Patents Examined by Joseph R. Kosack
  • Coloring composition, film, color filter, solid-state imaging element, and image display device
    Patent number: 11746239
    Abstract: A coloring composition includes a metal azo pigment, a compound having an ethylenically unsaturated bonding group, and a solvent, the metal azo pigment includes at least one kind of an anion selected from an azo compound represented by Formula (I) or an azo compound having a tautomeric structure of the azo compound represented by Formula (I), two or more kinds of metal ions, and a melamine compound, and in Formula (I), R1 and R2 each independently represent OH or NR5R6, R3 and R4 each independently represent ?O or ?NR7, and R5 to R7 each independently represent a hydrogen atom or an alkyl group.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: September 5, 2023
    Assignee: FUJIFILM Corporation
    Inventors: Shoichi Nakamura, Kazuya Ota, Haruki Inabe
  • Chalcone-based chemotherapeutic compound for triple negative breast cancer
    Patent number: 11746104
    Abstract: Provided herein are compounds, compositions, and methods useful for the treatment of breast cancer, particularly triple negative breast cancers. In certain aspects, provided herein are compounds of formula (I): or a pharmaceutically acceptable salt or solvate thereof. In certain aspects, provided herein are compositions comprising any of the compounds provided herein. In certain aspects, provided herein are methods for the treatment of cancer in a subject in need thereof comprising administering to the subject an effective amount of any of the compounds or compositions provided herein.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: September 5, 2023
    Assignee: QATAR UNIVERSITY
    Inventors: Ashraf Khalil, Ala-Eddin Al Moustafa, Dana H. Elkhalifa, Feras Alali
  • Protein-polymer nanoassemblies and intracellular protein delivery
    Patent number: 11746172
    Abstract: The invention provides novel polymer-protein conjugates and molecular assemblies for controlled intracellular delivery of proteins, and compositions and methods of preparation and use thereof.
    Type: Grant
    Filed: July 19, 2020
    Date of Patent: September 5, 2023
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Bin Liu
  • DREADD actuators
    Patent number: 11739063
    Abstract: Disclosed is a compound of formula (I) in which R1, R2, and R3 are as described herein. Also provided are pharmaceutical compositions comprising the compound of formula (I) and methods of using the compound of formula (I), including a method of treating a disease or disorder and a method for effectuating a G-protein coupled receptor (GPCR)-mediated response in a subject.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: August 29, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Johns Hopkins University
    Inventors: Jordi Bonaventura, Juan Luis Gomez, Andrew Horti, Feng Hu, Michael Michaelides, Martin Pomper, Marta Sanchez-Soto
  • Method for fluoroalkylation of enamines
    Patent number: 11739066
    Abstract: The invention discloses a method for fluoroalkylation of enamines with a fluoro alkyl halide in the presence of a base.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: August 29, 2023
    Assignee: Arxada AG
    Inventors: Christoph Taeschler, Matthias Beller, Helfried Neumann, Florian Fischer, Shaoke Zhang, Fei Ye, Stefan Ellinger, Florencio Zaragoza Doerwald
  • Coating composition and organic light-emitting device
    Patent number: 11737300
    Abstract: The present disclosure relates to a coating composition and an organic light emitting device.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: August 22, 2023
    Assignee: LG Chem, Ltd.
    Inventors: Ho Gyu Lee, Jaesoon Bae, Seog Jae Seo, Jaechol Lee, Jiyeon Shin, Leehyeon Baek
  • Broad spectrum antivirulence, anti-persistence compounds
    Patent number: 11731946
    Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 22, 2023
    Assignees: The General Hospital Corporation, Aptuit (Verona) SRL, An Evotec Company
    Inventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti
  • Prodrugs of a CDK inhibitor for treating cancers
    Patent number: 11725020
    Abstract: There are provided compounds of Formula I, and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for inhibition or modulation of the activity of cyclin dependent kinases (CDK) and/or glycogen synthase kinase-3 (GSK-3), for the treatment of disease states or conditions mediated by cyclin dependent kinases and/or glycogen synthase kinase-3, including cancers.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: August 15, 2023
    Assignees: RISEN (SUZHOU) PHARMA TECH CO., LTD., SHANGHAI JUNSHl BIOSCIENCES CO., LTD.
    Inventors: Jiasheng Lu, Jiamin Gu, Gang Chen, Xiaolin Zhang, Feng Zhou, Xianqi Kong
  • Conjugates of tumor necrosis factor inhibitors to functionalized polymers
    Patent number: 11723981
    Abstract: This document relates to conjugates of TNF inhibitors or derivatives thereof and functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such conjugates.
    Type: Grant
    Filed: June 8, 2022
    Date of Patent: August 15, 2023
    Assignee: QuiaPEG Pharmaceuticals AB
    Inventor: Marek Kwiatkowski
  • JAK kinase inhibitor compounds for treatment of respiratory disease
    Patent number: 11718616
    Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: August 8, 2023
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Paul R. Fatheree, John R. Jacobsen, Anne-Marie Beausoleil, Gary E. L. Brandt, Melissa Fleury, Lan Jiang, Cameron Smith, Steven D. E. Sullivan, Lori Jean Van Orden, Pierre-Jean Colson, Gene Timothy Fass, Miroslav Rapta, Noah Benjamin, Marta Dabros, Venkat R. Thalladi
  • 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
    Patent number: 11713304
    Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: August 1, 2023
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Stefan Nikolaus Gradl, Duy Nguyen, Knut Eis, Judith Günther, Timo Stellfeld, Andreas Janzer, Sven Christian, Thomas Müller, Sherif El Sheikh, David B. Sykes, Steven James Ferrara, Michael Kröber, Claudia Merz, Michael Niehues, Martina Schäfer, Katja Zimmermann, Carl Friedrich Nising
  • Selective alkylation of cyclopentadiene
    Patent number: 11708380
    Abstract: Provided is a process for the mono-alkylation of cyclopentadiene, utilizing a cyclopentadiene magnesium halide and a metal salt of an alkyl or aryl sulfonate as co-reactant with an alkyl halide alkylating reactant. The process provides facile methodology for the mono-alkylation of cyclopentadiene, with conversions as high as about 96 percent and selectivity for mono-alkylation (over higher level alkylation, such as di- or tri-) as high as about 99%.
