Patents Examined by Jennifer C Sawyer
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Patent number: 11975132Abstract: The presently disclosed subject-matter provides specific compositions, conjugates, device, kits and systems for depleting fibrinolytic agents from biological fluids. The presently disclosed subject-matter further relates to the resulting biological fluid products that are devoid in fibrinolytic activity, therapeutic methods and uses thereof. The conjugates comprise a particle, at least one linker and at least one amino acid, derivative thereof or analog thereof being at least one of 4-(aminomethyl)-cyclo-hexane-carboxylic acid (tranexamic acid), epsilon-amino caproic acid, lysine, cyclohexanecarboxylic acid and 4-methyl-cyclohexanecarboxylic acid. A plurality of different conjugates (e.g. differing in particle size or type of linker) can be used.Type: GrantFiled: February 28, 2019Date of Patent: May 7, 2024Assignee: PLAS-FREE LTDInventors: Abd Alrauf Hijazi, Zeev Dvashi
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Patent number: 11970432Abstract: The present invention provides a process for preparing 2-methyl-N-(2?-methylbutyl)butanamide of the following formula (1): the process comprising: subjecting an ?-arylethyl-2-methylbutylamine compound of the following general formula (2): wherein Ar represents a substituted or unsubstituted aryl group having 6 to 20 carbon atoms, to N-2-methylbutyrylation to form an N-?-arylethyl-2-methyl-N-(2?-methylbutyl)butanamide compound of the following general formula (3): wherein Ar is as defined above, and removing the ?-arylethyl group of the resulting compound (3) to form 2-methyl-N-(2?-methylbutyl)butanamide (1).Type: GrantFiled: February 28, 2023Date of Patent: April 30, 2024Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takeshi Kinsho, Yusuke Nagae, Shogo Tsukaguchi, Yasuhiko Kutsuwada, Tatsuya Hojo, Takeru Watanabe
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Patent number: 11964259Abstract: A catalyst composition for hydrogenating 4,4?-methylenedianiline derivatives is provided. The catalyst composition includes a carrier including aluminum oxide and magnesium oxide, a rhodium-ruthenium active layer loaded on the surface of the carrier, and a solvent including an organic amine. The weight percentage of magnesium oxide in the carrier is between 12% and 30%. A method for preparing 4,4?-methylene bis(cyclohexylamine) derivatives using the catalyst composition is also provided.Type: GrantFiled: December 28, 2020Date of Patent: April 23, 2024Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Chao-Huang Chen, Jyun-Da Wu, Tzong-Shyan Lu, Ying-Chieh Lee
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Patent number: 11958860Abstract: The present invention discloses a crystal form A of a compound, where the compound is S-(?)-2,3-methylenedioxy-5,8,13,13a-tetrahydro-10,11-dimethoxy-6H-dibenzo[a, g]quinolizine, and an X-ray powder diffraction pattern of the crystal form A includes three or more 2? values selected from the group consisting of: 12.21±0.2°, 13.381±0.2°, 15.181±0.2°, 16.171±0.2°, 17.101±0.2°, 19.801±0.2°, 21.511±0.2°, 24.391±0.2°, and 25.321±0.2°. The crystal form A of the compound of the present invention does not contain water and a solvent, has high stability and low hygroscopicity, and is suitable for patent medicine.Type: GrantFiled: December 7, 2021Date of Patent: April 16, 2024Assignee: Jiangsu Kanion Pharmaceutical Co., Ltd.Inventors: Wei Xiao, Wei Zhang, Yingguang Li, Qingming Guo, Shasha Gu, Hanfei Hu
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Patent number: 11932588Abstract: The disclosure provides a process for preparing solid tri(C1-C4 alkyl)ammonium dihydrogen phosphates such as triethylammonium dihydrogen phosphate, in high yield, and in a free-flowing particulate form. The solid product advantageously possesses less than about 1500 ppm of aprotic organic solvents, less than about 1500 ppm of C1-C5 alkanols, and less than about 500 ppm of water, as determined by Karl Fischer titration.Type: GrantFiled: November 10, 2022Date of Patent: March 19, 2024Assignee: ENTEGRIS, INC.Inventors: Jonathan W. Dube, Christopher Brown, Keith Hao-Kiet Huynh, Hitendra Patel
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Patent number: 11932590Abstract: Provided are an inhibitor for RuO4 gas generation used in a manufacturing process of a semiconductor element, that inhibits a RuO4 gas generated when a semiconductor wafer containing ruthenium and a treatment liquid are brought into contact, and a method for inhibiting the RuO4 gas. Specifically, provided is an inhibitor for RuO4 gas generation for inhibiting a RuO4 gas generated when a semiconductor wafer containing ruthenium and a treatment liquid are brought into contact in semiconductor formation steps, wherein the inhibitor includes an onium salt consisting of an onium ion and a bromine-containing ion. Also provided is a method for inhibiting RuO4 gas generation by adding the inhibitor to a ruthenium treatment liquid or a ruthenium-containing liquid used in semiconductor formation steps.Type: GrantFiled: September 23, 2020Date of Patent: March 19, 2024Assignee: TOKUYAMA CORPORATIONInventors: Tomoaki Sato, Yuki Kikkawa, Takafumi Shimoda, Takayuki Negishi
