Patents Examined by Kailash C. Srivastava
  • Kit comprising elastase
    Patent number: 8568716
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: October 29, 2013
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • System comprising elastase
    Patent number: 8562983
    Abstract: The invention provides systems for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: October 22, 2013
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Gold nanoparticle based protease imaging probes and use thereof
    Patent number: 8551727
    Abstract: Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: October 8, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Ick-Chan Kwon, Kui-Won Choi, Kwang-Meyung Kim, Cheol-Hee Ahn, In-Chan Youn, Seul-Ki Lee, Kyeong-Soon Park
  • Detecting micro-organisms in an electrocoating process
    Patent number: 8541194
    Abstract: Use of a micro-organism detection device to rapidly evaluate the presence of microorganisms in an electrocoating process.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: September 24, 2013
    Assignee: Valspar Sourcing, Inc.
    Inventors: Lonnie L. Pillar, Michael J. Bourdeau, Michael A. Contos, Robert A. Sailer
  • Composition comprising a progenitor/precursor cell population
    Patent number: 8541232
    Abstract: A population of cultured cells is provided that comprises at least 10% of a sub-population of cells that: stain as CD31 Bright, demonstrate uptake of Ac-LDL+, and secrete both IL-8 and angiogenin.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: September 24, 2013
    Assignee: Kwalata Trading Limited
    Inventors: Yael Porat, Valentin Fulga, Svetlana Porozov, Adina Belleli
  • Non-photosynthetic micro-organisms enriched with organic selenium from seleno-hydroxyacid compounds and applications thereof in the field of nutrition, cosmetics and pharmacueuticals
    Patent number: 8535931
    Abstract: The invention relates to the enrichment of non-photosynthetic micro-organisms with organic selenium, and more particularly with selenomethionine, from a compound of the seleno-hydroxyacid type such as 2-hydroxy-4-methylseleno-butanoic acid in the (D, L) form or in the form of an enantiomer, salt, ester, or amide derivative of said compound, and to the use of micro-organisms, particularly bacteria thus enriched in the fields of animal or human nutrition, cosmetics, or pharmaceuticals.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: September 17, 2013
    Assignee: Tetrahedron
    Inventors: Jean-Claude Yadan, Marc Moutet
  • Protein concentrates and isolates, and processes for the production thereof from toasted oilseed meal
    Patent number: 8535907
    Abstract: Protein concentrates and protein isolates, in addition to processes for the production of protein concentrates and protein isolates, are disclosed. In particular, the disclosure relates to the removal of fiber from a toasted oilseed meal using low g-force centrifugation.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: September 17, 2013
    Assignee: Bioexx Specialty Proteins Ltd.
    Inventor: Qingnong Nelson Tang
  • Yeast strains and their uses in the production of lipids
    Patent number: 8529886
    Abstract: The invention is directed to isolated microorganisms, as well as biomasses, cultures, microbial oils, and compositions thereof. The invention also provides methods of producing the microbial oils and methods of using the isolated microorganisms, biomasses, and microbial oils.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: September 10, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, William R. Barclay, Paul Warren Behrens
  • Methods of prolonging patency of hemodialysis access
    Patent number: 8524226
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation. The invention further includes methods for prolonging patency of hemodialysis access.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: September 3, 2013
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Block-shaped scaffold for tissue engineering and production method thereof
    Patent number: 8518432
    Abstract: A block-shaped scaffold for a tissue engineering with improved shape stability and less volume change in water is produce by the steps of approximate-uniformly mixing the particle-shaped material having 100 to 2000 ?m diameter with a solution, where a biodegradable polymer is dissolved with an organic solvent, freezing, drying it to remove the solvent, pulverizing thus obtained intermediate product, dissolving it with a liquid, where the biodegradable polymer is not dissolved, to remove the particle-shaped material taking thus obtained intermediate product into a mold, and pressing and heating it, the scaffold having ununiform and continuous holes occupying 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure with 5 to 50 ?m diameter, elastic coefficient being 0.1 to 2.5 MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: August 27, 2013
    Assignee: GC Corporation
    Inventors: Katsushi Yamamoto, Katsuyuki Yamanaka, Youko Suda, Tadashi Kaneko
  • High throughput screening platform for high ethanol production
    Patent number: 8507231
    Abstract: Provided herein are high throughput methods for converting starch-containing plant material to ethanol, wherein the conversion process is performed at a small scale. This high-throughput screening platform permits the evaluation of the ethanol obtained from starch-containing plant material in a rapid and efficient manner. The methods include obtaining a plurality of samples of starch-containing plant material and drying the samples to achieve a desired moisture level. The dried samples are liquefied under conditions sufficient to hydrolyze the starch-containing plant material to soluble dextrinized substrates. The liquefied samples are fermented in small volume headspace vials for a period of less than about 96 hours, and fermentation is terminated by pasteurization. Ethanol production is evaluated using headspace gas chromatography.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: August 13, 2013
    Assignee: Syngenta Participations AG
    Inventors: Jason Abbas, George Aux, Joe Byrum, My Nguyen, Kirk Noel, Mark P Seymour
  • Anaerobic production of hydrogen and other chemical products
    Patent number: 8501463
    Abstract: Described herein are methods for producing chemical products by anaerobically fermenting a particular biomass using anaerobic bacteria. Such chemical products include hydrogen and other gases, acetic acid and other volatile organic acids, solvents, solids, and salts of volatile organic acids.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: August 6, 2013
    Assignee: Anaerobe Systems
    Inventors: Marion E. Cox, Laura M. Nondorf, Steven M. Cox
  • Composition comprising corn flour and saccharification enzymes
    Patent number: 8497082
    Abstract: The present invention describes compositions having aqueous corn flour and saccharification enzyme mixtures. In this composition all of the corn flour has particle size of 0.5 mm or less.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: July 30, 2013
    Assignee: Poet Research, Inc.
