium and a precision-cut tissue slice placed on a tissue culture insert, wherein the precision-cut tissue slice is maintained in a highly oxygenated atmosphere containing at least 50% oxygen and wherein said culture is rotationally agitated facilitating intermittent submersion of the tissue slice in the culture medium. Also provided are methods of culturing a tissue and methods of using the culture system for selecting a drug for the treatment of a disease.Type: GrantFiled: April 3, 2018Date of Patent: March 5, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Ravid Straussman, Nancy Gavert
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Patent number: 11910793Abstract: Multifunctional agricultural adjuvant compositions (“MAACs”) include at least one liquid component and one or more solid agricultural particles dispersed in the liquid component. The liquid component may include at least one methylated seed oil. Examples of the solid agricultural particles include ammonium sulfate, other water conditioners, amino acids, or polymers. The MAAC exhibits one or more desired functions depending on the quantity and composition of the liquid component, the quantity and composition of the solid agricultural particles, and, optionally, adding one or more surfactants and/or one or more additional components (e.g., rheology modifiers) to the MAAC. The desired functions of the MAAC may include at least one of a water conditioner, a surfactant, a high surfactant oil concentrate, a crop oil concentrate, or a drift reduction and a deposition adjuvant.Type: GrantFiled: January 23, 2020Date of Patent: February 27, 2024Assignee: WinField Solutions, LLCInventors: Christine M. Colby, Elizabeth Alonzi, Danny M. Brown
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Patent number: 11905304Abstract: Agricultural products, such as pesticides, plant growth regulators, fungicides, herbicides, and insecticides, may be formulated to include one or more surfactants, from one or more surfactant classes, such as siloxane derivatives of amino acids that have surface-active properties.Type: GrantFiled: December 10, 2020Date of Patent: February 20, 2024Assignee: AdvanSix Resins & Chemicals LLCInventor: Edward Asirvatham
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Patent number: 11890381Abstract: A present invention relates to a natural lubricant composition, a tablet comprising a natural lubricant composition and a preparation method thereof. The Natural Lubricant composition for a tablet comprises an active lubricant ingredient selected from a corn flour, a corn starch, and an arrowroot flour. The Natural Lubricant composition for a tablet also comprises a natural oil.Type: GrantFiled: September 8, 2021Date of Patent: February 6, 2024Assignee: NITIKA PHARMACEUTICAL SPECIALITIES PVT. LTD.Inventor: Ravleen Singh Khurana
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Patent number: 11882834Abstract: Compounds of the formula (I), (I) wherein the substituents are as defined in claim 1, useful as pesticides, and especially fungicides.Type: GrantFiled: November 27, 2018Date of Patent: January 30, 2024Assignee: SYNGENTA PARTICIPATIONS AGInventors: Martin Pouliot, Stefano Rendine
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Patent number: 11884781Abstract: The present invention relates to supramolecular biomedical polymers comprising quadruple hydrogen bonding units and to a process for preparing such a supramolecular biomedical polymer and porous biomedical implants thereof. The supramolecular biomedical polymers are particularly suitable for the production of porous biomedical implants that need high strength, elasticity, durability, and slow biodegradation, e.g. medical implants for living tissue regeneration within a mammal, such as the treatment of cardio-vascular diseases, medical prolapses, and hernias.Type: GrantFiled: May 19, 2020Date of Patent: January 30, 2024Assignee: SUPRAPOLIX B.V.Inventors: Tristan Mes, Anton Willem Bosman, Joris Wilhelmus Peeters, Henricus Marie Janssen
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Patent number: 11865206Abstract: The present invention relates to a ready-to-use solution of carmustine that does not require dissolution or dilution of the carmustine prior to addition to saline and dextrose parenteral solutions. In particular, the invention relates to a stable liquid pharmaceutical composition containing carmustine in the form of ready-to-use solution and method for preparing the same.Type: GrantFiled: December 28, 2022Date of Patent: January 9, 2024Assignee: EMCURE PHARMACEUTICALS LTDInventors: Sougata Pramanick, Aasiya Aslam Burhan, Mukund Keshav Gurjar, Hiren Pravinbhai Patel, Deepak Pragjibhai Gondaliya
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Patent number: 11802241Abstract: Methods of increasing soil water content are described. The methods may include applying a soil enhancement agent to the soil, where the soil enhancement agent includes one or both of (i) lactobionic acid and (ii) at least one salt of lactobionic acid. Treated soils with increased soil water content are also described. The treated soils may include a soil enhancement agent absorbed into the soil. The soil enhancement agent may include at least one salt of a lactobionic acid. Cations from the at least one salt of a lactobionic acid may aggregate at least a portion of the particles in the soil.Type: GrantFiled: July 9, 2018Date of Patent: October 31, 2023Assignee: Leprino Foods CompanyInventor: Richard K. Merrill