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Patent number: 11926580Abstract: A hydropersulfide precursor compound having the formula (I): formula (I) as defined in the specification. A process for preparing the hydropersulfide precursor, and a method of using the precursor to generate hydropersulfide are also described.Type: GrantFiled: August 30, 2019Date of Patent: March 12, 2024Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: John Pasquale Toscano, Vinayak S. Khodade
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Patent number: 11926574Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of a mental health disease or disorder.Type: GrantFiled: June 8, 2022Date of Patent: March 12, 2024Assignee: Atai Therapeutics Inc.Inventors: Glenn Short, Robert B. Perni, Benjamin Robert Difrancesco, Tanweer A. Khan
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Patent number: 11912644Abstract: Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.Type: GrantFiled: November 1, 2022Date of Patent: February 27, 2024Assignee: Celgene CorporationInventors: John F. Traverse, Michael J. Zacuto, Weihong Zhang, Kirsten Faye Johnson, Maryll E. Geherty, Christopher Marton
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Patent number: 11905229Abstract: A method of synthesizing diclofenac sodium, including: subjecting aniline and chloroacetic acid to amidation to obtain 2-chloro-N-phenylacetamide; subjecting 2-chloro-N-phenylacetamide and 2,6-dichlorophenol to condensation reaction to obtain 2-(2,6-dichlorophenoxy)-N-phenylacetamide; subjecting 2-(2,6-dichlorophenoxy)-N-phenylacetamide to Smiles rearrangement in the presence of an inorganic base to obtain N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide; subjecting N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide and thionyl chloride to chlorination to obtain N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide; subjecting N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide to Friedel-Crafts alkylation in the presence of a Lewis acid catalyst to obtain 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one; and subjecting 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one to hydrolysis in the presence of an inorganic base to obtain diclofenac sodium.Type: GrantFiled: February 22, 2023Date of Patent: February 20, 2024Assignee: Fudan UniversityInventors: Fener Chen, Dang Cheng, Lulu Wang, Ge Meng, Yingtang Ning, Zedu Huang
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Patent number: 11884609Abstract: The present disclosure pertains to a process for manufacturing ethyleneamine compounds selected from the group of ethyleneamines and hydroxyethylethyleneamines wherein the process comprises two reaction sequences.Type: GrantFiled: February 13, 2020Date of Patent: January 30, 2024Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.Inventors: Rolf Krister Edvinsson, Antoon Jacob Berend Ten Kate, Michiel Jozef Thomas Raaijmakers, Rens Veneman, Slavisa Jovic, Lawien Feisal Zubeir, Eike Nicolas Kantzer, Ina Ehlers, Hendrik Van Dam, Karl Fredrik Lake
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Patent number: 11878954Abstract: Process for manufacturing ethyleneamine compounds selected from the group of ethyleneamines and hydroxyethylethyleneamines wherein the process comprises two reaction sequences.Type: GrantFiled: February 13, 2020Date of Patent: January 23, 2024Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.Inventors: Antoon Jacob Berend Ten Kate, Rolf Krister Edvinsson, Michiel Jozef Thomas Raaijmakers, Rens Veneman, Slavisa Jovic, Lawien Zubeir, Eike Nicolas Kantzer, Ina Ehlers, Hendrik Van Dam, Karl Fredrik Lake
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Patent number: 11857352Abstract: The present invention provides a composition comprising the compound having the structure: or a salt of the compound; 4-amino-2-[19F]-fluorobenzoic acid or a salt of 4-amino-2-[19F]-fluorobenzoic acid; and at least one acceptable carrier.Type: GrantFiled: September 6, 2017Date of Patent: January 2, 2024Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Peter Tonge, Zhuo Zhang, Peter Smith-Jones, Li Liu, Hui Wang
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Patent number: 11851390Abstract: A two-step one-pot process for reacting glycolaldehyde with an aminating agent in the presence of a reactive organic fluid for instance a reactive solvent is provided. The first step comprises of contacting glycolaldehyde with an aminating agent in the presence of a reactive fluid for instance a reactive solvent under inert atmosphere to produce unsaturated intermediates, and reacting the reaction mixture obtained in step 1 with hydrogen in the presence of a supported hydrogenation catalyst in a second step.Type: GrantFiled: April 4, 2019Date of Patent: December 26, 2023Inventors: Michiel Jules Y Pelckmans, William Hendrick Faveere, Bert Sels
