Patents Examined by Louisa Lao
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Patent number: 7563923Abstract: The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2-oxo-2{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid.Type: GrantFiled: September 19, 2006Date of Patent: July 21, 2009Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Vinod Kumar Kansal, Brijnath P. Chaurasia, Anand Prakash Tiwari
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Patent number: 7491781Abstract: A solid, hydrocarbon-insoluble, catalyst component useful in polymerizing olefins containing magnesium, titanium, and halogen further contains an internal electron donor comprising a compound containing electron donating substituents with a structure: wherein D1 and D2 are selected individually from and R, R2, R3, R4, R5, R6, and R7 individually are hydrocarbon or substituted hydrocarbon groups containing 1 to 20 carbon atoms and R2, R3, R4, R6, and R7 may be hydrogen; R4 may be —NR2; and wherein groups R1 and R2, R2 and R3, R3 and R4, R3 and R5, and groups R6 and R7 may be joined to form a cyclic structure.Type: GrantFiled: March 1, 2006Date of Patent: February 17, 2009Assignee: INEOS USA LLCInventors: Roger Uhrhammer, John P. Lalka
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Patent number: 7485745Abstract: The invention relates to mixtures composed of dialkylphosphinic esters and of further components, which comprise A) from 98 to 100% by weight of monocarboxy-functionalized dialkylphosphinic esters of the formula (I) in which R1, R2, R3, R4, R5, R6, and R7 are identical or different and, independently of one another, are H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, and/or phenyl, Y is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, 2-hydroxyethyl, 2,3-dihydroxypropyl, 2-hydroxypropyl, 3-hydroxypropyl, 4-hydroxybutyl, 3-hydroxybutyl, 2-hydroxybutyl, and/or 6-hydroxyhexyl, allyl, and/or glycerol, X is H, Li, Na, K or NH4, or X is defined as for Y, and then X and Y are two identical radicals or two different radicals of the above organic radicals, and B) from 0 to 2% by weight of halogens, where the entirety of the components always amounts to 100% by weight.Type: GrantFiled: March 6, 2007Date of Patent: February 3, 2009Assignee: Clariant International Ltd.Inventors: Wiebke Maas, Werner Krause, Harald Bauer
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Patent number: 7482485Abstract: A major object of the invention is to provide such a method for extracting slurry that is not inhibited in extraction of slurry by a released and accumulated matter or a solid matter sedimented and accumulated at the bottom of the vessel. The invention relates to a method for extracting slurry by extracting slurry from an agitation vessel having a bottom face and a side wall and housing the slurry, characterized in that the slurry is extracted from an open end of a slurry extraction tube provided at the side wall of the agitation vessel. More preferably, a normal line direction of a surface of the open end is in a direction of an angle with respect to a downstream direction of a flow of the slurry caused by agitation of 0° or more and less than 90°.Type: GrantFiled: March 3, 2005Date of Patent: January 27, 2009Assignee: Teijin LimitedInventors: Tetsuya Chikatsune, Hiroshi Horiuchi
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Patent number: 7476762Abstract: Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided: or a pharmaceutically acceptable salt thereof, wherein, R1-R7 are defined herein. Also provided are methods for preparing compounds of the following structure: wherein, R9, m, n, p, r, and s are defined herein.Type: GrantFiled: April 19, 2007Date of Patent: January 13, 2009Assignee: WyethInventors: Asaf Ragim Alimardanov, Jean Schmid, Jay Thomas Afragola, Gulnaz Khafizova
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Patent number: 7476759Abstract: Compounds of Formula (I): wherein: R1 is optionally substituted —C4-12 alkyl, —C2-10alkylcycloalkyl, —C2-6alkylheterocycloalkyl, —C2-6alkylaryl, optionally substituted 5- or 6-membered aryl or heteroaryl with the proviso that R2 in not pyridinyl; Z is a bond, CH2, O, S, SO, SO2, NR4, OCR4R5 or CR4R5O; or Z, R1 and Q together form an optionally substituted fused tricyclic group; Q is an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X is COR3; R2 is CONH2, CO2H, CO2R7, SO2R7 or SO2NR8R9, with the proviso that R2 is not CO2R7, when X is CONH2; R3 is OR6 or NR8R9; R4 and R5 each independently is H, C1-6 alkyl or C1-4 alkylaryl; R6 is H or C1-6 alkyl; R7 is C1-6 alkyl; and R8 and R9 each independently is H or C1-6 alkyl; or R8 and R9 together with the nitrogen atom to which they are attached form a 5- or 6-membered ring which may optionally include 1 or more further heteroatoms selected from O, S and N; or physiologically functional derivatives thereof, with the proviso that formula (I) cType: GrantFiled: August 12, 2004Date of Patent: January 13, 2009Assignee: Glaxo Group LimitedInventors: Ian Holmes, Stephen Paul Watson
