Patents Examined by Joseph R. Kosack
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Patent number: 11925640Abstract: Provided herein are methods and materials for improving arteriovenous fistula (AVF) maturation and/or maintaining AVF functionality. For example, methods and materials for using one or more senolytic agents to improve AVF maturation, to maintain AVF functionality, and/or to maintain the patency of an AVF are provided. Methods and materials for using one or more senolytic agents to maintain functionality and/or patency of a venous graft (e.g., a venous graft that bypasses an occluded artery) also are provided.Type: GrantFiled: June 21, 2019Date of Patent: March 12, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Karl A. Nath, James L. Kirkland, Tamar Tchkonia
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Patent number: 11919910Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 9, 2022Date of Patent: March 5, 2024Assignee: Enanta Pharmaceuticals, Inc.Inventors: Guoqiang Wang, Ruichao Shen, Xuechao Xing, Yong He, Matthew C. Rhodes, Yat Sun Or
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Patent number: 11919833Abstract: Provided is a method for producing a methyl-adduct compound, the method including methylating, in the presence of potassium carbonate and dimethyl carbonate, a dinitrile compound represented by Formula (1) below to obtain a methyl-adduct compound represented by Formula (2) below: where in Formula (2), R1˜R4 each independently represent hydrogen or methyl, and from one to three of R1˜R4 are each methyl.Type: GrantFiled: April 12, 2022Date of Patent: March 5, 2024Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Aoi Yokoo Yamazoe, Yutaka Kanbara
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Patent number: 11912704Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of aryl-cycloheptene scaffolds. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising an aryl-cycloheptene structure. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to modularly and scalably assemble common such cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: GrantFiled: August 7, 2019Date of Patent: February 27, 2024Assignee: University of Florida Research Foundation, Inc.Inventors: Alexander James Grenning, Ehsan Fereyduni
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Patent number: 11912714Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 9, 2022Date of Patent: February 27, 2024Assignee: Enanta Pharmaceuticals, Inc.Inventors: Hui Cao, Wei Li, Xuri Gao, Jiajun Zhang, Xiaowen Peng, Jorden Kass, Ruichao Shen, Guoqiang Wang, Yat Sun Or
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Patent number: 11912648Abstract: The invention relates to a method for preparing C—H acidic (meth)acrylates and the uses thereof.Type: GrantFiled: July 10, 2019Date of Patent: February 27, 2024Assignee: Evonik Operations GmbHInventors: Marcel Treskow, Maik Caspari, Thorben Schütz, Steffen Krill
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Patent number: 11905287Abstract: Disclosed are novel analogs of cytisine, a process for their preparation, pharmaceutical compositions containing them, and their use in the prevention of or treatment of CNS disorders including addictive disorders.Type: GrantFiled: March 3, 2023Date of Patent: February 20, 2024Assignee: THE UNIVERSITY OF BRISTOLInventors: Timothy Charles Gallagher, Hugo Rego Campello
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Patent number: 11897863Abstract: Indazole derivatives represented by formula (I) or stereoisomers, tautomers, and pharmaceutically acceptable salts thereof are provided. A preparation method of indazole derivatives represented by formula (I) and a method of use of the indazole derivatives as therapeutic agents is also provided.Type: GrantFiled: August 15, 2019Date of Patent: February 13, 2024Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yongping Lu, Cheng Ye, Wenjian Qian, Taishan Hu, Lei Chen
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Patent number: 11886118Abstract: A material for forming an organic film, including: a compound for forming an organic film shown by the following general formula (1A); and an organic solvent, where W1 represents a tetravalent organic group, n1 an integer of 0 or 1, n2 an integer of 1 to 3, and R1 an alkynyl group having 2 to 10 carbon atoms. A compound for forming an organic film is cured not only under air, but also under film formation conditions of inert gas, and forms an organic film having not only excellent heat resistance and properties of filling and planarizing a pattern formed on a substrate, but also favorable adhesion to a substrate, and a material for forming an organic film containing the compound, and a substrate for manufacturing a semiconductor device using the material, a method for forming an organic film using the material, and a patterning process using the material.Type: GrantFiled: February 22, 2021Date of Patent: January 30, 2024Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Daisuke Kori, Takashi Sawamura, Keisuke Niida, Seiichiro Tachibana
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Patent number: 11884612Abstract: There are provided, inter alia, compositions and methods for covalently binding peptides to proteins.Type: GrantFiled: March 16, 2017Date of Patent: January 30, 2024Assignee: The Regents of the University of CaliforniaInventors: Lei Wang, Christian Hoppmann
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Patent number: 11883419Abstract: Pol ? protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol ?. The compounds were shown to directly interact with Pol ? and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.Type: GrantFiled: June 25, 2018Date of Patent: January 30, 2024Assignees: ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI, SABANCI UNIVERSITESI, KOC UNIVERSITESIInventors: Meltem Muftuoglu, Batu Erman, Burak Erman
