Abstract: A voltage driver can be operated to power an electrowetting lens of an eye-implantable or eye-mountable device. The voltage driver includes a first charge pump that outputs a first voltage having a first polarity and a second charge pump that outputs a second voltage having a second polarity, where the second polarity is an opposite polarity of the first polarity. The voltage driver can be operated to charge the electrowetting lens by coupling the first charge pump to the electrowetting lens and, after charging the electrowetting lens, discharge the electrowetting lens by coupling the second charge pump to the electrowetting lens. In operation, charging and discharging the electrowetting lens adjusts an optical power of the electrowetting lens and can thus adjust an optical power available for vision when the electrowetting lens is implanted in or mounted on an eye.

Abstract: A replacement heart valve assembly has a stent frame and a replacement valve. The replacement valve has a plurality of leaflets and a valve frame. The leaflets are attached to the valve frame. Further, the assembly has a plurality of suspension struts attached to the stent frame and the valve frame. The valve frame is suspended within the stent frame via the suspension struts. In some embodiments, the assembly further has a sealing member attached to the stent frame to prevent leakage around the replacement heart valve assembly.

Abstract: A device for improving the function of a heart valve comprises a first loop-shaped support, which is configured to abut a first side of the heart valve. A first flange unit is may be configured as a fabric sleeve covering the loop-shaped support. A portion of the fabric sleeve forms a flange that is attached to the annulus when said first loop-shaped support is abutting said heart valve. The flange is provideable by folding at least a portion of said sleeve over itself for forming a double layer of opposing fabrics thereof, such that said sleeve comprises a flange portion extending from said first loop-shaped support configured to overlap a surface of and form a collar around, at least a portion of said annulus.

Abstract: The present disclosure provides an endoprosthesis where a preferably polymeric coating has a number of surface features such as protrusions or textures that are arranged in a micropattern. The endoprosthesis optionally has an expanded state and a contracted state, and in some cases includes a stent with a polymeric coating attached to an outer surface of the stent. The stent may have an inner surface defining a lumen, an outer surface, and a stent thickness defined between the inner surface and outer surface. The stent may comprise a plurality of surface textures extending from the stent surfaces, wherein the textures are arranged in a macropattern.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems and methods that include a self-expanding endoprosthesis having a reduced configuration and a deployed configuration. The self-expanding endoprosthesis may include a self-expanding stent element having an enlarged diameter and a graft component attached to at least a portion of the self-expanding stent element and having an enlarged diameter less than the enlarged diameter of the self-expanding stent element in the deployed configuration.

Abstract: An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including one or more interleukins, and an outer portion including an immunomodulatory stimulant such as an antigen.

Abstract: A foldable intraocular lens, made from a foldable soft material, for implantation in a ciliary sulcus of an eye having an iris, is provided with an optically active lens part having an optical axis and at least four haptics unitary with the optically active lens part and uniformly spaced about a periphery of the optically active lens part. The optically active lens part having a non-convex rim between any two neighboring haptics being free from surface irregularities that interfere with the iris. Each haptic comprising a closed loop, and a shoulder connecting the loop with the optically active lens part, the haptic loops being elastically deformable in a plane perpendicular to the optical axis of the optically active lens part in a direction toward the optically active lens part.

Abstract: A stent graft assembly with a sacrificial entry/exit port is disclosed. A first sacrificial port extends from a first branch stent graft and is configured to face a second branch stent graft when the stent graft assembly is in an expanded configuration. Likewise, a second sacrificial port can be provided, and can extend from the second branch stent graft and configured to face the first branch stent graft when the stent graft assembly is in the expanded configuration. The first and optional second sacrificial ports are configured to transition between (i) an open configuration to enable a guidewire or other surgical tool to pass from the first branch stent graft to the second branch stent graft while bypassing the main body, and (ii) a closed configuration to inhibit blood flow therethrough.

Abstract: The present invention relates to an intraocular lens comprising: a primary lens (1000) having a first focal length, a first surface, and a second surface; a secondary lens (2000) having at least two focal lengths, a first surface (2100), and a second surface (2200), wherein the second surface (2200) of the secondary lens (2000) conforms to the first surface of the primary lens (1000), while the secondary lens (2000) is attached to the primary lens (1000) by peelable adhesive forces over substantially its second surface (2200).

Abstract: An ophthalmic device includes an optic and a haptic structure coupled with the optic. The optic includes an optic axis. The haptic structure is coupled to the optic. The haptic structure retains the ophthalmic device within a capsular bag of a patient's eye. At least a portion of the haptic structure has a cross-section and a peripheral surface forming an outer periphery of a portion of the cross-section. At least a portion of the peripheral surface contacts the capsular bag and is smoothly curved.

Abstract: An accommodating intraocular lens (IOL) can be implanted either alone or as part of a two-part lens assembly. The IOL comprises an optic, a flexible membrane and a peripheral edge coupling the optic and the flexible membrane. The peripheral edge comprises an external circumferential surface having a height and a force transmitting area defined along a portion of the height of the external circumferential surface. A closed volume spaces apart the optic and the flexible membrane. The optic is axially displaced and the flexible membrane changes in curvature about a central axis when a radial compressive force is applied to the force transmitting area. A volume defined by the closed volume remains fixed when the optic is axially displaced and the flexible membrane changes in curvature and/or when the radial compressive force is applied to the force transmitting area.

