Abstract: An apparatus for cooling tissues which are treated with an energy-based device, such as a laser, is disclosed. The apparatus comprises a spray nozzle which generates an atomized liquid spray for the treatment area, wherein the atomized liquid spray is based on a mixture of liquid and gas. Further, the spray nozzle comprises at least one liquid outlet which ejects a liquid, and at least one gas outlet which ejects a gas stream. Besides, the apparatus for cooling comprises at least one delivery means for delivering pressurized gas to the spray nozzle; and a pumping means for the liquid, wherein the pumping means is configured to operate in pulses.

Abstract: The present invention relates to the field of medical devices, and specifically to a packaging structure and a packaging method for a retinal prosthesis implanted chip, including a high-density stimulation electrode component processed by a glass substrate, wherein the stimulation electrode component comprises the glass substrate, and a plurality of stimulation electrodes and a pad structure provided on the glass substrate; the stimulation electrodes are formed through cutting out metal pins on the metal and then pouring with glass; the stimulation electrode component is connected to an ASIC chip; a glass packaging cover is covered on the ASIC chip, the glass packaging cover is provided with a metal feedthrough structure for communicating with the stimulation chip; and the packaging cover covers and encapsulates the pad structure.

Abstract: Systems, devices, and methods for monitoring and assessing immunotherapy toxicity are discussed. An exemplary system receives physiologic information from a patient using an ambulatory medical device. In response to an immunotherapy such as CAR T-cell therapy, the system determines a toxicity indication using the received physiologic information. A therapy can be initiated or adjusted using the toxicity indication.

Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

Abstract: A method that may include the steps of positioning a contact assembly, including a plurality of electrically conductive contacts that are respectively connected to a plurality of lead wires, on a shell formed from a first resilient material to form an electrode array sub-assembly, positioning the electrode array subassembly in a cochlear implant electrode array mold, and introducing a second resilient material into the mold to form a cochlear implant electrode array flexible body, on which the contacts are located, that is defined by the first and second flexible materials.

Abstract: A surgical system includes an insertion assembly and a drape shroud assembly mounted on the insertion assembly. When a sleeve of a surgical drape draping the insertion assembly is fastened to the drape shroud assembly, the sleeve is divided into two pockets. Instead of managing one long tube, the management problem of the drape sleeve is reduced to managing a plurality of shorter tubes. Shorter tubes make it easier for excess sleeve material to accordion as the tube length shortens instead of possibly bowing out and contacting a part of the insertion assembly or some other part of the surgical system.

Abstract: Apnea events may be detected based on a primary biomarker, e.g., respiration, in the one or more physiological signals. The apnea events may be characterized as one of an obstructive sleep apnea (OSA) event, a central sleep apnea (CSA) event, or a combination OSA/CSA event based on a secondary biomarker, e.g., a frequency spectrum or a morphology of the respirations in the one or more physiological signals. A first electrical stimulation may be provided to treat OSA in response to a first one or more of the apnea events being characterized as OSA events. A second electrical stimulation may be provided to treat CSA in response to a second one or more of apnea events being characterized as CSA events. A third electrical stimulation may be provided to treat combination OSA/CSA in response to a third one or more of the apnea events being characterized as combination OSA/CSA events.

Abstract: A treatment assembly can have an inner layer having an inner surface and an outer surface and defining a plurality of openings extending therethrough. The treatment assembly can further comprise a plurality of plates, each plate being at least partially received within a respective opening of the plurality of openings of the inner layer. The treatment assembly can further comprise treatment circuitry comprising a cable having a plurality of electrical leads and a plurality of lead ends, each electrical lead being electrically connected to a respective lead end of the plurality of lead ends. A cover layer can be attached to the outer surface of the inner layer and overlie the plurality of lead ends of the cable. The plurality of lead ends can be in contact with respective plates of the plurality of plates to define a plurality of electrodes.

Abstract: A system and apparatus is disclosed for indicating a window of fertility based on the fertility awareness method (FAM).

Abstract: The present disclosure provides systems and methods for exogenous neurostimulation. An exogenous neurostimulation system includes an electrode pad comprising a plurality of electrodes configured to be applied to skin of a patient, and a pulse generator communicatively coupled to the electrode pad, the pulse generator operable to generate burst waveforms for delivery to the skin of the patient via the electrode pad.