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Patent number: 7473796Abstract: New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the ?-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.Type: GrantFiled: July 16, 2007Date of Patent: January 6, 2009Assignee: Immunogen Inc.Inventors: Ravi V. J. Chari, Wayne C. Widdison
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Patent number: 7470812Abstract: The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2-oxo-2{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid.Type: GrantFiled: August 21, 2007Date of Patent: December 30, 2008Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Vinod Kumar Kansal, Brijnath P. Chaurasia, Anand Prakash Tiwari
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Patent number: 7470809Abstract: The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis(2-methoxyethoxy)aluminate (Red-Al) to the corresponding alcohol; d) chlorinating the alcohol obtained in step c); e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2): f1) reacting the product obtained in step d) with sodium cyanide; f2) hydrolysing the product obtained in step f1).Type: GrantFiled: August 26, 2005Date of Patent: December 30, 2008Assignee: Janssen Pharmaceutica N.V.Inventors: Michel Joseph Maurice André Guillaume, Yolande Lydia Lang, Armin Roessler, Lars Ulmer, Stefan Marcel Herman Leurs, Dirk De Smaele
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Patent number: 7470826Abstract: The invention relates to a process for removing and recovering nitrating acid mixtures, in particular nitric acid, sulphuric acid and oxides of nitrogen, from the nitrated crude products occurring in the nitration of nitratable aromatic compounds after the nitrating acid has been separated off, by acidic scrubbing by means of a multistage extraction process, the extraction process comprising a cross-current extraction with downstream countercurrent extraction. The process permits essentially complete recovery of the abovementioned acids, including the oxides of nitrogen, in high concentrations, so that they can be recycled to the nitration and no longer pollute the wastewater.Type: GrantFiled: October 16, 2006Date of Patent: December 30, 2008Assignee: Josef Meissner GmbH & Co. KGInventors: Heinrich Hermann, Jürgen Gebauer, Peter Konieczny, Mirko Händel
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Patent number: 7468467Abstract: Process for obtaining a hydrofluoroalkane which is purified of organic impurities, according to which the hydrofluoroalkane containing organic impurities is subjected to at least one purification treatment chosen from (a) a treatment with chlorine in the presence of a initiator (b) a reaction with hydrogen fluoride (c) a distillation in which the purified hydrofluoroalkane is removed from the top of the distillation column or from the side (d) an extractive distillation (e) an adsorption onto a solid adsorbent (f) a reaction with a compound containing oxygen, and (g) a reaction with a compound containing oxygen and a gas-phase reaction with a reagent capable of reacting with at least some of the organic impurities, with the exception of a reaction with elemental chlorine.Type: GrantFiled: January 3, 2007Date of Patent: December 23, 2008Assignee: Solvay S.A.Inventors: Vincent Wilmet, Francine Janssens, Lionel Casaubon Seignour, Philippe Krafft, Alain Lambert, Olivier Buyle
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Patent number: 7468456Abstract: An improved process for producing an aromatic carboxylic acid from an aromatic alkyl hydrocarbon is described, wherein the improvement comprises using the same aromatic alkyl hydrocarbon as the azeotropic agent for separation of acetic acid and methyl acetate from water via azeotropic distillation. The process of this invention has considerable advantages over other known processes, particularly in regards to consumption of the azeotropic agent and utilities, formation of undesirable impurities and operating costs.Type: GrantFiled: July 11, 2006Date of Patent: December 23, 2008Assignee: ANT CorporationInventors: Myron Myonkee Lee, Duk-Jun Kwon, Dong-Won Lee, Alexander Jongwon Lee
