Patents Examined by Jennifer M. H. Tichy
  • Preparation of purified collagen solution from porcine skin
    Patent number: 11008379
    Abstract: A method of preparing a purified collagen solution from porcine skin may include receiving and inspecting the porcine skin; treating the porcine skin with a sodium hydroxide treatment, resulting in a sodium hydroxide processed skin; treating the sodium hydroxide processed skin with an ethanol treatment, resulting in ethanol treated processed skin; producing liquid collagen from the ethanol treated processed skin; clarifying the liquid collagen; and concentrating the clarified liquid collagen.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: May 18, 2021
    Assignee: Sigmagraft, Inc.
    Inventors: Qi Wang, Dae Kyu Chang
  • Sulfur dioxide and/or sulfurous acid pretreatment with sulfur dioxide recovery
    Patent number: 10995314
    Abstract: A process for producing ethanol from lignocellulosic biomass includes adding at least one of sulfur dioxide and sulfurous acid to the lignocellulosic biomass to provide an equivalent sulfur dioxide loading of at least 10 wt % sulfur dioxide to dry lignocellulosic biomass. The acidified lignocellulosic biomass is pretreated at a temperature above about 185° C. and for a pretreatment time less than about 10 minutes, to provide a pretreated biomass composition wherein the biomass is readily hydrolyzed by enzymes. Advantageously, sulfur dioxide from at least one of the flash stream and a stream derived from the flash is recovered and recycled back into the process.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: May 4, 2021
    Assignee: Iogen Corporation
    Inventors: Brian Foody, Daniel G. MacDonald, Kristin Martens, Natacha Leduc, John Dechman, Robert Griffin
  • Transplantation implant for promoting hair growth
    Patent number: 10993904
    Abstract: The present disclosure relates to a transplantation implant that includes stem cells having an ability of secreting a cytokine that having a hair-growing function.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 4, 2021
    Assignee: Inscobee Inc.
    Inventors: Seung-Kwon Noh, Jung-Soo Park, In-Soo You
  • Method of culturing
    Patent number: 10988509
    Abstract: A method for cost-effectively and efficiently culturing Akkermansia muciniphilais is disclosed. High biomass yields can be obtained on chemically defined media. This allows for large scale production of A. muciniphila suitable for use in humans, such as for pharmaceutical or food applications. The A. muciniphila can be produced free of animal-derived products, thereby allowing a broad-range of applications.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: April 27, 2021
    Assignee: WAGENINGEN UNIVERSITEIT
    Inventors: Clara Belzer, Willem Meindert De Vos
  • Vacuum-assisted plasma separation
    Patent number: 10989706
    Abstract: A plasma separation system and process for providing filtered plasma from a blood sample is described. The system may include a blood separation well having a separation membrane for filtering the blood sample. The filtering process may be aided by the use of a negative or positive pressure source attached to the plasma separation system.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: April 27, 2021
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Michael S. Wilson, Jay Li, Kenneth P. Galano
  • Formulation for storage, transportation, and delivery of protein rich conditioned medium
    Patent number: 10988731
    Abstract: A method of creating a protein rich conditioned medium. The method includes culturing mesenchymal stem cells in a container utilizing a first growth medium, allowing a time period for proliferation of the mesenchymal stem cells until a desired level of confluence is achieved in the container, discarding a supernatant from the container, adding a second medium to the container, incubating the mesenchymal stem cells, and collecting the conditioned medium. The method produces significantly higher quantities of byproducts secreted by the mesenchymal stem cells. Byproducts are usable for wound healing, disease treatment, cosmetic, or other beneficial effects when applied or otherwise delivered to a patient.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: April 27, 2021
    Assignee: HOPE BIOSCIENCES, LLC
    Inventors: Hyeonggeun Park, Fred Haisam Khoury
  • Compositions comprising bacterial strain
    Patent number: 10987387
    Abstract: The invention provides compositions comprising bacterial strains for treating and preventing cancer.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: April 27, 2021
    Assignee: 4D Pharma Research Limited
    Inventors: Imke Elisabeth Mulder, Emma Raftis, Delphine Louise Claudette Caly, Emma Elizabeth Clare Hennessy
  • Method of preparing a faecal microbiota sample
    Patent number: 10980839
    Abstract: The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between ?15° C. and ?100° C. Steps b) to e) are carried out in anaerobiosis.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 20, 2021
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Patricia Lepage, Christel Maillet, Sylvie Rabot, Fernanda Fonseca, Hervé Blottiere
  • Partially renewable transportation fuel
    Patent number: 10981784
    Abstract: According to the present invention, organic material is converted to biogas through anaerobic digestion and the biogas is purified to yield a combustible fluid feedstock comprising methane. A fuel production facility utilizes or arranges to utilize combustible fluid feedstock to generate renewable hydrogen that is used to hydrogenate crude oil derived hydrocarbons in a process to make transportation or heating fuel. The renewable hydrogen is combined with crude oil derived hydrocarbons that have been desulfurized under conditions to hydrogenate the liquid hydrocarbon with the renewable hydrogen or alternatively, the renewable hydrogen can be added to a reactor operated so as to simultaneously desulfurize and hydrogenate the hydrocarbons. The present invention enables a party to receive a renewable fuel credit for the transportation or heating fuel.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: April 20, 2021
    Assignee: Iogen Corporation
    Inventor: Brian Foody
  • Brain function improving agent
    Patent number: 10980849
    Abstract: A novel agent useful for improving brain function is provided. The active ingredient in this agent is a Bifidobacterium breve and/or a Bifidobacterium breve-containing cultured material is provided.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: April 20, 2021
    Assignee: MORINAGA MILK INDUSTRY CO., LTD.