Abstract: A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame has a supra-annular region, a subannular region, and a transannular region therebetween. The flow control component is mounted to the outer frame such that at least a portion of the flow control component is disposed in the transannular region. The prosthetic valve has a delivery configuration for side-delivery via a delivery catheter and is expandable when the prosthetic valve is released from the delivery catheter. The subannular region of the outer frame is disposable in a first configuration as the prosthetic valve is seated in an annulus of a native heart valve and is transitionable to a second configuration after the prosthetic valve is seated in the annulus of the native heart valve.

Abstract: A stent having an inner surface and an outer surface, at least a portion of the outer surface of the stent comprising a dissolvable adhesive polymer or a degradable adhesive polymer disposed on at least a portion of the outer surface of the stent, the adhesive is activated by exposure to an aqueous environment, the dissolvable adhesive polymer dissolves over time in an aqueous environment, the dissolvable adhesive polymer or the degradable adhesive polymer has a surface tack of about 2 psi to about 14 psi.

Abstract: An ophthalmic implant for drug delivery. The implant includes a primary intracapsular device coupled to a secondary device, wherein, when implanted in a patient's eye, the primary intracapsular device is held in place by the patient's capsular bag and the secondary device is held in place by the primary intracapsular device. The implant may be inserted in the eye by injecting the primary intracapsular device into the eye either before or after attaching the secondary device to the primary intracapsular device, and subsequently positioning the joined secondary device and primary intracapsular device with the primary intracapsular device held in place by the patient's capsular bag and the secondary device held in place by the primary intracapsular device. The secondary device may be designed to hold a tertiary device that can be implanted and attached at the time of surgery or anytime postoperatively.

Abstract: An implant has a support structure (e.g., alloplastic) such as a stent or a scaffold, and a functional element (e.g., a heart valve) including or made of bacterial cellulose. At least a part of the support structure is embedded in the functional element or in an extension thereof so as to connect the functional element to the structural element via positive fit.

Abstract: An accommodating intraocular lens implant includes an anterior floating lens unit, a posterior lens unit, an anterior rim complex disposed such that the anterior floating lens unit is movable toward and away from the anterior rim complex. A plurality of levers are in jointed connection with: the anterior floating lens unit at respective first longitudinal sites along the levers, the anterior rim complex at respective second longitudinal sites along the levers, and the posterior lens unit at respective third longitudinal sites along the levers. The respective second longitudinal sites are longitudinally between the respective first and the respective third longitudinal sites. The levers are arranged (a) such that the third longitudinal sites serve as respective fulcrums for the plurality of levers, and (b) to move the anterior floating lens unit toward and away from the anterior rim complex, in the anterior-posterior direction. Other embodiments are also described.

Abstract: An artificial valve for implantation in a mammal body, in or adjacent to a mammal blood vessel, the artificial valve comprising a casing and a closing mechanism, with at least part of said closing mechanism being a first moving part adapted to make movements relative to said casing. The movements are movements to assume a fully open and a fully closed position for opening and closing, respectively, the blood flow through said blood vessel, as well as at least one position in between said fully open and fully closed positions. The first moving part is adapted to receive energy for at least one of its movements at least in part from an energy device which is also comprised in the artificial valve and arranged to be placed external to said blood vessel.

Abstract: A medical device is disclosed that reinforces weakened or degenerated areas of at least a portion of a leaflet (24) Of the heart valve. Function of a heart valve is thus improved. The medical device comprises at least a first partly flexible leaflet reinforcement patch (30) having an extension between an inner section (34) and an outer section (32), wherein said outer section (32) is configured to be oriented towards said annulus,and said inner section (34) is configured to be oriented towards said inner section of said valve tissue, and at least a portion of said inner section (34) of said flexible leaflet reinforcement patch (32) having at least one of said plurality of leaflets (24) in juxtaposition to said portion of said inner section (34), and said portion of said inner section (34) being positioned to provide reinforcement to said plurality of leaflets (24).

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include an implantable medical device and a constraining line conduit arranged around a circumference of the implantable medical device. The apparatuses, systems, and methods may also include a constraining line arranged through the constraining line conduit.

Abstract: The present technology is directed to an adjustable power intraocular lens comprising a container, an optical fluid in the container, and a transport substance in solution with the optical fluid. The container has an optical component and a peripheral component extending around at least a portion of the optical component. The optical component has an anterior optical element, a posterior optical element, and a fluid chamber having a chamber volume between the anterior optical element and the posterior optical element. The transport substance is configured to pass through the container. The adjustable power intraocular lens further comprises volume control elements in the container. The volume control elements are configured to be activated by a non-invasive energy and upon activation release the transport substance into the optical fluid to decrease the chamber volume and/or absorb the transport substance from the optical fluid to increase the chamber volume.