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Patent number: 7468455Abstract: The invention provides methods, apparatus and chemical systems for making vinyl acetate from ethylene, oxygen, and acetic acid.Type: GrantFiled: October 20, 2005Date of Patent: December 23, 2008Assignees: Velocys, Inc., Celanese International CorporationInventors: Terry Mazanec, Victor J. Johnston, Michael Huckman, Sean P. Fitzgerald, James A. Foster, Daniel Lindley, Anna Lee Tonkovich, Francis P. Daly, Leslie Wade, Tony Hammock, Thomas Yuschak, Bin Yang, Kai Jarosch
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Patent number: 7465826Abstract: The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2-oxo-2{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid.Type: GrantFiled: August 21, 2007Date of Patent: December 16, 2008Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Vinod Kumar Kansal, Brijnath P. Chaurasia, Anand Prakash Tiwari
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Patent number: 7462368Abstract: The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as insulin, to a target.Type: GrantFiled: March 14, 2007Date of Patent: December 9, 2008Assignee: Emisphere Technologies, Inc.Inventors: Satej Bhandarkar, Shingai Majuru, Halina Levchik
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Patent number: 7446220Abstract: The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.Type: GrantFiled: September 19, 2006Date of Patent: November 4, 2008Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Vinod Kumar Kansal, Brijnath P. Chaurasia, V. Govardhan Rao, Anand Prakash Tiwari
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Patent number: 7439390Abstract: The present invention relates to a sequence for the preparation of amino acids, for example alpha-amino acids, in particular methionine, by making use of an amidocarbonylation reaction in the presence of a cobalt carbonyl catalyst and separating the catalyst in the form of a Co(N-amino acid)2 compound.Type: GrantFiled: May 14, 2005Date of Patent: October 21, 2008Assignee: Degussa AGInventors: Martin Hateley, Thomas Häussner, Christoph Weckbecker, Klaus Huthmacher, Dieter Buss
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Patent number: 7435840Abstract: The invention relates to compounds having a structural element of formula (I) in an aromatic hydrocarbon ring, wherein: M represents —Li, —MgX3, (C1-C18-Alkyl)3Sn—, —ZnX3 or —B(O—C1-C4-Alkyl)2; X1 and X2, independent of one another, represent O or N, and C-bound hydrocarbon radicals or heterohydrocarbon radicals are bound to the free bonds of the O and N atoms; group —C?C—, together with C atoms, forms a hydrocarbon aromatic compound and represents X3 Cl, Br or I. The inventive compounds are easily obtained by directly substituting the hydrogen in the ortho position to the P atom with metalation reagents. The metal atoms can then be substituted by a reactive electrophilic compound. The group —P(X1—)(X2—) - - - -(BH3)0,1 can then be converted into a secondary phosphine group. The inventive method enables the production of monophosphines and diphosphines even on a large scale, which are valuable ligands for metal complexes serving as catalysts for, e.g. enantioselective hydrogenations.Type: GrantFiled: December 10, 2004Date of Patent: October 14, 2008Assignee: Solvias AGInventors: Andreas Pfaltz, Matthias Lotz, Marc Schönleber, Benoît Pugin, Martin Kesselgruber, Marc Thommen
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Patent number: 7432403Abstract: The invention relates to cyclopalladated compounds containing bis-diphenyiphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopeptidase families, involved in the development and metastases of malignant tumors, e.g. of the thyroid. An exemplary compound is shown in the figure. The compounds are able te modulate the immunological system due to their action on the enzymes and their interaction with DNA molecules.Type: GrantFiled: August 22, 2003Date of Patent: October 7, 2008Assignee: Fundação De Amparo À Pesquisa Do Estado de São PauloInventors: Antonio Carlos Fávero Caires, Claudia Bincoletto Trindade, Ivarne Luis dos Santos Tersariol
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Patent number: 7427685Abstract: Therapeutic compounds according to one of the structures below are disclosed herein.Type: GrantFiled: October 26, 2006Date of Patent: September 23, 2008Assignee: Allergan, Inc.Inventors: Yariv Donde, Robert M. Burk