    Inventors: Yodai Kobayashi, Tetsuya Kuhara, Kanetada Shimizu, Takumi Sato
  • for treating obesity and associated metabolic disorders
    Patent number: 10973862
    Abstract: Bifidobacterium longum AH1362 (NCIMB 41715) produces a polysaccharide and increases energy excretion. The strain is used in the prevention or treatment of obesity and obesity-related metabolic syndrome.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: April 13, 2021
    Assignee: PrecisionBiotics Group Limited
    Inventors: Barry Kiely, Eileen Frances Murphy, Selena Healy
  • Controlled induction of human pancreatic progenitors produces functional beta-like cells
    Patent number: 10975355
    Abstract: Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 13, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Matthias Hebrok, Holger Andreas Russ
  • Treating biomass to produce materials useful for biofuels
    Patent number: 10961595
    Abstract: Fermentable sugar useful for the production of biofuels can be produced from biomass by contacting the biomass with a solution containing at least one ?-hydroxysulfonic acid. The ?-hydroxysulfonic acid can be easily removed from the product and recycled.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: March 30, 2021
    Assignee: SHELL OIL COMPANY
    Inventors: Paul Richard Weider, Robert Lawrence Blackbourn
  • Method of banking stem cells
    Patent number: 10959425
    Abstract: A method of banking stem cells by harvesting stem cells from an individual and culturing the harvested stem cells to generate a P0 culture. The method includes storing a desired amount of P0 stem cells via cryopreservation and subculturing a portion of the P0 stem cells to generate a P1 culture. A desired amount of P1 stems cells can then be stored via cryopreservation and further generations can be stored as desired.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: March 30, 2021
    Assignee: HOPE BIOSCIENCES, LLC
    Inventor: Hyeonggeun Park
  • Tissue graft
    Patent number: 10953140
    Abstract: The present invention is directed to a method of producing a tissue graft, comprising at least steps of providing a gel, seeding the gel with cells of at least a first and/or cells of a second type, and culturing of the cells of the first and/or cells of the second type in said gel until the formation of at least one first biostructure in the gel by the cells of the first type and/or the cells of the second type.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: March 23, 2021
    Assignee: UNIVERSITAT ZURICH
    Inventors: Ernst Reichmann, Daniela Marino, Agnieszka Sylwia Klar
  • Method for producing fermented carotenoid using carotenoid-producing bacteria obtained by using cobalt-containing culturing medium
    Patent number: 10947574
    Abstract: The present invention provides a method for high yield and stable production of carotenoids through microbial culture. The present invention provides a method for culture of carotenoid-producing bacteria, which comprises culturing carotenoid-producing bacteria in a medium containing cobalt or a cobalt salt at a concentration of 0.005 ?mol/L to 20 ?mol/L.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: March 16, 2021
    Assignee: ENEOS CORPORATION
    Inventors: Tetsuhisa Yata, Hisashi Yoneda, Mitsutoshi Azuma, Kazuaki Hirasawa
  • Low oxygen culture conditions for maintaining retinal progenitor cell multipotency
    Patent number: 10947501
    Abstract: The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors following transplantation. The described methods provide cells that can treat a number of ocular diseases, including retinitis pigmentosa and age-related macular degeneration.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: March 16, 2021
    Assignee: The Schepens Eye Research Institute
    Inventors: Michael J. Young, Budd A. Tucker, Petr Y. Baranov
  • Bioengineered human corneal stromal tissue
    Patent number: 10940239
    Abstract: Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct are provided.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: March 9, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yiqin Du, James L. Funderburgh, William R. Wagner, Jian Wu
  • Method and kit for identifying lupus anticoagulant (LA) associated with antiphospholipid syndrome
    Patent number: 10935560
    Abstract: The invention described herein relates to a method and kit for the diagnosis of antiphospholipid syndrome in patients, wherein a coagulation inhibitor and normal pooled plasma mixture reduce the factor deficiency effect of patient plasma, and coagulation inhibitor interference in patient plasma, and increases specificity and the sensitivity for detecting lupus anticoagulants in the patient's blood in a phospholipid-dependent clotting assay.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: March 2, 2021
    Assignee: Instrumentation Laboratory Company
    Inventors: Ralph E. Bottenus, Zhenghua Cao
  • Human adipose tissue white and ‘brown-on-white’ progenitors for reconstructive and metabolic therapies
    Patent number: 10927348
    Abstract: Methods for preparation of prospectively identified human adipose stem cells enriched populations thereof, e.g., for therapy.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: February 23, 2021
    Assignee: University of Massachusetts
    Inventor: Silvia Corvera