Patents Examined by Jennifer C Sawyer
  • Patent number: 11739049
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: August 29, 2023
    Assignee: Grünenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Helmut Heinrich Buschmann, Joerg Holenz, Stefan Gladow
  • Patent number: 11738323
    Abstract: The present invention relates to a method for purification of liquid compositions containing at least one sphingolipid and the use of a specific clay mineral for the purification of such liquid compositions.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: August 29, 2023
    Assignee: Clariant Produkte (Deutschland) GmbH
    Inventors: Carina Bitterwolf, Joern Kretzschmar, Lina Tubes, Benjamin Fuerst
  • Patent number: 11739044
    Abstract: The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: August 29, 2023
    Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.
    Inventors: Ming-Hsi Chuang, Lin-Hsiang Chuang, Ming-Hsuan Lu, Wen-Peng Shen, Yun-Chen Lin, Chi-Hsuan Chuang
  • Patent number: 11731934
    Abstract: The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: August 22, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Daiqing Liao, William R. Roush, Ryan L. Stowe
  • Patent number: 11724984
    Abstract: Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: August 15, 2023
    Inventor: Thomas Daly
  • Patent number: 11724981
    Abstract: A cationic surfactant and a method of making the cationic surfactant are described. The method comprises reacting a lipophilic bio-based material having at least one epoxy functional group and a hydrophilic organic compound having at least one cationic functional group and at least one hydroxyl functional group to form a reaction product containing a stable ether linkage connecting the lipophilic bio-based material to the organic compound. At least a portion of the cationic functional groups is neutralized or ion exchanged with an organic acid. Incorporation of the simple organic acid reduces the surfactant's aquatic toxicity and acts as a substrate to encourage co-digestion of the surfactant molecule, making the compound more biodegradable.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 15, 2023
    Assignee: Battelle Memorial Institute
    Inventors: Ramanathan S. Lalgudi, Robert J. Cain, Manoj Kumar Valluri
  • Patent number: 11718578
    Abstract: The invention provides a method for synthesizing a compound of formula wherein each R independently represents an optionally substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy, acyl, carboxyl, hydroxyl, halogen, amino, nitro, cyano, sulfo or sulfhydryl group, in ortho, meta or para position to the cycloalkylamine moiety; R1 and R2 each independently represents a hydrogen atom, a lower alkyl group or a cycloalkyl group; R3 represents a hydrogen group, substituted aryl, heteroaryl, alkyl, perfluoroalkyl, cycloalkyl, alkoxy, aryloxy group; Y represents an oxygen atom, a sulfur atom, a NH group, a NR4 group or a CH2 group; R4 represents a hydrogen atom or an alkyl, aryl or a heteroaryl group; and n and m each independently represents an integer from 1 to 5; or a pharmaceutically acceptable salt thereof; or a precursor thereof; wherein the method comprises one or more of the following steps: (a) reacting a compound of formula (II) wherein R, R3, Y, n and m are as defined abo
    Type: Grant
    Filed: January 21, 2022
    Date of Patent: August 8, 2023
    Assignee: UNIVERSITÉ DE LIÈGE
    Inventors: Thomas Toupy, Romaric Gerardy, Jean-Christophe Monbaliu, Diego Collin, Victor-Emmanuel Kassin
  • Patent number: 11702382
    Abstract: A method of reducing color in an alkanolamine, the method comprising: contacting the alkanolamine with an amount of an aqueous solution effective to provide 5 to 1000 parts per million by weight of an alkali metal borohydride, based on parts by weight of the alkanolamine; and 0.5 to 10,000 parts per million by weight of an alkali metal hydroxide, based on parts by weight of the alkanolamine; preferably wherein the color-reduced alkanolamine is not distilled after the contacting.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: July 18, 2023
    Assignee: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Feng Xu, Flaiyh Al-Anazi
  • Patent number: 11697632
    Abstract: The present disclosure encompasses a composition comprising three-dimensional shapes, wherein each shape consists essentially of choline chloride, and methods of making such three-dimensional shapes.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: July 11, 2023
    Assignee: Balchem Corporation
    Inventors: Jerry Edgar, Michael Ibrahim
  • Patent number: 11685712
    Abstract: The present invention provides a route for synthesizing monofunctional thiuram compounds that is safe, environmentally friendly, and cost effective. This method specifically involves synthesizing a monofunctional thiuram by (1) reacting a tetraorganylthiuram disulfide with an organyl mercaptan to produce the monofunctional thiuram and a dithiocarbamate metal salt or a dithiocarbamate metalloid salt under basic conditions, (2) separating the monofunctional thiuram in an organic phase from the dithiocarbamate metal salt or the dithiocarbamate metalloid salt in an aqueous phase, and (3) recovering the monofunctional thiuram from the aqueous phase. The monofunctional thiuram compounds made in accordance with this invention are of particular value as accelerators for use in the vulcanization of rubber. The use of these monofunctional thiuram compounds as accelerators provides good cure rates and as well as good scorch safety.