Abstract: The present invention relates to an electrocardiography (ECG) connector comprising two lead wire terminals (40a, 40b), each for connection with a respective signal line of a respective lead wire (204, 205), four measurement terminals (41a, 41b, 42a, 42b), each for connection with a respective measurement line (208a, 208b, 208c, 208d) of a connection cable (208), four resistors (43a, 43b, 44a, 44b), each coupled with their first end to a respective measurement terminal (41a, 41b, 42a, 42b), wherein two resistors (43a, 44a) are coupled with their second end to a first lead wire terminal (40a) and the other two resistors (43b, 44b) are coupled with their second end to the second lead wire terminal (40b), and four voltage clamping elements (45a, 45b, 46a, 46b), each coupled with their first end to a respective measurement terminal (43a, 43b, 44a, 44b) and with their second end to a common coupling point (47).

Abstract: Systems for treatment of glaucoma comprise an excimer laser, a plurality of fiber probes, and a processor. Each fiber probe is attachable to the excimer laser to treat a subject having glaucoma by delivering shots from the laser. The processor is configured to monitor and limit a variable number of shots delivered by each fiber probe, the number of shots delivered by each fiber probe programmable within a range. Methods of treating glaucoma include programming a fiber probe to deliver a number of shots from an excimer laser. The fiber probe is inserted into an eye of a subject having glaucoma and adjusted to a position transverse to Schlemm's canal in the eye. A plurality of shots is applied from the excimer laser source while the probe is in the transverse position, thereby treating glaucoma by creating a plurality of perforations in Schlemm's canal and/or the trabecular meshwork.

Abstract: A browser-based biological tracking system connects a computer to a set of wearable sensors. The system includes an application that is automatically downloaded from a server in response to a user accessing a webpage. The application sends data streams from the sensors to the server. The server calculates readings which are then displayed in a webpage. The set of sensors may include multiple types of sensors which utilize different communication interfaces. Some readings, called aggregate insights, are computed based on measurements from multiple sensors.

Abstract: A system for controlling blood pressure includes a wearable interface having an internal contact surface, the wearable interface configured to at least partially encircle a first portion of a first limb of a subject, a sensing module carried by the wearable interface and configured to determine at least a change in blood pressure of the first limb of the subject, and an energy application module carried by the wearable interface and configured to apply energy of two or more types to the first limb of the subject.

Abstract: An intravascular device for pumping blood includes a catheter comprising a membrane chamber located between a proximal end and a distal end of the catheter. An inflatable membrane is disposed within the membrane chamber. The intravascular device includes a first one-way valve and optionally a second one-way valve configured to permit blood flow in a first direction. The first one-way valve may be positioned proximal to the membrane chamber, and the second one-way valve may be positioned distal to the membrane chamber. Methods related to intravascular devices and their respective use are provided.

Abstract: The present application relates to an outlet graft for a blood pump as well as to a system comprising a blood pump and an outlet graft that is connected to an outlet of the blood pump. The outlet graft includes a first end opposite a second end such that a longitudinal axis is formed between the first and second ends. The second end is connectable to a blood vessel and a lumen with a closed cover. A first strip included in the cover extends parallel to the longitudinal axis and is made of a material that is of a higher contrast under x-rays than the cover.

Abstract: A therapeutic apparatus for treating damaged tissue on a limb or body of a subject includes a wearable adapted to cover and be secured to the limb or body of a subject over damaged tissue. The wearable being configured to reduce pressure on the damaged tissue and adapted to deliver one or more treatments selected from the group consisting of heat, oxygen, electrical current, and light to the damaged tissue.

Abstract: Presented are concepts for monitoring cardio-respiratory function of a patient. One such concept comprises detecting light or sound from the sublingual vasculature using a sublingual sensor unit adapted to be positioned at a sublingual vasculature of the patient's tongue and to generate a sensor output signal based on the detected light or sound. A processing unit adapted to receive at least one of the sensor unit output signal, wherein the sensor unit and the processing unit are arranged to analyze the venous component in the sensor output signal. An output signal from the sublingual sensor may then be used to provide information on cardio-respiratory parameters like respiration rate and respiration rate variability, for example.

Abstract: The application generally relates to olfaction as a biomarker, more particularly as a prognostic biomarker or biological predictor, of neurosensory disease or disorder and/or of neurocognitive disease or disorder, in subjects whose nervous system has been infected by an infectious agent, such as by a neurotropic virus, bacterium, protozoan parasite, fungus or prion, more particularly by a neurotropic virus.

Abstract: The adhesive extenders can be used to cover and surround the medical electrode assemblies on the skin of a patient. A wearable monitor can be used to obtain electrogram data from the patient via the electrodes.