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Patent number: 11839213Abstract: The present invention relates to antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same. The compositions may comprise one or more of a peracid, a hydroperoxide, a bis(hydroperoxide), or an epoxide.Type: GrantFiled: April 9, 2021Date of Patent: December 12, 2023Assignee: ARMIS BIOPHARMA, INC.Inventors: Edwin Neas, Scott Noblitt
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Patent number: 11834388Abstract: This application relates to pharmaceutical engineering, and more particularly to a continuous-flow preparation method of diclofenac sodium. The continuous-flow preparation method includes: subjecting aniline and chloroacetic acid to amidation to obtain 2-chloro-N-phenylacetamide (3); subjecting 2-chloro-N-phenylacetamide (3) and 2,6-dichlorophenol to continuous condensation to obtain N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide (5); subjecting N-(2,6-dichlorophenyl)-2-hydroxy-N-phenylacetamide (5) and thionyl chloride to chlorination to obtain N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide (6); subjecting N-(2,6-dichlorophenyl)-2-chloro-N-phenylacetamide (6) to Friedel-Crafts alkylation in the presence of aluminum chloride to obtain 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one (7); and subjecting 1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-one (7) to hydrolysis to obtain the diclofenac sodium.Type: GrantFiled: February 22, 2023Date of Patent: December 5, 2023Assignee: Fudan UniversityInventors: Fener Chen, Dang Cheng, Lulu Wang, Ge Meng, Yingtang Ning
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Patent number: 11834389Abstract: A method of making N-(2,4-dinitrophenyl)-4-nitrobenzamide from a mixture of 2,4-dinitroaniline, 4-nitrobenzoyl chloride, and solid acid catalyst in an organic solvent, wherein the solid acid catalyst is not soluble in the organic solvent, the solid acid catalyst being an acidic clay, an ion exchange resin, a beta zeolite, a sulfonated tetrafluoroethylene-based fluoropolymer-copolymer, or some mixture of these.Type: GrantFiled: May 18, 2021Date of Patent: December 5, 2023Assignee: DUPONT SAFETY & CONSTRUCTION, INC.Inventors: James A. Schultz, Sourav Kumar Sengupta, Venkateswara Rao Surisetty
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Patent number: 11834387Abstract: Provided are a quaternary ammonium salt and a preparation method and use thereof as an inhibitor, and a water-based drilling fluid and use thereof. The quaternary ammonium salt has a structure shown in formula I, wherein, in the formula I, R1 is selected from the group consisting of —H and —COOH; R2 is selected from the group consisting of —H and —CH2—COOH; R3 is selected from the group consisting of —NH—CH2—CH2—CH2—NH2, —NH—CH2—CH2—NH2, —NH—CH2—CH2—OH, —O—CH2—CH2—NH2, —N—(CH2—CH2—OH)2, and —O—CH2—CH2—NH—CH2—CH2—OH; and n and m are independently 10 to 15.Type: GrantFiled: March 2, 2023Date of Patent: December 5, 2023Assignees: Yangtze University, Jingzhou Jiahua Technology Co., Ltd.Inventors: Mingbiao Xu, Fuchang You, Kai Jiao, Shusheng Zhou
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Patent number: 11827588Abstract: Novel 85Rb-enriched rubidium salt compounds of general formula 1, below and novel compounds of general formula 2, below. Compositions that contain at least one of the novel compounds and optionally further contain an antitumor drug. Methods that entail administering such compounds and compositions to treat cancer, optionally in combination with a conventional form of cancer therapy, such as chemotherapy and radiation treatment. When administered with a conventional form of cancer therapy, the compounds and compositions of the invention may be administered before, simultaneously with, or after administration of the conventional form of cancer therapy.Type: GrantFiled: March 16, 2022Date of Patent: November 28, 2023Assignee: Vector Vitale IP LLCInventors: Peter Novak, Maxim Temnikov, Oleksandr Balakin
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Patent number: 11825739Abstract: Provided is a boron-containing compound suitable for the material of a blue light-emitting diode and an organic light-emitting diode using the same. The boron-containing compound has a structure represented by the formula (1): X is each independently —NR1—, —CR2R3—, —O— or —S—. In the —NR1— and —CR2R3—, R1 to R3 are each independently hydrogen, deuterium, an alkyl group having 1 to 6 carbon atoms or an aryl group having 5 to 30 core atoms, and R2 and R3 may connect with each other to form a ring. Cy1 is an aryl group having 5 to 30 core atoms. All or part of hydrogen atoms in the formula (1) may be substituted by deuterium, a halogen, an alkyl group having 1 to 6 carbon atoms, an aryl group having 5 to 30 core atoms, a substituted or unsubstituted silyl group, a substituted or unsubstituted amino group, or cyano group.Type: GrantFiled: January 5, 2021Date of Patent: November 21, 2023Assignee: FLASK CORPORATION C/O YONEZAWA CAMPUS, NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITYInventors: Hisayuki Kawamura, Masahiro Igarashi