    Type: Grant
    Filed: August 24, 2022
    Date of Patent: June 27, 2023
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Thomas Franklin Spilker, Ji Yang Jin, Frank J. Feher
  • Patent number: 11673859
    Abstract: The present invention relates to an N-(4-((4-(3-phenylureido)phenyl)sulfonyl)phenyl)benzenesulfonamide in the polymorphic form ?18.9, characterised by an x-ray powder diffractogram having the Bragg angles (2?/CuK?) 10.9, 11.7, 14.6, 15.0, 15.8, 16.6, 17.6, 18.9, 19.4, 20.9, 21.2, 22.0, 23.3, 24.4, 24.7, 26.1, 27.4, 29.4, 34.2, or in the polymorphic form ?21.2, characterised by an x-ray powder diffractogram having the Bragg angles (2?/CuK?) 8.7, 9.8, 10.8, 13.2, 13.9, 14.9, 15.2, 16.0, 17.4, 17.7, 18.7, 20.4, 21.2, 21.6, 22.3, 23.0, 23.3, 23.9, 24.4, 25.0, 25.8, 26.6, 28.1, 28.9, 29.4, 30.1, 30.6, 31.8, 34.5, 35.3, 35.6, 36.9, a method for production thereof, use thereof as a colour developer in a heat-sensitive recording material, and a heat-sensitive recording material comprising N-(4-((4-(3-phenylureido)phenyl)sulfonyl)phenyl)benzenesulfonamide in the polymorphic form ?18.9 or in the polymorphic form ?21.2.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: June 13, 2023
    Assignee: KOEHLER PAPER SE
    Inventors: Michael Horn, Timo Stalling, Christian Schnick
  • Patent number: 11655204
    Abstract: A novel promotor which contains an aniline derivative is introduced. By using the promotor alone, the time and temperature of the curing reaction of the vinyl ester resin can be controlled by the unique steric effect and electronic properties of the aniline derivative. A method for preparing the above promotor is also introduced.
    Type: Grant
    Filed: February 21, 2021
    Date of Patent: May 23, 2023
    Assignee: NATIONAL CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Yi-Kang Lan, Chi-Wi Ong, Yong-Yun Zhang
  • Patent number: 11629119
    Abstract: The present invention provides a process for preparing 2-methyl-N-(2?-methylbutyl) butanamide of the following formula (1):the process comprising: subjecting an ?-arylethyl-2-methylbutylamine compound of the following general formula (2): wherein Ar represents a substituted or unsubstituted aryl group having 6 to 20 carbon atoms, to N-2-methylbutyrylation to form an N-?-arylethyl-2-methyl-N-(2?-methylbutyl)butanamide compound of the following general formula (3): wherein Ar is as defined above, and removing the ?-arylethyl group of the resulting compound (3) to form 2-methyl-N-(2? -methylbutyl)butanamide (1).