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Patent number: 11761949Abstract: A method for assessing susceptibility to nausea of a patient comprises assessing the GSH recycling dependent antioxidant activity of the patient's blood cells prior to receiving an emetogenic agent, e.g., a cytostatic agent or a surgical anesthetic.Type: GrantFiled: October 9, 2017Date of Patent: September 19, 2023Assignee: Lankenau Institute for Medical ResearchInventor: Margaretha Wallon
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Patent number: 11723878Abstract: Implementations set forth herein relate to systems, methods, and apparatuses associated with fullerene-containing materials. In some implementations, a fullerene-containing material is disposed over a substrate of a smoke-able product in order to inhibit an allergic response (e.g., coughing) from a user who smokes or otherwise ingests the smoke-able product. Various fullerene-containing materials can be generated using a carbon substance that undergoes one or more process operations in order for fullerene molecules to be available for inclusion in the various materials. In some implementations, one or more other fullerene-containing materials can be generated through an at least partially organic process of feeding a particular plant a fullerene-containing plant food.Type: GrantFiled: December 21, 2020Date of Patent: August 15, 2023Inventor: Aaron Self
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Patent number: 11696886Abstract: Provided is a cosmetic having a unique soft and springy feeling in use, capable of stably formulating therein a UV protector, and providing a light feeling in use such that the cosmetic is separated into pieces when applied to the skin. The present invention relates to a cosmetic characterized by comprising (A) a (meth)acrylic acid/an alkyl (meth)acrylate/a (meth)acrylic acid-POE monoalkyl ether ester copolymer, (B) a UV protector, (C) a nonionic surfactant, and (D) a higher alcohol.Type: GrantFiled: May 30, 2018Date of Patent: July 11, 2023Assignee: SHISEIDO COMPANY, LTD.Inventors: Daiki Arai, Hideki Shimizu, Tetsuro Yonezawa
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Patent number: 11678669Abstract: Process for conferring a protection against a pathogen upon a plant by elicitation by an aqueous composition, the active agents of which are extracted from edible fungi (parasol mushroom, pleurotus, button mushroom). An alkaline extraction is carried out, then an enzymatic hydrolysis, to obtain a fraction less than 100 kDa. The process consists in spraying the aerial parts of the plant with the composition obtained in this way; this thereby acts to combat cryptogamic diseases of plants such as vines, fruit trees, vegetable crops and cereals.Type: GrantFiled: October 13, 2017Date of Patent: June 20, 2023Assignee: UNIVERSITE DE LIMOGESInventors: Céline Faugeron, Vincent Gloaguen, Cédric Astier, Charlotte Moine
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Patent number: 11678665Abstract: The present invention relates to herbicidal) active pyridyl-/pyrimidyl-pyrazine derivatives, as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions comprising such derivatives, as well as to the use of such compounds and compositions in controlling undesirable plant growth: in particular the use in controlling weeds, in crops of useful plants.Type: GrantFiled: September 18, 2018Date of Patent: June 20, 2023Assignee: Syngenta Participations AGInventors: Jeffrey Steven Wailes, Neil Brian Carter, John Martin Clough, John Williams
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Patent number: 11679099Abstract: The present disclosure relates a method of treating chondrosarcoma or suppressing metastasis or recurrence thereof by regulating HIF-2?. The present method can be effectively used for treating chondrosarcoma or suppressing metastasis or recurrence thereof by inhibiting HIF-2? during the development and metastasis of chondrosarcoma, particularly dedifferentiated chondrosarcoma.Type: GrantFiled: May 13, 2020Date of Patent: June 20, 2023Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Jin-Hong Kim, Hyeonkyeong Kim, Hyeon-Seop Kim, Yongsik Cho
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Patent number: 11661433Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.Type: GrantFiled: May 9, 2019Date of Patent: May 30, 2023Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Matthew Hartman, Koushambi Mitra
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Patent number: 11633415Abstract: The present invention includes CSNK1A1 inhibitors that are useful in treating or preventing a cancer in a subject. In certain embodiments, the cancer comprises a hematological cancer, such as but not limited to acute myeloid leukemia (AML) and/or MDS (myelodysplastic syndrome, including 5q-MDS). In other embodiments, the cancer comprises colon cancer.Type: GrantFiled: March 30, 2018Date of Patent: April 25, 2023Assignees: THE BROAD INSTITUTE, INC., DANA-FARBER CANCER INSTITUTE, INC.Inventors: Steven M. Corsello, Todd R. Golub, Eric Stefan, Robert Hilgraf