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Patent number: 11884619Abstract: A method for esterification of one or more carboxylic acid groups in a compound containing one or more carboxylic acid groups wherein the esterification reagent is a diazo-compound of formula: wherein the R1 and R2 groups of the diazo compound are selected such that the corresponding organic compound of formula: exhibits a —C—H pKa value between 18 and 29 as measured in DMSO. Specific reagents and methods for esterification are provided. The esterification reagents provided exhibit high selectivity for esterification of carboxylic acid groups over reaction with amine, alcohol or thiol groups in the compound containing one or more carboxylic acid groups. The method can be used to selectively esterify carboxylic acid groups in peptides or proteins.Type: GrantFiled: July 8, 2021Date of Patent: January 30, 2024Assignee: Wisconsin Alumni Research FoundationInventors: Ronald T. Raines, Nicholas McGrath
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Patent number: 11878977Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: August 10, 2022Date of Patent: January 23, 2024Assignee: Theravance Biopharma R&D IP, LLCInventors: Paul R. Fatheree, Gary E. L. Brandt, Cameron Smith, Steven D. E. Sullivan, Lori Jean Van Orden, Melanie A. Kleinschek, Glenn D. Crater
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Patent number: 11873315Abstract: Provided herein are diaryl and arylalkyl phosphonates, useful as intermediates in, for example, the synthesis of leukocyte elastase inhibitors, potassium channel modulators, chemiluminescence materials, and flame retardants, and methods for making same. Also provided are N-heterocyclic phosphorodiamidic acids (NHPAs) useful in reactions such as, for example, in the preparation of diaryl and arylalkyl phosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: January 24, 2022Date of Patent: January 16, 2024Assignee: THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGASInventors: Jun Yong Kang, Hai Huang
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Patent number: 11873272Abstract: The disclosure relates generally novel sulfur containing glycerol mono-ester derivatives and methods useful for treating gram positive, gram negative, fungal and envelope viral infections in a patient.Type: GrantFiled: January 31, 2023Date of Patent: January 16, 2024Assignee: Niche Biopharmaceuticals LLCInventors: Dayton T. Reardan, Paul Brennan, Patrick Schlievert
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Patent number: 11866393Abstract: Disclosed are 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane and a preparation method thereof. The 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane is a compound represented by formula I, or an enantiomer, a raceme or a diastereomer thereof. The compound of formula I could be prepared by using a racemic or optically active 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-6,6?-diol as a raw material through a series of reactions. The 7,7?-dihalo-3,3,3?,3?-tetramethyl-1,1?-spirobiindane is a key intermediate for preparing 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-based phosphine ligand compounds represented by formula II or III.Type: GrantFiled: March 22, 2022Date of Patent: January 9, 2024Assignee: Zhejiang UniversityInventors: Xufeng Lin, Linxi Yao, Shirui Chang, Lei Wang
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Patent number: 11858881Abstract: A method for manufacturing a higher purity nitrile solvent by purifying a nitrile solvent containing an impurity, e.g an imine. The nitrile solvent may contain an imine and a conjugated diene, a carbonyl compound, or a high-boiling material as impurities. A method for purifying a nitrile solvent, such as isobutyronitrile, including bringing nitrile solvent containing an imine, e.g., as an impurity, into contact with an acidic aqueous solution having a pH of 3 or less, such as hydrochloric acid; bringing the nitrile solvent having been contacted with acidic aqueous solution into contact with an aqueous sodium hydrogen sulfite solution; bringing the nitrile solvent having been contacted with the aqueous sodium hydrogen sulfite solution into contact with an alkaline aqueous solution, such as an aqueous sodium hydroxide solution; and distilling the nitrile solvent having been contacted with the alkaline aqueous solution.Type: GrantFiled: February 26, 2019Date of Patent: January 2, 2024Assignee: NIPPON SODA CO., LTD.Inventors: Shota Saito, Ryoji Wada, Keiichiro Matsuda, Ryoyo Nakashima, Fuminori Komatsu
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Patent number: 11858922Abstract: The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 or R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.Type: GrantFiled: February 16, 2017Date of Patent: January 2, 2024Assignees: THE UNIVERSITY OF QUEENSLAND, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLINInventors: Luke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder, Angus Murray Macleod, David John Miller
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Patent number: 11851436Abstract: The present disclosure relates to a compound of Formula (0): a stereoisomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof. The present disclosure also relates to uses of the compound.Type: GrantFiled: June 3, 2022Date of Patent: December 26, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Philip Reigan, Kimberly A. Casalvieri
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Patent number: 11845723Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.Type: GrantFiled: December 18, 2020Date of Patent: December 19, 2023Assignee: Gilead Sciences, Inc.Inventors: Masaaki Sawa, Mai Arai, Ryoko Nakai, Hirokazu Matsumoto, Catherine Pugh, Eric Hu, Juan Guerrero, Jesse Jacobsen, Jonathan William Medley, Jie Xu, Latesh Lad, Leena Patel, Michael Graupe, Qingming Zhu, Stephen Holmbo, Tetsuya Kobayashi, Will Watkins, Yasamin Moazami, Suet C. Yeung, Julian A. Codelli, Heath A. Weaver