Abstract: A prosthetic heart valve can include a radially collapsible and expandable annular frame having a plurality of struts defining openings. The prosthetic heart valve can further include a plurality of leaflets that regulate the flow of blood through the frame. The prosthetic heart valve can also include a sealing member mounted on the frame and having an inner layer and an outer layer. At least the outer layer is mounted on the outside of the frame, and the inner layer covers at least the openings in the frame between adjacent cusp portions of adjacent leaflets and the inner layer does not cover one or more openings in the frame at locations facing the outflow surfaces of the leaflets to permit retrograde blood to flow through the one or more uncovered openings in the frame and into space between the outer layer and the frame.

Abstract: The present invention relates to an endoluminal device for implantation in a body lumen, such as a pancreatic duct. The device is provided with a distal end region having greater flexibility than that of a medial region of the device.

Abstract: In certain embodiments, an ophthalmic lens includes an optic having an anterior surface, a posterior surface, and an optical axis. At least one of the anterior surface and the posterior surface includes a first zone extending from the optical axis to a first radial boundary and a second zone extending from the first radial boundary to the edge of the optic. The first zone includes an inner region and an outer region separated by a phase shift feature, the phase shift comprising a ridge extending outwardly from the inner region and the outer region.

Abstract: A prosthetic heart valve includes a valve frame (2), on which a plurality of valve leaflets (8) are fixed, and a fastening area for fastening in a blood vessel, which axially adjoins the valve frame (2). A stabilizing ring (14) is arranged in the fastening area. The stabilizing ring (14) defines a predetermined shape and a predetermined diameter of the fastening area and has at least one predetermined expansion point (22), whereby it is possible to expand the stabilizing ring (14) by an action of radial force on an inner circumference.

Abstract: The invention relates to an apparatus for changing the refractive power of the cornea (1), in particular for correcting hyperopia or presbyopia, exhibiting injection means (13, 15) having at least one hollow needle (15) for injecting at least one optically transparent filling material having a predetermined refractive index into an intrastromal corneal pocket (7), characterized by a controllable injection drive (17) that is coupled at least indirectly to the injection means (13, 15) and is designed for changing an amount, to be injected, of the at least one filling material; a device for optical coherence tomography (OCT) (19) that is designed for monitoring the area of the corneal pocket (7) by means of measurement of depth profiles of the cornea (1) on a repeatedly cycled-through scan pattern; and a computing unit (21) that is designed and/or configured to determine from the measurement data of the OCT device (19) at least the radius of curvature of the front (3) of the cornea (1) keeping pace temporally wi

Abstract: An accommodating intraocular lens device is provided. The accommodating intraocular lens device comprises a base assembly and a power lens. The base assembly comprises a first open end, a second end coupled to a base lens, and a haptic surrounding a central cavity. The haptic may comprise an outer periphery, an inner surface and a height between a first edge and a second edge. The power lens is configured to fit within the central cavity. The power lens may comprise a first side, a second side, a peripheral edge coupling the first and second sides, and a closed cavity configured to house a fluid. The first side of the power lens may be positioned at a predetermined distance from the first edge of the haptic.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with fold(s) extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between the inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes. A third lens component coupled to the first or second component provides additional optical power.

Abstract: Medical procedures and devices suitable for reducing the risk of embolic cerebrovascular events, including but not limited to cardioembolic stroke, that result from emboli entering the right or left common carotid artery. The invention uses a combination of intracranial flow diverting stent technologies and carotid stent technologies to achieve clinical objectives of embolic stroke prevention without thromboembolic and/or vascular stenosis complication. Such a stent has struts that generate high radial forces for endothelial apposition, and a mesh with interstices sufficiently small to prevent clinically significant-sized embolic material from passing therethrough from the common carotid artery into the internal carotid artery, but sufficiently large to enable blood and small clinically insignificant-sized embolic material to pass therethrough from the common carotid artery into the internal carotid artery.

Abstract: A device includes an annular, elastic band having a rectangular cross section. A foil band is affixed to a surface of the elastic band. A contiguous fabric sheath is configured to encase the elastic band and foil band.

Abstract: A device for implantation into an eye for supporting an intraocular lens during and following surgery. The device may include a ring and at least one support. The ring may have an open portion defined between a first eyelet on a first end and a second eyelet on a second end, the ring being radially compressible. The at least one support may be defined internally of the ring and have a position on which a lens is nestably engaged with the at least one support above a tear in the capsular bag of the eye.

Abstract: The invention relates to a neovaginal prosthesis formed by an essentially cylindrical hollow main body comprising a closed upper end and an open lower end, and a securing plate intended to connect to the lower end of the main body.

Abstract: Intraocular lenses (IOLs) that improve lens stability by, for example, increasing anterior-posterior stiffness of the IOL, increasing anterior-posterior dimensions of the IOL and/or increasing contact area with the equator of the bag to resist movement of the IOL as the bag collapses over time. These IOLs may be non-modular (single component) or modular (multiple component). In modular embodiments, the IOL system may include intraocular base and optic components, which, when combined, form a modular IOL.

Abstract: A stent for use in hollow tubular organs, comprising a continuous tubular or cylindrical inner cavity which is delimited by a wall. The wall is formed in a tubular or cylindrical manner about an axis which runs in a longitudinal direction and has a structure which surrounds the wall. The structure is made of elements, and the elements are made of loops which are arranged about the longitudinal axis in the radial direction. The elements are rigidly connected via connection points such that a tubular or cylindrical single-piece wall structure is produced, and the stent has acute angles in the region of the connection points.

Abstract: A stent comprising a tubular member, a lumen extending through the tubular member, a first retention structure and a second retention structure at opposite ends of the tubular member. The first retention structure comprises multiple coils and a removable anti-coiling material over the multiple coils of the first retention structure to present the multiple coils as an elongated extension of the tubular member, whereupon removal of the removable anti-coiling material at least one of the multiple coils of the first retention structure is presented and any excess coils can be trimmed.

Abstract: Example medical stents are disclosed. An example stent includes a tubular framework including an inner surface, an outer surface and a lumen extending therethrough. Additionally, the stent includes a tissue ingrowth scaffold extending along a portion of the outer surface of the tubular framework, wherein the tissue ingrowth scaffold is spaced radially away from the outer surface of the tubular framework to define an expansion cavity therebetween and wherein the tissue ingrowth scaffold permits tissue ingrowth along a portion thereof. Further, the stent includes an expandable member positioned within at least a portion of the expansion cavity.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, via a device implanted in a mammal, sensing a ciliary muscle movement and/or force and/or converting the ciliary muscle movement and/or force to a signal and/or a predetermined form of power.

Abstract: The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance devices for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, and one or more of the following: transseptal sheath, anchor delivery catheter, implant delivery catheter, and clip delivery catheter; and methods for transcatheter implantation of a coaptation element across a heart valve.

Abstract: A multifocal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffractive orders corresponding a range of vision between near and distance vision. The constructive interference produces a near focus, a distance focus corresponding to the base power of the ophthalmic lens, and an intermediate focus between the near focus and the distance focus.

Abstract: A multifocal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffractive orders corresponding a range of vision between near and distance vision. The constructive interference produces a near focus, a distance focus corresponding to the base power of the ophthalmic lens, and an intermediate focus between the near focus and the distance focus. A diffraction efficiency of at least one of the diffractive orders is suppressed to less than ten percent.