Abstract: An implantable medical device may include a telemetry module, a sensing module, a therapy delivery module, and a processor. The processor may be configured to detect a patient event based on data generated by the sensing module, operate the IMD in a first mode in which the telemetry module is disabled and the therapy delivery module is at least partially disabled when the patient event is not detected, and operate the IMD in a second mode in which the telemetry module is enabled and the therapy delivery module is at least partially disabled when the patient event is detected. In some examples, the processor is configured to, in the second mode, generate a notification of the cardiac arrhythmia and transmit the notification to an external device via the telemetry module. The external device may reside inside an MRI room or outside the MRI room, and may communicate with other devices.

Abstract: The artificial percept of light may be created by electrically stimulating the neurons of the retina. While a photolithographed array internal to the retina provides superior resolution, an array external to the retina provides easier implantation and improved manufacturability. Therefore it is advantageous to supply a high-resolution electrode array internal to the sclera, near the fovea and a lower-resolution electrode array external to the sclera near the periphery of the retina. It is advantageous to encourage current to flow through the retina by providing a physically separate and distinct electrode array and return electrode. The high-resolution electrode array and lower-resolution electrode array may be return electrodes for the other, or completely separate return electrodes may be provided.

Abstract: The physiological condition of a person is determined in physiological condition determining system by using a sensor for sampling a plurality of heart beats of the person, and using a control unit to perform the acts of: extracting a series of cardiac R-R intervals from the heart beat samples, providing a two-dimensional representation of subsequent R-R intervals, wherein two subsequent R-R interval forms an entry in the two-dimensional representation resulting in a plurality of entries, determining a centroid, an average radius and an average rotation frequency for the plurality of entries in the two-dimensional representation, determining a plurality of distances between the radius and each of the entries in the two-dimensional representation, and determining the physiological condition of the person using the radius in combination with the plurality of distances.

Abstract: A computer-implemented method for fitting a medical implant to a recipient, the medical implant being operative to stimulate a physiological system of the recipient over a plurality of stimulation channels. The method includes: determining, based on measurements, an initial stimulation profile for the plurality of stimulation channels; determining a representative stimulus level of the initial stimulation profile; determining a fitting stimulation profile by modifying the shape a shape of the initial stimulation based on the representative stimulus level profile; and configuring the medical implant according to the fitting stimulation profile.

Abstract: According to an embodiment of a method for using an implantable device to deliver a hypertension therapy to a patient, an activity level is sensed using the implantable medical device. The implantable device may be programmed with a mapping of the sensed activity level to intensity levels for the hypertension therapy. The method may determine a desired intensity for the hypertension therapy as a function of both a circadian rhythm template and the sensed activity level, and use the implantable device to deliver the hypertension therapy using the desired intensity.

Abstract: A non-invasive electrical stimulation device shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in which the electrode(s) are in contact. The stimulation device is configured to produce a peak pulse voltage that is sufficient to produce a physiologically effective electric field in the vicinity of a target nerve, but not to substantially stimulate other nerves and muscles that lie between the vicinity of the target nerve and patient's skin. Current is passed through the electrodes in bursts of preferably five sinusoidal pulses, wherein each pulse within a burst has a duration of preferably 200 microseconds, and bursts repeat at preferably at 15-50 bursts per second.

Abstract: Methods and devices for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. In certain embodiments, the devices include a magnetic stimulator having coils with toroidal windings, which are in contact with an electrically conducting medium that is adapted to conform to the contour of a target body surface of a patient. The coils induce an electric current and/or an electric field within the patient, thereby stimulating nerve fibers within the patient. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium.

Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is obesity. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.

Abstract: A heart monitor computes ST segment deviation as the difference in the value of an electrocardiogram signal at the ST and PQ points of a heartbeat. The ST point is found based on slope criteria and temporal criteria. The maximum (positive) slope of the QRS (maxQRS) is located. Within a preset window after the maxQRS point, the processor searches for a sample at which the second finite difference is less than a threshold that is a function of average QRS amplitude. If such a qualifying sample is found, the processor examines its location relative to the location of an adaptive window that is centered on a sample that is an adaptively determined distance from the peak of the R wave. If the qualifying point is within the adaptive window, it is chosen as the ST point. If the qualifying point is after the adaptive window, the ST point is set at the end of the adaptive window. Finally, if the qualifying point is before the adaptive window, the ST point is selected at the beginning of the adaptive window.