    Type: Grant
    Filed: May 24, 2022
    Date of Patent: April 18, 2023
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeshi Kinsho, Yusuke Nagae, Shogo Tsukaguchi, Yasuhiko Kutsuwada, Tatsuya Hojo, Takeru Watanabe
  • Patent number: 11629114
    Abstract: The present invention generally relates to processes for purification, recovery, and conversion of chlorophenol salts (e.g., 2,5-dichlorophenol and salts thereof). In various aspects, the present invention is related to removing one or more impurities from chlorophenol salt-containing process streams and/or recovering chlorophenol salts from process streams for use of the recovered chlorophenol elsewhere in an integrated process. Process streams that may be treated in accordance with the present invention include those incorporating one or more chlorophenol salts in a feed mixture and also those where one or more chlorophenol salts are present in a product or by-product stream of an integrated process. For example, conversion processes of the present invention are suitable as one piece of an integrated process for producing 3,6-dichloro-2-methoxybenzoic acid (dicamba) or a salt or ester thereof or a process for producing 2,4-dichlorophenoxyacetic acid (2,4-D) or a salt or ester thereof.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: April 18, 2023
    Assignee: Monsanto Technology LLC
    Inventors: Howard C. Berk, Bruno de Kort, John Joseph Parlow, Amy E. Stroman, Junqiu Yang
  • Patent number: 11608310
    Abstract: The invention relates to bis(aniline) compounds containing multiple arylethynyl, alkylethynyl, ethynyl groups or their combinations, processes of making such compounds and materials comprising such compounds. Such, bis(aniline) compounds preferably comprise multiple phenylethynyl (PE) groups, i.e. 2-4 PE moieties. Such compounds are useful monomers for the preparation of polyimides, polyamides and poly(amide-imides) whose post-fabrication crosslinking chemistry (i.e. reaction temperature) can be controlled by the number of PE per repeat unit as well as finding utility in thermosetting matrix resins, 3D printable resins, and as high-carbon-content precursors to carbon-carbon composites.
    Type: Grant
    Filed: March 20, 2021
    Date of Patent: March 21, 2023
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, Zhenning Yu
  • Patent number: 11608314
    Abstract: The present invention relates to a crystalline form of compound 3-((L-valyl)amino)-3,3-dideuterium-1-propanesulfonic acid, preparation method and uses thereof.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: March 21, 2023
    Assignee: RISEN (SUZHOU) PHARMA TECH CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Daiqiang Hu, Xianqi Kong
  • Patent number: 11608313
    Abstract: The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof a diastereomer thereof, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: March 21, 2023
    Assignee: Tohoku University
    Inventors: Shigeki Moriguchi, Kohji Fukunaga, Yoshiharu Iwabuchi
  • Patent number: 11602148
    Abstract: A crystalline form of oxamyl is provided. The crystalline form of oxamyl is of formula (I): A crystal preparation process, the analyses of the crystal through various analytical methods, and using the crystalline form to prepare a stable agrochemical formulation is also provided. The use of various solvents towards the crystalline form preparation conditions is also provided.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: March 14, 2023
    Assignee: JIANGSU ROTAM CHEMISTRY CO., LTD
    Inventor: James Timothy Bristow
  • Patent number: 11596927
    Abstract: Disclosed are catalysts comprised of platinum and gold. The catalysts are generally useful for the selective oxidation of compositions comprised of a primary alcohol group and at least one secondary alcohol group wherein at least the primary alcohol group is converted to a carboxyl group. More particularly, the catalysts are supported catalysts including particles comprising gold and particles comprising platinum, wherein the molar ratio of platinum to gold is in the range of about 100:1 to about 1:4, the platinum is essentially present as Pt(0) and the platinum-containing particles are of a size in the range of about 2 to about 50 nm. Also disclosed are methods for the oxidative chemocatalytic conversion of carbohydrates to carboxylic acids or derivatives thereof. Additionally, methods are disclosed for the selective oxidation of glucose to glucaric acid or derivatives thereof using catalysts comprising platinum and gold. Further, methods are disclosed for the production of such catalysts.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: March 7, 2023
    Assignee: Archer-Daniels-Midland Company
    Inventors: Vincent J. Murphy, James Shoemaker, Guang Zhu, Raymond Archer, George Frederick Salem, Eric L. Dias
  • Patent number: 11591291
    Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: February 28, 2023
    Assignee: Saudi Arabian Oil Company
    Inventors: Xuan Zhang, Ming Han, Jinxun Wang