Abstract: The invention concerns a composition useful for the manufacture of vaccines containing particles having the immunogenic properties characteristic of the antigen HBsAg, these particles being more particularly characterized by the fact that the said particles equally contain a receptor for polymerized human albumin. They are obtained by transformation of human or animal cells by a vector containing a DNA sequence coding for the S and pre-S regions of a genome of viral hepatitis B, this DNA sequence being placed under the direct control of a promoter permitting the effective transcription of the said sequence in the human or animal cells transformable by the said vector.

Abstract: The present invention is directed to a method for poteniating the therapeutic effects of selected NMDA antagonists.

Abstract: Clear, stable, efficacious, aqueous microemulsions of a pyrethroid insecticide, optionally with another agriculturally active ingredient, are provided herein. The aqueous microemulsions are obtained by providing an inert matrix composition containing a defined mixture of nonionic surfactants, optionally including an anionic surfactant, mixing with a pyrethroid to form a microemulsion concentrate, and diluting with water. Preferably, the aqueous microemulsion includes an N-alkyl (C.sub.1 -C.sub.4) pyrrolidone therein as a cosolvent in the microemulsion system.

Abstract: New methods and feed compositions are disclosed for enhancing the reduction of coccidial-induced intestinal lesions in poultry and for enhancing shank pigmentation in poultry. Such methods comprise coadministering zeolite and coccidiostats, such as in a feed mixture or by separate administration.

Abstract: A composition and method for controlling fleas and flea larvae in substrate such as carpeting is disclosed in which a solution and a boron-containing compound are impregnated into the substrate and then extracted, leaving a crystalline boron residue which contaminates the food supply of the insects and abrades the insects' exoskeleton for causing desiccation.

Abstract: The growth rate of meat-producing animals as well as the yield and quality of the meat obtained therefrom is improved by administering to the animal prior to its sexual maturation an effective amount of a female gonadal steroidal compound; namely, an estrogen or progestagen compound and preferably a mixture thereof, sufficient to delay development of the gonadal function of the animal, e.g., spermatogenesis. Such administration is terminated sufficiently prior to slaughter of the animal that the administered steroidal compound has been substantially completely removed from the animal's system which before slaughter exhibits levels of the corresponding natural hormones therein substantially within normal limits. In mammals, administration is preferably by injection, but in fish, shellfish and poultry, the active steroidal compound is incorporated at low levels in the usual feed therefor.

Abstract: Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated therein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.

Abstract: A teat dip composition useful for the treatment of mastitis in dairy cows. The composition in application form is in the form of an oil-in-water emulsion. The oil phase includes an unsaturated fatty acid, for example linseed oil fatty acid, having a carbon chan length in the range of C16 to C20.

Abstract: A therapeutic coolant for the local treatment of burn is provided wherein said coolant consisting of squalene, squalane, or mixtures thereof.A method of treating burn is provided wherein said method comprising :applying a therapeutic coolant cooled to a temperature range from -10 to -60.degree. C., said coolant selected from the group consisting essentially of squalene, squalane, or mixtures thereof.

Abstract: A method of stabilizing aqueous microemulsions against hydrolysis or phase separation of the active ingredient therein comprising buffer the microemulsion to acidic conditions using a surface active hydrophobic acid having a pKa of about 2-5, which have a hydrophobic group capable of entering micelles to preclude an undesired increase in electrolyte strength in the bulk aqueous medium. The method is particularly applicable to active ingredients which ordinarily hydrolyze under basic conditions, or precipitate in an acid medium buffered by conventional inorganic acids. An embodiment of the invention comprises an aqueous microemulsion of a carbamate ester which is stabilized against hydrolysis or precipitation at a pH of about 6.5 with a buffer of nonylphenyl ethoxylated phosphoric acid.

Abstract: Compounds are described which are useful for lowering the activity of .alpha..sub.2 -PI, for the treatment of myocardial infarctions and cerebral infarctions, as urokinase secretion accelerators, as antithrombotic agents and to accelerate the fibrinolysis accelerating effect.

Abstract: A method for treating laminitis in equine livestock with tylosin which comprises dosing the equine or delivering to the lower alimentary canal a pharmaceutically effective quantity of an agent comprising tylosin. The method may be used for treating equine livestock which are subjected to a high carbohydrate diet by controlling lactic acid concentration in the hind gut. The agent acts to improve efficiency of feed utilization in the equine by increasing the production of propionate during fermentative digestion in the hind gut and allows feeding to the equine diets containing high levels of a readily fermentable carbohydrate.

Abstract: A method of using veratridine to inhibit nerve impulses, and a composition of matter including veratridine and epinephrine, is provided. Application of veratridine proximal to a nerve causes depolarization of the nerve membrane, thereby blocking transmission of nerve impules. C-fiber selectivity is demonstrated in vitro in rabbit vagus nerves. Veratridine displays extended anesthetic activity over long periods of time when compared to similar local anesthetics, with no local toxicity. Systemic toxicity is reduced by co-injection with epinephrine.

Abstract: Sustained and enhanced antipyretic response is elicited in a mammalian organism in need of such treatment, i.e., a mammal suffering from elevated body temperature (fever), by administering thereto a unit dosage sustainedly enhancing, antipyretically effective amount of the free acid S(+) flurbiprofen enantiomer, said enantiomer being substantially free of its R(-) flurbiprofen antipode.

Abstract: Described is a method of decreasing the weight in mammals to a desired level comprising orally administering thereto an effective weight reducing amount of a non-toxic anion exchange resin containing composition for a desired period of time to achieve a desired weight reduction. Compositions useful for reducing weight in patients contain an anion exchange resin such as cholestyramine, colestipol or polidexide, with bran and optionally, artificial sweeteners and flavors.

Abstract: 3,5-Dihalogeno-1,2,6-thiadiazin-4-ones of the formula ##STR1## in which R.sub.1 and R.sub.2 independently of one another are chlorine, fluorine or bromine, in particular 3,5-dichloro-1,2,6-thiadiazin-4-one, are excellently suitable for use as biocides for the protection of industrial materials and for water systems, for example for wood, plastics, paints, oils, adhesives and industrial water circulation systems.

Abstract: An oxygen scavenging composition for use with foods, cosmetics, and pharmaceuticals comprising a combination of a metal that can exist in two redox states at ambient conditions, and a radical oxygen scavenger. The oxygen scavenging system is also effective in inhibiting the growth of yeasts, molds, and most aerobic bacteria.

Abstract: Disclosed is a method for preventing the transmission of an ectoparasite-borne pathogen to a mammal exposed to predation by the ectoparasite, wherein a time delay exists between attachment of the ectoparasite to the mammal and transmission of the pathogen from the ectoparasite to the mammal. The method comprises applying to the mammal an ectoparacide to kill the ectoparasite in place on the mammal, without necessarily finding or mechanically detaching the ectoparasite, at a time after the exposure of the mammal to the ectoparasite, and within the time delay, thereby preventing transmission of the pathogen from the ectoparasite to the mammal.

Abstract: A method of treatment of anxiety in benzodiazepine-withdrawn patients by administering BMY 14802 or, preferably, the R-(+)- enantiomer to a patient in need of such treatment.

Abstract: The invention relates to the use of the benzo[b]-thiophene-2-carboximidamide derivative having formula I ##STR1## or pharmaceutically acceptable salts thereof, for the preparation of a medicament which is suitable for the treatment of heart failure, having high bioavailability without inducing nausea, vomiting and/or restlessness.