    Inventor: Stephen M. Lewis
  • strain and bacteriocin
    Patent number: 8470583
    Abstract: The present invention relates to an isolated Lactobacillus paracasei bacterium, deposited as NRRL B-50314, that secretes a bacteriocin. More specifically, the bacteriocin has antibacterial activity against a range of Gram-positive bacteria, including but not limited to Listeria monocytogenes, Staphylococcus aureus, Enterococcus faecalis, and other Lactobacillus species. Additionally, the bacteriocin has antibacterial activity against methicillin resistant Staphylococcus aureus.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: June 25, 2013
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventors: Siqing Liu, Kenneth M. Bischoff, Brian J. Wilkinson
  • Composition comprising raw starch for the production of ethanol
    Patent number: 8470550
    Abstract: Disclosed herein are compositions for producing ethanol, which compositions comprise raw starch and amylase enzymes.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: June 25, 2013
    Assignee: Poet Research, Inc.
    Inventor: Stephen M. Lewis
  • Dynamic thermoresponsive nanoparticles for stabilization of enzymes at high temperatures
    Patent number: 8460907
    Abstract: The present invention provides a thermoresponsive nanoparticle useful for the stabilization of enzymes in environments having a temperature greater than thirty degrees Centigrade. The thermoresponsive nanoparticle has (a) a functionalized enzyme conjugate having one or more enzymes or biological catalysts, the enzymes or biological catalysts are modified with palmitic acid N-hydroxysuccinimide ester and acrylic acid N-hydroxysuccinimide ester, and (b) a thermally responsive polymer, wherein the functionalized enzyme conjugate is encapsulated within the thermally responsive polymer. A nanocatalyst is provided that has one or more proteins. The proteins are covalently immobilized and encapsulated within a thermally responsive polymer shell. The proteins are one or more enzymes or biological catalysts. A method for protecting the proteins is also set forth.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: June 11, 2013
    Assignee: ICx-Agentase
    Inventors: Jeremy P. Walker, Anna M. Leech
  • Liquid tissue preparation from histopathologically processed biological samples, tissues and cells
    Patent number: 8455215
    Abstract: The current invention provides a method for directly converting histopathologically processed biological samples, tissues, and cells into a multi-use biomolecule lysate. This method allows for simultaneous extraction, isolation, solubilization, and storage of all biomolecules contained within the histopathologically processed biological sample, thereby forming a representative library of said sample. This multi-use biomolecule lysate is dilutable, soluble, capable of being fractionated, and used in any number of subsequent experiments.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: June 4, 2013
    Assignee: Expression Pathology, Inc.
    Inventors: Marlene M. Darfler, David B. Krizman
  • Method and compositions for improving animal health
    Patent number: 8455005
    Abstract: Products as well as methods for reducing plaque in a domestic animal are provided. The product comprises retorted milk.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: June 4, 2013
    Assignee: Nestec S.A.
    Inventors: Carolyn Jean Cupp, Gerardo Perez-Camargo
  • Formulation and delivery of subspecies and in combination for broadspectrum activity and management of resistance to biological mosquito larvicides
    Patent number: 8454983
    Abstract: A method for controlling Dipteran larvae or a method for inhibiting the development of larvicidal resistance, controlling resistant populations and reducing resistance levels in Diptera by introducing a larvicidally-effective amount of a combination of a strain of Bacillus thuringiensis subspecies israelensis and a strain of Bacillus sphaericus into an environment containing Dipteran larvae; and a composition of the combination are disclosed. Preferably both strains are non-genetically modified.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: June 4, 2013
    Assignee: Valent BioSciences Corporation
    Inventors: Peter DeChant, Bala N. Devisetty
  • Methods for determining chemotherapeutic agents targeting alpha-glucan pathways and uses thereof
    Patent number: 8455214
    Abstract: The present invention provides methods for determining a putative antibacterial, the methods comprising determining whether the putative antibacterial inhibits GlgE or Rv3032. The present invention also provides the antibacterial, the pharmaceutical composition and the method of making the antibacterial as well as a method of treating a subject infected with a bacterial comprising administration of the antibacterial.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: June 4, 2013
    Assignees: Albert Einstein College of Medicine of Yeshiva University, Plant Bioscience Limited
    Inventors: William R. Jacobs, Jr., Rainer Kalscheuer, Stephen Bornemann, Karl Syson