Abstract: An electromagnetic interference immune defibrillator lead has a first electromagnetic insulating layer. A first layer is formed on the first electromagnetic insulating layer, the first layer having a plurality of first conductive rings composed of first conductive material, each first conductive ring being separated by first insulating material. A second electromagnetic insulating layer is formed on the first layer. A second layer is, formed on the second electromagnetic insulating layer, the second layer having a plurality of second conductive rings composed of second conductive material, each second conductive ring being separated by second insulating material. A third electromagnetic insulating layer is formed on the second layer. The second conductive rings of second conductive material are positioned such that a second conductive ring overlaps a portion of a first conductive ring and overlaps a portion of a second conductive ring, the second conductive ring being adjacent to the first conductive ring.

Abstract: A paddle lead assembly for providing electrical stimulation of patient tissue includes a paddle body having a plurality of electrodes. At least one of the plurality of electrodes defines a removed center portion. At least one lead body is coupled to the paddle body. At least one terminal is disposed on each of the at least one lead bodies.

Abstract: Subdural arrays transmit electrocorticogram recordings wirelessly, across the patient's skull, allowing the craniotomy used for surgical placement of the arrays to be completely closed. In various embodiments, the arrays also respond to commands, applying signal patterns to the patient's brain for diagnostic and treatment purposes.

Abstract: A cardiac rhythm management system provides for the trending of a third heart sound (S3) index. The S3 index is a ratio, or an estimate of the ratio, of the number of S3 beats to the number of all heart beats, where the S3 beats are each a heart beat during which an occurrence of S3 is detected. An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including S3. An S3 detector detects occurrences of S3 from the acoustic signal. A heart sound processing system trends the S3 index on a periodic basis to allow continuous monitoring of the S3 activity level, which is indicative of conditions related to heart failure.

Abstract: Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease include non-invasive nerve stimulators. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.

Abstract: A method for trending heart failure measures cardiogenic impedance (CI) and obtains signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The method identifies correction factors based on the signals and applies the correction factors to the contractility estimates. A system for trending heart failure includes a contractility module to determine contractility estimates from CI measurements taken along at least a first vector through a heart, and a collection module to receive signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The system further includes a factor module to identify correction factors based on the signals and a correction module to apply the correction factors to the contractility estimates.

Abstract: A foldable intravascularly insertable blood pump employs an impeller with radially delivering vanes in combination with an annular deflection channel. The impeller is driven by a shaft extending through a catheter wherein the impeller and its envelope are foldable by relative displacement of the shaft and catheter.

Abstract: An implantable lead may have a distal assembly including a coupler and a fixation helix secured to the coupler. The fixation helix may be formed of a filar having a non-circular cross-sectional profile having a major dimension and a minor dimension. The major dimension may be disposed transversely to a longitudinal axis of the fixation helix.

Abstract: Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease wherein the treatment includes stimulating selected nerve fibers responsible for smooth muscle dilation at a selected region within a patient's neck, thereby reducing the magnitude of constriction of bronchial smooth muscle.

Abstract: A method for processing cardiac signals includes accepting, from a sensor system, a set of one or more signals, the signals including components of a desired cardiac signal and components of a substantially periodic interfering signal. The method is applicable for extraction of desired fetal cardiac signals from signals with interference from the maternal cardiac signal. A periodicity of the interfering signal is determined, and one or more iterations of mitigating an effect of a component of the signals that exhibit periodicity at the determined periodicity of the interfering signal are performed. In some examples, the method further includes determining a periodicity of the desired cardiac signal, and performing one or more iterations of enhancing an effect of a component of the signals that exhibit periodicity at the determined periodicity of the desired cardiac signal.

Abstract: A system example may include a vagus nerve stimulator, a physiological parameter monitor and a controller. The stimulator may be configured to deliver vagus nerve stimulation in a recurring succession of stimulation cycles, where the vagus nerve stimulation is provided for a portion of each cycle and not provided for another portion each stimulation cycle. The monitor may be configured to monitor a physiological parameter within the portion of each cycle when the stimulation is generated and within another portion of each cycle when the stimulation is not generated. The controller may be configured to determine a change in the sensed physiological parameter where the change reflects a difference in the sensed physiological parameter between the portions of a stimulation cycle, compare the detected change to a target change to provide a comparison result, and adjust the vagus nerve stimulation based on the comparison result.