    Type: Grant
    Filed: October 21, 2021
    Date of Patent: July 25, 2023
    Assignee: ENTEGRIS, INC.
    Inventors: Paul Hinkle, Scott A. Laneman, Victoria Weidner
  • Phenylpyrrolidinone formyl peptide 2 receptor agonists
    Patent number: 11708327
    Abstract: The disclosure relates to compounds of Formulae (I)-(IX), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: July 25, 2023
    Assignee: Bristol-Myers Squibb Company
    Inventors: Pravin Sudhakar Shirude, Vishweshwaraiah Baligar, Balaji Seshadri, Amit Kumar Chattopadhyay, Nicholas R. Wurtz, Ellen K. Kick
  • Environmentally-friendly hydroazidation of olefins
    Patent number: 11708320
    Abstract: The present invention provides processes for the synthesis of organic azides, intermediates for the production thereof, and compositions related thereto.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: July 25, 2023
    Assignee: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventor: Hao Xu
  • Sulfuric acid ester or salt thereof, and surfactant
    Patent number: 11708324
    Abstract: A sulfuric acid ester containing a plurality of carbonyl groups or a salt thereof, and a surfactant. The sulfuric acid ester is a compound represented by the following formula: R1—C(?O)—R2—C(?O)—R3—OSO3X wherein R1, R2 and R3 are defined herein; X is H, a metal atom, NR44, imidazolium optionally containing a substituent, pyridinium optionally containing a substituent, or phosphonium optionally containing a substituent, where R4s are each H or an organic group and are the same as or different from each other; and any two of R1, R2, and R3 optionally bind to each other to form a ring. Also disclosed is a surfactant containing the sulfuric acid ester and an aqueous dispersant containing the sulfuric acid ester.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: July 25, 2023
    Assignee: DAIKIN INDUSTRIES. LTD.
    Inventors: Satoru Yoneda, Manabu Fujisawa, Kazuya Asano, Takahiro Kitahara, Masahiro Higashi, Akiyoshi Yamauchi, Sumi Ishihara, Yosuke Kishikawa
  • Method for preparing (dimethylaminomethylene) malononitrile using a micro reaction system
    Patent number: 11708321
    Abstract: A method for preparing (dimethylaminomethylene) malononitrile by using a micro reaction system. Cyanoacetamide, N,N-dimethylformamide and a catalyst are mixed to obtain a mixture, and the mixture and phosphorus oxychloride are simultaneously pumped into the micro reaction system that includes a micromixer and a microchannel reactor connected in series for continuous dehydration condensation. After adjusted to a target pH, the crude product is subjected to continuous liquid-liquid extraction with an organic solvent in a centrifugal extraction unit comprising a plurality of annular centrifugal extractors connected in series. The organic phase is collected to obtain the target product (dimethyl aminomethylene) malononitrile.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: July 25, 2023
    Assignee: Fudan University
    Inventors: Fener Chen, Dang Cheng, Meifen Jiang, Minjie Liu, Huashan Huang, Lulu Wang
  • Nanoprobe-metal chelator complexes
    Patent number: 11702545
    Abstract: Provided herein are compounds that are able to bind metal ions (e.g., free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: July 18, 2023
    Assignees: The General Hospital Corporation, Northeastern University
    Inventors: Hak Soo Choi, Jonghan Kim, Georges El Fakhri
  • Tetraphenylphenoxy tungsten oxo alkylidene complexes and methods of making same and use thereof
    Patent number: 11702436
    Abstract: The invention relates to tungsten oxo alkylidene complexes ligated with a tetraphenylphenoxy ligand and a neutral ligand such as a phosphine or a pyridine, and method of making the complexes. The complexes are useful as catalysts for performing a ring-opening metathesis polymerization of dicyclopentadiene to poly(dicyclopentadiene).
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: July 18, 2023
    Assignee: Verbio Vereinigte BioEnergie AG
    Inventors: Henrik Gulyas, Benedek Vakulya
  • Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
    Patent number: 11691978
    Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: July 4, 2023
    Assignee: ASTRAZENECA AB
    Inventors: Johan Olof Broddefalk, Hans Fredrik Emtenâs, Kenneth Lars Granberg, Malin Anita Lemurell, Daniel Tor Pettersen, Alleyn Thomas Plowright, Lars Johan Andreas Ulander
  • Processes of preparing a JAK1 inhibitor
    Patent number: 11685731
    Abstract: The present application provides processes for preparing 4-[3-(cyanomethyl)-3-(3?,5?-dimethyl-1H, 1?H-4,4?-bipyrazol-1-yl)azetidin-1-yl]-2,5-difluoro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]benzamide, and phosphoric acid salt thereof, which is useful as a selective (Janus kinase 1) JAK1 inhibitor, as well as salt forms and intermediates related thereto.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: June 27, 2023
    Assignee: Incyte Corporation
    Inventors: Jiacheng Zhou, Yingrui Dai, Zhongjiang Jia, Yongchun Pan, James M. Parks, Anthony J. Tomaine, Jianji Wang, Aibin Zhang