Abstract: This invention provides orthopedic cement compositions, containing calcium phosphate component, an anion-donating accelerator to promote rapid setting, and a calcium aluminate component. Further provided are methods for orthopedic repair, including placing the cement at said surgical site by applying low shearing force to said cement to initiate flow.

Abstract: Systems and methods for radiographic imaging of tissue using a radio-opaque imaging agent that in one embodiment accumulates intracellularly in tissue in proportion to its functional, or physiological, activity. In one embodiment, the imaging agent is a cell membrane-permeable, radio-opaque, high affinity ligand for an intracellular target. The imaging agent is administered to a patient, and after an accumulation interval, radiographic images are acquired. The imaging agent preferentially accumulates in certain types of tissue and increases its radio-opacity. The tissue being examined is transilluminated by X-ray beams with preselected different mean energy spectra, and a separate radiographic image is acquired during transillumination by each beam. An image processing system may perform a weighted combination of the acquired images to produce a single displayed image. The system and method thus provides a functional image displayed with the anatomical detail and spatial resolution of a radiographic image.

Abstract: The present invention provides an antialopecia agent which is a drug for protecting, reducing or preventing alopecia frequently occurring as the side effect of anticancer agents, wherein the drug inflicts neither any pain nor unpleasantness on patients under the treatment with anticancer agents and has a high safety; and foods or beverages containing this antialopecia agent. The antialopecia agent of the present invention is characterized by containing oolong tea extract as the active ingredient.

Abstract: The present invention provides therapeutic formulations for solutions of &Dgr;9-tetrahydrocannabinol (&Dgr;9 THC) to be delivered by metered dose inhalers. The formulations, which use, non-CFC propellants, provide a stable aerosol-deliverable source of &Dgr;9 THC for the treatment of various medical conditions, such as: nausea and vomiting associated with chemotherapy-muscle spasticity; pain; anorexia associated with AIDS wasting syndrome, epilepsy; glaucoma; bronchial asthma; and mood disorders.

Abstract: A method for denaturing allergens with an effective amount of a rare earth metal salt.

Abstract: A composition for the treatment of skin consists essentially of a carboxylated, acidic amino acid obtained by acidifying an acidic amino acid with a carboxylic acid. The resultant material, which is also referred to as a tricarboxylic acid or an amino fruit acid, has significant benefit for the treatment of a number of skin conditions. In addition, the composition of the present invention is very noncaustic to skin, even when employed at a pH as low as 0.5. Also disclosed herein are therapeutic methods and compositions which employ the carboxylated acidic amino acids.

Abstract: A composition, comprising, in a physiologically acceptable medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of caring for the skin, in particular of the face, and more especially for treating, that is to say decreasing, erasing and/or smoothing out, wrinkles and/or fine lines of the skin.

Abstract: A bioconjugate including a nanoparticle covalently linked to a biological vector molecule. The nanoparticle is a generally radioactive metal ion and most typically a metal sulfide or metal oxide. The biological vector molecule is typically a monoclonal antibody or fragment of a monoclonal antibody or a peptide having a known affinity to cancer cells. One or more additional, different biological moieties may be covalently linked to the nanoparticle in addition to the biological vector molecule to enhance its activity. The bioconjugate of the present invention has utility as an effective radiopharmaceutical to deliver a radiolabel in tumor treatment.

Abstract: The use of oxathiazolones of formula is described R1 is phenyl unsubstituted or substituted by one or more C1-C5 alkyl, hydroxyl, halogen substituents or by a 1,3,4-oxathiazol-2-one radical. in the antimicrobial treatment of surfaces. The compounds exhibit a pronounced action against pathogenic gram-positive and gram-negative bacteria, and also against yeasts and moulds.

Abstract: A nanoemulsion, the oily globules of which have a number-average size of less than 100 nm, comprising a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from esters of a fatty acid and of a sugar and ethers of a fatty alcohol and of a sugar, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The nanoemulsion may be used for cosmetics and dermatological applications, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract: Linear extended polymeric paramagnetic chelates for use as MRI contrast agents are synthesized by conjugating DTPA chelator moieties to higher than 90% of the monomer residues of the polyamino acid backbone chain. The resulting polymer can be labeled with Gd, since each chelator moiety holds a Gd ion, and the resulting conformation is of an unfolded, extended linear type, capable of entering small pores and moving around obstacles in the extracellular space of tissues. The efficient production of these extended polymers is critical for the application of such contrast agents to medical imaging. One such agent is a reptating polymer containing technetium-99.

Abstract: The present invention refers to a process for stabilizing LAA in an aqueous medium, which includes the step of contacting the LAA with at least one-compound capable of forming hydrogen bridges with the LAA. In another aspect, the invention relates to a stable aqueous LAA composition which includes, in addition to the ascorbic acid, at least one compound which is linked to the LAA by hydrogen bridges, and to a process for preparing it. The present invention further relates to an emulsion including, in its aqueous phase, at least one compound linked to levogyre ascorbic acid (LAA) by hydrogen bridges. Further according to the present invention a vitamin product is provided, in which a stable LAA composition as described above is contained in organic envelopes which enable a gradual and prolonged release of the LAA into the organism. The vitamin product may further include a compound capable of stimulating the metabolism of the fibroblasts.

Abstract: This invention comprises low residue cosmetic compositions (especially underarm products) which are made by combining an active ingredient; a silicone gel material itself comprising an elastomer composition; and at least one selected surfactant having an HLB value in the range of 8-16. The compositions of this invention exhibit reduced or eliminated film formation when applied to the skin and increased availABILity of the active ingredient.

Abstract: The present invention relates to a cosmetic or pharmaceutical composition for topical application to the skin afflicted with rosacea and treated with a retinoid. The composition for treating rosacea comprises an anti-irritating component and several other components for treating rosacea. The other components form a mixture of a salicylic acid, a phytosphingosine, green tea, hinokitiol, gorgonian extract, and polysaccharide. The invention also provides a method for decreasing the irritation on the skin caused by the heightened sensitivity experienced by skin suffering from rosacea. The other components are effective in treating the rosacea condition, but particularly, in treating the telangiectasic symptom of rosacea.

Abstract: A process for making technical di/triglyceride mixtures involving: (a) providing a vegetable oil; and (b) partially transesterifying the vegetable oil by reacting it with a component selected from the group consisting of a mixture of glycerol and a fatty acid corresponding to formula I: R1COOH  (I) wherein R1CO is an acyl group having from 6 to 10 carbon atoms, a mixture of glycerol and a methyl ester of the fatty acid of formula I, and a triglyceride based on the fatty acid of formula I.

Abstract: The present invention discloses a topical composition consisting of combinations of mineral oil, vegetable shortening, vitamin E, purified water and other ingredients to form useful therapeutic, dermatological, pharmaceutical, medical or cosmetic compositions for treatment of skin maladies and disorders, namely eczema.

Abstract: A composition and method for lubricating and protecting the oral cavity generally and specifically the teeth, gums and tongue using a flavored petrolatum. In the preferred embodiment, the composition contains about 96%-98% (w/w) of petrolatum and about 2%-4% (w/w) of flavoring. The composition is liberally applied to the affected areas of the oral cavity to lubricate and protect those areas during dental or medical procedures having an aesthetically pleasing flavor without leaving an undesirable aftertaste.

Abstract: The invention relates to a collagen product containing collagen of marine origin with a low odor. The collagen product includes one or more collagens or derivatives thereof, including hydrolyzates, with a low odor, at least part of the collagen or the derivatives being of marine origin and having been subjected to a deodorization treatment, particularly with an oxidizing substance such as a sulfite, hydrogen peroxide or ozone, at any stage of the manufacture of the collagen product. The invention also makes it possible to improve the mechanical properties and to use this low-odor collagen product in cosmetic or pharmaceutical products.

Abstract: Powders treated with silicones represented by the following formula (1): R1aR2bR3cSiO(4−a−b−c)/2  (1) wherein R1, R2, R3 a, b and c are as defined herein, are suitable for use in cosmetic materials.

Abstract: The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (1) in which X is —O—, —S— or —NR3; R1 represents in particular a hydrogen atom or a C114 C40 alkyl radical; R2 represents in particular a hydrogen atom or an optionally substituted alkyl radical; R3 represents a hydrogen atom or an alkyl radical; R4 represents a hydrogen atom or a radical such as NH2, OH, SH, —CHOHCH3, —CONH2; n is a number greater than 1 such that the poly-aminoacid derivative molecular weight ranges between 200 and 200000. The invention also concerns the use of said derivatives for keratinous fibre strengthening and care.